Tom Brady led the NFL in passing touchdowns in the 2021 regular season with 43.
Next came Matthew Stafford (41) and Justin Herbert (38) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Passing TDs |
|---|---|---|---|---|
| 1 | Tom Brady | TB | UNK | 43 |
| 2 | Matthew Stafford | LAR | QB | 41 |
| 3 | Justin Herbert | LAC | QB | 38 |
| 4 | Aaron Rodgers | PIT | QB | 37 |
| 5 | Dak Prescott | DAL | QB | 37 |
| 6 | Patrick Mahomes | KC | QB | 37 |
| 7 | Josh Allen | BUF | QB | 36 |
| 8 | Joe Burrow | CIN | QB | 34 |
| 9 | Kirk Cousins | LV | QB | 33 |
| 10 | Carson Wentz | MIN | QB | 27 |
| 11 | Russell Wilson | NYG | QB | 25 |
| 12 | Kyler Murray | MIN | QB | 24 |
| 13 | Derek Carr | LV | UNK | 23 |
| 14 | Mac Jones | SF | QB | 22 |
| 15 | Ben Roethlisberger | PIT | UNK | 22 |
| 16 | Ryan Tannehill | TEN | UNK | 21 |
| 17 | Jimmy Garoppolo | LAR | QB | 20 |
| 18 | Matt Ryan | IND | UNK | 20 |
| 19 | Taylor Heinicke | WSH | UNK | 20 |
| 20 | Jared Goff | DET | QB | 19 |
| 21 | Tua Tagovailoa | ATL | QB | 16 |
| 22 | Davis Mills | HOU | QB | 16 |
| 23 | Lamar Jackson | BAL | QB | 16 |
| 24 | Jalen Hurts | PHI | QB | 16 |
| 25 | Trevor Lawrence | JAX | QB | 12 |