| 13/08/2021 | 21:00 | Valencia vs Getafe | 1-0 |
| 14/08/2021 | 19:30 | Mallorca vs Real Betis | 1-1 |
| 14/08/2021 | 19:30 | Cádiz vs Levante | 1-1 |
| 14/08/2021 | 22:00 | Osasuna vs Espanyol | 0-0 |
| 14/08/2021 | 22:00 | Deportivo Alavés vs Real Madrid | 1-4 |
| 15/08/2021 | 17:30 | Celta de Vigo vs Atlético Madrid | 1-2 |
| 15/08/2021 | 20:00 | FC Barcelona vs Real Sociedad | 4-2 |
| 15/08/2021 | 22:15 | Sevilla vs Rayo Vallecano | 3-0 |
| 16/08/2021 | 20:00 | Villarreal vs Granada | 0-0 |
| 16/08/2021 | 22:00 | Elche vs Athletic Club | 0-0 |
| 20/08/2021 | 21:00 | Real Betis vs Cádiz | 1-1 |
| 21/08/2021 | 17:00 | Deportivo Alavés vs Mallorca | 0-1 |
| 21/08/2021 | 19:30 | Granada vs Valencia | 1-1 |
| 21/08/2021 | 19:30 | Espanyol vs Villarreal | 0-0 |
| 21/08/2021 | 22:00 | Athletic Club vs FC Barcelona | 1-1 |
| 22/08/2021 | 17:00 | Real Sociedad vs Rayo Vallecano | 1-0 |
| 22/08/2021 | 19:30 | Atlético Madrid vs Elche | 1-0 |
| 22/08/2021 | 22:00 | Levante vs Real Madrid | 3-3 |
| 23/08/2021 | 20:00 | Getafe vs Sevilla | 0-1 |
| 23/08/2021 | 22:00 | Osasuna vs Celta de Vigo | 0-0 |
| 27/08/2021 | 20:00 | Mallorca vs Espanyol | 1-0 |
| 27/08/2021 | 22:15 | Valencia vs Deportivo Alavés | 3-0 |
| 28/08/2021 | 17:00 | Celta de Vigo vs Athletic Club | 0-1 |
| 28/08/2021 | 19:30 | Real Sociedad vs Levante | 1-0 |
| 28/08/2021 | 19:30 | Elche vs Sevilla | 1-1 |
| 28/08/2021 | 22:00 | Real Betis vs Real Madrid | 0-1 |
| 29/08/2021 | 17:00 | FC Barcelona vs Getafe | 2-1 |
| 29/08/2021 | 19:30 | Cádiz vs Osasuna | 2-3 |
| 29/08/2021 | 19:30 | Rayo Vallecano vs Granada | 4-0 |
| 29/08/2021 | 22:00 | Atlético Madrid vs Villarreal | 2-2 |
| 11/09/2021 | 18:30 | Levante vs Rayo Vallecano | 1-1 |
| 11/09/2021 | 21:00 | Athletic Club vs Mallorca | 2-0 |
| 12/09/2021 | 14:00 | Espanyol vs Atlético Madrid | 1-2 |
| 12/09/2021 | 16:15 | Osasuna vs Valencia | 1-4 |
| 12/09/2021 | 18:30 | Cádiz vs Real Sociedad | 0-2 |
| 12/09/2021 | 21:00 | Real Madrid vs Celta de Vigo | 5-2 |
| 13/09/2021 | 20:00 | Getafe vs Elche | 0-1 |
| 13/09/2021 | 22:00 | Granada vs Real Betis | 1-2 |
| 21/12/2021 | 19:00 | Villarreal vs Deportivo Alavés | 5-2 |
| 21/12/2021 | 21:30 | Sevilla vs FC Barcelona | 1-1 |
| 17/09/2021 | 21:00 | Celta de Vigo vs Cádiz | 1-2 |
| 18/09/2021 | 14:00 | Rayo Vallecano vs Getafe | 3-0 |
| 18/09/2021 | 16:15 | Atlético Madrid vs Athletic Club | 0-0 |
| 18/09/2021 | 18:30 | Elche vs Levante | 1-1 |
| 18/09/2021 | 21:00 | Deportivo Alavés vs Osasuna | 0-2 |
| 19/09/2021 | 14:00 | Mallorca vs Villarreal | 0-0 |
| 19/09/2021 | 16:15 | Real Sociedad vs Sevilla | 0-0 |
| 19/09/2021 | 18:30 | Real Betis vs Espanyol | 2-2 |
| 19/09/2021 | 21:00 | Valencia vs Real Madrid | 1-2 |
| 20/09/2021 | 21:00 | FC Barcelona vs Granada | 1-1 |
| 21/09/2021 | 19:30 | Getafe vs Atlético Madrid | 1-2 |
| 21/09/2021 | 22:00 | Athletic Club vs Rayo Vallecano | 1-2 |
| 21/09/2021 | 22:00 | Levante vs Celta de Vigo | 0-2 |
| 22/09/2021 | 19:30 | Espanyol vs Deportivo Alavés | 1-0 |
| 22/09/2021 | 19:30 | Sevilla vs Valencia | 3-1 |
| 22/09/2021 | 22:00 | Villarreal vs Elche | 4-1 |
| 22/09/2021 | 22:00 | Real Madrid vs Mallorca | 6-1 |
| 23/09/2021 | 19:30 | Granada vs Real Sociedad | 2-3 |
| 23/09/2021 | 19:30 | Osasuna vs Real Betis | 1-3 |
| 23/09/2021 | 22:00 | Cádiz vs FC Barcelona | 0-0 |
| 25/09/2021 | 14:00 | Deportivo Alavés vs Atlético Madrid | 1-0 |
| 25/09/2021 | 16:15 | Valencia vs Athletic Club | 1-1 |
| 25/09/2021 | 18:30 | Sevilla vs Espanyol | 2-0 |
| 25/09/2021 | 21:00 | Real Madrid vs Villarreal | 0-0 |
| 26/09/2021 | 14:00 | Mallorca vs Osasuna | 2-3 |
| 26/09/2021 | 16:15 | FC Barcelona vs Levante | 3-0 |
| 26/09/2021 | 18:30 | Rayo Vallecano vs Cádiz | 3-1 |
| 26/09/2021 | 18:30 | Real Sociedad vs Elche | 1-0 |
| 26/09/2021 | 21:00 | Real Betis vs Getafe | 2-0 |
| 27/09/2021 | 21:00 | Celta de Vigo vs Granada | 1-0 |
| 01/10/2021 | 21:00 | Athletic Club vs Deportivo Alavés | 1-0 |
| 02/10/2021 | 14:00 | Osasuna vs Rayo Vallecano | 1-0 |
| 02/10/2021 | 16:15 | Mallorca vs Levante | 1-0 |
| 02/10/2021 | 18:30 | Cádiz vs Valencia | 0-0 |
| 02/10/2021 | 21:00 | Atlético Madrid vs FC Barcelona | 2-0 |
| 03/10/2021 | 14:00 | Elche vs Celta de Vigo | 1-0 |
| 03/10/2021 | 16:15 | Espanyol vs Real Madrid | 2-1 |
| 03/10/2021 | 18:30 | Getafe vs Real Sociedad | 1-1 |
| 03/10/2021 | 18:30 | Villarreal vs Real Betis | 2-0 |
| 03/10/2021 | 21:00 | Granada vs Sevilla | 1-0 |
| 16/10/2021 | 18:30 | Levante vs Getafe | 0-0 |
| 16/10/2021 | 21:00 | Real Sociedad vs Mallorca | 1-0 |
| 17/10/2021 | 14:00 | Rayo Vallecano vs Elche | 2-1 |
| 17/10/2021 | 16:15 | Celta de Vigo vs Sevilla | 0-1 |
| 17/10/2021 | 18:30 | Villarreal vs Osasuna | 1-2 |
| 17/10/2021 | 21:00 | FC Barcelona vs Valencia | 3-1 |
| 18/10/2021 | 19:00 | Deportivo Alavés vs Real Betis | 0-1 |
| 18/10/2021 | 21:00 | Espanyol vs Cádiz | 2-0 |
| 01/12/2021 | 21:00 | Real Madrid vs Athletic Club | 1-0 |
| 22/12/2021 | 19:00 | Granada vs Atlético Madrid | 2-1 |
| 22/10/2021 | 21:00 | Osasuna vs Granada | 1-1 |
| 23/10/2021 | 14:00 | Valencia vs Mallorca | 2-2 |
| 23/10/2021 | 16:15 | Cádiz vs Deportivo Alavés | 0-2 |
| 23/10/2021 | 18:30 | Elche vs Espanyol | 2-2 |
| 23/10/2021 | 21:00 | Athletic Club vs Villarreal | 2-1 |
| 24/10/2021 | 14:00 | Sevilla vs Levante | 5-3 |
| 24/10/2021 | 16:15 | FC Barcelona vs Real Madrid | 1-2 |
| 24/10/2021 | 18:30 | Real Betis vs Rayo Vallecano | 3-2 |
| 24/10/2021 | 21:00 | Atlético Madrid vs Real Sociedad | 2-2 |
| 25/10/2021 | 21:00 | Getafe vs Celta de Vigo | 0-3 |
| 26/10/2021 | 19:00 | Deportivo Alavés vs Elche | 1-0 |
| 26/10/2021 | 21:00 | Espanyol vs Athletic Club | 1-1 |
| 26/10/2021 | 21:30 | Villarreal vs Cádiz | 3-3 |
| 27/10/2021 | 19:00 | Mallorca vs Sevilla | 1-1 |
| 27/10/2021 | 19:00 | Rayo Vallecano vs FC Barcelona | 1-0 |
| 27/10/2021 | 20:00 | Real Betis vs Valencia | 4-1 |
| 27/10/2021 | 21:30 | Real Madrid vs Osasuna | 0-0 |
| 28/10/2021 | 19:00 | Celta de Vigo vs Real Sociedad | 0-2 |
| 28/10/2021 | 20:00 | Granada vs Getafe | 1-1 |
| 28/10/2021 | 21:30 | Levante vs Atlético Madrid | 2-2 |
| 30/10/2021 | 14:00 | Elche vs Real Madrid | 1-2 |
| 30/10/2021 | 16:15 | Sevilla vs Osasuna | 2-0 |
| 30/10/2021 | 18:30 | Valencia vs Villarreal | 2-0 |
| 30/10/2021 | 21:00 | FC Barcelona vs Deportivo Alavés | 1-1 |
| 31/10/2021 | 14:00 | Cádiz vs Mallorca | 1-1 |
| 31/10/2021 | 16:15 | Atlético Madrid vs Real Betis | 3-0 |
| 31/10/2021 | 18:30 | Getafe vs Espanyol | 2-1 |
| 31/10/2021 | 21:00 | Real Sociedad vs Athletic Club | 1-1 |
| 01/11/2021 | 18:30 | Rayo Vallecano vs Celta de Vigo | 0-0 |
| 01/11/2021 | 21:00 | Levante vs Granada | 0-3 |
| 05/11/2021 | 21:00 | Athletic Club vs Cádiz | 0-1 |
| 06/11/2021 | 14:00 | Espanyol vs Granada | 2-0 |
| 06/11/2021 | 16:15 | Celta de Vigo vs FC Barcelona | 3-3 |
| 06/11/2021 | 18:30 | Deportivo Alavés vs Levante | 2-1 |
| 06/11/2021 | 21:00 | Real Madrid vs Rayo Vallecano | 2-1 |
| 07/11/2021 | 14:00 | Villarreal vs Getafe | 1-0 |
| 07/11/2021 | 16:15 | Valencia vs Atlético Madrid | 3-3 |
| 07/11/2021 | 18:30 | Mallorca vs Elche | 2-2 |
| 07/11/2021 | 18:30 | Osasuna vs Real Sociedad | 0-2 |
| 07/11/2021 | 21:00 | Real Betis vs Sevilla | 0-2 |
| 19/11/2021 | 21:00 | Levante vs Athletic Club | 0-0 |
| 20/11/2021 | 14:00 | Celta de Vigo vs Villarreal | 1-1 |
| 20/11/2021 | 16:15 | Sevilla vs Deportivo Alavés | 2-2 |
| 20/11/2021 | 18:30 | Atlético Madrid vs Osasuna | 1-0 |
| 20/11/2021 | 21:00 | FC Barcelona vs Espanyol | 1-0 |
| 21/11/2021 | 14:00 | Getafe vs Cádiz | 4-0 |
| 21/11/2021 | 16:15 | Granada vs Real Madrid | 1-4 |
| 21/11/2021 | 18:30 | Elche vs Real Betis | 0-3 |
| 21/11/2021 | 21:00 | Real Sociedad vs Valencia | 0-0 |
| 22/11/2021 | 21:00 | Rayo Vallecano vs Mallorca | 3-1 |
| 26/11/2021 | 21:00 | Athletic Club vs Granada | 2-2 |
| 27/11/2021 | 14:00 | Deportivo Alavés vs Celta de Vigo | 1-2 |
| 27/11/2021 | 16:15 | Valencia vs Rayo Vallecano | 1-1 |
| 27/11/2021 | 18:30 | Mallorca vs Getafe | 0-0 |
| 27/11/2021 | 21:00 | Villarreal vs FC Barcelona | 1-3 |
| 28/11/2021 | 14:00 | Real Betis vs Levante | 3-1 |
| 28/11/2021 | 16:15 | Espanyol vs Real Sociedad | 1-0 |
| 28/11/2021 | 18:30 | Cádiz vs Atlético Madrid | 1-4 |
| 28/11/2021 | 21:00 | Real Madrid vs Sevilla | 2-1 |
| 29/11/2021 | 21:00 | Osasuna vs Elche | 1-1 |
| 03/12/2021 | 21:00 | Granada vs Deportivo Alavés | 2-1 |
| 04/12/2021 | 14:00 | Sevilla vs Villarreal | 1-0 |
| 04/12/2021 | 16:15 | FC Barcelona vs Real Betis | 0-1 |
| 04/12/2021 | 18:30 | Atlético Madrid vs Mallorca | 1-2 |
| 04/12/2021 | 21:00 | Real Sociedad vs Real Madrid | 0-2 |
| 05/12/2021 | 14:00 | Rayo Vallecano vs Espanyol | 1-0 |
| 05/12/2021 | 16:15 | Elche vs Cádiz | 3-1 |
| 05/12/2021 | 18:30 | Levante vs Osasuna | 0-0 |
| 05/12/2021 | 21:00 | Celta de Vigo vs Valencia | 1-2 |
| 06/12/2021 | 21:00 | Getafe vs Athletic Club | 0-0 |
| 10/12/2021 | 21:00 | Mallorca vs Celta de Vigo | 0-0 |
| 11/12/2021 | 14:00 | Espanyol vs Levante | 4-3 |
| 11/12/2021 | 16:15 | Deportivo Alavés vs Getafe | 1-1 |
| 11/12/2021 | 18:30 | Valencia vs Elche | 2-1 |
| 11/12/2021 | 21:00 | Athletic Club vs Sevilla | 0-1 |
| 12/12/2021 | 14:00 | Villarreal vs Rayo Vallecano | 2-0 |
| 12/12/2021 | 16:15 | Osasuna vs FC Barcelona | 2-2 |
| 12/12/2021 | 18:30 | Real Betis vs Real Sociedad | 4-0 |
| 12/12/2021 | 21:00 | Real Madrid vs Atlético Madrid | 2-0 |
| 13/12/2021 | 21:00 | Cádiz vs Granada | 1-1 |
| 17/12/2021 | 21:00 | Celta de Vigo vs Espanyol | 3-1 |
| 18/12/2021 | 14:00 | Rayo Vallecano vs Deportivo Alavés | 2-0 |
| 18/12/2021 | 16:15 | Real Sociedad vs Villarreal | 1-3 |
| 18/12/2021 | 18:30 | FC Barcelona vs Elche | 3-2 |
| 18/12/2021 | 21:00 | Sevilla vs Atlético Madrid | 2-1 |
| 19/12/2021 | 14:00 | Granada vs Mallorca | 4-1 |
| 19/12/2021 | 16:15 | Athletic Club vs Real Betis | 3-2 |
| 19/12/2021 | 18:30 | Getafe vs Osasuna | 1-0 |
| 19/12/2021 | 21:00 | Real Madrid vs Cádiz | 0-0 |
| 20/12/2021 | 21:00 | Levante vs Valencia | 3-4 |
| 22/12/2021 | 21:30 | Athletic Club vs Real Madrid | 1-2 |
| 16/01/2022 | 14:00 | Elche vs Villarreal | 1-0 |
| 18/01/2022 | 20:00 | Real Betis vs Deportivo Alavés | 4-0 |
| 18/01/2022 | 21:30 | Cádiz vs Espanyol | 2-2 |
| 19/01/2022 | 19:00 | Celta de Vigo vs Osasuna | 2-0 |
| 19/01/2022 | 21:30 | Valencia vs Sevilla | 1-1 |
| 20/01/2022 | 19:00 | Getafe vs Granada | 4-2 |
| 16/02/2022 | 19:00 | Atlético Madrid vs Levante | 0-1 |
| 02/03/2022 | 21:00 | Mallorca vs Real Sociedad | 0-2 |
| 24/04/2022 | 21:00 | FC Barcelona vs Rayo Vallecano | 0-1 |
| 31/12/2021 | 16:15 | Valencia vs Espanyol | 1-2 |
| 02/01/2022 | 14:00 | Getafe vs Real Madrid | 1-0 |
| 02/01/2022 | 16:15 | Atlético Madrid vs Rayo Vallecano | 2-0 |
| 02/01/2022 | 16:15 | Elche vs Granada | 0-0 |
| 02/01/2022 | 18:30 | Deportivo Alavés vs Real Sociedad | 1-1 |
| 02/01/2022 | 18:30 | Real Betis vs Celta de Vigo | 0-2 |
| 02/01/2022 | 21:00 | Mallorca vs FC Barcelona | 0-1 |
| 03/01/2022 | 19:00 | Villarreal vs Levante | 5-0 |
| 03/01/2022 | 21:00 | Osasuna vs Athletic Club | 1-3 |
| 03/01/2022 | 21:15 | Cádiz vs Sevilla | 0-1 |
| 08/01/2022 | 14:00 | Levante vs Mallorca | 2-0 |
| 08/01/2022 | 16:15 | Real Sociedad vs Celta de Vigo | 1-0 |
| 08/01/2022 | 18:30 | Granada vs FC Barcelona | 1-1 |
| 08/01/2022 | 21:00 | Real Madrid vs Valencia | 4-1 |
| 09/01/2022 | 14:00 | Rayo Vallecano vs Real Betis | 1-1 |
| 09/01/2022 | 16:15 | Sevilla vs Getafe | 1-0 |
| 09/01/2022 | 18:30 | Deportivo Alavés vs Athletic Club | 0-0 |
| 09/01/2022 | 18:30 | Osasuna vs Cádiz | 2-0 |
| 09/01/2022 | 21:00 | Villarreal vs Atlético Madrid | 2-2 |
| 10/01/2022 | 21:00 | Espanyol vs Elche | 1-2 |
| 21/01/2022 | 21:00 | Espanyol vs Real Betis | 1-4 |
| 22/01/2022 | 14:00 | Levante vs Cádiz | 0-2 |
| 22/01/2022 | 16:15 | Villarreal vs Mallorca | 3-0 |
| 22/01/2022 | 18:30 | Sevilla vs Celta de Vigo | 2-2 |
| 22/01/2022 | 21:00 | Atlético Madrid vs Valencia | 3-2 |
| 23/01/2022 | 14:00 | Granada vs Osasuna | 0-2 |
| 23/01/2022 | 16:15 | Real Madrid vs Elche | 2-2 |
| 23/01/2022 | 18:30 | Real Sociedad vs Getafe | 0-0 |
| 23/01/2022 | 18:30 | Rayo Vallecano vs Athletic Club | 0-1 |
| 23/01/2022 | 21:00 | Deportivo Alavés vs FC Barcelona | 0-1 |
| 04/02/2022 | 21:00 | Getafe vs Levante | 3-0 |
| 05/02/2022 | 14:00 | Elche vs Deportivo Alavés | 3-1 |
| 05/02/2022 | 16:15 | Mallorca vs Cádiz | 2-1 |
| 05/02/2022 | 18:30 | Celta de Vigo vs Rayo Vallecano | 2-0 |
| 05/02/2022 | 21:00 | Osasuna vs Sevilla | 0-0 |
| 06/02/2022 | 14:00 | Valencia vs Real Sociedad | 0-0 |
| 06/02/2022 | 16:15 | FC Barcelona vs Atlético Madrid | 4-2 |
| 06/02/2022 | 18:30 | Real Betis vs Villarreal | 0-2 |
| 06/02/2022 | 21:00 | Real Madrid vs Granada | 1-0 |
| 07/02/2022 | 21:00 | Athletic Club vs Espanyol | 2-1 |
| 11/02/2022 | 21:00 | Sevilla vs Elche | 2-0 |
| 12/02/2022 | 14:00 | Cádiz vs Celta de Vigo | 0-0 |
| 12/02/2022 | 16:15 | Villarreal vs Real Madrid | 0-0 |
| 12/02/2022 | 18:30 | Rayo Vallecano vs Osasuna | 0-3 |
| 12/02/2022 | 21:00 | Atlético Madrid vs Getafe | 4-3 |
| 13/02/2022 | 14:00 | Deportivo Alavés vs Valencia | 2-1 |
| 13/02/2022 | 16:15 | Levante vs Real Betis | 2-4 |
| 13/02/2022 | 18:30 | Real Sociedad vs Granada | 2-0 |
| 13/02/2022 | 21:00 | Espanyol vs FC Barcelona | 2-2 |
| 14/02/2022 | 21:00 | Mallorca vs Athletic Club | 3-2 |
| 18/02/2022 | 21:00 | Elche vs Rayo Vallecano | 2-1 |
| 19/02/2022 | 14:00 | Granada vs Villarreal | 1-4 |
| 19/02/2022 | 16:15 | Osasuna vs Atlético Madrid | 0-3 |
| 19/02/2022 | 18:30 | Cádiz vs Getafe | 1-1 |
| 19/02/2022 | 21:00 | Real Madrid vs Deportivo Alavés | 3-0 |
| 20/02/2022 | 14:00 | Espanyol vs Sevilla | 1-1 |
| 20/02/2022 | 16:15 | Valencia vs FC Barcelona | 1-4 |
| 20/02/2022 | 18:30 | Real Betis vs Mallorca | 2-1 |
| 20/02/2022 | 21:00 | Athletic Club vs Real Sociedad | 4-0 |
| 21/02/2022 | 21:00 | Celta de Vigo vs Levante | 1-1 |
| 25/02/2022 | 21:00 | Levante vs Elche | 3-0 |
| 26/02/2022 | 14:00 | Mallorca vs Valencia | 0-1 |
| 26/02/2022 | 16:15 | Getafe vs Deportivo Alavés | 2-2 |
| 26/02/2022 | 18:30 | Rayo Vallecano vs Real Madrid | 0-1 |
| 26/02/2022 | 21:00 | Atlético Madrid vs Celta de Vigo | 2-0 |
| 27/02/2022 | 14:00 | Villarreal vs Espanyol | 5-1 |
| 27/02/2022 | 16:15 | Sevilla vs Real Betis | 2-1 |
| 27/02/2022 | 18:30 | Real Sociedad vs Osasuna | 1-0 |
| 27/02/2022 | 21:00 | FC Barcelona vs Athletic Club | 4-0 |
| 28/02/2022 | 21:00 | Granada vs Cádiz | 0-0 |
| 04/03/2022 | 21:00 | Deportivo Alavés vs Sevilla | 0-0 |
| 05/03/2022 | 14:00 | Osasuna vs Villarreal | 1-0 |
| 05/03/2022 | 16:15 | Espanyol vs Getafe | 2-0 |
| 05/03/2022 | 18:30 | Valencia vs Granada | 3-1 |
| 05/03/2022 | 21:00 | Real Madrid vs Real Sociedad | 4-1 |
| 06/03/2022 | 14:00 | Cádiz vs Rayo Vallecano | 2-0 |
| 06/03/2022 | 16:15 | Elche vs FC Barcelona | 1-2 |
| 06/03/2022 | 18:30 | Celta de Vigo vs Mallorca | 4-3 |
| 06/03/2022 | 21:00 | Real Betis vs Atlético Madrid | 1-3 |
| 07/03/2022 | 21:00 | Athletic Club vs Levante | 3-1 |
| 11/03/2022 | 21:00 | Atlético Madrid vs Cádiz | 2-1 |
| 12/03/2022 | 14:00 | Levante vs Espanyol | 1-1 |
| 12/03/2022 | 16:15 | Granada vs Elche | 0-1 |
| 12/03/2022 | 18:30 | Villarreal vs Celta de Vigo | 1-0 |
| 12/03/2022 | 21:00 | Getafe vs Valencia | 0-0 |
| 13/03/2022 | 14:00 | Rayo Vallecano vs Sevilla | 1-1 |
| 13/03/2022 | 16:15 | Real Betis vs Athletic Club | 1-0 |
| 13/03/2022 | 18:30 | Real Sociedad vs Deportivo Alavés | 1-0 |
| 13/03/2022 | 21:00 | FC Barcelona vs Osasuna | 4-0 |
| 14/03/2022 | 21:00 | Mallorca vs Real Madrid | 0-3 |
| 18/03/2022 | 21:00 | Athletic Club vs Getafe | 1-1 |
| 19/03/2022 | 14:00 | Deportivo Alavés vs Granada | 2-3 |
| 19/03/2022 | 16:15 | Elche vs Valencia | 0-1 |
| 19/03/2022 | 18:30 | Osasuna vs Levante | 3-1 |
| 19/03/2022 | 21:00 | Rayo Vallecano vs Atlético Madrid | 0-1 |
| 20/03/2022 | 14:00 | Espanyol vs Mallorca | 1-0 |
| 20/03/2022 | 16:15 | Celta de Vigo vs Real Betis | 0-0 |
| 20/03/2022 | 16:15 | Cádiz vs Villarreal | 1-0 |
| 20/03/2022 | 18:30 | Sevilla vs Real Sociedad | 0-0 |
| 20/03/2022 | 21:00 | Real Madrid vs FC Barcelona | 0-4 |
| 02/04/2022 | 14:00 | Getafe vs Mallorca | 1-0 |
| 02/04/2022 | 16:15 | Levante vs Villarreal | 2-0 |
| 02/04/2022 | 18:30 | Celta de Vigo vs Real Madrid | 1-2 |
| 02/04/2022 | 21:00 | Atlético Madrid vs Deportivo Alavés | 4-1 |
| 03/04/2022 | 14:00 | Athletic Club vs Elche | 2-1 |
| 03/04/2022 | 16:15 | Real Betis vs Osasuna | 4-1 |
| 03/04/2022 | 18:30 | Granada vs Rayo Vallecano | 2-2 |
| 03/04/2022 | 18:30 | Valencia vs Cádiz | 0-0 |
| 03/04/2022 | 21:00 | FC Barcelona vs Sevilla | 1-0 |
| 04/04/2022 | 21:00 | Real Sociedad vs Espanyol | 1-0 |
| 08/04/2022 | 21:00 | Sevilla vs Granada | 4-2 |
| 09/04/2022 | 14:00 | Cádiz vs Real Betis | 1-2 |
| 09/04/2022 | 16:15 | Mallorca vs Atlético Madrid | 1-0 |
| 09/04/2022 | 18:30 | Villarreal vs Athletic Club | 1-1 |
| 09/04/2022 | 21:00 | Real Madrid vs Getafe | 2-0 |
| 10/04/2022 | 14:00 | Osasuna vs Deportivo Alavés | 1-0 |
| 10/04/2022 | 16:15 | Espanyol vs Celta de Vigo | 1-0 |
| 10/04/2022 | 18:30 | Elche vs Real Sociedad | 1-2 |
| 10/04/2022 | 21:00 | Levante vs FC Barcelona | 2-3 |
| 11/04/2022 | 21:00 | Rayo Vallecano vs Valencia | 1-1 |
| 15/04/2022 | 21:00 | Real Sociedad vs Real Betis | 0-0 |
| 16/04/2022 | 14:00 | Elche vs Mallorca | 3-0 |
| 16/04/2022 | 16:15 | Deportivo Alavés vs Rayo Vallecano | 1-0 |
| 16/04/2022 | 18:30 | Valencia vs Osasuna | 1-2 |
| 16/04/2022 | 21:00 | Getafe vs Villarreal | 1-2 |
| 17/04/2022 | 14:00 | Granada vs Levante | 1-4 |
| 17/04/2022 | 16:15 | Atlético Madrid vs Espanyol | 2-1 |
| 17/04/2022 | 18:30 | Athletic Club vs Celta de Vigo | 0-2 |
| 17/04/2022 | 21:00 | Sevilla vs Real Madrid | 2-3 |
| 18/04/2022 | 21:00 | FC Barcelona vs Cádiz | 0-1 |
| 19/04/2022 | 19:00 | Mallorca vs Deportivo Alavés | 2-1 |
| 19/04/2022 | 21:00 | Real Betis vs Elche | 0-1 |
| 19/04/2022 | 21:30 | Villarreal vs Valencia | 2-0 |
| 20/04/2022 | 19:00 | Atlético Madrid vs Granada | 0-0 |
| 20/04/2022 | 20:00 | Celta de Vigo vs Getafe | 0-2 |
| 20/04/2022 | 21:30 | Osasuna vs Real Madrid | 1-3 |
| 21/04/2022 | 19:00 | Levante vs Sevilla | 2-3 |
| 21/04/2022 | 19:00 | Espanyol vs Rayo Vallecano | 0-1 |
| 21/04/2022 | 20:00 | Cádiz vs Athletic Club | 2-3 |
| 21/04/2022 | 21:30 | Real Sociedad vs FC Barcelona | 0-1 |
| 29/04/2022 | 21:00 | Sevilla vs Cádiz | 1-1 |
| 30/04/2022 | 14:00 | Deportivo Alavés vs Villarreal | 2-1 |
| 30/04/2022 | 16:15 | Real Madrid vs Espanyol | 4-0 |
| 30/04/2022 | 18:30 | Valencia vs Levante | 1-1 |
| 30/04/2022 | 21:00 | Athletic Club vs Atlético Madrid | 2-0 |
| 01/05/2022 | 14:00 | Elche vs Osasuna | 1-1 |
| 01/05/2022 | 16:15 | Granada vs Celta de Vigo | 1-1 |
| 01/05/2022 | 18:30 | Rayo Vallecano vs Real Sociedad | 1-1 |
| 01/05/2022 | 21:00 | FC Barcelona vs Mallorca | 2-1 |
| 02/05/2022 | 21:00 | Getafe vs Real Betis | 0-0 |
| 06/05/2022 | 21:00 | Levante vs Real Sociedad | 2-1 |
| 07/05/2022 | 15:00 | Mallorca vs Granada | 2-6 |
| 07/05/2022 | 16:15 | Athletic Club vs Valencia | 0-0 |
| 07/05/2022 | 18:30 | Cádiz vs Elche | 3-0 |
| 07/05/2022 | 18:30 | Celta de Vigo vs Deportivo Alavés | 4-0 |
| 07/05/2022 | 21:00 | Real Betis vs FC Barcelona | 1-2 |
| 08/05/2022 | 14:00 | Getafe vs Rayo Vallecano | 0-0 |
| 08/05/2022 | 16:15 | Villarreal vs Sevilla | 1-1 |
| 08/05/2022 | 18:30 | Espanyol vs Osasuna | 1-1 |
| 08/05/2022 | 21:00 | Atlético Madrid vs Real Madrid | 1-0 |
| 10/05/2022 | 19:00 | Valencia vs Real Betis | 0-3 |
| 10/05/2022 | 20:00 | Granada vs Athletic Club | 1-0 |
| 10/05/2022 | 21:30 | FC Barcelona vs Celta de Vigo | 3-1 |
| 11/05/2022 | 19:00 | Osasuna vs Getafe | 1-1 |
| 11/05/2022 | 19:00 | Deportivo Alavés vs Espanyol | 2-1 |
| 11/05/2022 | 20:30 | Sevilla vs Mallorca | 0-0 |
| 11/05/2022 | 21:30 | Elche vs Atlético Madrid | 0-2 |
| 12/05/2022 | 19:00 | Real Sociedad vs Cádiz | 3-0 |
| 12/05/2022 | 20:00 | Rayo Vallecano vs Villarreal | 1-5 |
| 12/05/2022 | 21:30 | Real Madrid vs Levante | 6-0 |
| 14/05/2022 | 18:30 | Espanyol vs Valencia | 1-1 |
| 15/05/2022 | 19:30 | Villarreal vs Real Sociedad | 1-2 |
| 15/05/2022 | 19:30 | Levante vs Deportivo Alavés | 3-1 |
| 15/05/2022 | 19:30 | Cádiz vs Real Madrid | 1-1 |
| 15/05/2022 | 19:30 | Getafe vs FC Barcelona | 0-0 |
| 15/05/2022 | 19:30 | Mallorca vs Rayo Vallecano | 2-1 |
| 15/05/2022 | 19:30 | Celta de Vigo vs Elche | 1-0 |
| 15/05/2022 | 19:30 | Real Betis vs Granada | 2-0 |
| 15/05/2022 | 19:30 | Atlético Madrid vs Sevilla | 1-1 |
| 15/05/2022 | 19:30 | Athletic Club vs Osasuna | 2-0 |
| 20/05/2022 | 21:00 | Rayo Vallecano vs Levante | 2-4 |
| 20/05/2022 | 21:00 | Real Madrid vs Real Betis | 0-0 |
| 21/05/2022 | 17:30 | Valencia vs Celta de Vigo | 2-0 |
| 22/05/2022 | 17:30 | Elche vs Getafe | 3-1 |
| 22/05/2022 | 20:00 | Osasuna vs Mallorca | 0-2 |
| 22/05/2022 | 20:00 | Granada vs Espanyol | 0-0 |
| 22/05/2022 | 20:00 | Deportivo Alavés vs Cádiz | 0-1 |
| 22/05/2022 | 22:00 | Sevilla vs Athletic Club | 1-0 |
| 22/05/2022 | 22:00 | Real Sociedad vs Atlético Madrid | 1-2 |
| 22/05/2022 | 22:00 | FC Barcelona vs Villarreal | 0-2 |