Bills vs Panthers: head to head

Frequently asked questions

Who leads the Bills vs Panthers series?

The Bills lead 2-0 over the 2 games since 2021.

When did the Bills last play the Panthers?

26 October 2025, in Week 8 of the 2025 season: the Bills won 40-9 at Bank of America Stadium.

What is the average score when the Bills play the Panthers?

47 points a game: the Bills average 35.5 and the Panthers 11.5 in their 2 meetings since 2021.

What is the biggest win in the Bills vs Panthers series?

The Bills won by 31, 40-9, in Week 8 of 2025.