New England Patriots vs Los Angeles Chargers Prediction, Odds & Props — Week 12

The New England Patriots visit the Los Angeles Chargers in Week 12 of the 2026 NFL season, on Sunday, November 29 at 8:20 PM ET at SoFi Stadium. Dome · Matrixturf. The Patriots are 5-4 (2nd in the AFC East), the Chargers 0-8 (4th in the AFC West). The Patriots went 4-2 down the stretch, the Chargers 0-6.

In 2026 the Patriots scored 23.4 points per game (14th in the NFL) and allowed 23 (15th in the NFL); the Chargers scored 15.1 (32nd in the NFL) and allowed 27.4 (28th in the NFL).

Head-to-head, the recent series reads NE 4–2 over the last 6 meetings, at an average total of 39.5; against the spread it is NE 4–2, and the total has gone OVER 3–3. NE have taken 4 of the last 6 but have yet to win at home in the series — 2 of the 6 landed inside a score.

Injury report: 22 players out and 21 questionable across the two teams — Ben Brown (NE C, Out), Carlton Davis III (NE CB, Out), TreVeyon Henderson (NE RB, Out) and Reggie Gilliam (NE FB, IR, designated to return).

All Patriots v Chargers games

• New England Patriots stats, schedule and roster
• Los Angeles Chargers stats, schedule and roster

NE have taken 4 of the last 6 but have yet to win at home in the series — 2 of the 6 landed inside a score.