Atlético Mineiro scored the most goals in the Copa Sudamericana in 2025, with 22 goals from 15 games. Once Caldas were next on 21.
Independiente had the most goals per game in the Copa Sudamericana in 2025, with 2.1 a game, 17 goals from eight games. Boston River were next on 2.0.
| Rank | Team | Goals Scored |
|---|---|---|
| 1 | Atlético Mineiro | 22 |
| 2 | Once Caldas | 21 |
| 3 | Independiente | 17 |
| 4 | Fluminense | 16 |
| 5 | Lanús | 15 |
| 6 | Mushuc Runa | 14 |
| 7 | Universidad Católica | 13 |
| 8 | Huracán | 12 |
| 9 | Cienciano | 12 |
| 10 | Boston River | 12 |
| 11 | Godoy Cruz | 11 |
| 12 | Guaraní | 11 |
| 13 | Palestino | 9 |
| 14 | América de Cali | 9 |
| 15 | Grêmio | 9 |
| 16 | Vasco da Gama | 9 |
| 17 | Caracas | 9 |
| 18 | Nacional Potosí | 8 |
| 19 | Academia Puerto Cabello | 8 |
| 20 | Deportes Iquique | 7 |
| 21 | Unión Española | 6 |
| 22 | Cerro Largo | 5 |
| 23 | Corinthians | 5 |
| 24 | Atlético Grau | 5 |
| 25 | Cruzeiro | 5 |
| 26 | Melgar | 5 |
| 27 | Gualberto Villarroel SJ | 5 |
| 28 | Defensa y Justicia | 4 |
| 29 | Sportivo Luqueño | 4 |
| 30 | Vitória | 3 |
| 31 | Racing | 3 |
| 32 | Unión Santa Fe | 2 |