| 28th Oct 2025 | 18:00 | Constància vs Girona | 2-3 |
| 28th Oct 2025 | 18:00 | Ourense CF vs Real Oviedo | 4-2 |
| 28th Oct 2025 | 18:00 | Atlético Tordesillas vs Burgos | 1-2 |
| 28th Oct 2025 | 18:30 | UCAM Murcia vs Cádiz | 1-3 |
| 28th Oct 2025 | 18:30 | SD Logroñés vs Racing Santander | 0-4 |
| 28th Oct 2025 | 18:30 | Langreo vs Racing Ferrol | 0-0 |
| 28th Oct 2025 | 19:00 | Maracena vs Valencia | 0-5 |
| 28th Oct 2025 | 19:00 | Inter de Valdemoro vs Getafe | 0-11 |
| 28th Oct 2025 | 19:00 | Roda vs Granada | 1-5 |
| 28th Oct 2025 | 19:00 | UD San Fernando vs Albacete | 0-3 |
| 28th Oct 2025 | 19:00 | Tropezón vs Cultural Leonesa | 1-3 |
| 28th Oct 2025 | 19:00 | Guadalajara vs Cacereño | 2-1 |
| 28th Oct 2025 | 19:00 | Rayo Majadahonda vs Talavera CF | 1-4 |
| 28th Oct 2025 | 19:30 | Utebo FC vs Huesca | 0-3 |
| 28th Oct 2025 | 19:30 | RSD Alcalá vs Tenerife | 0-4 |
| 28th Oct 2025 | 20:00 | Toledo vs Sevilla | 1-4 |
| 28th Oct 2025 | 20:00 | Negreira vs Real Sociedad | 0-3 |
| 28th Oct 2025 | 20:00 | Extremadura 1924 vs Las Palmas | 3-1 |
| 29th Oct 2025 | 17:00 | Poblense vs Sabadell | 1-2 |
| 29th Oct 2025 | 18:00 | CE Sant Jordi vs Osasuna | 0-5 |
| 29th Oct 2025 | 18:00 | Los Garres vs Elche | 0-4 |
| 29th Oct 2025 | 18:00 | Mutilvera vs Real Zaragoza | 1-3 |
| 29th Oct 2025 | 18:00 | CD Ebro vs Tarazona | 1-1 |
| 29th Oct 2025 | 18:30 | La Union Atletico vs Ceuta | 0-2 |
| 29th Oct 2025 | 19:00 | Atlètic Sant Just vs Mallorca | 0-2 |
| 29th Oct 2025 | 19:00 | Portugalete vs Real Valladolid | 1-0 |
| 29th Oct 2025 | 19:00 | Azuaga vs Leganés | 1-4 |
| 29th Oct 2025 | 19:00 | Lorca Deportiva vs Almería | 0-2 |
| 29th Oct 2025 | 19:00 | Naxara CD vs SD Eibar | 2-4 |
| 29th Oct 2025 | 19:00 | Caudal vs Sporting Gijón | 0-1 |
| 29th Oct 2025 | 19:00 | Atlético Astorga vs Mirandés | 1-1 |
| 29th Oct 2025 | 19:00 | Cieza vs Córdoba | 1-0 |
| 29th Oct 2025 | 19:00 | Sant Andreu vs Teruel | 2-1 |
| 29th Oct 2025 | 19:00 | Numancia vs Arenas de Getxo | 3-0 |
| 29th Oct 2025 | 19:00 | Navalcarnero vs Merida | 2-1 |
| 29th Oct 2025 | 19:00 | Torrent vs Juventud Torremolinos | 3-1 |
| 29th Oct 2025 | 19:30 | Puente Genil vs FC Cartagena | 0-1 |
| 29th Oct 2025 | 19:30 | UD Ourense vs Pontevedra | 1-1 |
| 29th Oct 2025 | 19:30 | Reddis vs Europa | 2-2 |
| 29th Oct 2025 | 20:00 | Lucena vs Villarreal | 0-6 |
| 29th Oct 2025 | 20:00 | Yuncos vs Rayo Vallecano | 1-6 |
| 29th Oct 2025 | 20:00 | Real Jaén vs Eldense | 1-3 |
| 29th Oct 2025 | 20:00 | Quintanar del Rey vs UD Ibiza | 1-1 |
| 30th Oct 2025 | 18:00 | Puerto de Vega vs Celta de Vigo | 0-2 |
| 30th Oct 2025 | 18:00 | Orihuela vs Levante | 3-4 |
| 30th Oct 2025 | 18:30 | Valle Egüés vs FC Andorra | 1-5 |
| 30th Oct 2025 | 19:00 | Getxo vs Deportivo Alavés | 0-7 |
| 30th Oct 2025 | 19:00 | UD Logroñés vs Ponferradina | 1-3 |
| 30th Oct 2025 | 19:00 | Atlético Baleares vs Gimnàstic Tarragona | 2-0 |
| 30th Oct 2025 | 19:00 | Real Ávila vs Real Avilés | 1-0 |
| 30th Oct 2025 | 20:00 | Palma del Río vs Real Betis | 1-7 |
| 30th Oct 2025 | 20:00 | Atlètic Lleida vs Espanyol | 1-2 |
| 30th Oct 2025 | 20:00 | Samano vs Deportivo La Coruña | 1-5 |
| 30th Oct 2025 | 20:00 | Union Estepona vs Málaga | 1-3 |
| 30th Oct 2025 | 20:00 | Antoniano vs Castellón | 1-0 |
| 30th Oct 2025 | 20:00 | Real Murcia vs Antequera | 1-1 |
| 2nd Dec 2025 | 18:00 | Numancia vs Mallorca | 2-3 |
| 2nd Dec 2025 | 18:00 | CD Ebro vs Osasuna | 3-5 |
| 2nd Dec 2025 | 18:00 | Portugalete vs Deportivo Alavés | 0-3 |
| 2nd Dec 2025 | 18:00 | Racing Ferrol vs Huesca | 0-2 |
| 2nd Dec 2025 | 19:00 | Guadalajara vs Ceuta | 1-0 |
| 2nd Dec 2025 | 20:00 | Navalcarnero vs Getafe | 2-3 |
| 3rd Dec 2025 | 19:00 | Eldense vs Almería | 2-1 |
| 3rd Dec 2025 | 19:00 | Real Murcia vs Cádiz | 3-2 |
| 3rd Dec 2025 | 19:00 | Mirandés vs Sporting Gijón | 0-2 |
| 3rd Dec 2025 | 19:00 | Talavera CF vs Málaga | 2-1 |
| 3rd Dec 2025 | 19:00 | Cultural Leonesa vs FC Andorra | 4-2 |
| 3rd Dec 2025 | 20:00 | Torrent vs Real Betis | 1-4 |
| 3rd Dec 2025 | 20:00 | Reddis vs Real Sociedad | 0-2 |
| 3rd Dec 2025 | 20:00 | Antoniano vs Villarreal | 1-1 |
| 3rd Dec 2025 | 20:00 | Ourense CF vs Girona | 2-1 |
| 3rd Dec 2025 | 20:00 | Cieza vs Levante | 0-1 |
| 3rd Dec 2025 | 20:00 | Quintanar del Rey vs Elche | 1-2 |
| 3rd Dec 2025 | 20:00 | Pontevedra vs SD Eibar | 0-3 |
| 4th Dec 2025 | 18:00 | Real Ávila vs Rayo Vallecano | 1-2 |
| 4th Dec 2025 | 18:00 | Atlético Baleares vs Espanyol | 1-0 |
| 4th Dec 2025 | 18:00 | Leganés vs Albacete | 1-2 |
| 4th Dec 2025 | 18:00 | Sabadell vs Deportivo La Coruña | 0-2 |
| 4th Dec 2025 | 19:00 | Ponferradina vs Racing Santander | 1-2 |
| 4th Dec 2025 | 20:00 | Extremadura 1924 vs Sevilla | 1-2 |
| 4th Dec 2025 | 20:00 | FC Cartagena vs Valencia | 1-2 |
| 4th Dec 2025 | 20:00 | Sant Andreu vs Celta de Vigo | 1-1 |
| 4th Dec 2025 | 20:00 | Real Zaragoza vs Burgos | 0-1 |
| 4th Dec 2025 | 21:00 | Tenerife vs Granada | 0-1 |
| 16th Dec 2025 | 18:00 | Deportivo La Coruña vs Mallorca | 1-0 |
| 16th Dec 2025 | 18:00 | SD Eibar vs Elche | 0-1 |
| 16th Dec 2025 | 20:00 | Eldense vs Real Sociedad | 1-2 |
| 16th Dec 2025 | 20:00 | Sporting Gijón vs Valencia | 0-2 |
| 16th Dec 2025 | 20:30 | Guadalajara vs FC Barcelona | 0-2 |
| 17th Dec 2025 | 17:00 | Cultural Leonesa vs Levante | 1-0 |
| 17th Dec 2025 | 18:00 | Atlético Baleares vs Atlético Madrid | 2-3 |
| 17th Dec 2025 | 18:00 | Albacete vs Celta de Vigo | 2-2 |
| 17th Dec 2025 | 18:00 | Huesca vs Osasuna | 2-4 |
| 17th Dec 2025 | 18:00 | Racing Santander vs Villarreal | 2-1 |
| 17th Dec 2025 | 20:00 | Deportivo Alavés vs Sevilla | 1-0 |
| 17th Dec 2025 | 20:00 | Talavera CF vs Real Madrid | 2-3 |
| 18th Dec 2025 | 18:00 | Burgos vs Getafe | 3-1 |
| 18th Dec 2025 | 18:00 | Ourense CF vs Athletic Club | 0-1 |
| 18th Dec 2025 | 20:00 | Real Murcia vs Real Betis | 0-2 |
| 6th Jan 2026 | 18:00 | Granada vs Rayo Vallecano | 1-3 |
| 13th Jan 2026 | 20:00 | Deportivo La Coruña vs Atlético Madrid | 0-1 |
| 13th Jan 2026 | 20:00 | Real Sociedad vs Osasuna | 2-2 |
| 13th Jan 2026 | 20:00 | Cultural Leonesa vs Athletic Club | 3-4 |
| 14th Jan 2026 | 20:00 | Deportivo Alavés vs Rayo Vallecano | 2-0 |
| 14th Jan 2026 | 20:00 | Real Betis vs Elche | 2-1 |
| 14th Jan 2026 | 20:00 | Albacete vs Real Madrid | 3-2 |
| 15th Jan 2026 | 20:00 | Burgos vs Valencia | 0-2 |
| 15th Jan 2026 | 20:15 | Racing Santander vs FC Barcelona | 0-2 |
| 3rd Feb 2026 | 20:00 | Albacete vs FC Barcelona | 1-2 |
| 4th Feb 2026 | 20:00 | Deportivo Alavés vs Real Sociedad | 2-3 |
| 4th Feb 2026 | 20:00 | Valencia vs Athletic Club | 1-2 |
| 5th Feb 2026 | 20:00 | Real Betis vs Atlético Madrid | 0-5 |
| 11th Feb 2026 | 20:00 | Athletic Club vs Real Sociedad | 0-1 |
| 12th Feb 2026 | 20:00 | Atlético Madrid vs FC Barcelona | 4-0 |
| 3rd Mar 2026 | 20:00 | FC Barcelona vs Atlético Madrid | 3-0 |
| 4th Mar 2026 | 20:00 | Real Sociedad vs Athletic Club | 1-0 |
| 18th Apr 2026 | 20:00 | Atlético Madrid vs Real Sociedad | 2-2 |