James Cook III has scored the game's first touchdown 0 times in 2026 season for the Buffalo Bills — 0 per game.
In 2025 he scored the game's first touchdown 3 times in 17 games.
James Cook III has scored the game's first touchdown in 0 of his last 10 games.
| Game | Opponent | Result | First TD |
|---|---|---|---|
| 2026 Week 9 | at Minnesota Vikings | W 23–6 | No |
| 2026 Week 8 | vs Baltimore Ravens | W 36–10 | No |
| 2026 Week 6 | at Las Vegas Raiders | W 33–30 | No |
| 2026 Week 5 | at Los Angeles Rams | W 37–34 | No |
| 2026 Week 4 | vs New England Patriots | L 26–29 | No |
| 2026 Week 3 | vs Los Angeles Chargers | W 24–16 | No |
| 2026 Week 2 | vs Detroit Lions | W 41–31 | No |
| 2026 Week 1 | at Houston Texans | W 36–31 | No |
| 2025 DIV | at Denver Broncos | L 30–33 | No |
| 2025 WC | at Jacksonville Jaguars | W 27–24 | No |
| 2025 Week 18 | vs New York Jets | W 35–8 | No |
| 2025 Week 17 | vs Philadelphia Eagles | L 12–13 | No |
| 2025 Week 16 | at Cleveland Browns | W 23–20 | No |
| 2025 Week 15 | at New England Patriots | W 35–31 | No |
| 2025 Week 14 | vs Cincinnati Bengals | W 39–34 | No |
| 2025 Week 13 | at Pittsburgh Steelers | W 26–7 | No |
| 2025 Week 12 | at Houston Texans | L 19–23 | Yes |
| 2025 Week 11 | vs Tampa Bay Buccaneers | W 44–32 | No |
| 2025 Week 10 | at Miami Dolphins | L 13–30 | No |
| 2025 Week 9 | vs Kansas City Chiefs | W 28–21 | No |