New England Patriots vs Detroit Lions Prediction, Odds & Props — Week 10

The New England Patriots visit the Detroit Lions in Week 10 of the 2026 NFL season, on Sunday, November 15 at 9:30 AM ET at FC Bayern Munich Stadium. Dome · Fieldturf. The Patriots are 5-4 (2nd in the AFC East), the Lions 6-2 (2nd in the NFC North). The Patriots went 4-2 down the stretch, the Lions 5-1.

The market has DET -2.5 with a total of 51.0.

In 2026 the Patriots scored 23.4 points per game (14th in the NFL) and allowed 23 (15th in the NFL); the Lions scored 27.8 (5th in the NFL) and allowed 23.6 (17th in the NFL).

Head-to-head, the recent series reads DET 1–1 over the last 2 meetings, at an average total of 32.5; against the spread it is DET 1–1, and the total has gone UNDER 2–0. The last 2 meetings are split 1–1.

Injury report: 25 players out and 23 questionable across the two teams — Ben Brown (NE C, Out), Jackson Meeks (DET WR, Out), Kerby Joseph (DET S, Reserve/PUP) and Carlton Davis III (NE CB, Out).

Best price across 8 sportsbooks: NE +141 at Kalshi and DET -135 at Kalshi on the moneyline, the spread DET -3 (-102) and the total 51.5 (over +100). The Props tab prices 45 player props for this game — passing, rushing and receiving yards, receptions and anytime touchdown markets — at Bet365's lines.

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• New England Patriots stats, schedule and roster
• Detroit Lions stats, schedule and roster

The last 2 meetings are split 1–1.