The Detroit Lions visit the Arizona Cardinals in Week 5 of the 2026 NFL season, on Sunday, October 11 at 4:25 PM ET at State Farm Stadium. Grass. The Lions are 1-1 (3rd in the NFC North), the Cardinals 1-1 (4th in the NFC West). The Lions went 3-3 down the stretch, the Cardinals 1-5.
In 2026 the Lions scored 31 points per game (5th in the NFL) and allowed 35.5 (31st in the NFL); the Cardinals scored 16.5 (25th in the NFL) and allowed 22.5 (14th in the NFL).
Head-to-head, the recent series reads DET 4–0 over the last 5 meetings, at an average total of 39.6; against the spread it is DET 4–1, and the total has gone UNDER 4–1. DET have taken 4 of the last 5 but have yet to win at home in the series — 3 of the 5 landed inside a score.
Injury report: 21 players out and 27 questionable across the two teams — Thomas Harper (DET S, Injured reserve), Ben Bartch (DET G, Out), Dadrion Taylor-Demerson (ARI S, Out) and Will Johnson (ARI CB, Injured reserve).
Frequently asked questions
When do the Lions play the Cardinals?
Detroit Lions at Arizona Cardinals is Week 5 of the 2026 NFL season, kicking off on Sunday, October 11 at 4:25 PM ET at State Farm Stadium.
What is the head-to-head record between the Lions and the Cardinals?
The recent series is DET 4–0 over the last 5 meetings — the last one finished DET 20–13 in 2024 (Week 3), and against the spread the series is DET 4–1.
Who is injured for Lions vs Cardinals?
75 players carry a designation: 21 out and 27 questionable, including Thomas Harper (DET S, Injured reserve), Ben Bartch (DET G, Out), Dadrion Taylor-Demerson (ARI S, Out) and Will Johnson (ARI CB, Injured reserve). The report refreshes with the data sync before game days and the model prices designations in automatically.