49ers vs Jaguars: head to head

Frequently asked questions

Who leads the 49ers vs Jaguars series?

The 49ers lead 2-1 over the 3 games since 2021.

When did the 49ers last play the Jaguars?

28 September 2025, in Week 4 of the 2025 season: the Jaguars won 26-21 at Levi's Stadium.

What is the average score when the 49ers play the Jaguars?

41.3 points a game: the 49ers average 28.3 and the Jaguars 13 in their 3 meetings since 2021.

What is the biggest win in the 49ers vs Jaguars series?

The 49ers won by 31, 34-3, in Week 10 of 2023.