Vitória conceded the fewest goals in the Copa Sudamericana in 2025, with 4 goals from six games. Fluminense and Corinthians were next on 5.
Fluminense had the fewest goals conceded per game in the Copa Sudamericana in 2025, with 0.5 a game, 5 goals from ten games. Lanús were next on 0.6.
| Rank | Team | Goals Against |
|---|---|---|
| 1 | Vitória | 4 |
| 2 | Fluminense | 5 |
| 3 | Corinthians | 5 |
| 4 | Mushuc Runa | 6 |
| 5 | Huracán | 6 |
| 6 | Grêmio | 7 |
| 7 | Unión Española | 7 |
| 8 | Cruzeiro | 7 |
| 9 | Defensa y Justicia | 7 |
| 10 | Lanús | 8 |
| 11 | Independiente | 8 |
| 12 | Godoy Cruz | 8 |
| 13 | América de Cali | 8 |
| 14 | Unión Santa Fe | 8 |
| 15 | Academia Puerto Cabello | 8 |
| 16 | Universidad Católica | 9 |
| 17 | Once Caldas | 9 |
| 18 | Atlético Grau | 9 |
| 19 | Sportivo Luqueño | 9 |
| 20 | Cienciano | 10 |
| 21 | Melgar | 10 |
| 22 | Cerro Largo | 11 |
| 23 | Caracas | 11 |
| 24 | Atlético Mineiro | 12 |
| 25 | Vasco da Gama | 13 |
| 26 | Nacional Potosí | 13 |
| 27 | Boston River | 14 |
| 28 | Racing | 14 |
| 29 | Palestino | 15 |
| 30 | Gualberto Villarroel SJ | 15 |
| 31 | Deportes Iquique | 16 |
| 32 | Guaraní | 18 |