Bills vs Saints: head to head

Frequently asked questions

Who leads the Bills vs Saints series?

The Bills lead 2-0 over the 2 games since 2021.

When did the Bills last play the Saints?

28 September 2025, in Week 4 of the 2025 season: the Bills won 31-19 at Highmark Stadium.

What is the average score when the Bills play the Saints?

43.5 points a game: the Bills average 31 and the Saints 12.5 in their 2 meetings since 2021.

What is the biggest win in the Bills vs Saints series?

The Bills won by 25, 31-6, in Week 12 of 2021.