Jamaal Williams led the NFL in rushing touchdowns in the 2022 regular season with 17.
Next came Derrick Henry (13) and Jalen Hurts (13) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Rushing TDs |
|---|---|---|---|---|
| 1 | Jamaal Williams | NO | UNK | 17 |
| 2 | Derrick Henry | BAL | RB | 13 |
| 3 | Jalen Hurts | PHI | QB | 13 |
| 4 | Austin Ekeler | WSH | RB | 13 |
| 5 | Josh Jacobs | GB | RB | 12 |
| 6 | Nick Chubb | HOU | RB | 12 |
| 7 | Ezekiel Elliott | DAL | UNK | 12 |
| 8 | Miles Sanders | DAL | RB | 11 |
| 9 | Saquon Barkley | PHI | RB | 10 |
| 10 | Kenneth Walker III | KC | RB | 9 |
| 11 | Tony Pollard | TEN | RB | 9 |
| 12 | Christian McCaffrey | SF | RB | 8 |
| 13 | Justin Fields | KC | QB | 8 |
| 14 | Dalvin Cook | DAL | UNK | 8 |
| 15 | Cordarrelle Patterson | PIT | UNK | 8 |
| 16 | Najee Harris | LAC | RB | 7 |
| 17 | Taysom Hill | NO | QB | 7 |
| 18 | Daniel Jones | IND | QB | 7 |
| 19 | Josh Allen | BUF | QB | 7 |
| 20 | Joe Mixon | CIN | RB | 7 |
| 21 | Cam Akers | SEA | RB | 7 |
| 22 | James Conner | ARI | RB | 7 |
| 23 | AJ Dillon | CAR | RB | 7 |
| 24 | Latavius Murray | BUF | UNK | 6 |
| 25 | Joe Burrow | CIN | QB | 5 |