| 07/08/2021 | 16:00 | Bolton Wanderers vs Milton Keynes Dons | 3-3 |
| 07/08/2021 | 16:00 | Cambridge United vs Oxford United | 1-1 |
| 07/08/2021 | 16:00 | Crewe Alexandra vs Cheltenham Town | 1-1 |
| 07/08/2021 | 16:00 | Doncaster Rovers vs AFC Wimbledon | 1-2 |
| 07/08/2021 | 16:00 | Fleetwood Town vs Portsmouth | 0-1 |
| 07/08/2021 | 16:00 | Gillingham vs Lincoln City | 1-1 |
| 07/08/2021 | 16:00 | Ipswich Town vs Morecambe | 2-2 |
| 07/08/2021 | 16:00 | Rotherham United vs Plymouth Argyle | 2-0 |
| 07/08/2021 | 16:00 | Shrewsbury Town vs Burton Albion | 0-1 |
| 07/08/2021 | 16:00 | Sunderland vs Wigan Athletic | 2-1 |
| 07/08/2021 | 16:00 | Wycombe Wanderers vs Accrington Stanley | 2-1 |
| 07/08/2021 | 18:30 | Charlton Athletic vs Sheffield Wednesday | 0-0 |
| 14/08/2021 | 16:00 | AFC Wimbledon vs Bolton Wanderers | 3-3 |
| 14/08/2021 | 16:00 | Accrington Stanley vs Cambridge United | 2-1 |
| 14/08/2021 | 16:00 | Burton Albion vs Ipswich Town | 2-1 |
| 14/08/2021 | 16:00 | Cheltenham Town vs Wycombe Wanderers | 1-3 |
| 14/08/2021 | 16:00 | Lincoln City vs Fleetwood Town | 2-1 |
| 14/08/2021 | 16:00 | Milton Keynes Dons vs Sunderland | 1-2 |
| 14/08/2021 | 16:00 | Morecambe vs Shrewsbury Town | 2-0 |
| 14/08/2021 | 16:00 | Oxford United vs Charlton Athletic | 2-1 |
| 14/08/2021 | 16:00 | Plymouth Argyle vs Gillingham | 1-0 |
| 14/08/2021 | 16:00 | Portsmouth vs Crewe Alexandra | 2-0 |
| 14/08/2021 | 16:00 | Sheffield Wednesday vs Doncaster Rovers | 2-0 |
| 14/08/2021 | 16:00 | Wigan Athletic vs Rotherham United | 1-0 |
| 17/08/2021 | 20:45 | AFC Wimbledon vs Gillingham | 1-1 |
| 17/08/2021 | 20:45 | Accrington Stanley vs Doncaster Rovers | 1-0 |
| 17/08/2021 | 20:45 | Burton Albion vs Sunderland | 1-0 |
| 17/08/2021 | 20:45 | Cheltenham Town vs Ipswich Town | 2-1 |
| 17/08/2021 | 20:45 | Lincoln City vs Bolton Wanderers | 0-1 |
| 17/08/2021 | 20:45 | Milton Keynes Dons vs Charlton Athletic | 2-1 |
| 17/08/2021 | 20:45 | Morecambe vs Rotherham United | 0-1 |
| 17/08/2021 | 20:45 | Oxford United vs Crewe Alexandra | 1-0 |
| 17/08/2021 | 20:45 | Plymouth Argyle vs Cambridge United | 1-1 |
| 17/08/2021 | 20:45 | Portsmouth vs Shrewsbury Town | 1-0 |
| 17/08/2021 | 20:45 | Sheffield Wednesday vs Fleetwood Town | 1-0 |
| 17/08/2021 | 20:45 | Wigan Athletic vs Wycombe Wanderers | 1-1 |
| 21/08/2021 | 14:15 | Rotherham United vs Sheffield Wednesday | 0-2 |
| 21/08/2021 | 16:00 | Bolton Wanderers vs Oxford United | 2-1 |
| 21/08/2021 | 16:00 | Cambridge United vs Burton Albion | 3-0 |
| 21/08/2021 | 16:00 | Charlton Athletic vs Wigan Athletic | 0-2 |
| 21/08/2021 | 16:00 | Crewe Alexandra vs Accrington Stanley | 0-1 |
| 21/08/2021 | 16:00 | Doncaster Rovers vs Portsmouth | 0-0 |
| 21/08/2021 | 16:00 | Fleetwood Town vs Cheltenham Town | 3-2 |
| 21/08/2021 | 16:00 | Gillingham vs Morecambe | 2-1 |
| 21/08/2021 | 16:00 | Ipswich Town vs Milton Keynes Dons | 2-2 |
| 21/08/2021 | 16:00 | Shrewsbury Town vs Plymouth Argyle | 0-3 |
| 21/08/2021 | 16:00 | Sunderland vs AFC Wimbledon | 1-0 |
| 21/08/2021 | 16:00 | Wycombe Wanderers vs Lincoln City | 1-0 |
| 27/08/2021 | 20:45 | Burton Albion vs Cheltenham Town | 1-1 |
| 28/08/2021 | 14:00 | Rotherham United vs Doncaster Rovers | 2-0 |
| 28/08/2021 | 16:00 | Cambridge United vs Bolton Wanderers | 1-0 |
| 28/08/2021 | 16:00 | Charlton Athletic vs Crewe Alexandra | 2-0 |
| 28/08/2021 | 16:00 | Ipswich Town vs AFC Wimbledon | 2-2 |
| 28/08/2021 | 16:00 | Milton Keynes Dons vs Accrington Stanley | 2-0 |
| 28/08/2021 | 16:00 | Morecambe vs Sheffield Wednesday | 1-0 |
| 28/08/2021 | 16:00 | Oxford United vs Lincoln City | 3-1 |
| 28/08/2021 | 16:00 | Plymouth Argyle vs Fleetwood Town | 1-1 |
| 28/08/2021 | 16:00 | Shrewsbury Town vs Gillingham | 2-1 |
| 28/08/2021 | 16:00 | Sunderland vs Wycombe Wanderers | 3-1 |
| 28/08/2021 | 16:00 | Wigan Athletic vs Portsmouth | 1-0 |
| 04/09/2021 | 16:00 | AFC Wimbledon vs Oxford United | 3-1 |
| 04/09/2021 | 16:00 | Accrington Stanley vs Shrewsbury Town | 1-0 |
| 04/09/2021 | 16:00 | Cheltenham Town vs Milton Keynes Dons | 1-1 |
| 06/09/2021 | 21:00 | Bolton Wanderers vs Burton Albion | 0-0 |
| 14/09/2021 | 20:45 | Lincoln City vs Rotherham United | 1-1 |
| 21/09/2021 | 20:45 | Crewe Alexandra vs Morecambe | 1-3 |
| 21/09/2021 | 20:45 | Gillingham vs Charlton Athletic | 1-1 |
| 21/09/2021 | 20:45 | Portsmouth vs Plymouth Argyle | 2-2 |
| 26/10/2021 | 20:45 | Doncaster Rovers vs Cambridge United | 1-1 |
| 02/11/2021 | 20:45 | Fleetwood Town vs Wigan Athletic | 2-3 |
| 02/11/2021 | 20:45 | Sheffield Wednesday vs Sunderland | 3-0 |
| 02/11/2021 | 20:45 | Wycombe Wanderers vs Ipswich Town | 1-4 |
| 11/09/2021 | 16:00 | Burton Albion vs Gillingham | 1-1 |
| 11/09/2021 | 16:00 | Cambridge United vs Lincoln City | 1-5 |
| 11/09/2021 | 16:00 | Charlton Athletic vs Cheltenham Town | 1-2 |
| 11/09/2021 | 16:00 | Ipswich Town vs Bolton Wanderers | 2-5 |
| 11/09/2021 | 16:00 | Milton Keynes Dons vs Portsmouth | 1-0 |
| 11/09/2021 | 16:00 | Morecambe vs AFC Wimbledon | 3-4 |
| 11/09/2021 | 16:00 | Oxford United vs Wycombe Wanderers | 0-0 |
| 11/09/2021 | 16:00 | Plymouth Argyle vs Sheffield Wednesday | 3-0 |
| 11/09/2021 | 16:00 | Rotherham United vs Fleetwood Town | 2-4 |
| 11/09/2021 | 16:00 | Shrewsbury Town vs Crewe Alexandra | 1-1 |
| 11/09/2021 | 16:00 | Sunderland vs Accrington Stanley | 2-1 |
| 11/09/2021 | 16:00 | Wigan Athletic vs Doncaster Rovers | 2-1 |
| 18/09/2021 | 16:00 | AFC Wimbledon vs Plymouth Argyle | 0-1 |
| 18/09/2021 | 16:00 | Accrington Stanley vs Wigan Athletic | 1-4 |
| 18/09/2021 | 16:00 | Bolton Wanderers vs Rotherham United | 0-2 |
| 18/09/2021 | 16:00 | Cheltenham Town vs Oxford United | 1-0 |
| 18/09/2021 | 16:00 | Crewe Alexandra vs Burton Albion | 2-0 |
| 18/09/2021 | 16:00 | Doncaster Rovers vs Morecambe | 1-0 |
| 18/09/2021 | 16:00 | Fleetwood Town vs Sunderland | 2-2 |
| 18/09/2021 | 16:00 | Gillingham vs Milton Keynes Dons | 1-4 |
| 18/09/2021 | 16:00 | Lincoln City vs Ipswich Town | 0-1 |
| 18/09/2021 | 16:00 | Portsmouth vs Cambridge United | 1-2 |
| 18/09/2021 | 16:00 | Sheffield Wednesday vs Shrewsbury Town | 1-1 |
| 18/09/2021 | 16:00 | Wycombe Wanderers vs Charlton Athletic | 2-1 |
| 25/09/2021 | 16:00 | Burton Albion vs Lincoln City | 1-2 |
| 25/09/2021 | 16:00 | Cambridge United vs Fleetwood Town | 2-2 |
| 25/09/2021 | 16:00 | Charlton Athletic vs Portsmouth | 2-2 |
| 25/09/2021 | 16:00 | Ipswich Town vs Sheffield Wednesday | 1-1 |
| 25/09/2021 | 16:00 | Milton Keynes Dons vs Wycombe Wanderers | 1-0 |
| 25/09/2021 | 16:00 | Morecambe vs Accrington Stanley | 3-3 |
| 25/09/2021 | 16:00 | Oxford United vs Gillingham | 1-1 |
| 25/09/2021 | 16:00 | Plymouth Argyle vs Doncaster Rovers | 2-1 |
| 25/09/2021 | 16:00 | Rotherham United vs Crewe Alexandra | 1-1 |
| 25/09/2021 | 16:00 | Shrewsbury Town vs AFC Wimbledon | 2-1 |
| 25/09/2021 | 16:00 | Sunderland vs Bolton Wanderers | 1-0 |
| 25/09/2021 | 16:00 | Wigan Athletic vs Cheltenham Town | 2-0 |
| 28/09/2021 | 20:45 | Burton Albion vs Portsmouth | 2-1 |
| 28/09/2021 | 20:45 | Cambridge United vs Gillingham | 0-2 |
| 28/09/2021 | 20:45 | Charlton Athletic vs Bolton Wanderers | 1-4 |
| 28/09/2021 | 20:45 | Ipswich Town vs Doncaster Rovers | 6-0 |
| 28/09/2021 | 20:45 | Milton Keynes Dons vs Fleetwood Town | 3-3 |
| 28/09/2021 | 20:45 | Morecambe vs Lincoln City | 2-0 |
| 28/09/2021 | 20:45 | Oxford United vs Accrington Stanley | 5-1 |
| 28/09/2021 | 20:45 | Plymouth Argyle vs Crewe Alexandra | 1-1 |
| 28/09/2021 | 20:45 | Rotherham United vs AFC Wimbledon | 3-0 |
| 28/09/2021 | 20:45 | Shrewsbury Town vs Wycombe Wanderers | 1-2 |
| 28/09/2021 | 20:45 | Sunderland vs Cheltenham Town | 5-0 |
| 28/09/2021 | 20:45 | Wigan Athletic vs Sheffield Wednesday | 1-2 |
| 02/10/2021 | 16:00 | AFC Wimbledon vs Burton Albion | 1-1 |
| 02/10/2021 | 16:00 | Accrington Stanley vs Ipswich Town | 2-1 |
| 02/10/2021 | 16:00 | Bolton Wanderers vs Shrewsbury Town | 2-1 |
| 02/10/2021 | 16:00 | Cheltenham Town vs Rotherham United | 0-2 |
| 02/10/2021 | 16:00 | Crewe Alexandra vs Cambridge United | 2-2 |
| 02/10/2021 | 16:00 | Doncaster Rovers vs Milton Keynes Dons | 2-1 |
| 02/10/2021 | 16:00 | Fleetwood Town vs Charlton Athletic | 1-2 |
| 02/10/2021 | 16:00 | Gillingham vs Wigan Athletic | 0-2 |
| 02/10/2021 | 16:00 | Lincoln City vs Plymouth Argyle | 2-2 |
| 02/10/2021 | 16:00 | Portsmouth vs Sunderland | 4-0 |
| 02/10/2021 | 16:00 | Sheffield Wednesday vs Oxford United | 1-2 |
| 02/10/2021 | 16:00 | Wycombe Wanderers vs Morecambe | 4-3 |
| 09/10/2021 | 16:00 | Ipswich Town vs Shrewsbury Town | 2-1 |
| 09/10/2021 | 16:00 | Plymouth Argyle vs Burton Albion | 2-1 |
| 09/10/2021 | 16:00 | Sheffield Wednesday vs Bolton Wanderers | 1-0 |
| 09/10/2021 | 16:00 | Wycombe Wanderers vs Gillingham | 2-0 |
| 26/10/2021 | 20:45 | Wigan Athletic vs Lincoln City | 1-2 |
| 02/11/2021 | 20:45 | Charlton Athletic vs Rotherham United | 1-1 |
| 02/11/2021 | 20:45 | Crewe Alexandra vs Doncaster Rovers | 1-1 |
| 02/11/2021 | 20:45 | Morecambe vs Cambridge United | 0-2 |
| 02/11/2021 | 20:45 | Portsmouth vs Cheltenham Town | 1-1 |
| 04/12/2021 | 16:00 | Accrington Stanley vs Fleetwood Town | 5-1 |
| 04/12/2021 | 16:00 | Sunderland vs Oxford United | 1-1 |
| 11/01/2022 | 20:45 | Milton Keynes Dons vs AFC Wimbledon | 1-0 |
| 15/10/2021 | 20:45 | Burton Albion vs Morecambe | 3-2 |
| 16/10/2021 | 16:00 | AFC Wimbledon vs Sheffield Wednesday | 2-2 |
| 16/10/2021 | 16:00 | Bolton Wanderers vs Wigan Athletic | 0-4 |
| 16/10/2021 | 16:00 | Cambridge United vs Ipswich Town | 2-2 |
| 16/10/2021 | 16:00 | Cheltenham Town vs Accrington Stanley | 1-0 |
| 16/10/2021 | 16:00 | Doncaster Rovers vs Wycombe Wanderers | 0-2 |
| 16/10/2021 | 16:00 | Fleetwood Town vs Crewe Alexandra | 3-0 |
| 16/10/2021 | 16:00 | Gillingham vs Sunderland | 1-2 |
| 16/10/2021 | 16:00 | Lincoln City vs Charlton Athletic | 2-1 |
| 16/10/2021 | 16:00 | Oxford United vs Plymouth Argyle | 1-3 |
| 16/10/2021 | 16:00 | Rotherham United vs Portsmouth | 4-1 |
| 16/10/2021 | 16:00 | Shrewsbury Town vs Milton Keynes Dons | 1-0 |
| 19/10/2021 | 20:45 | Cambridge United vs Sheffield Wednesday | 1-1 |
| 19/10/2021 | 20:45 | Charlton Athletic vs Accrington Stanley | 2-3 |
| 19/10/2021 | 20:45 | Cheltenham Town vs Morecambe | 3-1 |
| 19/10/2021 | 20:45 | Crewe Alexandra vs Sunderland | 0-4 |
| 19/10/2021 | 20:45 | Fleetwood Town vs Burton Albion | 0-1 |
| 19/10/2021 | 20:45 | Gillingham vs Doncaster Rovers | 1-0 |
| 19/10/2021 | 20:45 | Lincoln City vs AFC Wimbledon | 0-1 |
| 19/10/2021 | 20:45 | Oxford United vs Shrewsbury Town | 2-0 |
| 19/10/2021 | 20:45 | Plymouth Argyle vs Bolton Wanderers | 3-0 |
| 19/10/2021 | 20:45 | Portsmouth vs Ipswich Town | 0-4 |
| 19/10/2021 | 20:45 | Rotherham United vs Wycombe Wanderers | 0-0 |
| 19/10/2021 | 20:45 | Wigan Athletic vs Milton Keynes Dons | 1-2 |
| 23/10/2021 | 16:00 | AFC Wimbledon vs Wigan Athletic | 0-2 |
| 23/10/2021 | 16:00 | Accrington Stanley vs Portsmouth | 2-2 |
| 23/10/2021 | 16:00 | Bolton Wanderers vs Gillingham | 2-2 |
| 23/10/2021 | 16:00 | Burton Albion vs Oxford United | 1-3 |
| 23/10/2021 | 16:00 | Doncaster Rovers vs Cheltenham Town | 3-2 |
| 23/10/2021 | 16:00 | Ipswich Town vs Fleetwood Town | 2-1 |
| 23/10/2021 | 16:00 | Milton Keynes Dons vs Rotherham United | 0-3 |
| 23/10/2021 | 16:00 | Morecambe vs Plymouth Argyle | 1-1 |
| 23/10/2021 | 16:00 | Sheffield Wednesday vs Lincoln City | 1-1 |
| 23/10/2021 | 16:00 | Shrewsbury Town vs Cambridge United | 4-1 |
| 23/10/2021 | 16:00 | Sunderland vs Charlton Athletic | 0-1 |
| 23/10/2021 | 16:00 | Wycombe Wanderers vs Crewe Alexandra | 2-1 |
| 30/10/2021 | 16:00 | Cambridge United vs AFC Wimbledon | 1-0 |
| 30/10/2021 | 16:00 | Charlton Athletic vs Doncaster Rovers | 4-0 |
| 30/10/2021 | 16:00 | Cheltenham Town vs Sheffield Wednesday | 2-2 |
| 30/10/2021 | 16:00 | Crewe Alexandra vs Milton Keynes Dons | 1-4 |
| 30/10/2021 | 16:00 | Fleetwood Town vs Wycombe Wanderers | 3-3 |
| 30/10/2021 | 16:00 | Gillingham vs Accrington Stanley | 0-0 |
| 30/10/2021 | 16:00 | Lincoln City vs Shrewsbury Town | 1-1 |
| 30/10/2021 | 16:00 | Oxford United vs Morecambe | 3-1 |
| 30/10/2021 | 16:00 | Plymouth Argyle vs Ipswich Town | 2-1 |
| 30/10/2021 | 16:00 | Portsmouth vs Bolton Wanderers | 1-0 |
| 30/10/2021 | 16:00 | Rotherham United vs Sunderland | 5-1 |
| 30/10/2021 | 16:00 | Wigan Athletic vs Burton Albion | 2-0 |
| 12/11/2021 | 21:00 | Bolton Wanderers vs Crewe Alexandra | 2-0 |
| 13/11/2021 | 16:00 | Accrington Stanley vs Plymouth Argyle | 1-4 |
| 13/11/2021 | 16:00 | Burton Albion vs Charlton Athletic | 0-1 |
| 13/11/2021 | 16:00 | Ipswich Town vs Oxford United | 0-0 |
| 13/11/2021 | 16:00 | Milton Keynes Dons vs Cambridge United | 4-1 |
| 13/11/2021 | 16:00 | Sheffield Wednesday vs Gillingham | 1-1 |
| 13/11/2021 | 16:00 | Wycombe Wanderers vs Portsmouth | 0-1 |
| 08/01/2022 | 16:00 | Doncaster Rovers vs Fleetwood Town | 0-1 |
| 11/01/2022 | 20:45 | Sunderland vs Lincoln City | 1-3 |
| 18/01/2022 | 20:45 | Morecambe vs Wigan Athletic | 1-2 |
| 01/02/2022 | 20:45 | AFC Wimbledon vs Cheltenham Town | 2-2 |
| 01/03/2022 | 20:45 | Shrewsbury Town vs Rotherham United | 0-0 |
| 20/11/2021 | 16:00 | Accrington Stanley vs Sheffield Wednesday | 2-3 |
| 20/11/2021 | 16:00 | Charlton Athletic vs Plymouth Argyle | 2-0 |
| 20/11/2021 | 16:00 | Cheltenham Town vs Shrewsbury Town | 2-1 |
| 20/11/2021 | 16:00 | Crewe Alexandra vs Gillingham | 2-0 |
| 20/11/2021 | 16:00 | Doncaster Rovers vs Lincoln City | 0-0 |
| 20/11/2021 | 16:00 | Fleetwood Town vs Morecambe | 1-2 |
| 20/11/2021 | 16:00 | Milton Keynes Dons vs Burton Albion | 1-0 |
| 20/11/2021 | 16:00 | Portsmouth vs AFC Wimbledon | 2-1 |
| 20/11/2021 | 16:00 | Rotherham United vs Cambridge United | 3-1 |
| 20/11/2021 | 16:00 | Sunderland vs Ipswich Town | 2-0 |
| 20/11/2021 | 16:00 | Wycombe Wanderers vs Bolton Wanderers | 1-0 |
| 01/02/2022 | 20:45 | Wigan Athletic vs Oxford United | 1-1 |
| 23/11/2021 | 20:45 | AFC Wimbledon vs Crewe Alexandra | 3-2 |
| 23/11/2021 | 20:45 | Burton Albion vs Accrington Stanley | 4-0 |
| 23/11/2021 | 20:45 | Cambridge United vs Wigan Athletic | 2-2 |
| 23/11/2021 | 20:45 | Gillingham vs Cheltenham Town | 0-2 |
| 23/11/2021 | 20:45 | Ipswich Town vs Rotherham United | 0-2 |
| 23/11/2021 | 20:45 | Lincoln City vs Portsmouth | 0-3 |
| 23/11/2021 | 20:45 | Morecambe vs Charlton Athletic | 2-2 |
| 23/11/2021 | 20:45 | Oxford United vs Fleetwood Town | 3-1 |
| 23/11/2021 | 20:45 | Plymouth Argyle vs Wycombe Wanderers | 0-3 |
| 23/11/2021 | 20:45 | Sheffield Wednesday vs Milton Keynes Dons | 2-1 |
| 23/11/2021 | 20:45 | Shrewsbury Town vs Sunderland | 1-1 |
| 23/11/2021 | 21:00 | Bolton Wanderers vs Doncaster Rovers | 3-0 |
| 27/11/2021 | 16:00 | AFC Wimbledon vs Fleetwood Town | 2-2 |
| 27/11/2021 | 16:00 | Bolton Wanderers vs Cheltenham Town | 2-2 |
| 27/11/2021 | 16:00 | Burton Albion vs Doncaster Rovers | 2-0 |
| 27/11/2021 | 16:00 | Cambridge United vs Sunderland | 1-2 |
| 27/11/2021 | 16:00 | Gillingham vs Portsmouth | 0-1 |
| 27/11/2021 | 16:00 | Morecambe vs Milton Keynes Dons | 0-4 |
| 27/11/2021 | 16:00 | Oxford United vs Rotherham United | 0-0 |
| 27/11/2021 | 16:00 | Plymouth Argyle vs Wigan Athletic | 1-2 |
| 27/11/2021 | 16:00 | Sheffield Wednesday vs Wycombe Wanderers | 2-2 |
| 27/11/2021 | 16:00 | Shrewsbury Town vs Charlton Athletic | 1-0 |
| 27/11/2021 | 16:15 | Lincoln City vs Accrington Stanley | 0-1 |
| 28/11/2021 | 16:00 | Ipswich Town vs Crewe Alexandra | 2-1 |
| 07/12/2021 | 20:45 | Accrington Stanley vs AFC Wimbledon | 0-2 |
| 07/12/2021 | 20:45 | Charlton Athletic vs Ipswich Town | 2-0 |
| 07/12/2021 | 20:45 | Cheltenham Town vs Cambridge United | 0-5 |
| 07/12/2021 | 20:45 | Crewe Alexandra vs Lincoln City | 2-0 |
| 07/12/2021 | 20:45 | Doncaster Rovers vs Oxford United | 1-2 |
| 07/12/2021 | 20:45 | Fleetwood Town vs Bolton Wanderers | 3-0 |
| 07/12/2021 | 20:45 | Portsmouth vs Sheffield Wednesday | 0-0 |
| 07/12/2021 | 20:45 | Rotherham United vs Gillingham | 5-1 |
| 07/12/2021 | 20:45 | Sunderland vs Morecambe | 5-0 |
| 07/12/2021 | 20:45 | Wycombe Wanderers vs Burton Albion | 2-1 |
| 08/12/2021 | 20:45 | Milton Keynes Dons vs Plymouth Argyle | 1-1 |
| 08/12/2021 | 20:45 | Wigan Athletic vs Shrewsbury Town | 2-1 |
| 11/12/2021 | 16:00 | Accrington Stanley vs Bolton Wanderers | 1-0 |
| 11/12/2021 | 16:00 | Charlton Athletic vs Cambridge United | 2-0 |
| 11/12/2021 | 16:00 | Cheltenham Town vs Lincoln City | 2-2 |
| 11/12/2021 | 16:00 | Crewe Alexandra vs Sheffield Wednesday | 0-2 |
| 11/12/2021 | 16:00 | Doncaster Rovers vs Shrewsbury Town | 1-0 |
| 11/12/2021 | 16:00 | Fleetwood Town vs Gillingham | 2-1 |
| 11/12/2021 | 16:00 | Milton Keynes Dons vs Oxford United | 1-2 |
| 11/12/2021 | 16:00 | Portsmouth vs Morecambe | 2-0 |
| 11/12/2021 | 16:00 | Rotherham United vs Burton Albion | 3-1 |
| 11/12/2021 | 16:00 | Sunderland vs Plymouth Argyle | 2-1 |
| 11/12/2021 | 16:00 | Wigan Athletic vs Ipswich Town | 1-1 |
| 11/12/2021 | 16:00 | Wycombe Wanderers vs AFC Wimbledon | 2-2 |
| 18/12/2021 | 16:00 | Cambridge United vs Rotherham United | 0-1 |
| 18/12/2021 | 16:00 | Ipswich Town vs Sunderland | 1-1 |
| 18/12/2021 | 16:00 | Morecambe vs Fleetwood Town | 0-0 |
| 18/12/2021 | 16:00 | Oxford United vs Wigan Athletic | 2-3 |
| 18/12/2021 | 16:00 | Plymouth Argyle vs Charlton Athletic | 1-0 |
| 18/12/2021 | 16:00 | Shrewsbury Town vs Cheltenham Town | 3-1 |
| 11/01/2022 | 21:00 | Bolton Wanderers vs Wycombe Wanderers | 0-2 |
| 18/01/2022 | 20:45 | AFC Wimbledon vs Portsmouth | 0-0 |
| 25/01/2022 | 20:45 | Burton Albion vs Milton Keynes Dons | 0-1 |
| 01/02/2022 | 20:45 | Gillingham vs Crewe Alexandra | 1-0 |
| 15/02/2022 | 20:45 | Lincoln City vs Doncaster Rovers | 0-1 |
| 15/03/2022 | 20:45 | Sheffield Wednesday vs Accrington Stanley | 1-1 |
| 26/12/2021 | 16:00 | Accrington Stanley vs Rotherham United | 1-0 |
| 26/12/2021 | 16:00 | Cheltenham Town vs Plymouth Argyle | 0-2 |
| 26/12/2021 | 16:00 | Fleetwood Town vs Shrewsbury Town | 0-3 |
| 26/12/2021 | 16:00 | Lincoln City vs Milton Keynes Dons | 2-3 |
| 27/12/2021 | 13:30 | Doncaster Rovers vs Sunderland | 0-3 |
| 08/01/2022 | 16:00 | Gillingham vs Ipswich Town | 0-4 |
| 01/03/2022 | 20:45 | Portsmouth vs Oxford United | 3-2 |
| 01/03/2022 | 20:45 | Sheffield Wednesday vs Burton Albion | 5-2 |
| 01/03/2022 | 20:45 | Wycombe Wanderers vs Cambridge United | 3-0 |
| 08/03/2022 | 21:00 | Bolton Wanderers vs Morecambe | 1-1 |
| 15/03/2022 | 20:45 | Crewe Alexandra vs Wigan Athletic | 0-2 |
| 05/04/2022 | 20:45 | AFC Wimbledon vs Charlton Athletic | 1-1 |
| 29/12/2021 | 20:45 | Ipswich Town vs Wycombe Wanderers | 1-0 |
| 29/12/2021 | 20:45 | Morecambe vs Crewe Alexandra | 1-2 |
| 29/12/2021 | 20:45 | Oxford United vs AFC Wimbledon | 3-0 |
| 29/12/2021 | 20:45 | Shrewsbury Town vs Accrington Stanley | 0-0 |
| 30/12/2021 | 20:45 | Sunderland vs Sheffield Wednesday | 5-0 |
| 18/01/2022 | 20:45 | Cambridge United vs Doncaster Rovers | 3-1 |
| 15/02/2022 | 20:45 | Burton Albion vs Bolton Wanderers | 3-1 |
| 01/03/2022 | 20:45 | Wigan Athletic vs Fleetwood Town | 2-0 |
| 08/03/2022 | 20:45 | Milton Keynes Dons vs Cheltenham Town | 3-1 |
| 15/03/2022 | 20:45 | Charlton Athletic vs Gillingham | 1-0 |
| 15/03/2022 | 20:45 | Plymouth Argyle vs Portsmouth | 1-0 |
| 15/03/2022 | 20:45 | Rotherham United vs Lincoln City | 2-1 |
| 01/01/2022 | 16:00 | Burton Albion vs Crewe Alexandra | 4-1 |
| 01/01/2022 | 16:00 | Charlton Athletic vs Wycombe Wanderers | 0-1 |
| 01/01/2022 | 16:00 | Milton Keynes Dons vs Gillingham | 0-0 |
| 01/01/2022 | 16:00 | Oxford United vs Cheltenham Town | 1-1 |
| 01/01/2022 | 16:00 | Rotherham United vs Bolton Wanderers | 2-1 |
| 02/01/2022 | 16:00 | Morecambe vs Doncaster Rovers | 4-3 |
| 02/01/2022 | 16:00 | Shrewsbury Town vs Sheffield Wednesday | 1-0 |
| 03/01/2022 | 16:00 | Cambridge United vs Portsmouth | 0-0 |
| 08/03/2022 | 20:45 | Ipswich Town vs Lincoln City | 2-0 |
| 08/03/2022 | 20:45 | Plymouth Argyle vs AFC Wimbledon | 2-0 |
| 08/03/2022 | 20:45 | Sunderland vs Fleetwood Town | 3-1 |
| 05/04/2022 | 20:45 | Wigan Athletic vs Accrington Stanley | 3-0 |
| 08/01/2022 | 13:30 | Wycombe Wanderers vs Sunderland | 3-3 |
| 08/01/2022 | 16:00 | Accrington Stanley vs Milton Keynes Dons | 1-1 |
| 08/01/2022 | 16:00 | Cheltenham Town vs Burton Albion | 1-1 |
| 08/01/2022 | 16:00 | Lincoln City vs Oxford United | 2-0 |
| 12/01/2022 | 20:45 | Crewe Alexandra vs Charlton Athletic | 2-1 |
| 25/01/2022 | 20:45 | AFC Wimbledon vs Ipswich Town | 0-2 |
| 25/01/2022 | 20:45 | Fleetwood Town vs Plymouth Argyle | 3-3 |
| 25/01/2022 | 20:45 | Gillingham vs Shrewsbury Town | 0-0 |
| 01/02/2022 | 20:45 | Doncaster Rovers vs Rotherham United | 0-5 |
| 01/02/2022 | 20:45 | Sheffield Wednesday vs Morecambe | 2-0 |
| 01/02/2022 | 21:00 | Bolton Wanderers vs Cambridge United | 2-0 |
| 26/04/2022 | 20:45 | Portsmouth vs Wigan Athletic | 3-2 |
| 15/01/2022 | 16:00 | AFC Wimbledon vs Morecambe | 0-0 |
| 15/01/2022 | 16:00 | Accrington Stanley vs Sunderland | 1-1 |
| 15/01/2022 | 16:00 | Bolton Wanderers vs Ipswich Town | 2-0 |
| 15/01/2022 | 16:00 | Cheltenham Town vs Charlton Athletic | 1-1 |
| 15/01/2022 | 16:00 | Crewe Alexandra vs Shrewsbury Town | 0-0 |
| 15/01/2022 | 16:00 | Doncaster Rovers vs Wigan Athletic | 1-2 |
| 15/01/2022 | 16:00 | Fleetwood Town vs Rotherham United | 1-0 |
| 15/01/2022 | 16:00 | Gillingham vs Burton Albion | 1-3 |
| 15/01/2022 | 16:00 | Lincoln City vs Cambridge United | 0-1 |
| 15/01/2022 | 16:00 | Portsmouth vs Milton Keynes Dons | 1-2 |
| 15/01/2022 | 16:00 | Sheffield Wednesday vs Plymouth Argyle | 4-2 |
| 15/01/2022 | 16:00 | Wycombe Wanderers vs Oxford United | 2-0 |
| 22/01/2022 | 16:00 | Burton Albion vs AFC Wimbledon | 1-1 |
| 22/01/2022 | 16:00 | Cambridge United vs Crewe Alexandra | 1-0 |
| 22/01/2022 | 16:00 | Charlton Athletic vs Fleetwood Town | 2-0 |
| 22/01/2022 | 16:00 | Ipswich Town vs Accrington Stanley | 2-1 |
| 22/01/2022 | 16:00 | Milton Keynes Dons vs Doncaster Rovers | 0-1 |
| 22/01/2022 | 16:00 | Morecambe vs Wycombe Wanderers | 3-2 |
| 22/01/2022 | 16:00 | Oxford United vs Sheffield Wednesday | 3-2 |
| 22/01/2022 | 16:00 | Plymouth Argyle vs Lincoln City | 1-2 |
| 22/01/2022 | 16:00 | Rotherham United vs Cheltenham Town | 1-0 |
| 22/01/2022 | 16:00 | Shrewsbury Town vs Bolton Wanderers | 0-1 |
| 22/01/2022 | 16:00 | Sunderland vs Portsmouth | 1-0 |
| 22/01/2022 | 16:00 | Wigan Athletic vs Gillingham | 3-2 |
| 29/01/2022 | 16:00 | AFC Wimbledon vs Shrewsbury Town | 1-1 |
| 29/01/2022 | 16:00 | Accrington Stanley vs Morecambe | 2-2 |
| 29/01/2022 | 16:00 | Bolton Wanderers vs Sunderland | 6-0 |
| 29/01/2022 | 16:00 | Cheltenham Town vs Wigan Athletic | 0-0 |
| 29/01/2022 | 16:00 | Crewe Alexandra vs Rotherham United | 0-2 |
| 29/01/2022 | 16:00 | Doncaster Rovers vs Plymouth Argyle | 1-3 |
| 29/01/2022 | 16:00 | Fleetwood Town vs Cambridge United | 1-1 |
| 29/01/2022 | 16:00 | Gillingham vs Oxford United | 2-7 |
| 29/01/2022 | 16:00 | Lincoln City vs Burton Albion | 1-2 |
| 29/01/2022 | 16:00 | Sheffield Wednesday vs Ipswich Town | 1-0 |
| 29/01/2022 | 16:00 | Wycombe Wanderers vs Milton Keynes Dons | 0-1 |
| 31/01/2022 | 20:45 | Portsmouth vs Charlton Athletic | 1-2 |
| 05/02/2022 | 16:00 | Burton Albion vs Sheffield Wednesday | 0-2 |
| 05/02/2022 | 16:00 | Charlton Athletic vs AFC Wimbledon | 3-2 |
| 05/02/2022 | 16:00 | Ipswich Town vs Gillingham | 1-0 |
| 05/02/2022 | 16:00 | Milton Keynes Dons vs Lincoln City | 2-1 |
| 05/02/2022 | 16:00 | Morecambe vs Bolton Wanderers | 1-1 |
| 05/02/2022 | 16:00 | Oxford United vs Portsmouth | 3-2 |
| 05/02/2022 | 16:00 | Rotherham United vs Accrington Stanley | 1-0 |
| 05/02/2022 | 16:00 | Shrewsbury Town vs Fleetwood Town | 1-1 |
| 05/02/2022 | 16:00 | Sunderland vs Doncaster Rovers | 1-2 |
| 15/02/2022 | 20:45 | Wigan Athletic vs Crewe Alexandra | 2-0 |
| 22/03/2022 | 20:45 | Plymouth Argyle vs Cheltenham Town | 2-0 |
| 05/04/2022 | 20:45 | Cambridge United vs Wycombe Wanderers | 1-4 |
| 08/02/2022 | 20:45 | AFC Wimbledon vs Rotherham United | 0-1 |
| 08/02/2022 | 20:45 | Accrington Stanley vs Oxford United | 2-0 |
| 08/02/2022 | 20:45 | Cheltenham Town vs Sunderland | 2-1 |
| 08/02/2022 | 20:45 | Crewe Alexandra vs Plymouth Argyle | 1-4 |
| 08/02/2022 | 20:45 | Doncaster Rovers vs Ipswich Town | 0-1 |
| 08/02/2022 | 20:45 | Fleetwood Town vs Milton Keynes Dons | 1-1 |
| 08/02/2022 | 20:45 | Gillingham vs Cambridge United | 1-0 |
| 08/02/2022 | 20:45 | Lincoln City vs Morecambe | 2-1 |
| 08/02/2022 | 20:45 | Portsmouth vs Burton Albion | 2-1 |
| 08/02/2022 | 20:45 | Sheffield Wednesday vs Wigan Athletic | 1-0 |
| 08/02/2022 | 20:45 | Wycombe Wanderers vs Shrewsbury Town | 0-0 |
| 08/02/2022 | 21:00 | Bolton Wanderers vs Charlton Athletic | 2-1 |
| 12/02/2022 | 16:00 | AFC Wimbledon vs Sunderland | 1-1 |
| 12/02/2022 | 16:00 | Accrington Stanley vs Crewe Alexandra | 4-1 |
| 12/02/2022 | 16:00 | Burton Albion vs Cambridge United | 2-2 |
| 12/02/2022 | 16:00 | Cheltenham Town vs Fleetwood Town | 2-0 |
| 12/02/2022 | 16:00 | Lincoln City vs Wycombe Wanderers | 1-1 |
| 12/02/2022 | 16:00 | Milton Keynes Dons vs Ipswich Town | 0-0 |
| 12/02/2022 | 16:00 | Morecambe vs Gillingham | 1-1 |
| 12/02/2022 | 16:00 | Oxford United vs Bolton Wanderers | 2-3 |
| 12/02/2022 | 16:00 | Plymouth Argyle vs Shrewsbury Town | 1-0 |
| 12/02/2022 | 16:00 | Portsmouth vs Doncaster Rovers | 4-0 |
| 12/02/2022 | 16:00 | Wigan Athletic vs Charlton Athletic | 2-1 |
| 13/02/2022 | 13:00 | Sheffield Wednesday vs Rotherham United | 0-2 |
| 18/02/2022 | 20:45 | Rotherham United vs Wigan Athletic | 1-1 |
| 19/02/2022 | 16:00 | Bolton Wanderers vs AFC Wimbledon | 4-0 |
| 19/02/2022 | 16:00 | Cambridge United vs Accrington Stanley | 2-0 |
| 19/02/2022 | 16:00 | Charlton Athletic vs Oxford United | 0-4 |
| 19/02/2022 | 16:00 | Doncaster Rovers vs Sheffield Wednesday | 1-3 |
| 19/02/2022 | 16:00 | Gillingham vs Plymouth Argyle | 0-2 |
| 19/02/2022 | 16:00 | Ipswich Town vs Burton Albion | 3-0 |
| 19/02/2022 | 16:00 | Sunderland vs Milton Keynes Dons | 1-2 |
| 19/02/2022 | 16:00 | Wycombe Wanderers vs Cheltenham Town | 5-5 |
| 08/03/2022 | 20:45 | Crewe Alexandra vs Portsmouth | 1-3 |
| 15/03/2022 | 20:45 | Shrewsbury Town vs Morecambe | 5-0 |
| 05/04/2022 | 20:45 | Fleetwood Town vs Lincoln City | 1-1 |
| 22/02/2022 | 20:45 | Cambridge United vs Plymouth Argyle | 2-0 |
| 22/02/2022 | 20:45 | Charlton Athletic vs Milton Keynes Dons | 0-2 |
| 22/02/2022 | 20:45 | Crewe Alexandra vs Oxford United | 0-1 |
| 22/02/2022 | 20:45 | Doncaster Rovers vs Accrington Stanley | 2-0 |
| 22/02/2022 | 20:45 | Gillingham vs AFC Wimbledon | 0-0 |
| 22/02/2022 | 20:45 | Ipswich Town vs Cheltenham Town | 0-0 |
| 22/02/2022 | 20:45 | Rotherham United vs Morecambe | 2-0 |
| 22/02/2022 | 20:45 | Shrewsbury Town vs Portsmouth | 1-2 |
| 22/02/2022 | 20:45 | Sunderland vs Burton Albion | 1-1 |
| 22/02/2022 | 20:45 | Wycombe Wanderers vs Wigan Athletic | 1-3 |
| 22/02/2022 | 21:00 | Bolton Wanderers vs Lincoln City | 3-1 |
| 26/04/2022 | 20:45 | Fleetwood Town vs Sheffield Wednesday | 2-3 |
| 26/02/2022 | 16:00 | AFC Wimbledon vs Doncaster Rovers | 2-2 |
| 26/02/2022 | 16:00 | Accrington Stanley vs Wycombe Wanderers | 3-2 |
| 26/02/2022 | 16:00 | Burton Albion vs Shrewsbury Town | 0-2 |
| 26/02/2022 | 16:00 | Cheltenham Town vs Crewe Alexandra | 1-2 |
| 26/02/2022 | 16:00 | Lincoln City vs Gillingham | 0-2 |
| 26/02/2022 | 16:00 | Milton Keynes Dons vs Bolton Wanderers | 2-0 |
| 26/02/2022 | 16:00 | Morecambe vs Ipswich Town | 1-1 |
| 26/02/2022 | 16:00 | Oxford United vs Cambridge United | 4-2 |
| 26/02/2022 | 16:00 | Plymouth Argyle vs Rotherham United | 0-1 |
| 26/02/2022 | 16:00 | Portsmouth vs Fleetwood Town | 3-3 |
| 26/02/2022 | 16:00 | Sheffield Wednesday vs Charlton Athletic | 2-0 |
| 26/02/2022 | 16:00 | Wigan Athletic vs Sunderland | 0-3 |
| 05/03/2022 | 16:00 | Cambridge United vs Shrewsbury Town | 0-0 |
| 05/03/2022 | 16:00 | Charlton Athletic vs Sunderland | 0-0 |
| 05/03/2022 | 16:00 | Cheltenham Town vs Doncaster Rovers | 4-0 |
| 05/03/2022 | 16:00 | Crewe Alexandra vs Wycombe Wanderers | 1-3 |
| 05/03/2022 | 16:00 | Fleetwood Town vs Ipswich Town | 0-2 |
| 05/03/2022 | 16:00 | Gillingham vs Bolton Wanderers | 0-3 |
| 05/03/2022 | 16:00 | Lincoln City vs Sheffield Wednesday | 3-1 |
| 05/03/2022 | 16:00 | Oxford United vs Burton Albion | 4-1 |
| 05/03/2022 | 16:00 | Plymouth Argyle vs Morecambe | 2-0 |
| 05/03/2022 | 16:00 | Portsmouth vs Accrington Stanley | 4-0 |
| 05/03/2022 | 16:00 | Rotherham United vs Milton Keynes Dons | 1-2 |
| 05/03/2022 | 16:00 | Wigan Athletic vs AFC Wimbledon | 1-0 |
| 12/03/2022 | 16:00 | AFC Wimbledon vs Lincoln City | 0-2 |
| 12/03/2022 | 16:00 | Accrington Stanley vs Charlton Athletic | 2-1 |
| 12/03/2022 | 16:00 | Bolton Wanderers vs Plymouth Argyle | 0-1 |
| 12/03/2022 | 16:00 | Burton Albion vs Fleetwood Town | 3-2 |
| 12/03/2022 | 16:00 | Doncaster Rovers vs Gillingham | 0-1 |
| 12/03/2022 | 16:00 | Ipswich Town vs Portsmouth | 0-0 |
| 12/03/2022 | 16:00 | Milton Keynes Dons vs Wigan Athletic | 1-1 |
| 12/03/2022 | 16:00 | Morecambe vs Cheltenham Town | 1-3 |
| 12/03/2022 | 16:00 | Sheffield Wednesday vs Cambridge United | 6-0 |
| 12/03/2022 | 16:00 | Shrewsbury Town vs Oxford United | 1-2 |
| 12/03/2022 | 16:00 | Sunderland vs Crewe Alexandra | 2-0 |
| 12/03/2022 | 16:00 | Wycombe Wanderers vs Rotherham United | 0-0 |
| 15/03/2022 | 20:45 | Wycombe Wanderers vs Fleetwood Town | 1-0 |
| 26/03/2022 | 16:00 | AFC Wimbledon vs Cambridge United | 0-1 |
| 26/03/2022 | 16:00 | Accrington Stanley vs Gillingham | 1-2 |
| 26/03/2022 | 16:00 | Doncaster Rovers vs Charlton Athletic | 0-1 |
| 26/03/2022 | 16:00 | Ipswich Town vs Plymouth Argyle | 1-0 |
| 26/03/2022 | 16:00 | Sheffield Wednesday vs Cheltenham Town | 4-1 |
| 26/03/2022 | 16:00 | Shrewsbury Town vs Lincoln City | 1-0 |
| 05/04/2022 | 20:45 | Milton Keynes Dons vs Crewe Alexandra | 2-1 |
| 05/04/2022 | 20:45 | Morecambe vs Oxford United | 2-1 |
| 05/04/2022 | 21:00 | Bolton Wanderers vs Portsmouth | 1-1 |
| 12/04/2022 | 20:45 | Burton Albion vs Wigan Athletic | 0-0 |
| 26/04/2022 | 20:45 | Sunderland vs Rotherham United | 1-1 |
| 19/03/2022 | 16:00 | Cambridge United vs Milton Keynes Dons | 0-1 |
| 19/03/2022 | 16:00 | Charlton Athletic vs Burton Albion | 2-0 |
| 19/03/2022 | 16:00 | Cheltenham Town vs AFC Wimbledon | 3-1 |
| 19/03/2022 | 16:00 | Crewe Alexandra vs Bolton Wanderers | 0-1 |
| 19/03/2022 | 16:00 | Fleetwood Town vs Doncaster Rovers | 0-0 |
| 19/03/2022 | 16:00 | Gillingham vs Sheffield Wednesday | 0-0 |
| 19/03/2022 | 16:00 | Lincoln City vs Sunderland | 0-0 |
| 19/03/2022 | 16:00 | Oxford United vs Ipswich Town | 1-1 |
| 19/03/2022 | 16:00 | Plymouth Argyle vs Accrington Stanley | 4-0 |
| 19/03/2022 | 16:00 | Portsmouth vs Wycombe Wanderers | 0-0 |
| 19/03/2022 | 16:00 | Rotherham United vs Shrewsbury Town | 0-3 |
| 19/03/2022 | 16:00 | Wigan Athletic vs Morecambe | 4-1 |
| 02/04/2022 | 13:30 | Wigan Athletic vs Bolton Wanderers | 1-1 |
| 02/04/2022 | 16:00 | Accrington Stanley vs Cheltenham Town | 4-4 |
| 02/04/2022 | 16:00 | Charlton Athletic vs Lincoln City | 1-2 |
| 02/04/2022 | 16:00 | Crewe Alexandra vs Fleetwood Town | 1-3 |
| 02/04/2022 | 16:00 | Ipswich Town vs Cambridge United | 0-1 |
| 02/04/2022 | 16:00 | Milton Keynes Dons vs Shrewsbury Town | 2-0 |
| 02/04/2022 | 16:00 | Morecambe vs Burton Albion | 3-0 |
| 02/04/2022 | 16:00 | Plymouth Argyle vs Oxford United | 1-0 |
| 02/04/2022 | 16:00 | Sheffield Wednesday vs AFC Wimbledon | 2-1 |
| 02/04/2022 | 16:00 | Sunderland vs Gillingham | 1-0 |
| 02/04/2022 | 16:00 | Wycombe Wanderers vs Doncaster Rovers | 2-0 |
| 12/04/2022 | 20:45 | Portsmouth vs Rotherham United | 3-0 |
| 09/04/2022 | 16:00 | AFC Wimbledon vs Milton Keynes Dons | 1-1 |
| 09/04/2022 | 16:00 | Bolton Wanderers vs Sheffield Wednesday | 1-1 |
| 09/04/2022 | 16:00 | Burton Albion vs Plymouth Argyle | 0-0 |
| 09/04/2022 | 16:00 | Cambridge United vs Morecambe | 2-1 |
| 09/04/2022 | 16:00 | Cheltenham Town vs Portsmouth | 1-0 |
| 09/04/2022 | 16:00 | Doncaster Rovers vs Crewe Alexandra | 2-0 |
| 09/04/2022 | 16:00 | Fleetwood Town vs Accrington Stanley | 1-2 |
| 09/04/2022 | 16:00 | Gillingham vs Wycombe Wanderers | 1-1 |
| 09/04/2022 | 16:00 | Lincoln City vs Wigan Athletic | 1-3 |
| 09/04/2022 | 16:00 | Oxford United vs Sunderland | 1-2 |
| 09/04/2022 | 16:00 | Rotherham United vs Charlton Athletic | 0-1 |
| 09/04/2022 | 16:00 | Shrewsbury Town vs Ipswich Town | 1-1 |
| 15/04/2022 | 16:00 | Accrington Stanley vs Burton Albion | 0-0 |
| 15/04/2022 | 16:00 | Charlton Athletic vs Morecambe | 2-3 |
| 15/04/2022 | 16:00 | Cheltenham Town vs Gillingham | 2-2 |
| 15/04/2022 | 16:00 | Crewe Alexandra vs AFC Wimbledon | 3-1 |
| 15/04/2022 | 16:00 | Doncaster Rovers vs Bolton Wanderers | 1-2 |
| 15/04/2022 | 16:00 | Fleetwood Town vs Oxford United | 2-3 |
| 15/04/2022 | 16:00 | Portsmouth vs Lincoln City | 3-2 |
| 15/04/2022 | 16:00 | Sunderland vs Shrewsbury Town | 3-2 |
| 15/04/2022 | 16:00 | Wycombe Wanderers vs Plymouth Argyle | 2-0 |
| 16/04/2022 | 13:30 | Rotherham United vs Ipswich Town | 1-0 |
| 16/04/2022 | 18:15 | Wigan Athletic vs Cambridge United | 1-2 |
| 16/04/2022 | 20:45 | Milton Keynes Dons vs Sheffield Wednesday | 2-3 |
| 18/04/2022 | 16:00 | AFC Wimbledon vs Wycombe Wanderers | 1-1 |
| 18/04/2022 | 16:00 | Bolton Wanderers vs Accrington Stanley | 3-1 |
| 18/04/2022 | 16:00 | Gillingham vs Fleetwood Town | 0-0 |
| 18/04/2022 | 16:00 | Lincoln City vs Cheltenham Town | 3-0 |
| 18/04/2022 | 16:00 | Morecambe vs Portsmouth | 1-1 |
| 18/04/2022 | 16:00 | Plymouth Argyle vs Sunderland | 0-0 |
| 18/04/2022 | 16:00 | Shrewsbury Town vs Doncaster Rovers | 3-3 |
| 19/04/2022 | 20:45 | Burton Albion vs Rotherham United | 2-0 |
| 19/04/2022 | 20:45 | Cambridge United vs Charlton Athletic | 0-2 |
| 19/04/2022 | 20:45 | Ipswich Town vs Wigan Athletic | 2-2 |
| 19/04/2022 | 20:45 | Oxford United vs Milton Keynes Dons | 1-0 |
| 19/04/2022 | 20:45 | Sheffield Wednesday vs Crewe Alexandra | 1-0 |
| 23/04/2022 | 16:00 | Accrington Stanley vs Lincoln City | 2-1 |
| 23/04/2022 | 16:00 | Charlton Athletic vs Shrewsbury Town | 2-0 |
| 23/04/2022 | 16:00 | Cheltenham Town vs Bolton Wanderers | 1-2 |
| 23/04/2022 | 16:00 | Crewe Alexandra vs Ipswich Town | 1-1 |
| 23/04/2022 | 16:00 | Doncaster Rovers vs Burton Albion | 2-0 |
| 23/04/2022 | 16:00 | Fleetwood Town vs AFC Wimbledon | 1-1 |
| 23/04/2022 | 16:00 | Milton Keynes Dons vs Morecambe | 2-0 |
| 23/04/2022 | 16:00 | Portsmouth vs Gillingham | 3-1 |
| 23/04/2022 | 16:00 | Rotherham United vs Oxford United | 2-1 |
| 23/04/2022 | 16:00 | Sunderland vs Cambridge United | 5-1 |
| 23/04/2022 | 16:00 | Wigan Athletic vs Plymouth Argyle | 1-1 |
| 23/04/2022 | 16:00 | Wycombe Wanderers vs Sheffield Wednesday | 1-0 |
| 30/04/2022 | 13:30 | AFC Wimbledon vs Accrington Stanley | 3-4 |
| 30/04/2022 | 13:30 | Bolton Wanderers vs Fleetwood Town | 4-2 |
| 30/04/2022 | 13:30 | Burton Albion vs Wycombe Wanderers | 1-2 |
| 30/04/2022 | 13:30 | Cambridge United vs Cheltenham Town | 2-2 |
| 30/04/2022 | 13:30 | Gillingham vs Rotherham United | 0-2 |
| 30/04/2022 | 13:30 | Lincoln City vs Crewe Alexandra | 2-1 |
| 30/04/2022 | 13:30 | Morecambe vs Sunderland | 0-1 |
| 30/04/2022 | 13:30 | Oxford United vs Doncaster Rovers | 1-1 |
| 30/04/2022 | 13:30 | Plymouth Argyle vs Milton Keynes Dons | 0-5 |
| 30/04/2022 | 13:30 | Sheffield Wednesday vs Portsmouth | 4-1 |
| 30/04/2022 | 13:30 | Shrewsbury Town vs Wigan Athletic | 0-3 |
| 30/04/2022 | 14:30 | Ipswich Town vs Charlton Athletic | 4-0 |
| 05/05/2022 | 20:45 | Wycombe Wanderers vs Milton Keynes Dons | 2-0 |
| 06/05/2022 | 20:45 | Sunderland vs Sheffield Wednesday | 1-0 |
| 08/05/2022 | 19:30 | Milton Keynes Dons vs Wycombe Wanderers | 1-0 |
| 09/05/2022 | 20:45 | Sheffield Wednesday vs Sunderland | 1-1 |
| 21/05/2022 | 16:00 | Sunderland vs Wycombe Wanderers | 2-0 |