Updated 22 August 2025, after the last game
| Round | Tie | Score | Went through |
|---|---|---|---|
| Round of 16 | Atlético Nacional vs São Paulo | 1-1 on aggregate, São Paulo won on penalties | São Paulo |
| Round of 16 | Fortaleza vs Vélez Sarsfield | 0-2 on aggregate | Vélez Sarsfield |
| Round of 16 | Flamengo vs Internacional | 3-0 on aggregate | Flamengo |
| Round of 16 | Universitario vs Palmeiras | 0-4 on aggregate | Palmeiras |
| Round of 16 | Libertad vs River Plate | 1-1 on aggregate, River Plate won on penalties | River Plate |
| Round of 16 | Cerro Porteño vs Estudiantes | 0-1 on aggregate | Estudiantes |
| Round of 16 | Peñarol vs Racing Club | 2-3 on aggregate | Racing Club |
| Round of 16 | Botafogo vs LDU Quito | 1-2 on aggregate | LDU Quito |