49ers vs Saints: head to head

Frequently asked questions

Who leads the 49ers vs Saints series?

The 49ers lead 3-1 over the 4 games since 2019.

When did the 49ers last play the Saints?

14 September 2025, in Week 2 of the 2025 season: the 49ers won 26-21 at Caesars Superdome.

What is the average score when the 49ers play the Saints?

48.5 points a game: the 49ers average 25 and the Saints 23.5 in their 4 meetings since 2019.

What is the biggest win in the 49ers vs Saints series?

The Saints won by 14, 27-13, in Week 10 of 2020.