| 26/02/2022 | 19:00 | Philadelphia Union vs Minnesota United | 1-1 |
| 26/02/2022 | 21:30 | Columbus Crew vs Vancouver Whitecaps | 4-0 |
| 26/02/2022 | 21:30 | Los Angeles FC vs Colorado Rapids | 3-0 |
| 26/02/2022 | 23:30 | Dallas vs Toronto | 1-1 |
| 26/02/2022 | 00:00 | DC United vs Charlotte | 3-0 |
| 26/02/2022 | 00:00 | Austin vs Cincinnati | 5-0 |
| 26/02/2022 | 00:00 | Inter Miami vs Chicago Fire | 0-0 |
| 26/02/2022 | 00:00 | SJ Earthquakes vs New York RB | 1-3 |
| 27/02/2022 | 01:30 | Portland Timbers vs New Inglaterra | 2-2 |
| 27/02/2022 | 19:00 | Orlando City vs CF Montréal | 2-0 |
| 27/02/2022 | 21:00 | Atlanta United vs Sporting KC | 3-1 |
| 27/02/2022 | 23:00 | LA Galaxy vs New York City | 1-0 |
| 28/02/2022 | 01:00 | Houston Dynamo vs Real Salt Lake | 0-0 |
| 28/02/2022 | 02:00 | Seattle Sounders vs Nashville SC | 0-1 |
| 05/03/2022 | 19:30 | New Inglaterra vs Dallas | 1-0 |
| 05/03/2022 | 20:00 | Toronto vs New York RB | 1-4 |
| 05/03/2022 | 21:30 | Sporting KC vs Houston Dynamo | 1-0 |
| 05/03/2022 | 22:00 | CF Montréal vs Philadelphia Union | 1-2 |
| 05/03/2022 | 23:30 | SJ Earthquakes vs Columbus Crew | 3-3 |
| 05/03/2022 | 00:00 | Cincinnati vs DC United | 0-1 |
| 05/03/2022 | 00:00 | Chicago Fire vs Orlando City | 0-0 |
| 05/03/2022 | 00:00 | Minnesota United vs Nashville SC | 1-1 |
| 05/03/2022 | 00:00 | Colorado Rapids vs Atlanta United | 3-0 |
| 05/03/2022 | 00:00 | Real Salt Lake vs Seattle Sounders | 1-0 |
| 05/03/2022 | 00:00 | Vancouver Whitecaps vs New York City | 0-0 |
| 06/03/2022 | 01:30 | Charlotte vs LA Galaxy | 0-1 |
| 06/03/2022 | 22:00 | Austin vs Inter Miami | 5-1 |
| 07/03/2022 | 04:00 | Los Angeles FC vs Portland Timbers | 1-1 |
| 12/03/2022 | 19:00 | New York City vs CF Montréal | 4-1 |
| 12/03/2022 | 19:30 | Columbus Crew vs Toronto | 2-1 |
| 12/03/2022 | 19:30 | Inter Miami vs Los Angeles FC | 0-2 |
| 12/03/2022 | 21:30 | Seattle Sounders vs LA Galaxy | 3-2 |
| 12/03/2022 | 00:30 | Houston Dynamo vs Vancouver Whitecaps | 2-1 |
| 13/03/2022 | 01:30 | DC United vs Chicago Fire | 0-2 |
| 13/03/2022 | 01:30 | New Inglaterra vs Real Salt Lake | 2-3 |
| 13/03/2022 | 01:30 | Orlando City vs Cincinnati | 1-2 |
| 13/03/2022 | 01:30 | Philadelphia Union vs SJ Earthquakes | 2-0 |
| 13/03/2022 | 02:30 | Dallas vs Nashville SC | 2-0 |
| 13/03/2022 | 03:00 | Colorado Rapids vs Sporting KC | 2-0 |
| 13/03/2022 | 04:00 | Portland Timbers vs Austin | 1-0 |
| 13/03/2022 | 21:30 | Atlanta United vs Charlotte | 2-1 |
| 13/03/2022 | 00:00 | New York RB vs Minnesota United | 0-1 |
| 19/03/2022 | 18:00 | Cincinnati vs Inter Miami | 3-1 |
| 19/03/2022 | 18:00 | New York City vs Philadelphia Union | 0-2 |
| 19/03/2022 | 20:00 | Toronto vs DC United | 2-1 |
| 19/03/2022 | 20:30 | LA Galaxy vs Orlando City | 0-1 |
| 19/03/2022 | 21:00 | Atlanta United vs CF Montréal | 3-3 |
| 19/03/2022 | 23:00 | Chicago Fire vs Sporting KC | 3-1 |
| 19/03/2022 | 00:00 | Charlotte vs New Inglaterra | 3-1 |
| 20/03/2022 | 01:00 | Minnesota United vs SJ Earthquakes | 1-0 |
| 20/03/2022 | 01:30 | Houston Dynamo vs Colorado Rapids | 1-1 |
| 20/03/2022 | 01:30 | Dallas vs Portland Timbers | 4-1 |
| 20/03/2022 | 02:30 | Real Salt Lake vs Nashville SC | 2-1 |
| 20/03/2022 | 19:00 | New York RB vs Columbus Crew | 1-1 |
| 20/03/2022 | 21:30 | Austin vs Seattle Sounders | 1-1 |
| 21/03/2022 | 03:00 | Los Angeles FC vs Vancouver Whitecaps | 3-1 |
| 26/03/2022 | 22:00 | Charlotte vs Cincinnati | 2-0 |
| 26/03/2022 | 00:00 | Sporting KC vs Real Salt Lake | 1-0 |
| 27/03/2022 | 22:00 | Portland Timbers vs Orlando City | 1-1 |
| 02/04/2022 | 21:30 | Chicago Fire vs Dallas | 0-0 |
| 02/04/2022 | 22:00 | Cincinnati vs CF Montréal | 3-4 |
| 02/04/2022 | 22:00 | Toronto vs New York City | 2-1 |
| 02/04/2022 | 00:00 | Columbus Crew vs Nashville SC | 0-1 |
| 03/04/2022 | 01:30 | DC United vs Atlanta United | 0-1 |
| 03/04/2022 | 01:30 | New Inglaterra vs New York RB | 0-1 |
| 03/04/2022 | 01:30 | Orlando City vs Los Angeles FC | 2-4 |
| 03/04/2022 | 01:30 | Philadelphia Union vs Charlotte | 2-0 |
| 03/04/2022 | 01:30 | SJ Earthquakes vs Austin | 2-2 |
| 03/04/2022 | 02:00 | Minnesota United vs Seattle Sounders | 1-2 |
| 03/04/2022 | 02:00 | Vancouver Whitecaps vs Sporting KC | 1-0 |
| 03/04/2022 | 03:00 | Colorado Rapids vs Real Salt Lake | 1-1 |
| 03/04/2022 | 03:55 | Inter Miami vs Houston Dynamo | 1-3 |
| 03/04/2022 | 22:30 | Portland Timbers vs LA Galaxy | 1-3 |
| 09/04/2022 | 19:00 | Orlando City vs Chicago Fire | 1-0 |
| 09/04/2022 | 21:00 | Inter Miami vs New Inglaterra | 3-2 |
| 09/04/2022 | 22:00 | New York RB vs CF Montréal | 1-2 |
| 09/04/2022 | 00:00 | Philadelphia Union vs Columbus Crew | 1-0 |
| 10/04/2022 | 01:30 | LA Galaxy vs Los Angeles FC | 2-1 |
| 10/04/2022 | 02:00 | Real Salt Lake vs Toronto | 2-2 |
| 10/04/2022 | 02:30 | Dallas vs Colorado Rapids | 3-1 |
| 10/04/2022 | 02:30 | Houston Dynamo vs SJ Earthquakes | 4-3 |
| 10/04/2022 | 02:30 | Sporting KC vs Nashville SC | 1-2 |
| 10/04/2022 | 04:00 | Vancouver Whitecaps vs Portland Timbers | 2-3 |
| 10/04/2022 | 19:30 | Charlotte vs Atlanta United | 1-0 |
| 11/04/2022 | 01:30 | Austin vs Minnesota United | 1-0 |
| 16/04/2022 | 21:00 | CF Montréal vs Vancouver Whitecaps | 2-1 |
| 16/04/2022 | 21:30 | SJ Earthquakes vs Nashville SC | 2-2 |
| 16/04/2022 | 00:00 | Atlanta United vs Cincinnati | 0-0 |
| 16/04/2022 | 00:00 | Houston Dynamo vs Portland Timbers | 0-0 |
| 17/04/2022 | 01:00 | New York RB vs Dallas | 0-0 |
| 17/04/2022 | 01:30 | Columbus Crew vs Orlando City | 0-2 |
| 17/04/2022 | 01:30 | New Inglaterra vs Charlotte | 2-1 |
| 17/04/2022 | 01:30 | Toronto vs Philadelphia Union | 2-1 |
| 17/04/2022 | 02:00 | DC United vs Austin | 2-3 |
| 17/04/2022 | 02:00 | Chicago Fire vs LA Galaxy | 0-0 |
| 17/04/2022 | 02:00 | Minnesota United vs Colorado Rapids | 3-1 |
| 17/04/2022 | 04:00 | Seattle Sounders vs Inter Miami | 0-1 |
| 17/04/2022 | 19:00 | New York City vs Real Salt Lake | 6-0 |
| 17/04/2022 | 22:00 | Los Angeles FC vs Sporting KC | 3-1 |
| 23/04/2022 | 21:00 | Dallas vs Houston Dynamo | 2-1 |
| 23/04/2022 | 21:00 | Philadelphia Union vs CF Montréal | 1-1 |
| 23/04/2022 | 23:00 | Minnesota United vs Chicago Fire | 3-0 |
| 24/04/2022 | 01:30 | DC United vs New Inglaterra | 3-2 |
| 24/04/2022 | 02:30 | Austin vs Vancouver Whitecaps | 3-0 |
| 24/04/2022 | 02:30 | Sporting KC vs Columbus Crew | 0-0 |
| 24/04/2022 | 03:00 | Colorado Rapids vs Charlotte | 0-0 |
| 24/04/2022 | 04:00 | Portland Timbers vs Real Salt Lake | 0-0 |
| 24/04/2022 | 04:00 | SJ Earthquakes vs Seattle Sounders | 4-3 |
| 24/04/2022 | 04:30 | LA Galaxy vs Nashville SC | 1-0 |
| 24/04/2022 | 19:00 | Inter Miami vs Atlanta United | 2-1 |
| 24/04/2022 | 21:30 | Orlando City vs New York RB | 0-3 |
| 24/04/2022 | 23:00 | Cincinnati vs Los Angeles FC | 1-2 |
| 24/04/2022 | 23:00 | New York City vs Toronto | 5-4 |
| 30/04/2022 | 19:30 | Houston Dynamo vs Austin | 1-2 |
| 30/04/2022 | 21:00 | Toronto vs Cincinnati | 1-2 |
| 30/04/2022 | 21:30 | Real Salt Lake vs LA Galaxy | 1-0 |
| 30/04/2022 | 22:00 | CF Montréal vs Atlanta United | 2-1 |
| 01/05/2022 | 01:30 | New Inglaterra vs Inter Miami | 2-0 |
| 01/05/2022 | 01:30 | Columbus Crew vs DC United | 3-0 |
| 01/05/2022 | 01:30 | Orlando City vs Charlotte | 2-1 |
| 01/05/2022 | 02:00 | Chicago Fire vs New York RB | 1-2 |
| 01/05/2022 | 02:30 | Sporting KC vs Dallas | 2-2 |
| 01/05/2022 | 03:00 | Colorado Rapids vs Portland Timbers | 2-0 |
| 01/05/2022 | 19:00 | New York City vs SJ Earthquakes | 3-0 |
| 01/05/2022 | 22:00 | Nashville SC vs Philadelphia Union | 1-1 |
| 02/05/2022 | 04:00 | Los Angeles FC vs Minnesota United | 2-0 |
| 05/05/2022 | 01:30 | Cincinnati vs Toronto | 2-0 |
| 07/05/2022 | 21:30 | Charlotte vs Inter Miami | 1-0 |
| 07/05/2022 | 22:00 | CF Montréal vs Orlando City | 4-1 |
| 07/05/2022 | 00:00 | Atlanta United vs Chicago Fire | 4-1 |
| 08/05/2022 | 01:00 | New York RB vs Portland Timbers | 1-1 |
| 08/05/2022 | 01:00 | New York City vs Sporting KC | 0-0 |
| 08/05/2022 | 01:30 | DC United vs Houston Dynamo | 2-0 |
| 08/05/2022 | 01:30 | New Inglaterra vs Columbus Crew | 2-2 |
| 08/05/2022 | 02:00 | Minnesota United vs Cincinnati | 0-1 |
| 08/05/2022 | 02:30 | Dallas vs Seattle Sounders | 2-0 |
| 08/05/2022 | 04:00 | SJ Earthquakes vs Colorado Rapids | 1-0 |
| 08/05/2022 | 05:00 | Los Angeles FC vs Philadelphia Union | 2-2 |
| 08/05/2022 | 22:00 | Vancouver Whitecaps vs Toronto | 1-0 |
| 08/05/2022 | 23:00 | Nashville SC vs Real Salt Lake | 2-0 |
| 09/05/2022 | 01:35 | Austin vs LA Galaxy | 0-1 |
| 14/05/2022 | 21:00 | Toronto vs Orlando City | 0-1 |
| 14/05/2022 | 21:30 | Colorado Rapids vs Los Angeles FC | 2-0 |
| 15/05/2022 | 01:00 | Charlotte vs CF Montréal | 0-2 |
| 15/05/2022 | 01:00 | New York City vs Columbus Crew | 2-0 |
| 15/05/2022 | 01:00 | Vancouver Whitecaps vs SJ Earthquakes | 3-3 |
| 15/05/2022 | 01:30 | Philadelphia Union vs New York RB | 1-1 |
| 15/05/2022 | 02:00 | Chicago Fire vs Cincinnati | 1-2 |
| 15/05/2022 | 02:30 | Houston Dynamo vs Nashville SC | 2-0 |
| 15/05/2022 | 03:15 | Inter Miami vs DC United | 2-2 |
| 15/05/2022 | 03:30 | Real Salt Lake vs Austin | 2-1 |
| 15/05/2022 | 04:00 | Portland Timbers vs Sporting KC | 7-2 |
| 15/05/2022 | 04:30 | LA Galaxy vs Dallas | 1-3 |
| 15/05/2022 | 19:30 | Atlanta United vs New Inglaterra | 2-2 |
| 15/05/2022 | 22:00 | Seattle Sounders vs Minnesota United | 3-1 |
| 19/05/2022 | 01:30 | DC United vs New York City | 0-2 |
| 19/05/2022 | 01:30 | New York RB vs Chicago Fire | 3-3 |
| 19/05/2022 | 01:30 | Philadelphia Union vs Inter Miami | 0-0 |
| 19/05/2022 | 02:00 | Minnesota United vs LA Galaxy | 1-1 |
| 19/05/2022 | 02:30 | Houston Dynamo vs Seattle Sounders | 0-1 |
| 19/05/2022 | 02:30 | Sporting KC vs Colorado Rapids | 2-1 |
| 19/05/2022 | 02:30 | Nashville SC vs CF Montréal | 2-1 |
| 19/05/2022 | 04:00 | Vancouver Whitecaps vs Dallas | 2-1 |
| 19/05/2022 | 04:30 | Los Angeles FC vs Austin | 1-2 |
| 19/05/2022 | 04:30 | SJ Earthquakes vs Portland Timbers | 3-2 |
| 21/05/2022 | 00:30 | Columbus Crew vs Los Angeles FC | 0-2 |
| 21/05/2022 | 00:30 | DC United vs Toronto | 2-2 |
| 22/05/2022 | 01:20 | Cincinnati vs New Inglaterra | 2-3 |
| 22/05/2022 | 01:30 | Nashville SC vs Atlanta United | 2-2 |
| 22/05/2022 | 22:00 | CF Montréal vs Real Salt Lake | 1-2 |
| 22/05/2022 | 23:00 | Charlotte vs Vancouver Whitecaps | 2-1 |
| 22/05/2022 | 23:00 | New York City vs Chicago Fire | 1-0 |
| 22/05/2022 | 00:00 | Inter Miami vs New York RB | 2-0 |
| 23/05/2022 | 01:00 | Dallas vs Minnesota United | 1-2 |
| 23/05/2022 | 01:30 | SJ Earthquakes vs Sporting KC | 1-1 |
| 23/05/2022 | 02:00 | Austin vs Orlando City | 2-2 |
| 23/05/2022 | 02:00 | Colorado Rapids vs Seattle Sounders | 1-0 |
| 23/05/2022 | 02:00 | LA Galaxy vs Houston Dynamo | 0-3 |
| 23/05/2022 | 04:00 | Portland Timbers vs Philadelphia Union | 0-2 |
| 28/05/2022 | 00:00 | Los Angeles FC vs SJ Earthquakes | 3-2 |
| 29/05/2022 | 01:00 | Atlanta United vs Columbus Crew | 1-2 |
| 29/05/2022 | 01:00 | New York RB vs DC United | 4-1 |
| 29/05/2022 | 01:00 | Toronto vs Chicago Fire | 3-2 |
| 29/05/2022 | 01:30 | CF Montréal vs Cincinnati | 4-3 |
| 29/05/2022 | 01:30 | New Inglaterra vs Philadelphia Union | 1-1 |
| 29/05/2022 | 01:30 | Orlando City vs Dallas | 1-3 |
| 29/05/2022 | 02:00 | Inter Miami vs Portland Timbers | 2-1 |
| 29/05/2022 | 02:00 | Minnesota United vs New York City | 0-1 |
| 29/05/2022 | 03:00 | Colorado Rapids vs Nashville SC | 1-3 |
| 29/05/2022 | 03:00 | Sporting KC vs Vancouver Whitecaps | 0-1 |
| 29/05/2022 | 03:30 | Real Salt Lake vs Houston Dynamo | 3-0 |
| 29/05/2022 | 00:00 | LA Galaxy vs Austin | 4-1 |
| 30/05/2022 | 03:30 | Seattle Sounders vs Charlotte | 2-1 |
| 05/06/2022 | 01:00 | Vancouver Whitecaps vs Real Salt Lake | 2-1 |
| 11/06/2022 | 21:00 | Charlotte vs New York RB | 2-0 |
| 12/06/2022 | 02:00 | Nashville SC vs SJ Earthquakes | 0-0 |
| 12/06/2022 | 21:00 | Sporting KC vs New Inglaterra | 1-2 |
| 15/06/2022 | 04:30 | Seattle Sounders vs Vancouver Whitecaps | 4-0 |
| 16/06/2022 | 01:30 | New Inglaterra vs Orlando City | 1-1 |
| 18/06/2022 | 21:00 | Seattle Sounders vs Los Angeles FC | 1-1 |
| 18/06/2022 | 23:00 | LA Galaxy vs Portland Timbers | 1-1 |
| 19/06/2022 | 01:00 | New York RB vs Toronto | 2-0 |
| 19/06/2022 | 01:30 | Columbus Crew vs Charlotte | 1-1 |
| 19/06/2022 | 01:30 | CF Montréal vs Austin | 0-1 |
| 19/06/2022 | 01:30 | Orlando City vs Houston Dynamo | 2-1 |
| 19/06/2022 | 01:30 | Philadelphia Union vs Cincinnati | 1-1 |
| 19/06/2022 | 02:00 | Chicago Fire vs DC United | 1-0 |
| 19/06/2022 | 03:00 | Dallas vs Vancouver Whitecaps | 0-2 |
| 19/06/2022 | 03:30 | Real Salt Lake vs SJ Earthquakes | 2-0 |
| 19/06/2022 | 21:00 | Atlanta United vs Inter Miami | 2-0 |
| 19/06/2022 | 23:00 | New Inglaterra vs Minnesota United | 2-1 |
| 19/06/2022 | 23:00 | New York City vs Colorado Rapids | 1-1 |
| 19/06/2022 | 00:00 | Nashville SC vs Sporting KC | 1-2 |
| 25/06/2022 | 01:30 | Cincinnati vs Orlando City | 1-0 |
| 25/06/2022 | 21:00 | Seattle Sounders vs Sporting KC | 3-0 |
| 25/06/2022 | 23:00 | DC United vs Nashville SC | 1-3 |
| 26/06/2022 | 01:30 | CF Montréal vs Charlotte | 2-1 |
| 26/06/2022 | 01:30 | Toronto vs Atlanta United | 2-1 |
| 26/06/2022 | 02:00 | Houston Dynamo vs Chicago Fire | 2-0 |
| 26/06/2022 | 02:00 | Inter Miami vs Minnesota United | 2-1 |
| 26/06/2022 | 03:00 | Austin vs Dallas | 2-2 |
| 26/06/2022 | 04:00 | Real Salt Lake vs Columbus Crew | 0-0 |
| 26/06/2022 | 04:30 | Portland Timbers vs Colorado Rapids | 3-0 |
| 26/06/2022 | 21:00 | Los Angeles FC vs New York RB | 2-0 |
| 26/06/2022 | 00:00 | Philadelphia Union vs New York City | 2-1 |
| 27/06/2022 | 02:00 | Vancouver Whitecaps vs New Inglaterra | 0-0 |
| 30/06/2022 | 01:30 | Cincinnati vs New York City | 4-4 |
| 30/06/2022 | 01:30 | Toronto vs Columbus Crew | 1-2 |
| 30/06/2022 | 02:00 | Chicago Fire vs Philadelphia Union | 1-0 |
| 30/06/2022 | 04:00 | Seattle Sounders vs CF Montréal | 1-2 |
| 30/06/2022 | 04:30 | Los Angeles FC vs Dallas | 3-1 |
| 30/06/2022 | 04:30 | Portland Timbers vs Houston Dynamo | 2-1 |
| 30/06/2022 | 04:30 | LA Galaxy vs Minnesota United | 2-3 |
| 01/07/2022 | 01:00 | Charlotte vs Austin | 0-1 |
| 01/07/2022 | 02:00 | New York RB vs Atlanta United | 2-1 |
| 03/07/2022 | 01:30 | Toronto vs Seattle Sounders | 0-2 |
| 03/07/2022 | 04:00 | Vancouver Whitecaps vs Los Angeles FC | 1-0 |
| 03/07/2022 | 23:00 | New York City vs Atlanta United | 2-2 |
| 04/07/2022 | 01:30 | Columbus Crew vs Philadelphia Union | 0-0 |
| 04/07/2022 | 01:30 | New Inglaterra vs Cincinnati | 2-2 |
| 04/07/2022 | 02:00 | Minnesota United vs Real Salt Lake | 3-2 |
| 04/07/2022 | 02:00 | Sporting KC vs New York RB | 0-1 |
| 04/07/2022 | 02:30 | Houston Dynamo vs Charlotte | 1-2 |
| 04/07/2022 | 02:30 | Nashville SC vs Portland Timbers | 2-2 |
| 04/07/2022 | 03:00 | SJ Earthquakes vs Chicago Fire | 2-1 |
| 05/07/2022 | 01:00 | Orlando City vs DC United | 3-5 |
| 05/07/2022 | 03:00 | Colorado Rapids vs Austin | 2-3 |
| 05/07/2022 | 03:00 | Dallas vs Inter Miami | 1-1 |
| 05/07/2022 | 04:30 | LA Galaxy vs CF Montréal | 4-0 |
| 09/07/2022 | 01:30 | Philadelphia Union vs DC United | 7-0 |
| 09/07/2022 | 04:00 | Los Angeles FC vs LA Galaxy | 3-2 |
| 09/07/2022 | 04:30 | Vancouver Whitecaps vs Minnesota United | 1-3 |
| 09/07/2022 | 19:00 | New York City vs New Inglaterra | 4-2 |
| 09/07/2022 | 22:30 | Seattle Sounders vs Portland Timbers | 0-3 |
| 10/07/2022 | 01:00 | Atlanta United vs Austin | 0-3 |
| 10/07/2022 | 01:00 | Charlotte vs Nashville SC | 4-1 |
| 10/07/2022 | 01:30 | Cincinnati vs New York RB | 1-1 |
| 10/07/2022 | 01:30 | CF Montréal vs Sporting KC | 1-2 |
| 10/07/2022 | 01:30 | Toronto vs SJ Earthquakes | 2-2 |
| 10/07/2022 | 02:00 | Chicago Fire vs Columbus Crew | 2-3 |
| 10/07/2022 | 02:30 | Houston Dynamo vs Dallas | 2-2 |
| 10/07/2022 | 04:00 | Real Salt Lake vs Colorado Rapids | 2-2 |
| 10/07/2022 | 04:24 | Orlando City vs Inter Miami | 1-0 |
| 13/07/2022 | 03:00 | Austin vs Houston Dynamo | 3-1 |
| 14/07/2022 | 01:30 | Atlanta United vs Real Salt Lake | 2-1 |
| 14/07/2022 | 02:00 | Chicago Fire vs Toronto | 2-0 |
| 14/07/2022 | 02:00 | Cincinnati vs Vancouver Whitecaps | 2-2 |
| 14/07/2022 | 02:00 | DC United vs Columbus Crew | 2-2 |
| 14/07/2022 | 02:00 | Inter Miami vs Philadelphia Union | 1-2 |
| 14/07/2022 | 02:00 | Minnesota United vs Sporting KC | 1-1 |
| 14/07/2022 | 02:30 | Nashville SC vs Seattle Sounders | 1-0 |
| 14/07/2022 | 03:00 | Colorado Rapids vs Orlando City | 1-1 |
| 14/07/2022 | 03:00 | Dallas vs New York City | 0-1 |
| 14/07/2022 | 04:00 | LA Galaxy vs SJ Earthquakes | 2-3 |
| 17/07/2022 | 01:30 | CF Montréal vs Toronto | 1-0 |
| 17/07/2022 | 01:30 | Philadelphia Union vs New Inglaterra | 2-1 |
| 17/07/2022 | 02:00 | Chicago Fire vs Seattle Sounders | 1-0 |
| 17/07/2022 | 02:00 | Minnesota United vs DC United | 2-0 |
| 17/07/2022 | 03:00 | Colorado Rapids vs LA Galaxy | 2-0 |
| 17/07/2022 | 03:00 | Dallas vs Austin | 1-1 |
| 17/07/2022 | 03:22 | Inter Miami vs Charlotte | 3-2 |
| 17/07/2022 | 21:00 | Atlanta United vs Orlando City | 1-1 |
| 17/07/2022 | 23:00 | New York RB vs New York City | 0-1 |
| 18/07/2022 | 01:30 | Columbus Crew vs Cincinnati | 2-0 |
| 18/07/2022 | 02:30 | Nashville SC vs Los Angeles FC | 1-2 |
| 18/07/2022 | 03:30 | Real Salt Lake vs Sporting KC | 3-0 |
| 18/07/2022 | 03:30 | SJ Earthquakes vs Houston Dynamo | 1-2 |
| 18/07/2022 | 04:30 | Portland Timbers vs Vancouver Whitecaps | 1-1 |
| 24/07/2022 | 01:00 | New York City vs Inter Miami | 2-0 |
| 24/07/2022 | 01:30 | Cincinnati vs Nashville SC | 1-1 |
| 24/07/2022 | 01:30 | Columbus Crew vs New Inglaterra | 0-0 |
| 24/07/2022 | 01:30 | Orlando City vs Philadelphia Union | 0-1 |
| 24/07/2022 | 01:30 | Toronto vs Charlotte | 4-0 |
| 24/07/2022 | 02:00 | DC United vs CF Montréal | 1-2 |
| 24/07/2022 | 02:30 | Houston Dynamo vs Minnesota United | 1-2 |
| 24/07/2022 | 02:30 | Sporting KC vs Los Angeles FC | 0-2 |
| 24/07/2022 | 04:00 | Real Salt Lake vs Dallas | 0-1 |
| 24/07/2022 | 04:00 | Seattle Sounders vs Colorado Rapids | 2-1 |
| 24/07/2022 | 04:00 | Vancouver Whitecaps vs Chicago Fire | 1-3 |
| 24/07/2022 | 04:30 | Portland Timbers vs SJ Earthquakes | 2-1 |
| 25/07/2022 | 02:00 | Austin vs New York RB | 3-4 |
| 25/07/2022 | 03:30 | LA Galaxy vs Atlanta United | 2-0 |
| 30/07/2022 | 05:00 | Los Angeles FC vs Seattle Sounders | 2-1 |
| 30/07/2022 | 21:00 | Minnesota United vs Portland Timbers | 4-4 |
| 30/07/2022 | 23:00 | Chicago Fire vs Atlanta United | 0-0 |
| 31/07/2022 | 01:30 | CF Montréal vs New York City | 0-0 |
| 31/07/2022 | 01:30 | Philadelphia Union vs Houston Dynamo | 6-0 |
| 31/07/2022 | 02:00 | Inter Miami vs Cincinnati | 4-4 |
| 31/07/2022 | 02:00 | Nashville SC vs Vancouver Whitecaps | 1-1 |
| 31/07/2022 | 02:00 | New Inglaterra vs Toronto | 0-0 |
| 31/07/2022 | 02:30 | Sporting KC vs Austin | 0-2 |
| 31/07/2022 | 03:00 | Dallas vs LA Galaxy | 1-0 |
| 31/07/2022 | 04:00 | SJ Earthquakes vs Real Salt Lake | 2-2 |
| 31/07/2022 | 23:00 | DC United vs Orlando City | 2-1 |
| 03/08/2022 | 01:30 | New York RB vs Colorado Rapids | 4-5 |
| 03/08/2022 | 04:00 | Seattle Sounders vs Dallas | 1-0 |
| 04/08/2022 | 01:00 | Charlotte vs DC United | 3-0 |
| 04/08/2022 | 01:30 | Columbus Crew vs CF Montréal | 1-2 |
| 04/08/2022 | 04:30 | Portland Timbers vs Nashville SC | 1-1 |
| 04/08/2022 | 04:30 | SJ Earthquakes vs Inter Miami | 0-1 |
| 06/08/2022 | 04:30 | Vancouver Whitecaps vs Houston Dynamo | 2-1 |
| 06/08/2022 | 21:00 | Atlanta United vs Seattle Sounders | 2-1 |
| 07/08/2022 | 01:00 | Charlotte vs Chicago Fire | 2-3 |
| 07/08/2022 | 01:30 | Cincinnati vs Philadelphia Union | 3-1 |
| 07/08/2022 | 01:30 | Columbus Crew vs New York City | 3-2 |
| 07/08/2022 | 01:30 | DC United vs New York RB | 0-0 |
| 07/08/2022 | 01:30 | CF Montréal vs Inter Miami | 2-2 |
| 07/08/2022 | 01:30 | Orlando City vs New Inglaterra | 0-3 |
| 07/08/2022 | 02:00 | Nashville SC vs Toronto | 3-4 |
| 07/08/2022 | 02:30 | Sporting KC vs LA Galaxy | 4-2 |
| 07/08/2022 | 03:00 | Austin vs SJ Earthquakes | 3-3 |
| 07/08/2022 | 03:00 | Colorado Rapids vs Minnesota United | 4-3 |
| 07/08/2022 | 04:00 | Real Salt Lake vs Los Angeles FC | 1-4 |
| 07/08/2022 | 04:30 | Portland Timbers vs Dallas | 1-1 |
| 13/08/2022 | 00:00 | New York RB vs Orlando City | 0-1 |
| 14/08/2022 | 01:30 | Cincinnati vs Atlanta United | 2-2 |
| 14/08/2022 | 01:30 | New Inglaterra vs DC United | 1-0 |
| 14/08/2022 | 01:30 | Philadelphia Union vs Chicago Fire | 4-1 |
| 14/08/2022 | 01:30 | Toronto vs Portland Timbers | 3-1 |
| 14/08/2022 | 02:00 | Inter Miami vs New York City | 3-2 |
| 14/08/2022 | 03:00 | Austin vs Sporting KC | 4-3 |
| 14/08/2022 | 03:00 | Colorado Rapids vs Columbus Crew | 1-1 |
| 14/08/2022 | 03:00 | Dallas vs SJ Earthquakes | 4-1 |
| 14/08/2022 | 03:00 | Houston Dynamo vs CF Montréal | 2-3 |
| 14/08/2022 | 04:00 | LA Galaxy vs Vancouver Whitecaps | 5-2 |
| 14/08/2022 | 04:30 | Los Angeles FC vs Charlotte | 5-0 |
| 15/08/2022 | 03:25 | Nashville SC vs Minnesota United | 1-2 |
| 15/08/2022 | 04:00 | Seattle Sounders vs Real Salt Lake | 1-2 |
| 17/08/2022 | 04:30 | Los Angeles FC vs DC United | 1-0 |
| 18/08/2022 | 01:30 | Atlanta United vs New York RB | 1-2 |
| 18/08/2022 | 01:30 | Toronto vs New Inglaterra | 2-2 |
| 18/08/2022 | 02:00 | New York City vs Charlotte | 1-3 |
| 18/08/2022 | 03:00 | Dallas vs Philadelphia Union | 1-0 |
| 18/08/2022 | 04:00 | Vancouver Whitecaps vs Colorado Rapids | 2-1 |
| 20/08/2022 | 04:00 | LA Galaxy vs Seattle Sounders | 3-3 |
| 20/08/2022 | 00:00 | New York RB vs Cincinnati | 1-1 |
| 21/08/2022 | 01:30 | DC United vs Philadelphia Union | 0-6 |
| 21/08/2022 | 01:30 | CF Montréal vs New Inglaterra | 4-0 |
| 21/08/2022 | 02:00 | Minnesota United vs Austin | 2-1 |
| 21/08/2022 | 02:00 | Inter Miami vs Toronto | 2-1 |
| 21/08/2022 | 03:00 | Colorado Rapids vs Houston Dynamo | 1-1 |
| 21/08/2022 | 04:00 | Real Salt Lake vs Vancouver Whitecaps | 1-1 |
| 21/08/2022 | 04:00 | SJ Earthquakes vs Los Angeles FC | 2-1 |
| 21/08/2022 | 00:00 | Chicago Fire vs New York City | 0-2 |
| 21/08/2022 | 00:48 | Columbus Crew vs Atlanta United | 2-2 |
| 22/08/2022 | 01:00 | Charlotte vs Orlando City | 1-2 |
| 22/08/2022 | 01:55 | Sporting KC vs Portland Timbers | 4-1 |
| 22/08/2022 | 02:30 | Nashville SC vs Dallas | 4-0 |
| 27/08/2022 | 02:00 | Austin vs Los Angeles FC | 4-1 |
| 27/08/2022 | 04:00 | Portland Timbers vs Seattle Sounders | 2-1 |
| 27/08/2022 | 21:30 | Minnesota United vs Houston Dynamo | 2-1 |
| 28/08/2022 | 01:00 | New York RB vs Inter Miami | 3-1 |
| 28/08/2022 | 01:30 | Cincinnati vs Columbus Crew | 2-2 |
| 28/08/2022 | 01:30 | Philadelphia Union vs Colorado Rapids | 6-0 |
| 28/08/2022 | 02:00 | Chicago Fire vs CF Montréal | 0-2 |
| 28/08/2022 | 02:10 | Charlotte vs Toronto | 0-2 |
| 28/08/2022 | 02:30 | Sporting KC vs SJ Earthquakes | 1-0 |
| 28/08/2022 | 03:00 | Dallas vs Real Salt Lake | 1-1 |
| 28/08/2022 | 04:00 | Vancouver Whitecaps vs Nashville SC | 0-3 |
| 28/08/2022 | 22:00 | Atlanta United vs DC United | 3-2 |
| 29/08/2022 | 01:30 | Orlando City vs New York City | 2-1 |
| 29/08/2022 | 02:00 | New Inglaterra vs LA Galaxy | 1-2 |
| 01/09/2022 | 01:00 | Philadelphia Union vs Atlanta United | 4-1 |
| 01/09/2022 | 01:30 | Columbus Crew vs Inter Miami | 1-0 |
| 01/09/2022 | 01:30 | CF Montréal vs New York RB | 0-1 |
| 01/09/2022 | 01:30 | New Inglaterra vs Chicago Fire | 0-0 |
| 01/09/2022 | 01:30 | Toronto vs LA Galaxy | 2-2 |
| 01/09/2022 | 02:00 | New York City vs DC United | 1-2 |
| 01/09/2022 | 02:30 | Houston Dynamo vs Los Angeles FC | 2-1 |
| 01/09/2022 | 02:30 | Nashville SC vs Colorado Rapids | 4-1 |
| 01/09/2022 | 03:22 | Orlando City vs Seattle Sounders | 3-2 |
| 01/09/2022 | 03:30 | Real Salt Lake vs Minnesota United | 3-0 |
| 01/09/2022 | 04:51 | Austin vs Portland Timbers | 1-2 |
| 03/09/2022 | 21:30 | Minnesota United vs Dallas | 0-3 |
| 03/09/2022 | 23:30 | Columbus Crew vs Chicago Fire | 0-0 |
| 04/09/2022 | 01:00 | New York RB vs Philadelphia Union | 0-2 |
| 04/09/2022 | 01:30 | Cincinnati vs Charlotte | 2-0 |
| 04/09/2022 | 03:29 | Nashville SC vs Austin | 3-0 |
| 04/09/2022 | 23:30 | Portland Timbers vs Atlanta United | 2-1 |
| 05/09/2022 | 01:30 | DC United vs Colorado Rapids | 0-0 |
| 05/09/2022 | 01:30 | Toronto vs CF Montréal | 3-4 |
| 05/09/2022 | 02:00 | New Inglaterra vs New York City | 3-0 |
| 05/09/2022 | 02:00 | LA Galaxy vs Sporting KC | 2-2 |
| 05/09/2022 | 03:00 | Seattle Sounders vs Houston Dynamo | 2-1 |
| 05/09/2022 | 03:30 | SJ Earthquakes vs Vancouver Whitecaps | 2-0 |
| 05/09/2022 | 04:30 | Los Angeles FC vs Real Salt Lake | 2-0 |
| 08/09/2022 | 02:00 | New York City vs Cincinnati | 1-1 |
| 10/09/2022 | 01:30 | CF Montréal vs Columbus Crew | 2-2 |
| 10/09/2022 | 19:00 | Charlotte vs New York City | 1-0 |
| 10/09/2022 | 21:30 | Nashville SC vs LA Galaxy | 1-1 |
| 10/09/2022 | 00:00 | New York RB vs New Inglaterra | 2-1 |
| 11/09/2022 | 01:30 | Atlanta United vs Toronto | 4-2 |
| 11/09/2022 | 01:30 | Cincinnati vs SJ Earthquakes | 6-0 |
| 11/09/2022 | 01:30 | Philadelphia Union vs Orlando City | 5-1 |
| 11/09/2022 | 02:00 | Chicago Fire vs Inter Miami | 3-1 |
| 11/09/2022 | 02:00 | Seattle Sounders vs Austin | 3-0 |
| 11/09/2022 | 02:30 | Dallas vs Los Angeles FC | 2-1 |
| 11/09/2022 | 02:30 | Houston Dynamo vs Sporting KC | 0-0 |
| 11/09/2022 | 03:30 | Colorado Rapids vs Vancouver Whitecaps | 3-1 |
| 11/09/2022 | 03:30 | Real Salt Lake vs DC United | 0-0 |
| 11/09/2022 | 04:00 | Portland Timbers vs Minnesota United | 1-0 |
| 14/09/2022 | 01:30 | CF Montréal vs Chicago Fire | 3-2 |
| 14/09/2022 | 02:00 | Inter Miami vs Columbus Crew | 2-1 |
| 14/09/2022 | 02:00 | Minnesota United vs Los Angeles FC | 1-1 |
| 14/09/2022 | 02:30 | Houston Dynamo vs New Inglaterra | 3-1 |
| 14/09/2022 | 02:30 | Sporting KC vs DC United | 3-0 |
| 14/09/2022 | 00:55 | Orlando City vs Atlanta United | 0-1 |
| 15/09/2022 | 03:15 | Austin vs Real Salt Lake | 3-0 |
| 15/09/2022 | 04:00 | Colorado Rapids vs SJ Earthquakes | 2-1 |
| 15/09/2022 | 04:00 | Vancouver Whitecaps vs LA Galaxy | 3-0 |
| 17/09/2022 | 19:00 | New York City vs New York RB | 2-0 |
| 17/09/2022 | 21:30 | Atlanta United vs Philadelphia Union | 0-0 |
| 18/09/2022 | 01:30 | New Inglaterra vs CF Montréal | 0-1 |
| 18/09/2022 | 01:30 | Orlando City vs Toronto | 4-0 |
| 18/09/2022 | 02:00 | Chicago Fire vs Charlotte | 2-3 |
| 18/09/2022 | 02:30 | Sporting KC vs Minnesota United | 4-1 |
| 18/09/2022 | 03:00 | Austin vs Nashville SC | 1-1 |
| 18/09/2022 | 03:30 | Real Salt Lake vs Cincinnati | 1-2 |
| 18/09/2022 | 04:00 | Vancouver Whitecaps vs Seattle Sounders | 2-1 |
| 18/09/2022 | 04:30 | SJ Earthquakes vs Dallas | 1-1 |
| 18/09/2022 | 04:30 | LA Galaxy vs Colorado Rapids | 4-1 |
| 18/09/2022 | 19:00 | Columbus Crew vs Portland Timbers | 1-1 |
| 18/09/2022 | 23:00 | DC United vs Inter Miami | 2-3 |
| 19/09/2022 | 04:30 | Los Angeles FC vs Houston Dynamo | 3-1 |
| 25/09/2022 | 04:00 | SJ Earthquakes vs LA Galaxy | 2-3 |
| 28/09/2022 | 04:00 | Seattle Sounders vs Cincinnati | 1-1 |
| 01/10/2022 | 01:30 | Toronto vs Inter Miami | 0-1 |
| 01/10/2022 | 19:30 | New Inglaterra vs Atlanta United | 2-1 |
| 01/10/2022 | 21:30 | Colorado Rapids vs Dallas | 1-0 |
| 01/10/2022 | 23:30 | Charlotte vs Philadelphia Union | 4-0 |
| 02/10/2022 | 01:30 | Cincinnati vs Chicago Fire | 2-3 |
| 02/10/2022 | 01:30 | Columbus Crew vs New York RB | 2-1 |
| 02/10/2022 | 01:30 | CF Montréal vs DC United | 1-0 |
| 02/10/2022 | 04:00 | SJ Earthquakes vs Minnesota United | 2-0 |
| 02/10/2022 | 04:00 | Vancouver Whitecaps vs Austin | 2-0 |
| 02/10/2022 | 04:30 | LA Galaxy vs Real Salt Lake | 1-1 |
| 02/10/2022 | 19:00 | New York City vs Orlando City | 2-1 |
| 02/10/2022 | 21:00 | Portland Timbers vs Los Angeles FC | 1-2 |
| 02/10/2022 | 23:00 | Sporting KC vs Seattle Sounders | 1-0 |
| 03/10/2022 | 02:30 | Nashville SC vs Houston Dynamo | 1-2 |
| 06/10/2022 | 01:00 | Charlotte vs Columbus Crew | 2-2 |
| 06/10/2022 | 02:00 | Inter Miami vs Orlando City | 4-1 |
| 09/10/2022 | 20:30 | Atlanta United vs New York City | 1-2 |
| 09/10/2022 | 20:30 | Chicago Fire vs New Inglaterra | 1-1 |
| 09/10/2022 | 20:30 | DC United vs Cincinnati | 2-5 |
| 09/10/2022 | 20:30 | Inter Miami vs CF Montréal | 1-3 |
| 09/10/2022 | 20:30 | New York RB vs Charlotte | 2-0 |
| 09/10/2022 | 20:30 | Orlando City vs Columbus Crew | 2-1 |
| 09/10/2022 | 20:30 | Philadelphia Union vs Toronto | 4-0 |
| 09/10/2022 | 23:00 | Austin vs Colorado Rapids | 1-1 |
| 09/10/2022 | 23:00 | Dallas vs Sporting KC | 2-1 |
| 09/10/2022 | 23:00 | Houston Dynamo vs LA Galaxy | 1-3 |
| 09/10/2022 | 23:00 | Los Angeles FC vs Nashville SC | 0-1 |
| 09/10/2022 | 23:00 | Minnesota United vs Vancouver Whitecaps | 2-0 |
| 09/10/2022 | 23:00 | Real Salt Lake vs Portland Timbers | 3-1 |
| 09/10/2022 | 23:00 | Seattle Sounders vs SJ Earthquakes | 2-2 |
| 15/10/2022 | 18:00 | New York RB vs Cincinnati | 1-2 |
| 15/10/2022 | 21:00 | LA Galaxy vs Nashville SC | 1-0 |
| 16/10/2022 | 21:00 | Austin vs Real Salt Lake | 2-2 |
| 17/10/2022 | 02:00 | CF Montréal vs Orlando City | 2-0 |
| 18/10/2022 | 01:00 | New York City vs Inter Miami | 3-0 |
| 18/10/2022 | 03:30 | Dallas vs Minnesota United | 1-1 |
| 21/10/2022 | 02:00 | Philadelphia Union vs Cincinnati | 1-0 |
| 21/10/2022 | 04:00 | Los Angeles FC vs LA Galaxy | 3-2 |
| 23/10/2022 | 19:00 | CF Montréal vs New York City | 1-3 |
| 24/10/2022 | 02:00 | Austin vs Dallas | 2-1 |
| 30/10/2022 | 20:00 | Los Angeles FC vs Austin | 3-0 |
| 31/10/2022 | 01:00 | Philadelphia Union vs New York City | 3-1 |
| 05/11/2022 | 21:00 | Los Angeles FC vs Philadelphia Union | 3-3 |