Austin Ekeler led the NFL in touchdowns in the 2022 regular season with 18.
Next came Jamaal Williams (17) and Davante Adams (14) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Touchdowns |
|---|---|---|---|---|
| 1 | Austin Ekeler | WSH | RB | 18 |
| 2 | Jamaal Williams | NO | UNK | 17 |
| 3 | Davante Adams | LAR | WR | 14 |
| 4 | Derrick Henry | BAL | RB | 13 |
| 5 | Christian McCaffrey | SF | RB | 13 |
| 6 | Jalen Hurts | PHI | QB | 13 |
| 7 | Nick Chubb | HOU | RB | 13 |
| 8 | Josh Jacobs | GB | RB | 12 |
| 9 | Tony Pollard | TEN | RB | 12 |
| 10 | Ezekiel Elliott | DAL | UNK | 12 |
| 11 | Travis Kelce | KC | TE | 12 |
| 12 | Miles Sanders | DAL | RB | 11 |
| 13 | Stefon Diggs | NE | WR | 11 |
| 14 | A.J. Brown | PHI | WR | 11 |
| 15 | George Kittle | SF | TE | 11 |
| 16 | Najee Harris | LAC | RB | 10 |
| 17 | Dalvin Cook | DAL | UNK | 10 |
| 18 | Saquon Barkley | PHI | RB | 10 |
| 19 | Jerick McKinnon | KC | UNK | 10 |
| 20 | Justin Jefferson | MIN | WR | 9 |
| 21 | Taysom Hill | NO | QB | 9 |
| 22 | Amari Cooper | BUF | UNK | 9 |
| 23 | Ja'Marr Chase | CIN | WR | 9 |
| 24 | Kenneth Walker III | KC | RB | 9 |
| 25 | Joe Mixon | CIN | RB | 9 |