| 06/08/2021 | 21:15 | Sporting CP vs Vizela | 3-0 |
| 07/08/2021 | 13:45 | Arouca vs Estoril | 0-2 |
| 07/08/2021 | 19:00 | Moreirense vs Benfica | 1-2 |
| 07/08/2021 | 21:30 | Marítimo vs Sporting Braga | 0-2 |
| 08/08/2021 | 16:30 | Vitória Guimarães vs Portimonense | 0-1 |
| 08/08/2021 | 16:30 | Tondela vs Santa Clara | 3-0 |
| 08/08/2021 | 19:00 | Porto vs Belenenses | 2-0 |
| 08/08/2021 | 21:30 | Paços de Ferreira vs Famalicão | 2-0 |
| 09/08/2021 | 21:15 | Gil Vicente vs Boavista | 3-0 |
| 13/08/2021 | 21:15 | Estoril vs Vitória Guimarães | 0-0 |
| 14/08/2021 | 16:30 | Vizela vs Tondela | 2-1 |
| 14/08/2021 | 19:00 | Benfica vs Arouca | 2-0 |
| 14/08/2021 | 21:30 | Sporting Braga vs Sporting CP | 1-2 |
| 15/08/2021 | 16:30 | Portimonense vs Gil Vicente | 0-1 |
| 15/08/2021 | 19:00 | Famalicão vs Porto | 1-2 |
| 15/08/2021 | 21:30 | Santa Clara vs Moreirense | 2-2 |
| 16/08/2021 | 20:00 | Boavista vs Paços de Ferreira | 3-0 |
| 16/08/2021 | 22:15 | Belenenses vs Marítimo | 1-2 |
| 20/08/2021 | 20:00 | Arouca vs Famalicão | 2-1 |
| 20/08/2021 | 22:15 | Moreirense vs Sporting Braga | 2-3 |
| 21/08/2021 | 19:00 | Gil Vicente vs Benfica | 0-2 |
| 21/08/2021 | 21:30 | Sporting CP vs Belenenses | 2-0 |
| 22/08/2021 | 16:30 | Tondela vs Portimonense | 0-3 |
| 22/08/2021 | 19:00 | Marítimo vs Porto | 1-1 |
| 22/08/2021 | 21:30 | Vitória Guimarães vs Vizela | 4-0 |
| 23/08/2021 | 20:00 | Paços de Ferreira vs Estoril | 1-3 |
| 23/08/2021 | 22:15 | Boavista vs Santa Clara | 2-0 |
| 27/08/2021 | 20:00 | Belenenses vs Moreirense | 1-1 |
| 27/08/2021 | 22:15 | Estoril vs Marítimo | 2-1 |
| 28/08/2021 | 16:30 | Vizela vs Boavista | 1-1 |
| 28/08/2021 | 19:00 | Porto vs Arouca | 3-0 |
| 28/08/2021 | 21:30 | Famalicão vs Sporting CP | 1-1 |
| 29/08/2021 | 19:00 | Benfica vs Tondela | 2-1 |
| 29/08/2021 | 19:00 | Sporting Braga vs Vitória Guimarães | 0-0 |
| 29/08/2021 | 21:30 | Santa Clara vs Gil Vicente | 1-0 |
| 29/08/2021 | 21:30 | Portimonense vs Paços de Ferreira | 0-1 |
| 11/09/2021 | 16:30 | Paços de Ferreira vs Sporting Braga | 0-0 |
| 11/09/2021 | 19:00 | Santa Clara vs Benfica | 0-5 |
| 11/09/2021 | 21:30 | Sporting CP vs Porto | 1-1 |
| 12/09/2021 | 16:30 | Moreirense vs Famalicão | 2-2 |
| 12/09/2021 | 19:00 | Gil Vicente vs Vizela | 2-2 |
| 12/09/2021 | 19:00 | Boavista vs Portimonense | 1-1 |
| 12/09/2021 | 21:30 | Vitória Guimarães vs Belenenses | 0-0 |
| 13/09/2021 | 20:00 | Marítimo vs Arouca | 2-2 |
| 13/09/2021 | 22:15 | Tondela vs Estoril | 1-2 |
| 17/09/2021 | 21:15 | Portimonense vs Santa Clara | 2-1 |
| 18/09/2021 | 16:30 | Famalicão vs Marítimo | 0-0 |
| 18/09/2021 | 19:00 | Belenenses vs Gil Vicente | 1-1 |
| 18/09/2021 | 21:30 | Arouca vs Vitória Guimarães | 2-2 |
| 19/09/2021 | 16:30 | Vizela vs Paços de Ferreira | 1-1 |
| 19/09/2021 | 19:00 | Porto vs Moreirense | 5-0 |
| 19/09/2021 | 21:30 | Estoril vs Sporting CP | 0-1 |
| 20/09/2021 | 20:00 | Benfica vs Boavista | 3-1 |
| 20/09/2021 | 22:15 | Sporting Braga vs Tondela | 3-1 |
| 24/09/2021 | 20:00 | Sporting CP vs Marítimo | 1-0 |
| 24/09/2021 | 22:15 | Gil Vicente vs Porto | 1-2 |
| 25/09/2021 | 16:30 | Moreirense vs Arouca | 2-1 |
| 25/09/2021 | 19:00 | Vitória Guimarães vs Benfica | 1-3 |
| 25/09/2021 | 21:30 | Tondela vs Famalicão | 3-2 |
| 26/09/2021 | 19:00 | Santa Clara vs Sporting Braga | 1-1 |
| 26/09/2021 | 21:30 | Portimonense vs Vizela | 0-0 |
| 27/09/2021 | 20:00 | Paços de Ferreira vs Belenenses | 2-2 |
| 27/09/2021 | 22:15 | Boavista vs Estoril | 1-1 |
| 01/10/2021 | 20:00 | Marítimo vs Moreirense | 0-0 |
| 01/10/2021 | 22:15 | Famalicão vs Vitória Guimarães | 1-2 |
| 02/10/2021 | 16:30 | Vizela vs Santa Clara | 1-1 |
| 02/10/2021 | 19:00 | Porto vs Paços de Ferreira | 2-1 |
| 02/10/2021 | 21:30 | Arouca vs Sporting CP | 1-2 |
| 03/10/2021 | 16:30 | Belenenses vs Tondela | 0-2 |
| 03/10/2021 | 19:00 | Benfica vs Portimonense | 0-1 |
| 03/10/2021 | 19:00 | Estoril vs Gil Vicente | 2-2 |
| 03/10/2021 | 21:30 | Sporting Braga vs Boavista | 2-2 |
| 22/10/2021 | 21:15 | Vitória Guimarães vs Marítimo | 2-1 |
| 23/10/2021 | 16:30 | Santa Clara vs Famalicão | 0-2 |
| 23/10/2021 | 19:00 | Tondela vs Porto | 1-3 |
| 23/10/2021 | 21:30 | Sporting CP vs Moreirense | 1-0 |
| 24/10/2021 | 16:30 | Paços de Ferreira vs Arouca | 0-0 |
| 24/10/2021 | 19:00 | Vizela vs Benfica | 0-1 |
| 24/10/2021 | 21:30 | Portimonense vs Estoril | 0-2 |
| 25/10/2021 | 20:00 | Gil Vicente vs Sporting Braga | 0-1 |
| 25/10/2021 | 22:15 | Boavista vs Belenenses | 0-0 |
| 29/10/2021 | 21:15 | Arouca vs Tondela | 2-0 |
| 30/10/2021 | 18:00 | Porto vs Boavista | 4-1 |
| 30/10/2021 | 20:00 | Estoril vs Benfica | 1-1 |
| 30/10/2021 | 22:15 | Sporting CP vs Vitória Guimarães | 1-0 |
| 31/10/2021 | 16:30 | Marítimo vs Gil Vicente | 1-2 |
| 31/10/2021 | 19:00 | Belenenses vs Santa Clara | 2-1 |
| 31/10/2021 | 21:30 | Famalicão vs Vizela | 1-1 |
| 01/11/2021 | 20:00 | Sporting Braga vs Portimonense | 3-0 |
| 01/11/2021 | 22:15 | Moreirense vs Paços de Ferreira | 1-1 |
| 05/11/2021 | 20:00 | Gil Vicente vs Arouca | 1-1 |
| 05/11/2021 | 22:15 | Boavista vs Famalicão | 2-5 |
| 06/11/2021 | 16:30 | Vizela vs Estoril | 1-1 |
| 06/11/2021 | 19:00 | Portimonense vs Belenenses | 2-0 |
| 06/11/2021 | 21:30 | Vitória Guimarães vs Moreirense | 2-1 |
| 07/11/2021 | 15:00 | Tondela vs Marítimo | 4-2 |
| 07/11/2021 | 18:00 | Santa Clara vs Porto | 0-3 |
| 07/11/2021 | 20:00 | Paços de Ferreira vs Sporting CP | 0-2 |
| 07/11/2021 | 22:15 | Benfica vs Sporting Braga | 6-1 |
| 26/11/2021 | 21:15 | Moreirense vs Gil Vicente | 2-2 |
| 27/11/2021 | 16:30 | Famalicão vs Portimonense | 0-3 |
| 27/11/2021 | 19:00 | Arouca vs Boavista | 2-1 |
| 27/11/2021 | 21:30 | Belenenses vs Benfica | 0-7 |
| 28/11/2021 | 16:30 | Marítimo vs Paços de Ferreira | 2-0 |
| 28/11/2021 | 19:00 | Sporting CP vs Tondela | 2-0 |
| 28/11/2021 | 21:30 | Porto vs Vitória Guimarães | 2-1 |
| 29/11/2021 | 21:15 | Estoril vs Santa Clara | 2-2 |
| 30/11/2021 | 21:15 | Sporting Braga vs Vizela | 4-1 |
| 03/12/2021 | 20:00 | Portimonense vs Porto | 0-3 |
| 03/12/2021 | 22:15 | Benfica vs Sporting CP | 1-3 |
| 04/12/2021 | 19:00 | Boavista vs Marítimo | 1-1 |
| 04/12/2021 | 21:30 | Paços de Ferreira vs Vitória Guimarães | 1-2 |
| 05/12/2021 | 16:30 | Santa Clara vs Arouca | 2-1 |
| 05/12/2021 | 19:00 | Gil Vicente vs Famalicão | 4-0 |
| 05/12/2021 | 21:30 | Sporting Braga vs Estoril | 2-0 |
| 02/01/2022 | 19:30 | Vizela vs Belenenses | 2-0 |
| 03/01/2022 | 21:15 | Tondela vs Moreirense | 2-1 |
| 10/12/2021 | 21:15 | Paços de Ferreira vs Gil Vicente | 0-1 |
| 11/12/2021 | 16:30 | Marítimo vs Santa Clara | 4-1 |
| 11/12/2021 | 19:00 | Vitória Guimarães vs Tondela | 5-2 |
| 11/12/2021 | 21:30 | Sporting CP vs Boavista | 2-0 |
| 12/12/2021 | 16:30 | Moreirense vs Portimonense | 0-1 |
| 12/12/2021 | 16:30 | Belenenses vs Estoril | 0-1 |
| 12/12/2021 | 19:00 | Famalicão vs Benfica | 1-4 |
| 12/12/2021 | 21:30 | Porto vs Sporting Braga | 1-0 |
| 13/12/2021 | 21:15 | Arouca vs Vizela | 1-4 |
| 17/12/2021 | 20:00 | Santa Clara vs Vitória Guimarães | 1-0 |
| 17/12/2021 | 22:15 | Estoril vs Famalicão | 2-2 |
| 18/12/2021 | 16:30 | Tondela vs Paços de Ferreira | 0-1 |
| 18/12/2021 | 16:30 | Portimonense vs Arouca | 1-1 |
| 18/12/2021 | 21:30 | Gil Vicente vs Sporting CP | 0-3 |
| 19/12/2021 | 18:00 | Benfica vs Marítimo | 7-1 |
| 19/12/2021 | 18:00 | Boavista vs Moreirense | 1-0 |
| 19/12/2021 | 20:00 | Vizela vs Porto | 0-4 |
| 19/12/2021 | 22:00 | Sporting Braga vs Belenenses | 1-0 |
| 28/12/2021 | 18:00 | Tondela vs Gil Vicente | 0-3 |
| 28/12/2021 | 20:00 | Marítimo vs Vizela | 2-0 |
| 28/12/2021 | 22:00 | Moreirense vs Estoril | 1-0 |
| 29/12/2021 | 20:00 | Vitória Guimarães vs Boavista | 1-1 |
| 29/12/2021 | 22:00 | Sporting CP vs Portimonense | 3-2 |
| 30/12/2021 | 18:00 | Paços de Ferreira vs Santa Clara | 2-1 |
| 30/12/2021 | 20:00 | Arouca vs Sporting Braga | 0-6 |
| 30/12/2021 | 22:00 | Porto vs Benfica | 3-1 |
| 13/01/2022 | 19:00 | Famalicão vs Belenenses | 1-0 |
| 07/01/2022 | 19:30 | Santa Clara vs Sporting CP | 3-2 |
| 08/01/2022 | 16:30 | Vizela vs Moreirense | 0-1 |
| 08/01/2022 | 19:00 | Estoril vs Porto | 2-3 |
| 08/01/2022 | 21:30 | Boavista vs Tondela | 1-1 |
| 09/01/2022 | 16:30 | Portimonense vs Marítimo | 1-2 |
| 09/01/2022 | 19:00 | Benfica vs Paços de Ferreira | 2-0 |
| 09/01/2022 | 19:00 | Sporting Braga vs Famalicão | 2-2 |
| 09/01/2022 | 21:30 | Belenenses vs Arouca | 2-1 |
| 10/01/2022 | 21:15 | Gil Vicente vs Vitória Guimarães | 3-2 |
| 15/01/2022 | 16:30 | Boavista vs Gil Vicente | 1-1 |
| 15/01/2022 | 19:00 | Benfica vs Moreirense | 1-1 |
| 15/01/2022 | 19:00 | Sporting Braga vs Marítimo | 0-1 |
| 16/01/2022 | 16:30 | Santa Clara vs Tondela | 2-2 |
| 16/01/2022 | 19:00 | Vizela vs Sporting CP | 0-2 |
| 16/01/2022 | 19:30 | Famalicão vs Paços de Ferreira | 0-0 |
| 16/01/2022 | 21:30 | Belenenses vs Porto | 1-4 |
| 17/01/2022 | 21:15 | Portimonense vs Vitória Guimarães | 1-1 |
| 27/01/2022 | 21:15 | Estoril vs Arouca | 1-2 |
| 21/01/2022 | 20:00 | Arouca vs Benfica | 0-2 |
| 21/01/2022 | 22:15 | Paços de Ferreira vs Boavista | 1-1 |
| 22/01/2022 | 16:30 | Moreirense vs Santa Clara | 0-2 |
| 22/01/2022 | 19:00 | Tondela vs Vizela | 2-3 |
| 22/01/2022 | 21:30 | Sporting CP vs Sporting Braga | 1-2 |
| 23/01/2022 | 16:30 | Marítimo vs Belenenses | 1-1 |
| 23/01/2022 | 16:30 | Vitória Guimarães vs Estoril | 3-1 |
| 23/01/2022 | 19:00 | Gil Vicente vs Portimonense | 1-0 |
| 23/01/2022 | 21:30 | Porto vs Famalicão | 3-1 |
| 30/01/2022 | 16:30 | Vizela vs Vitória Guimarães | 3-2 |
| 30/01/2022 | 16:30 | Portimonense vs Tondela | 1-2 |
| 30/01/2022 | 19:00 | Sporting Braga vs Moreirense | 2-0 |
| 30/01/2022 | 21:30 | Porto vs Marítimo | 2-1 |
| 31/01/2022 | 20:00 | Estoril vs Paços de Ferreira | 0-0 |
| 31/01/2022 | 22:15 | Famalicão vs Arouca | 0-0 |
| 01/02/2022 | 21:15 | Santa Clara vs Boavista | 2-1 |
| 02/02/2022 | 20:00 | Benfica vs Gil Vicente | 1-2 |
| 02/02/2022 | 21:45 | Belenenses vs Sporting CP | 1-4 |
| 05/02/2022 | 16:30 | Marítimo vs Estoril | 0-0 |
| 05/02/2022 | 19:00 | Paços de Ferreira vs Portimonense | 1-1 |
| 05/02/2022 | 21:30 | Vitória Guimarães vs Sporting Braga | 2-1 |
| 06/02/2022 | 16:30 | Gil Vicente vs Santa Clara | 2-2 |
| 06/02/2022 | 16:30 | Boavista vs Vizela | 2-2 |
| 06/02/2022 | 19:00 | Arouca vs Porto | 0-2 |
| 06/02/2022 | 21:30 | Sporting CP vs Famalicão | 2-0 |
| 07/02/2022 | 20:00 | Tondela vs Benfica | 1-3 |
| 07/02/2022 | 22:15 | Moreirense vs Belenenses | 4-1 |
| 11/02/2022 | 21:15 | Porto vs Sporting CP | 2-2 |
| 12/02/2022 | 16:30 | Sporting Braga vs Paços de Ferreira | 2-1 |
| 12/02/2022 | 19:00 | Benfica vs Santa Clara | 2-1 |
| 12/02/2022 | 19:00 | Portimonense vs Boavista | 1-1 |
| 12/02/2022 | 21:30 | Estoril vs Tondela | 1-0 |
| 13/02/2022 | 16:30 | Famalicão vs Moreirense | 5-0 |
| 13/02/2022 | 19:00 | Belenenses vs Vitória Guimarães | 1-0 |
| 13/02/2022 | 21:30 | Vizela vs Gil Vicente | 0-1 |
| 14/02/2022 | 21:15 | Arouca vs Marítimo | 0-3 |
| 18/02/2022 | 21:15 | Boavista vs Benfica | 2-2 |
| 19/02/2022 | 16:30 | Gil Vicente vs Belenenses | 2-0 |
| 19/02/2022 | 19:00 | Paços de Ferreira vs Vizela | 2-1 |
| 19/02/2022 | 21:30 | Vitória Guimarães vs Arouca | 1-3 |
| 20/02/2022 | 16:30 | Marítimo vs Famalicão | 0-1 |
| 20/02/2022 | 19:00 | Sporting CP vs Estoril | 3-0 |
| 20/02/2022 | 21:00 | Moreirense vs Porto | 0-1 |
| 20/02/2022 | 21:45 | Tondela vs Sporting Braga | 0-1 |
| 21/02/2022 | 21:15 | Santa Clara vs Portimonense | 1-1 |
| 25/02/2022 | 21:15 | Belenenses vs Paços de Ferreira | 0-2 |
| 26/02/2022 | 16:30 | Famalicão vs Tondela | 2-1 |
| 26/02/2022 | 19:00 | Marítimo vs Sporting CP | 1-1 |
| 26/02/2022 | 21:30 | Arouca vs Moreirense | 1-1 |
| 27/02/2022 | 16:30 | Vizela vs Portimonense | 1-1 |
| 27/02/2022 | 19:00 | Benfica vs Vitória Guimarães | 3-0 |
| 27/02/2022 | 19:00 | Estoril vs Boavista | 2-3 |
| 27/02/2022 | 21:30 | Porto vs Gil Vicente | 1-1 |
| 28/02/2022 | 21:15 | Sporting Braga vs Santa Clara | 0-0 |
| 04/03/2022 | 21:15 | Gil Vicente vs Estoril | 0-0 |
| 05/03/2022 | 16:30 | Boavista vs Sporting Braga | 1-1 |
| 05/03/2022 | 19:00 | Portimonense vs Benfica | 1-2 |
| 05/03/2022 | 21:30 | Sporting CP vs Arouca | 2-0 |
| 06/03/2022 | 16:30 | Moreirense vs Marítimo | 0-1 |
| 06/03/2022 | 19:00 | Paços de Ferreira vs Porto | 2-4 |
| 06/03/2022 | 21:30 | Vitória Guimarães vs Famalicão | 2-1 |
| 06/03/2022 | 21:30 | Santa Clara vs Vizela | 3-1 |
| 07/03/2022 | 21:15 | Tondela vs Belenenses | 1-1 |
| 11/03/2022 | 21:15 | Benfica vs Vizela | 1-1 |
| 12/03/2022 | 16:30 | Famalicão vs Santa Clara | 0-0 |
| 12/03/2022 | 16:30 | Estoril vs Portimonense | 2-0 |
| 12/03/2022 | 19:00 | Arouca vs Paços de Ferreira | 0-1 |
| 12/03/2022 | 21:30 | Belenenses vs Boavista | 0-0 |
| 13/03/2022 | 16:30 | Marítimo vs Vitória Guimarães | 0-1 |
| 13/03/2022 | 19:00 | Porto vs Tondela | 4-0 |
| 13/03/2022 | 21:30 | Sporting Braga vs Gil Vicente | 0-1 |
| 14/03/2022 | 21:15 | Moreirense vs Sporting CP | 0-2 |
| 18/03/2022 | 21:15 | Vizela vs Famalicão | 1-1 |
| 19/03/2022 | 16:30 | Tondela vs Arouca | 2-2 |
| 19/03/2022 | 19:00 | Santa Clara vs Belenenses | 0-0 |
| 19/03/2022 | 21:30 | Vitória Guimarães vs Sporting CP | 1-3 |
| 20/03/2022 | 16:30 | Paços de Ferreira vs Moreirense | 2-1 |
| 20/03/2022 | 16:30 | Gil Vicente vs Marítimo | 1-1 |
| 20/03/2022 | 19:00 | Benfica vs Estoril | 2-1 |
| 20/03/2022 | 21:00 | Portimonense vs Sporting Braga | 1-2 |
| 20/03/2022 | 21:45 | Boavista vs Porto | 0-1 |
| 01/04/2022 | 21:15 | Sporting Braga vs Benfica | 3-2 |
| 02/04/2022 | 16:30 | Belenenses vs Portimonense | 2-0 |
| 02/04/2022 | 19:00 | Arouca vs Gil Vicente | 2-1 |
| 02/04/2022 | 19:00 | Estoril vs Vizela | 1-2 |
| 02/04/2022 | 21:30 | Famalicão vs Boavista | 1-2 |
| 03/04/2022 | 16:30 | Marítimo vs Tondela | 1-3 |
| 03/04/2022 | 19:00 | Moreirense vs Vitória Guimarães | 0-1 |
| 03/04/2022 | 21:30 | Sporting CP vs Paços de Ferreira | 2-0 |
| 04/04/2022 | 21:15 | Porto vs Santa Clara | 3-0 |
| 08/04/2022 | 21:15 | Gil Vicente vs Moreirense | 1-2 |
| 09/04/2022 | 16:30 | Paços de Ferreira vs Marítimo | 2-0 |
| 09/04/2022 | 19:00 | Benfica vs Belenenses | 3-1 |
| 09/04/2022 | 19:00 | Boavista vs Arouca | 1-0 |
| 09/04/2022 | 21:30 | Tondela vs Sporting CP | 1-3 |
| 10/04/2022 | 16:30 | Portimonense vs Famalicão | 1-0 |
| 10/04/2022 | 16:30 | Santa Clara vs Estoril | 2-0 |
| 10/04/2022 | 19:00 | Vitória Guimarães vs Porto | 0-1 |
| 10/04/2022 | 21:30 | Vizela vs Sporting Braga | 0-1 |
| 15/04/2022 | 16:30 | Arouca vs Santa Clara | 1-1 |
| 15/04/2022 | 19:00 | Famalicão vs Gil Vicente | 2-2 |
| 15/04/2022 | 21:30 | Vitória Guimarães vs Paços de Ferreira | 4-0 |
| 16/04/2022 | 16:30 | Moreirense vs Tondela | 2-0 |
| 16/04/2022 | 19:00 | Marítimo vs Boavista | 4-0 |
| 16/04/2022 | 19:00 | Belenenses vs Vizela | 1-0 |
| 16/04/2022 | 21:30 | Porto vs Portimonense | 7-0 |
| 17/04/2022 | 21:30 | Sporting CP vs Benfica | 0-2 |
| 18/04/2022 | 21:30 | Estoril vs Sporting Braga | 0-0 |
| 22/04/2022 | 21:15 | Vizela vs Arouca | 2-1 |
| 23/04/2022 | 16:30 | Portimonense vs Moreirense | 1-0 |
| 23/04/2022 | 19:00 | Benfica vs Famalicão | 0-0 |
| 23/04/2022 | 19:00 | Santa Clara vs Marítimo | 2-2 |
| 23/04/2022 | 21:30 | Gil Vicente vs Paços de Ferreira | 1-1 |
| 24/04/2022 | 19:00 | Estoril vs Belenenses | 2-2 |
| 24/04/2022 | 21:30 | Tondela vs Vitória Guimarães | 1-1 |
| 25/04/2022 | 19:00 | Sporting Braga vs Porto | 1-0 |
| 25/04/2022 | 21:30 | Boavista vs Sporting CP | 0-3 |
| 29/04/2022 | 21:15 | Famalicão vs Estoril | 3-1 |
| 30/04/2022 | 16:00 | Arouca vs Portimonense | 1-0 |
| 30/04/2022 | 18:00 | Marítimo vs Benfica | 0-1 |
| 30/04/2022 | 20:00 | Porto vs Vizela | 4-2 |
| 30/04/2022 | 22:00 | Belenenses vs Sporting Braga | 0-1 |
| 01/05/2022 | 16:30 | Vitória Guimarães vs Santa Clara | 1-1 |
| 01/05/2022 | 19:00 | Moreirense vs Boavista | 1-2 |
| 01/05/2022 | 21:30 | Sporting CP vs Gil Vicente | 4-1 |
| 02/05/2022 | 21:15 | Paços de Ferreira vs Tondela | 1-1 |
| 06/05/2022 | 21:15 | Boavista vs Vitória Guimarães | 1-1 |
| 07/05/2022 | 16:30 | Estoril vs Moreirense | 1-0 |
| 07/05/2022 | 19:00 | Benfica vs Porto | 0-1 |
| 07/05/2022 | 21:30 | Portimonense vs Sporting CP | 2-3 |
| 08/05/2022 | 16:30 | Gil Vicente vs Tondela | 3-0 |
| 08/05/2022 | 16:30 | Vizela vs Marítimo | 1-1 |
| 08/05/2022 | 19:00 | Sporting Braga vs Arouca | 1-0 |
| 08/05/2022 | 21:30 | Santa Clara vs Paços de Ferreira | 2-0 |
| 09/05/2022 | 21:15 | Belenenses vs Famalicão | 2-3 |
| 13/05/2022 | 21:15 | Paços de Ferreira vs Benfica | 0-2 |
| 14/05/2022 | 16:30 | Arouca vs Belenenses | 0-0 |
| 14/05/2022 | 16:30 | Tondela vs Boavista | 2-2 |
| 14/05/2022 | 16:30 | Moreirense vs Vizela | 4-1 |
| 14/05/2022 | 19:00 | Marítimo vs Portimonense | 0-1 |
| 14/05/2022 | 19:00 | Porto vs Estoril | 2-0 |
| 14/05/2022 | 21:30 | Sporting CP vs Santa Clara | 4-0 |
| 15/05/2022 | 19:00 | Famalicão vs Sporting Braga | 3-2 |
| 15/05/2022 | 21:30 | Vitória Guimarães vs Gil Vicente | 5-0 |