New York Giants vs Detroit Lions Prediction, Odds & Props — Week 16

The New York Giants visit the Detroit Lions in Week 16 of the 2026 NFL season, on Monday, December 28 at 8:15 PM ET at Ford Field. Dome · Fieldturf. The Giants are 5-2-1 (1st in the NFC East), the Lions 6-2 (2nd in the NFC North). The Giants went 4-1 down the stretch, the Lions 5-1.

In 2026 the Giants scored 22.8 points per game (16th in the NFL) and allowed 21.5 (12th in the NFL); the Lions scored 27.8 (5th in the NFL) and allowed 23.6 (17th in the NFL).

Head-to-head, the recent series reads DET 3–0 over the last 3 meetings, at an average total of 55.7; against the spread it is NYG 2–1, and the total has gone OVER 3–0. DET have won all 3 recent meetings and are unbeaten at home in the series — 2 of the 3 landed inside a score.

Injury report: 17 players out and 19 questionable across the two teams — Kerby Joseph (DET S, Reserve/PUP), Cam Skattebo (NYG RB, Out), Jack Campbell (DET LB, Injured reserve) and Jimmy Rolder (DET LB, Injured reserve).

All Giants v Lions games

• New York Giants stats, schedule and roster
• Detroit Lions stats, schedule and roster

DET have won all 3 recent meetings and are unbeaten at home in the series — 2 of the 3 landed inside a score.