49ers vs Bills: head to head

Frequently asked questions

Who leads the 49ers vs Bills series?

The Bills lead 2-0 over the 2 games since 2020.

When did the 49ers last play the Bills?

1 December 2024, in Week 13 of the 2024 season: the Bills won 35-10 at Highmark Stadium.

What is the average score when the 49ers play the Bills?

51.5 points a game: the 49ers average 17 and the Bills 34.5 in their 2 meetings since 2020.

What is the biggest win in the 49ers vs Bills series?

The Bills won by 25, 35-10, in Week 13 of 2024.