Indianapolis Colts vs Houston Texans Prediction, Odds & Props — Week 11

The Indianapolis Colts visit the Houston Texans in Week 11 of the 2026 NFL season, on Thursday, November 19 at 8:15 PM ET at Reliant Stadium. Astroturf. The Colts are 2-7 (3rd in the AFC South), the Texans 3-5 (2nd in the AFC South). The Colts went 1-5 down the stretch, the Texans 3-3.

In 2026 the Colts scored 20.4 points per game (24th in the NFL) and allowed 27.7 (30th in the NFL); the Texans scored 26.1 (9th in the NFL) and allowed 24 (18th in the NFL).

Head-to-head, the recent series reads HOU 5–1 over the last 6 meetings, at an average total of 46.8; against the spread it is IND 4–2, and the total has gone UNDER 4–2. HOU have taken 5 of the last 6 and are unbeaten at home in the series — 6 of the 6 landed inside a score.

Injury report: 18 players out and 21 questionable across the two teams — Jaylin Smith (HOU CB, IR, designated to return), Jake Hummel (HOU LB, IR, designated to return), Justin Walley (IND CB, Out) and Arden Key (IND DE, IR, designated to return).

All Colts v Texans games

• Indianapolis Colts stats, schedule and roster
• Houston Texans stats, schedule and roster

HOU have taken 5 of the last 6 and are unbeaten at home in the series — 6 of the 6 landed inside a score.