Jonathan Taylor led the NFL in rushing touchdowns in the 2021 regular season with 18.
Next came Damien Harris (15) and James Conner (15) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Rushing TDs |
|---|---|---|---|---|
| 1 | Jonathan Taylor | IND | RB | 18 |
| 2 | Damien Harris | BUF | RB | 15 |
| 3 | James Conner | ARI | RB | 15 |
| 4 | Joe Mixon | CIN | RB | 13 |
| 5 | Austin Ekeler | WSH | RB | 12 |
| 6 | Derrick Henry | BAL | RB | 10 |
| 7 | Ezekiel Elliott | DAL | UNK | 10 |
| 8 | Jalen Hurts | PHI | QB | 10 |
| 9 | Josh Jacobs | GB | RB | 9 |
| 10 | Deebo Samuel Sr. | WSH | WR | 8 |
| 11 | Nick Chubb | HOU | RB | 8 |
| 12 | Melvin Gordon III | BAL | UNK | 8 |
| 13 | Ryan Tannehill | TEN | UNK | 7 |
| 14 | David Montgomery | HOU | RB | 7 |
| 15 | Najee Harris | LAC | RB | 7 |
| 16 | Antonio Gibson | NE | RB | 7 |
| 17 | Devin Singletary | NYG | RB | 7 |
| 18 | Boston Scott | PHI | UNK | 7 |
| 19 | Josh Allen | BUF | QB | 6 |
| 20 | Cordarrelle Patterson | PIT | UNK | 6 |
| 21 | Dalvin Cook | DAL | UNK | 6 |
| 22 | Rashaad Penny | SEA | UNK | 6 |
| 23 | Darrel Williams | ARI | UNK | 6 |
| 24 | Latavius Murray | BUF | UNK | 6 |
| 25 | Kyler Murray | MIN | QB | 5 |