Patrick Mahomes led the NFL in passing touchdowns in the 2018 regular season with 50.
Next came Andrew Luck (39) and Matt Ryan (35) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Passing TDs |
|---|---|---|---|---|
| 1 | Patrick Mahomes | KC | QB | 50 |
| 2 | Andrew Luck | IND | UNK | 39 |
| 3 | Matt Ryan | IND | UNK | 35 |
| 4 | Russell Wilson | NYG | QB | 35 |
| 5 | Ben Roethlisberger | PIT | UNK | 34 |
| 6 | Drew Brees | NO | UNK | 32 |
| 7 | Philip Rivers | IND | QB | 32 |
| 8 | Jared Goff | DET | QB | 32 |
| 9 | Kirk Cousins | LV | QB | 30 |
| 10 | Tom Brady | TB | UNK | 29 |
| 11 | Baker Mayfield | TB | QB | 27 |
| 12 | Deshaun Watson | CLE | QB | 26 |
| 13 | Aaron Rodgers | PIT | QB | 25 |
| 14 | Cam Newton | CAR | UNK | 24 |
| 15 | Mitchell Trubisky | TEN | QB | 24 |
| 16 | Dak Prescott | DAL | QB | 22 |
| 17 | Carson Wentz | MIN | QB | 21 |
| 18 | Matthew Stafford | LAR | QB | 21 |
| 19 | Eli Manning | NYG | UNK | 21 |
| 20 | Andy Dalton | PHI | QB | 21 |
| 21 | Derek Carr | LV | UNK | 19 |
| 22 | Jameis Winston | NYG | QB | 19 |
| 23 | Case Keenum | CHI | QB | 18 |
| 24 | Ryan Fitzpatrick | MIA | UNK | 17 |
| 25 | Ryan Tannehill | TEN | UNK | 17 |