49ers vs Titans: head to head

Frequently asked questions

Who leads the 49ers vs Titans series?

The series is level at 1-1 over the 2 games since 2021.

When did the 49ers last play the Titans?

14 December 2025, in Week 15 of the 2025 season: the 49ers won 37-24 at Levi's Stadium.

What is the average score when the 49ers play the Titans?

49 points a game: the 49ers average 27 and the Titans 22 in their 2 meetings since 2021.

What is the biggest win in the 49ers vs Titans series?

The 49ers won by 13, 37-24, in Week 15 of 2025.