49ers vs Panthers: head to head

Frequently asked questions

Who leads the 49ers vs Panthers series?

The 49ers lead 3-0 over the 3 games since 2019.

When did the 49ers last play the Panthers?

24 November 2025, in Week 12 of the 2025 season: the 49ers won 20-9 at Levi's Stadium.

What is the average score when the 49ers play the Panthers?

48.3 points a game: the 49ers average 36 and the Panthers 12.3 in their 3 meetings since 2019.

What is the biggest win in the 49ers vs Panthers series?

The 49ers won by 38, 51-13, in Week 8 of 2019.