Jacksonville Jaguars vs Tennessee Titans Prediction, Odds & Props — Week 10

The Jacksonville Jaguars visit the Tennessee Titans in Week 10 of the 2026 NFL season, on Sunday, November 15 at 1:00 PM ET at Nissan Stadium. Open air · Grass. The Jaguars are 6-2 (1st in the AFC South), the Titans 1-7 (4th in the AFC South). The Jaguars went 5-1 down the stretch, the Titans 1-5.

The market has JAX -10.5 with a total of 46.5.

In 2026 the Jaguars scored 28.6 points per game (4th in the NFL) and allowed 15.1 (2nd in the NFL); the Titans scored 18 (28th in the NFL) and allowed 24.9 (22nd in the NFL).

Head-to-head, the recent series reads JAX 5–1 over the last 6 meetings, at an average total of 36.8; against the spread it is JAX 5–1, and the total has gone OVER 3–3. JAX have taken 5 of the last 6 — 3 of the 6 landed inside a score.

Injury report: 22 players out and 18 questionable across the two teams — Tommy Townsend (TEN P, Out), Jaylon Jones (TEN CB, Out), B.J. Green II (JAX DE, IR, designated to return) and James Williams Sr. (TEN LB, Injured reserve).

Best price across 8 sportsbooks: JAX -506 at Kalshi and TEN +506 at Kalshi on the moneyline, the spread TEN +10.5 (+102) and the total 46.5 (over +106). The Props tab prices 63 player props for this game — passing, rushing and receiving yards, receptions and anytime touchdown markets — at Bet365's lines.

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• Tennessee Titans stats, schedule and roster

JAX have taken 5 of the last 6 — 3 of the 6 landed inside a score.