Tom Brady led the NFL in passing yards in the 2021 regular season with 5,316.
Next came Justin Herbert (5,014) and Matthew Stafford (4,886) — the full top 50 is ranked below with team and position.
| Rank | Player | Team | Position | Passing Yards |
|---|---|---|---|---|
| 1 | Tom Brady | TB | UNK | 5,316 |
| 2 | Justin Herbert | LAC | QB | 5,014 |
| 3 | Matthew Stafford | LAR | QB | 4,886 |
| 4 | Patrick Mahomes | KC | QB | 4,839 |
| 5 | Derek Carr | LV | UNK | 4,804 |
| 6 | Joe Burrow | CIN | QB | 4,611 |
| 7 | Dak Prescott | DAL | QB | 4,449 |
| 8 | Josh Allen | BUF | QB | 4,407 |
| 9 | Kirk Cousins | LV | QB | 4,221 |
| 10 | Aaron Rodgers | PIT | QB | 4,115 |
| 11 | Matt Ryan | IND | UNK | 3,968 |
| 12 | Jimmy Garoppolo | LAR | QB | 3,810 |
| 13 | Mac Jones | SF | QB | 3,801 |
| 14 | Kyler Murray | MIN | QB | 3,787 |
| 15 | Ben Roethlisberger | PIT | UNK | 3,740 |
| 16 | Ryan Tannehill | TEN | UNK | 3,734 |
| 17 | Trevor Lawrence | JAX | QB | 3,641 |
| 18 | Carson Wentz | MIN | QB | 3,563 |
| 19 | Taylor Heinicke | WSH | UNK | 3,419 |
| 20 | Jared Goff | DET | QB | 3,245 |
| 21 | Jalen Hurts | PHI | QB | 3,144 |
| 22 | Russell Wilson | NYG | QB | 3,113 |
| 23 | Lamar Jackson | BAL | QB | 2,882 |
| 24 | Davis Mills | HOU | QB | 2,664 |
| 25 | Tua Tagovailoa | ATL | QB | 2,653 |