49ers vs Colts: head to head

Frequently asked questions

Who leads the 49ers vs Colts series?

The series is level at 1-1 over the 2 games since 2021.

When did the 49ers last play the Colts?

22 December 2025, in Week 16 of the 2025 season: the 49ers won 48-27 at Lucas Oil Stadium.

What is the average score when the 49ers play the Colts?

61.5 points a game: the 49ers average 33 and the Colts 28.5 in their 2 meetings since 2021.

What is the biggest win in the 49ers vs Colts series?

The 49ers won by 21, 48-27, in Week 16 of 2025.