Arizona Cardinals vs New Orleans Saints Prediction, Odds & Props — Week 16

The Arizona Cardinals visit the New Orleans Saints in Week 16 of the 2026 NFL season, on Sunday, December 27 at 1:00 PM ET at Caesars Superdome. Dome · Sportturf. The Cardinals are 3-6 (4th in the NFC West), the Saints 3-5 (1st in the NFC South). The Cardinals went 2-4 down the stretch, the Saints 2-4.

In 2026 the Cardinals scored 19.8 points per game (26th in the NFL) and allowed 28.3 (31st in the NFL); the Saints scored 23.1 (15th in the NFL) and allowed 27 (27th in the NFL).

Head-to-head, the recent series reads ARI 2–1 over the last 3 meetings, at an average total of 49.7; against the spread it is ARI 2–1, and the total has gone UNDER 2–1. ARI have taken 2 of the last 3 — 2 of the 3 landed inside a score.

Injury report: 21 players out and 31 questionable across the two teams — Zachary Carter (ARI DT, IR, designated to return), Hunter Long (ARI TE, IR, designated to return), Travis Etienne Jr. (NO RB, IR, designated to return) and Gardner Minshew II (ARI QB, Injured reserve).

All Cardinals v Saints games

Arizona Cardinals vs New Orleans Saints: team comparison (2026 season, NFL rank in brackets)
Arizona CardinalsNew Orleans Saints
Record3-63-5
Division4th NFC W1st NFC S
Last six resultsL L W L W LL L L W L W
Points / G19.8 (26th)23.1 (15th)
Total Yds / G333.8 (22nd)343.5 (16th)
Yards / Play4.9 (29th)5.2 (24th)
Pass Yds / G231.1 (20th)248.3 (13th)
Rush Yds / G102.7 (22nd)95.3 (26th)
3rd Down %38% (15th)43.5% (7th)
1st Downs / G20.2 (15th)20.5 (11th)
Turnover Diff0 (17th)-6 (28th)
Pts Allowed / G28.3 (31st)27 (27th)
Yds Allowed / G352.6 (19th)389.5 (30th)
Pass Yds Allowed230.7 (13th)255.6 (28th)
Rush Yds Allowed121.9 (19th)133.9 (29th)
Sacks19 (17th)23 (11th)
  • Arizona Cardinals stats, schedule and roster
  • New Orleans Saints stats, schedule and roster
Arizona Cardinals vs New Orleans Saints injury report
PlayerTeamPositionStatusInjury
Zachary CarterARIDTIR, designated to returnKnee
CJ DonaldsonNORBQuestionableShoulder
Andrew WingardARISQuestionableKnee
Noah FantNOTEQuestionableBack
Max MeltonARICBQuestionableKnee
Dante StillsARIDTQuestionableShoulder
Bam KnightARIRBQuestionableConcussion
Christen MillerNODTQuestionableKnee
Kelvin Banks Jr.NOOTQuestionableAnkle
David EdwardsNOGQuestionableKnee
Martin Emerson Jr.NOCBQuestionableShin
Alvin KamaraNORBQuestionableNot injury related - resting player
Hunter LongARITEIR, designated to returnKnee
Travis Etienne Jr.NORBIR, designated to returnHamstring
Gardner Minshew IIARIQBInjured reserveElbow
Michael WilsonARIWRInjured reserveNot injury related - resting player
Jon Gaines IIARIGQuestionableAnkle
Jayden WilliamsARIOTQuestionableKnee
Erik McCoyNOCDoubtfulBiceps
Hjalte FroholdtARICQuestionableConcussion
Roy LopezARIDTQuestionableToe
James ConnerARIRBIR, designated to returnFoot
Kenny YeboahARITEOutUndisclosed
Jeremiyah LoveARIRBInjured reserveAnkle
Kendrick BourneARIWRInjured reserveTibia
Jalen BrooksARIWRInjured reserveWrist
Tip ReimanARITEReserve/PUPAnkle
Paris Johnson Jr.ARIOTInjured reserveBiceps
Will JohnsonARICBInjured reserveAnkle
Kaleb ProctorARIDTInjured reserve
Dillon RadunzNOGInjured reserve
Josh MinkinsARISQuestionable
Xavier WeaverARIWRQuestionableHamstring
Mason TiptonNOWRReserve/PUPLeg
Trey BensonARIRBInjured reserveKnee
Moliki MatavaoNOTEInjured reserveKnee
Ty ChandlerNORBInjured reserveKnee
Rejzohn WrightNOCBInjured reserveHip
Bryan BreseeNODTInjured reserve
Joey BlountARISInjured reserve
Chase BisontisARIGInjured reserve
Nick SaldiveriNOOTReserve/PUPKnee
Torricelli Simpkins IIINOGQuestionable
Will ClappNOCInjured Reserve
Taysom HillNOQBQuestionable
Devin NealNORBInjured Reserve
Jack StollNOTEInjured Reserve
Ja'Lynn PolkNOWRQuestionable
Trey PalmerNOWRQuestionable
Landon YoungNOOTInjured Reserve
Barry WesleyNOOTInjured Reserve
Keeshawn SilverNODTOut
Zxavian HarrisNODTOut
Michael HeldmanNOLBInjured Reserve
Brock RechsteinerNOWRSUSP
Brien Taylor Jr.NODTQuestionable
David Long Jr.NOCBInjured Reserve
Jordyn TysonNOWRQuestionable
Lorenzo Styles Jr.NOSQuestionable
Jonah WilliamsARIOTInjured Reserve
Travis VokolekARITEInjured Reserve
Andre BaccelliaARIWRQuestionable
Jonah WilliamsARIDEQuestionable
Austin KeysARILBInjured Reserve
J.J. RussellARILBInjured Reserve
Jaden DavisARICBInjured Reserve
Bilal NicholsARIDTInjured Reserve
Channing TindallARILBQuestionable
Ihmir Smith-MarsetteARIWRQuestionable
Greg DortchARIWRInjured Reserve
Darren HallARISQuestionable
Jameson GeersARITEInjured Reserve
Marvin Harrison Jr.ARIWROut
Valentin SennARIOTQuestionable
Dadrion Taylor-DemersonARISQuestionable
Cameron RobertsonARILBOut
Garrett WilliamsARICBOut

ARI have taken 2 of the last 3 — 2 of the 3 landed inside a score.

Recent meetings
GameWinnerScoreVenue
2025 Week 1ARI20–13Caesars Superdome
2022 Week 7ARI42–34State Farm Stadium
2019 Week 8NO31–9Caesars Superdome

Frequently asked questions

When do the Cardinals play the Saints?

Arizona Cardinals at New Orleans Saints is Week 16 of the 2026 NFL season, kicking off on Sunday, December 27 at 1:00 PM ET at Caesars Superdome.

What is the head-to-head record between the Cardinals and the Saints?

The recent series is ARI 2–1 over the last 3 meetings — the last one finished ARI 20–13 in 2025 (Week 1), and against the spread the series is ARI 2–1.

Who is injured for Cardinals vs Saints?

77 players carry a designation: 21 out and 31 questionable, including Zachary Carter (ARI DT, IR, designated to return), Hunter Long (ARI TE, IR, designated to return), Travis Etienne Jr. (NO RB, IR, designated to return) and Gardner Minshew II (ARI QB, Injured reserve).

Cardinals v Saints: teams and standings

  • Arizona Cardinals
  • Arizona Cardinals Stats
  • New Orleans Saints
  • New Orleans Saints Stats
  • NFC West Standings
  • NFC Standings
  • NFC South Standings
  • NFL Power Rankings this week

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