| 13/08/2021 | 19:30 | Beşiktaş vs Rizespor | 3-0 |
| 14/08/2021 | 18:15 | Fatih Karagümrük vs Gaziantep F.K. | 3-2 |
| 14/08/2021 | 20:45 | Altay vs Kayserispor | 3-0 |
| 14/08/2021 | 20:45 | Hatayspor vs Kasımpaşa | 1-1 |
| 15/08/2021 | 18:15 | İstanbul Başakşehir vs Alanyaspor | 0-1 |
| 15/08/2021 | 20:45 | Antalyaspor vs Göztepe | 1-1 |
| 15/08/2021 | 20:45 | Adana Demirspor vs Fenerbahçe | 0-1 |
| 16/08/2021 | 18:15 | Yeni Malatyaspor vs Trabzonspor | 1-5 |
| 16/08/2021 | 18:15 | Sivasspor vs Konyaspor | 0-1 |
| 16/08/2021 | 20:45 | Giresunspor vs Galatasaray | 0-2 |
| 20/08/2021 | 19:30 | Kayserispor vs Adana Demirspor | 1-1 |
| 21/08/2021 | 18:15 | Kasımpaşa vs Giresunspor | 2-0 |
| 21/08/2021 | 18:15 | Rizespor vs Fatih Karagümrük | 0-0 |
| 21/08/2021 | 20:45 | Gaziantep F.K. vs Beşiktaş | 0-0 |
| 21/08/2021 | 20:45 | Alanyaspor vs Altay | 1-4 |
| 22/08/2021 | 18:15 | Konyaspor vs İstanbul Başakşehir | 2-1 |
| 22/08/2021 | 20:45 | Fenerbahçe vs Antalyaspor | 2-0 |
| 22/08/2021 | 20:45 | Göztepe vs Yeni Malatyaspor | 0-1 |
| 23/08/2021 | 18:15 | Trabzonspor vs Sivasspor | 2-1 |
| 23/08/2021 | 20:45 | Galatasaray vs Hatayspor | 2-1 |
| 27/08/2021 | 19:30 | Antalyaspor vs Rizespor | 3-2 |
| 27/08/2021 | 20:45 | Adana Demirspor vs Konyaspor | 1-1 |
| 28/08/2021 | 18:15 | Yeni Malatyaspor vs Gaziantep F.K. | 2-0 |
| 28/08/2021 | 18:15 | İstanbul Başakşehir vs Kayserispor | 0-1 |
| 28/08/2021 | 20:45 | Beşiktaş vs Fatih Karagümrük | 1-0 |
| 28/08/2021 | 20:45 | Hatayspor vs Alanyaspor | 5-0 |
| 29/08/2021 | 18:15 | Kasımpaşa vs Galatasaray | 2-2 |
| 29/08/2021 | 18:15 | Sivasspor vs Göztepe | 2-2 |
| 29/08/2021 | 20:45 | Giresunspor vs Trabzonspor | 0-1 |
| 29/08/2021 | 20:45 | Altay vs Fenerbahçe | 0-2 |
| 11/09/2021 | 16:00 | Fatih Karagümrük vs Adana Demirspor | 4-0 |
| 11/09/2021 | 16:00 | Konyaspor vs Altay | 3-1 |
| 11/09/2021 | 19:00 | Beşiktaş vs Yeni Malatyaspor | 3-0 |
| 11/09/2021 | 19:00 | Kayserispor vs Kasımpaşa | 2-0 |
| 12/09/2021 | 16:00 | Fenerbahçe vs Sivasspor | 1-1 |
| 12/09/2021 | 16:00 | Rizespor vs Hatayspor | 0-2 |
| 12/09/2021 | 19:00 | Trabzonspor vs Galatasaray | 2-2 |
| 12/09/2021 | 19:00 | Göztepe vs İstanbul Başakşehir | 2-1 |
| 13/09/2021 | 19:00 | Gaziantep F.K. vs Antalyaspor | 2-0 |
| 13/09/2021 | 19:00 | Alanyaspor vs Giresunspor | 1-0 |
| 17/09/2021 | 19:00 | Yeni Malatyaspor vs Fatih Karagümrük | 3-4 |
| 17/09/2021 | 19:00 | Altay vs Göztepe | 2-1 |
| 18/09/2021 | 12:30 | Sivasspor vs Gaziantep F.K. | 1-1 |
| 18/09/2021 | 15:00 | Kasımpaşa vs Trabzonspor | 0-1 |
| 18/09/2021 | 18:00 | Antalyaspor vs Beşiktaş | 2-3 |
| 18/09/2021 | 18:00 | Adana Demirspor vs Rizespor | 3-1 |
| 19/09/2021 | 12:30 | Giresunspor vs Konyaspor | 0-0 |
| 19/09/2021 | 15:00 | Galatasaray vs Alanyaspor | 0-1 |
| 19/09/2021 | 18:00 | İstanbul Başakşehir vs Fenerbahçe | 2-0 |
| 19/09/2021 | 18:00 | Hatayspor vs Kayserispor | 2-1 |
| 21/09/2021 | 16:00 | Fatih Karagümrük vs Antalyaspor | 0-0 |
| 21/09/2021 | 16:00 | Rizespor vs Altay | 1-2 |
| 21/09/2021 | 19:00 | Beşiktaş vs Adana Demirspor | 3-3 |
| 21/09/2021 | 19:00 | Yeni Malatyaspor vs Sivasspor | 0-1 |
| 22/09/2021 | 16:00 | Gaziantep F.K. vs İstanbul Başakşehir | 1-0 |
| 22/09/2021 | 19:00 | Kayserispor vs Galatasaray | 3-0 |
| 22/09/2021 | 19:00 | Göztepe vs Hatayspor | 0-2 |
| 23/09/2021 | 16:00 | Konyaspor vs Trabzonspor | 2-2 |
| 23/09/2021 | 19:00 | Alanyaspor vs Kasımpaşa | 2-0 |
| 23/09/2021 | 19:00 | Fenerbahçe vs Giresunspor | 2-1 |
| 24/09/2021 | 19:00 | Altay vs Beşiktaş | 2-1 |
| 25/09/2021 | 12:30 | Sivasspor vs Fatih Karagümrük | 4-0 |
| 25/09/2021 | 15:00 | Antalyaspor vs Yeni Malatyaspor | 1-0 |
| 25/09/2021 | 18:00 | Adana Demirspor vs Gaziantep F.K. | 4-0 |
| 26/09/2021 | 12:30 | Giresunspor vs Kayserispor | 1-1 |
| 26/09/2021 | 15:00 | İstanbul Başakşehir vs Rizespor | 3-0 |
| 26/09/2021 | 15:00 | Hatayspor vs Fenerbahçe | 1-2 |
| 26/09/2021 | 18:00 | Galatasaray vs Göztepe | 2-1 |
| 27/09/2021 | 19:00 | Kasımpaşa vs Konyaspor | 2-2 |
| 27/09/2021 | 19:00 | Trabzonspor vs Alanyaspor | 1-1 |
| 01/10/2021 | 19:00 | Fatih Karagümrük vs İstanbul Başakşehir | 3-1 |
| 01/10/2021 | 19:00 | Antalyaspor vs Adana Demirspor | 1-2 |
| 02/10/2021 | 12:30 | Konyaspor vs Alanyaspor | 1-1 |
| 02/10/2021 | 15:00 | Kayserispor vs Trabzonspor | 1-2 |
| 02/10/2021 | 15:00 | Göztepe vs Giresunspor | 0-1 |
| 02/10/2021 | 18:00 | Beşiktaş vs Sivasspor | 2-1 |
| 03/10/2021 | 12:30 | Yeni Malatyaspor vs Hatayspor | 0-2 |
| 03/10/2021 | 15:00 | Gaziantep F.K. vs Altay | 4-1 |
| 03/10/2021 | 15:00 | Fenerbahçe vs Kasımpaşa | 2-1 |
| 03/10/2021 | 18:00 | Rizespor vs Galatasaray | 2-3 |
| 15/10/2021 | 19:00 | İstanbul Başakşehir vs Beşiktaş | 3-2 |
| 16/10/2021 | 12:30 | Giresunspor vs Rizespor | 2-0 |
| 16/10/2021 | 15:00 | Sivasspor vs Antalyaspor | 2-2 |
| 16/10/2021 | 18:00 | Adana Demirspor vs Yeni Malatyaspor | 0-2 |
| 17/10/2021 | 12:30 | Kasımpaşa vs Göztepe | 1-2 |
| 17/10/2021 | 15:00 | Galatasaray vs Konyaspor | 1-0 |
| 17/10/2021 | 15:00 | Altay vs Fatih Karagümrük | 0-1 |
| 17/10/2021 | 19:00 | Trabzonspor vs Fenerbahçe | 3-1 |
| 18/10/2021 | 19:00 | Alanyaspor vs Kayserispor | 6-3 |
| 18/10/2021 | 19:00 | Hatayspor vs Gaziantep F.K. | 2-1 |
| 22/10/2021 | 19:00 | Yeni Malatyaspor vs Altay | 2-1 |
| 23/10/2021 | 12:30 | Rizespor vs Kasımpaşa | 2-1 |
| 23/10/2021 | 15:00 | Gaziantep F.K. vs Giresunspor | 1-1 |
| 23/10/2021 | 15:00 | Konyaspor vs Kayserispor | 2-0 |
| 23/10/2021 | 19:00 | Göztepe vs Trabzonspor | 0-1 |
| 24/10/2021 | 12:30 | Fatih Karagümrük vs Hatayspor | 1-1 |
| 24/10/2021 | 15:00 | Antalyaspor vs İstanbul Başakşehir | 1-2 |
| 24/10/2021 | 15:00 | Sivasspor vs Adana Demirspor | 1-1 |
| 24/10/2021 | 18:00 | Fenerbahçe vs Alanyaspor | 1-2 |
| 25/10/2021 | 19:00 | Beşiktaş vs Galatasaray | 2-1 |
| 29/10/2021 | 19:00 | Trabzonspor vs Rizespor | 2-1 |
| 30/10/2021 | 12:30 | Kasımpaşa vs Yeni Malatyaspor | 2-0 |
| 30/10/2021 | 15:00 | Altay vs Sivasspor | 1-1 |
| 30/10/2021 | 15:00 | Hatayspor vs Beşiktaş | 1-0 |
| 30/10/2021 | 19:00 | Konyaspor vs Fenerbahçe | 2-1 |
| 31/10/2021 | 11:30 | Kayserispor vs Fatih Karagümrük | 2-1 |
| 31/10/2021 | 14:00 | Alanyaspor vs Göztepe | 2-2 |
| 31/10/2021 | 17:00 | Galatasaray vs Gaziantep F.K. | 2-0 |
| 01/11/2021 | 18:00 | Giresunspor vs Antalyaspor | 1-2 |
| 01/11/2021 | 18:00 | İstanbul Başakşehir vs Adana Demirspor | 2-1 |
| 05/11/2021 | 18:00 | Gaziantep F.K. vs Kasımpaşa | 2-0 |
| 05/11/2021 | 18:00 | Rizespor vs Alanyaspor | 2-0 |
| 06/11/2021 | 11:30 | Sivasspor vs Giresunspor | 0-0 |
| 06/11/2021 | 14:00 | Yeni Malatyaspor vs İstanbul Başakşehir | 1-3 |
| 06/11/2021 | 14:00 | Antalyaspor vs Altay | 1-0 |
| 06/11/2021 | 17:00 | Beşiktaş vs Trabzonspor | 1-2 |
| 07/11/2021 | 11:30 | Göztepe vs Konyaspor | 0-2 |
| 07/11/2021 | 14:00 | Fatih Karagümrük vs Galatasaray | 1-1 |
| 07/11/2021 | 14:00 | Adana Demirspor vs Hatayspor | 1-0 |
| 07/11/2021 | 17:00 | Fenerbahçe vs Kayserispor | 2-2 |
| 20/11/2021 | 11:30 | Hatayspor vs Antalyaspor | 3-1 |
| 20/11/2021 | 14:00 | Giresunspor vs Yeni Malatyaspor | 1-0 |
| 20/11/2021 | 14:00 | İstanbul Başakşehir vs Sivasspor | 2-1 |
| 20/11/2021 | 17:00 | Alanyaspor vs Beşiktaş | 2-0 |
| 21/11/2021 | 11:30 | Kasımpaşa vs Fatih Karagümrük | 1-3 |
| 21/11/2021 | 14:00 | Konyaspor vs Rizespor | 3-0 |
| 21/11/2021 | 14:00 | Altay vs Adana Demirspor | 1-3 |
| 21/11/2021 | 17:00 | Galatasaray vs Fenerbahçe | 1-2 |
| 22/11/2021 | 18:00 | Trabzonspor vs Gaziantep F.K. | 3-0 |
| 22/11/2021 | 18:00 | Kayserispor vs Göztepe | 1-1 |
| 26/11/2021 | 18:00 | Adana Demirspor vs Kasımpaşa | 0-0 |
| 26/11/2021 | 18:00 | İstanbul Başakşehir vs Altay | 0-0 |
| 27/11/2021 | 11:30 | Antalyaspor vs Alanyaspor | 3-0 |
| 27/11/2021 | 14:00 | Rizespor vs Kayserispor | 1-0 |
| 27/11/2021 | 17:00 | Beşiktaş vs Giresunspor | 0-4 |
| 28/11/2021 | 11:30 | Gaziantep F.K. vs Konyaspor | 3-2 |
| 28/11/2021 | 14:00 | Fatih Karagümrük vs Trabzonspor | 0-2 |
| 28/11/2021 | 14:00 | Sivasspor vs Hatayspor | 4-0 |
| 28/11/2021 | 17:00 | Yeni Malatyaspor vs Galatasaray | 0-0 |
| 29/11/2021 | 18:00 | Göztepe vs Fenerbahçe | 1-1 |
| 03/12/2021 | 18:00 | Kasımpaşa vs Beşiktaş | 1-1 |
| 04/12/2021 | 11:30 | Alanyaspor vs Sivasspor | 0-1 |
| 04/12/2021 | 14:00 | Trabzonspor vs Adana Demirspor | 2-0 |
| 04/12/2021 | 17:00 | Galatasaray vs Altay | 2-2 |
| 05/12/2021 | 11:30 | Kayserispor vs Antalyaspor | 2-0 |
| 05/12/2021 | 14:00 | Giresunspor vs Fatih Karagümrük | 3-1 |
| 05/12/2021 | 14:00 | Hatayspor vs İstanbul Başakşehir | 0-3 |
| 05/12/2021 | 17:00 | Fenerbahçe vs Rizespor | 4-0 |
| 06/12/2021 | 18:00 | Konyaspor vs Yeni Malatyaspor | 0-0 |
| 06/12/2021 | 18:00 | Göztepe vs Gaziantep F.K. | 2-1 |
| 10/12/2021 | 18:00 | Altay vs Hatayspor | 1-2 |
| 11/12/2021 | 11:30 | Fatih Karagümrük vs Konyaspor | 1-4 |
| 11/12/2021 | 14:00 | İstanbul Başakşehir vs Kasımpaşa | 2-1 |
| 11/12/2021 | 14:00 | Rizespor vs Göztepe | 3-1 |
| 11/12/2021 | 17:00 | Antalyaspor vs Trabzonspor | 2-1 |
| 12/12/2021 | 11:30 | Adana Demirspor vs Giresunspor | 1-0 |
| 12/12/2021 | 14:00 | Yeni Malatyaspor vs Alanyaspor | 2-6 |
| 12/12/2021 | 17:00 | Beşiktaş vs Kayserispor | 4-2 |
| 13/12/2021 | 16:00 | Sivasspor vs Galatasaray | 1-0 |
| 13/12/2021 | 18:30 | Gaziantep F.K. vs Fenerbahçe | 3-2 |
| 17/12/2021 | 18:00 | Giresunspor vs Altay | 3-1 |
| 18/12/2021 | 11:30 | Kasımpaşa vs Sivasspor | 1-3 |
| 18/12/2021 | 14:00 | Trabzonspor vs Hatayspor | 2-0 |
| 18/12/2021 | 14:00 | Konyaspor vs Antalyaspor | 1-0 |
| 18/12/2021 | 17:00 | Galatasaray vs İstanbul Başakşehir | 1-1 |
| 18/12/2021 | 17:00 | Alanyaspor vs Adana Demirspor | 1-3 |
| 19/12/2021 | 11:30 | Rizespor vs Yeni Malatyaspor | 1-0 |
| 19/12/2021 | 14:00 | Kayserispor vs Gaziantep F.K. | 0-0 |
| 19/12/2021 | 14:00 | Göztepe vs Fatih Karagümrük | 0-1 |
| 19/12/2021 | 17:00 | Fenerbahçe vs Beşiktaş | 2-2 |
| 21/12/2021 | 15:00 | Antalyaspor vs Kasımpaşa | 1-1 |
| 21/12/2021 | 15:00 | İstanbul Başakşehir vs Giresunspor | 3-1 |
| 21/12/2021 | 18:00 | Adana Demirspor vs Galatasaray | 2-0 |
| 21/12/2021 | 18:00 | Altay vs Trabzonspor | 1-2 |
| 22/12/2021 | 15:00 | Sivasspor vs Rizespor | 1-1 |
| 22/12/2021 | 15:00 | Hatayspor vs Konyaspor | 1-3 |
| 22/12/2021 | 18:00 | Gaziantep F.K. vs Alanyaspor | 2-1 |
| 22/12/2021 | 18:00 | Fatih Karagümrük vs Fenerbahçe | 1-1 |
| 23/12/2021 | 15:00 | Yeni Malatyaspor vs Kayserispor | 2-2 |
| 23/12/2021 | 18:00 | Beşiktaş vs Göztepe | 2-1 |
| 25/12/2021 | 11:30 | Kasımpaşa vs Altay | 2-0 |
| 25/12/2021 | 14:00 | Giresunspor vs Hatayspor | 0-1 |
| 25/12/2021 | 14:00 | Galatasaray vs Antalyaspor | 2-0 |
| 25/12/2021 | 17:00 | Trabzonspor vs İstanbul Başakşehir | 0-0 |
| 26/12/2021 | 11:30 | Rizespor vs Gaziantep F.K. | 0-1 |
| 26/12/2021 | 14:00 | Alanyaspor vs Fatih Karagümrük | 1-1 |
| 26/12/2021 | 14:00 | Göztepe vs Adana Demirspor | 1-1 |
| 26/12/2021 | 17:00 | Fenerbahçe vs Yeni Malatyaspor | 2-0 |
| 27/12/2021 | 18:00 | Kayserispor vs Sivasspor | 3-0 |
| 27/12/2021 | 18:00 | Konyaspor vs Beşiktaş | 1-0 |
| 07/01/2022 | 18:00 | Trabzonspor vs Yeni Malatyaspor | 1-0 |
| 08/01/2022 | 11:30 | Gaziantep F.K. vs Fatih Karagümrük | 3-1 |
| 08/01/2022 | 14:00 | Alanyaspor vs İstanbul Başakşehir | 1-1 |
| 08/01/2022 | 14:00 | Kasımpaşa vs Hatayspor | 3-1 |
| 08/01/2022 | 17:00 | Galatasaray vs Giresunspor | 0-1 |
| 09/01/2022 | 11:30 | Konyaspor vs Sivasspor | 0-1 |
| 09/01/2022 | 14:00 | Göztepe vs Antalyaspor | 4-0 |
| 09/01/2022 | 14:00 | Kayserispor vs Altay | 1-0 |
| 09/01/2022 | 17:00 | Rizespor vs Beşiktaş | 2-2 |
| 10/01/2022 | 18:00 | Fenerbahçe vs Adana Demirspor | 1-2 |
| 14/01/2022 | 18:00 | Beşiktaş vs Gaziantep F.K. | 1-0 |
| 14/01/2022 | 18:00 | Yeni Malatyaspor vs Göztepe | 1-2 |
| 15/01/2022 | 11:30 | Adana Demirspor vs Kayserispor | 1-1 |
| 15/01/2022 | 14:00 | Sivasspor vs Trabzonspor | 1-1 |
| 15/01/2022 | 14:00 | Fatih Karagümrük vs Rizespor | 2-0 |
| 15/01/2022 | 17:00 | Antalyaspor vs Fenerbahçe | 1-1 |
| 16/01/2022 | 11:30 | Altay vs Alanyaspor | 0-2 |
| 16/01/2022 | 14:00 | Giresunspor vs Kasımpaşa | 0-2 |
| 16/01/2022 | 17:00 | Hatayspor vs Galatasaray | 4-2 |
| 22/02/2022 | 18:00 | İstanbul Başakşehir vs Konyaspor | 2-1 |
| 18/01/2022 | 18:00 | Fatih Karagümrük vs Beşiktaş | 0-1 |
| 18/01/2022 | 18:00 | Konyaspor vs Adana Demirspor | 1-0 |
| 19/01/2022 | 15:00 | Göztepe vs Sivasspor | 2-1 |
| 19/01/2022 | 16:00 | Kayserispor vs İstanbul Başakşehir | 1-0 |
| 19/01/2022 | 18:00 | Trabzonspor vs Giresunspor | 1-1 |
| 19/01/2022 | 18:00 | Fenerbahçe vs Altay | 2-1 |
| 20/01/2022 | 15:00 | Rizespor vs Antalyaspor | 2-1 |
| 20/01/2022 | 15:00 | Alanyaspor vs Hatayspor | 6-0 |
| 20/01/2022 | 18:00 | Galatasaray vs Kasımpaşa | 1-3 |
| 23/02/2022 | 18:00 | Gaziantep F.K. vs Yeni Malatyaspor | 0-0 |
| 22/01/2022 | 11:30 | Yeni Malatyaspor vs Beşiktaş | 1-1 |
| 22/01/2022 | 14:00 | Adana Demirspor vs Fatih Karagümrük | 5-0 |
| 22/01/2022 | 14:00 | Sivasspor vs Fenerbahçe | 1-1 |
| 22/01/2022 | 17:00 | İstanbul Başakşehir vs Göztepe | 1-2 |
| 23/01/2022 | 11:30 | Kasımpaşa vs Kayserispor | 3-1 |
| 23/01/2022 | 11:30 | Hatayspor vs Rizespor | 0-0 |
| 23/01/2022 | 14:00 | Antalyaspor vs Gaziantep F.K. | 0-0 |
| 23/01/2022 | 14:00 | Giresunspor vs Alanyaspor | 1-3 |
| 23/01/2022 | 14:00 | Altay vs Konyaspor | 0-1 |
| 23/01/2022 | 17:00 | Galatasaray vs Trabzonspor | 1-2 |
| 04/02/2022 | 18:00 | Konyaspor vs Giresunspor | 1-0 |
| 04/02/2022 | 18:00 | Kayserispor vs Hatayspor | 4-3 |
| 05/02/2022 | 11:30 | Gaziantep F.K. vs Sivasspor | 5-1 |
| 05/02/2022 | 14:00 | Trabzonspor vs Kasımpaşa | 1-0 |
| 05/02/2022 | 14:00 | Fatih Karagümrük vs Yeni Malatyaspor | 1-0 |
| 05/02/2022 | 17:00 | Fenerbahçe vs İstanbul Başakşehir | 0-1 |
| 06/02/2022 | 14:00 | Alanyaspor vs Galatasaray | 1-1 |
| 06/02/2022 | 14:00 | Rizespor vs Adana Demirspor | 1-3 |
| 06/02/2022 | 17:00 | Beşiktaş vs Antalyaspor | 0-0 |
| 06/02/2022 | 17:00 | Göztepe vs Altay | 0-2 |
| 11/02/2022 | 18:00 | Altay vs Rizespor | 0-0 |
| 12/02/2022 | 14:00 | İstanbul Başakşehir vs Gaziantep F.K. | 2-0 |
| 12/02/2022 | 14:00 | Giresunspor vs Fenerbahçe | 1-2 |
| 12/02/2022 | 17:00 | Galatasaray vs Kayserispor | 1-1 |
| 13/02/2022 | 11:30 | Sivasspor vs Yeni Malatyaspor | 2-1 |
| 13/02/2022 | 14:00 | Antalyaspor vs Fatih Karagümrük | 3-0 |
| 13/02/2022 | 17:00 | Kasımpaşa vs Alanyaspor | 2-2 |
| 13/02/2022 | 17:00 | Trabzonspor vs Konyaspor | 2-1 |
| 14/02/2022 | 18:00 | Adana Demirspor vs Beşiktaş | 1-1 |
| 14/02/2022 | 18:00 | Hatayspor vs Göztepe | 2-1 |
| 18/02/2022 | 18:00 | Konyaspor vs Kasımpaşa | 4-4 |
| 18/02/2022 | 18:00 | Rizespor vs İstanbul Başakşehir | 0-2 |
| 19/02/2022 | 11:30 | Yeni Malatyaspor vs Antalyaspor | 1-2 |
| 19/02/2022 | 14:00 | Kayserispor vs Giresunspor | 2-1 |
| 19/02/2022 | 17:00 | Beşiktaş vs Altay | 1-0 |
| 20/02/2022 | 11:30 | Gaziantep F.K. vs Adana Demirspor | 0-3 |
| 20/02/2022 | 14:00 | Alanyaspor vs Trabzonspor | 0-4 |
| 20/02/2022 | 14:00 | Fatih Karagümrük vs Sivasspor | 1-0 |
| 20/02/2022 | 17:00 | Fenerbahçe vs Hatayspor | 2-0 |
| 21/02/2022 | 18:00 | Göztepe vs Galatasaray | 2-3 |
| 25/02/2022 | 18:00 | Adana Demirspor vs Antalyaspor | 0-0 |
| 25/02/2022 | 18:00 | Trabzonspor vs Kayserispor | 3-2 |
| 26/02/2022 | 14:00 | İstanbul Başakşehir vs Fatih Karagümrük | 1-2 |
| 26/02/2022 | 17:00 | Sivasspor vs Beşiktaş | 2-3 |
| 27/02/2022 | 11:30 | Altay vs Gaziantep F.K. | 3-2 |
| 27/02/2022 | 11:30 | Giresunspor vs Göztepe | 3-1 |
| 27/02/2022 | 14:00 | Hatayspor vs Yeni Malatyaspor | 5-2 |
| 27/02/2022 | 14:00 | Alanyaspor vs Konyaspor | 5-1 |
| 27/02/2022 | 17:00 | Galatasaray vs Rizespor | 4-2 |
| 28/02/2022 | 18:00 | Kasımpaşa vs Fenerbahçe | 1-2 |
| 04/03/2022 | 18:00 | Yeni Malatyaspor vs Adana Demirspor | 1-0 |
| 05/03/2022 | 14:00 | Rizespor vs Giresunspor | 1-2 |
| 05/03/2022 | 14:00 | Göztepe vs Kasımpaşa | 2-3 |
| 05/03/2022 | 17:00 | Konyaspor vs Galatasaray | 2-0 |
| 06/03/2022 | 14:00 | Fatih Karagümrük vs Altay | 0-0 |
| 06/03/2022 | 17:00 | Fenerbahçe vs Trabzonspor | 1-1 |
| 06/03/2022 | 17:00 | Antalyaspor vs Sivasspor | 1-0 |
| 07/03/2022 | 18:00 | Kayserispor vs Alanyaspor | 1-2 |
| 07/03/2022 | 18:00 | Beşiktaş vs İstanbul Başakşehir | 2-2 |
| 07/03/2022 | 18:00 | Gaziantep F.K. vs Hatayspor | 2-2 |
| 12/03/2022 | 11:30 | Hatayspor vs Fatih Karagümrük | 3-0 |
| 12/03/2022 | 14:00 | Altay vs Yeni Malatyaspor | 1-0 |
| 12/03/2022 | 14:00 | Kasımpaşa vs Rizespor | 3-1 |
| 12/03/2022 | 17:00 | Trabzonspor vs Göztepe | 4-2 |
| 13/03/2022 | 11:30 | Kayserispor vs Konyaspor | 2-3 |
| 13/03/2022 | 14:00 | Adana Demirspor vs Sivasspor | 2-3 |
| 13/03/2022 | 17:00 | Alanyaspor vs Fenerbahçe | 2-5 |
| 14/03/2022 | 14:00 | İstanbul Başakşehir vs Antalyaspor | 0-1 |
| 14/03/2022 | 18:00 | Galatasaray vs Beşiktaş | 2-1 |
| 14/03/2022 | 18:00 | Giresunspor vs Gaziantep F.K. | 2-1 |
| 18/03/2022 | 18:00 | Rizespor vs Trabzonspor | 3-2 |
| 18/03/2022 | 18:00 | Fatih Karagümrük vs Kayserispor | 3-0 |
| 19/03/2022 | 11:30 | Yeni Malatyaspor vs Kasımpaşa | 0-2 |
| 19/03/2022 | 14:00 | Göztepe vs Alanyaspor | 0-2 |
| 19/03/2022 | 14:00 | Adana Demirspor vs İstanbul Başakşehir | 2-1 |
| 19/03/2022 | 17:00 | Beşiktaş vs Hatayspor | 1-1 |
| 20/03/2022 | 11:30 | Antalyaspor vs Giresunspor | 4-1 |
| 20/03/2022 | 11:30 | Sivasspor vs Altay | 2-1 |
| 20/03/2022 | 14:00 | Gaziantep F.K. vs Galatasaray | 3-1 |
| 20/03/2022 | 17:00 | Fenerbahçe vs Konyaspor | 2-1 |
| 02/04/2022 | 12:30 | Giresunspor vs Sivasspor | 2-2 |
| 02/04/2022 | 15:00 | Altay vs Antalyaspor | 1-2 |
| 02/04/2022 | 15:00 | Kayserispor vs Fenerbahçe | 0-4 |
| 02/04/2022 | 19:30 | Galatasaray vs Fatih Karagümrük | 2-0 |
| 03/04/2022 | 12:30 | Kasımpaşa vs Gaziantep F.K. | 2-1 |
| 03/04/2022 | 15:00 | Konyaspor vs Göztepe | 3-0 |
| 03/04/2022 | 15:00 | Alanyaspor vs Rizespor | 2-1 |
| 03/04/2022 | 19:30 | Trabzonspor vs Beşiktaş | 1-1 |
| 04/04/2022 | 19:30 | İstanbul Başakşehir vs Yeni Malatyaspor | 1-0 |
| 04/04/2022 | 19:30 | Hatayspor vs Adana Demirspor | 0-0 |
| 09/04/2022 | 12:30 | Fatih Karagümrük vs Kasımpaşa | 3-2 |
| 09/04/2022 | 15:00 | Göztepe vs Kayserispor | 1-2 |
| 09/04/2022 | 15:00 | Rizespor vs Konyaspor | 2-1 |
| 09/04/2022 | 19:30 | Gaziantep F.K. vs Trabzonspor | 0-0 |
| 09/04/2022 | 19:30 | Beşiktaş vs Alanyaspor | 4-1 |
| 10/04/2022 | 12:30 | Yeni Malatyaspor vs Giresunspor | 0-1 |
| 10/04/2022 | 15:00 | Sivasspor vs İstanbul Başakşehir | 0-2 |
| 10/04/2022 | 15:00 | Adana Demirspor vs Altay | 3-1 |
| 10/04/2022 | 19:30 | Fenerbahçe vs Galatasaray | 2-0 |
| 11/04/2022 | 19:30 | Antalyaspor vs Hatayspor | 4-1 |
| 15/04/2022 | 19:30 | Trabzonspor vs Fatih Karagümrük | 1-1 |
| 15/04/2022 | 19:30 | Kayserispor vs Rizespor | 1-1 |
| 16/04/2022 | 12:30 | Hatayspor vs Sivasspor | 1-1 |
| 16/04/2022 | 15:00 | Alanyaspor vs Antalyaspor | 1-3 |
| 16/04/2022 | 15:00 | Altay vs İstanbul Başakşehir | 1-1 |
| 16/04/2022 | 19:30 | Fenerbahçe vs Göztepe | 2-0 |
| 17/04/2022 | 12:30 | Konyaspor vs Gaziantep F.K. | 4-1 |
| 17/04/2022 | 15:00 | Kasımpaşa vs Adana Demirspor | 4-0 |
| 17/04/2022 | 19:30 | Giresunspor vs Beşiktaş | 0-0 |
| 18/04/2022 | 19:30 | Galatasaray vs Yeni Malatyaspor | 2-0 |
| 22/04/2022 | 19:30 | Rizespor vs Fenerbahçe | 0-6 |
| 23/04/2022 | 15:00 | Fatih Karagümrük vs Giresunspor | 2-1 |
| 23/04/2022 | 15:00 | Gaziantep F.K. vs Göztepe | 1-1 |
| 23/04/2022 | 19:30 | Adana Demirspor vs Trabzonspor | 1-3 |
| 24/04/2022 | 15:00 | Yeni Malatyaspor vs Konyaspor | 2-3 |
| 24/04/2022 | 15:00 | İstanbul Başakşehir vs Hatayspor | 3-0 |
| 24/04/2022 | 19:30 | Altay vs Galatasaray | 0-1 |
| 24/04/2022 | 19:30 | Antalyaspor vs Kayserispor | 1-1 |
| 25/04/2022 | 19:30 | Beşiktaş vs Kasımpaşa | 0-3 |
| 25/04/2022 | 19:30 | Sivasspor vs Alanyaspor | 1-0 |
| 29/04/2022 | 19:30 | Fenerbahçe vs Gaziantep F.K. | 3-2 |
| 29/04/2022 | 19:30 | Giresunspor vs Adana Demirspor | 2-0 |
| 30/04/2022 | 15:00 | Konyaspor vs Fatih Karagümrük | 1-2 |
| 30/04/2022 | 15:00 | Kasımpaşa vs İstanbul Başakşehir | 2-3 |
| 30/04/2022 | 19:30 | Trabzonspor vs Antalyaspor | 2-2 |
| 30/04/2022 | 19:30 | Hatayspor vs Altay | 0-1 |
| 01/05/2022 | 15:00 | Kayserispor vs Beşiktaş | 2-3 |
| 01/05/2022 | 15:00 | Alanyaspor vs Yeni Malatyaspor | 2-1 |
| 01/05/2022 | 19:30 | Galatasaray vs Sivasspor | 2-3 |
| 01/05/2022 | 19:30 | Göztepe vs Rizespor | 1-7 |
| 06/05/2022 | 19:00 | Hatayspor vs Trabzonspor | 1-1 |
| 06/05/2022 | 19:00 | Gaziantep F.K. vs Kayserispor | 1-1 |
| 07/05/2022 | 15:00 | Fatih Karagümrük vs Göztepe | 3-1 |
| 07/05/2022 | 16:00 | Sivasspor vs Kasımpaşa | 1-3 |
| 07/05/2022 | 18:00 | Adana Demirspor vs Alanyaspor | 1-2 |
| 07/05/2022 | 19:00 | İstanbul Başakşehir vs Galatasaray | 0-0 |
| 08/05/2022 | 15:00 | Altay vs Giresunspor | 1-1 |
| 08/05/2022 | 15:00 | Yeni Malatyaspor vs Rizespor | 1-3 |
| 08/05/2022 | 19:00 | Beşiktaş vs Fenerbahçe | 1-1 |
| 09/05/2022 | 19:00 | Antalyaspor vs Konyaspor | 3-2 |
| 14/05/2022 | 19:00 | Kayserispor vs Yeni Malatyaspor | 3-0 |
| 15/05/2022 | 15:00 | Göztepe vs Beşiktaş | 0-2 |
| 15/05/2022 | 15:00 | Trabzonspor vs Altay | 2-1 |
| 15/05/2022 | 18:00 | Konyaspor vs Hatayspor | 3-1 |
| 15/05/2022 | 19:00 | Alanyaspor vs Gaziantep F.K. | 3-0 |
| 15/05/2022 | 19:00 | Fenerbahçe vs Fatih Karagümrük | 0-0 |
| 15/05/2022 | 19:00 | Kasımpaşa vs Antalyaspor | 2-4 |
| 15/05/2022 | 19:00 | Giresunspor vs İstanbul Başakşehir | 1-1 |
| 16/05/2022 | 19:00 | Rizespor vs Sivasspor | 1-2 |
| 16/05/2022 | 19:00 | Galatasaray vs Adana Demirspor | 3-2 |
| 20/05/2022 | 19:00 | Antalyaspor vs Galatasaray | 1-1 |
| 20/05/2022 | 19:00 | Gaziantep F.K. vs Rizespor | 2-0 |
| 21/05/2022 | 15:00 | Altay vs Kasımpaşa | 2-4 |
| 21/05/2022 | 15:00 | Sivasspor vs Kayserispor | 2-1 |
| 21/05/2022 | 18:00 | Yeni Malatyaspor vs Fenerbahçe | 0-5 |
| 21/05/2022 | 19:00 | Beşiktaş vs Konyaspor | 1-1 |
| 22/05/2022 | 15:00 | İstanbul Başakşehir vs Trabzonspor | 3-1 |
| 22/05/2022 | 15:00 | Fatih Karagümrük vs Alanyaspor | 0-1 |
| 22/05/2022 | 18:00 | Adana Demirspor vs Göztepe | 7-0 |
| 22/05/2022 | 19:00 | Hatayspor vs Giresunspor | 4-1 |