Cardinals vs Colts: head to head

Frequently asked questions

Who leads the Cardinals vs Colts series?

The Colts lead 2-0 over the 2 games since 2021.

When did the Cardinals last play the Colts?

12 October 2025, in Week 6 of the 2025 season: the Colts won 31-27 at Lucas Oil Stadium.

What is the average score when the Cardinals play the Colts?

48 points a game: the Cardinals average 21.5 and the Colts 26.5 in their 2 meetings since 2021.

What is the biggest win in the Cardinals vs Colts series?

The Colts won by 6, 22-16, in Week 16 of 2021.