Jonathan Taylor and Austin Ekeler shared the NFL lead in touchdowns in 2021 with 20.
Next came James Conner (18) and Cooper Kupp (16) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Touchdowns |
|---|---|---|---|---|
| 1 | Jonathan Taylor | IND | RB | 20 |
| 2 | Austin Ekeler | WSH | RB | 20 |
| 3 | James Conner | ARI | RB | 18 |
| 4 | Cooper Kupp | SEA | WR | 16 |
| 5 | Joe Mixon | CIN | RB | 16 |
| 6 | Damien Harris | BUF | RB | 15 |
| 7 | Deebo Samuel Sr. | WSH | WR | 14 |
| 8 | Mike Evans | SF | WR | 14 |
| 9 | Ja'Marr Chase | CIN | WR | 13 |
| 10 | Ezekiel Elliott | DAL | UNK | 12 |
| 11 | DK Metcalf | PIT | WR | 12 |
| 12 | Cordarrelle Patterson | PIT | UNK | 11 |
| 13 | Davante Adams | LAR | WR | 11 |
| 14 | Derrick Henry | BAL | RB | 10 |
| 15 | Jalen Hurts | PHI | QB | 10 |
| 16 | Justin Jefferson | MIN | WR | 10 |
| 17 | Stefon Diggs | NE | WR | 10 |
| 18 | Najee Harris | LAC | RB | 10 |
| 19 | Antonio Gibson | NE | RB | 10 |
| 20 | Melvin Gordon III | BAL | UNK | 10 |
| 21 | Aaron Jones Sr. | MIN | RB | 10 |
| 22 | Travis Kelce | KC | TE | 10 |
| 23 | Nick Chubb | HOU | RB | 9 |
| 24 | Alvin Kamara | NO | RB | 9 |
| 25 | Josh Jacobs | GB | RB | 9 |