| 13/08/2021 | 20:00 | Go Ahead Eagles vs SC Heerenveen | 0-1 |
| 14/08/2021 | 16:30 | RKC Waalwijk vs AZ | 1-0 |
| 14/08/2021 | 18:45 | Heracles Almelo vs PSV | 0-2 |
| 14/08/2021 | 20:00 | Fortuna Sittard vs FC Twente | 2-1 |
| 14/08/2021 | 21:00 | Ajax vs NEC Nijmegen | 5-0 |
| 15/08/2021 | 12:15 | SC Cambuur vs FC Groningen | 1-2 |
| 15/08/2021 | 14:30 | PEC Zwolle vs Vitesse | 0-1 |
| 15/08/2021 | 14:30 | FC Utrecht vs Sparta Rotterdam | 4-0 |
| 15/08/2021 | 16:45 | Willem II vs Feyenoord | 0-4 |
| 20/08/2021 | 20:00 | NEC Nijmegen vs PEC Zwolle | 2-0 |
| 21/08/2021 | 18:45 | SC Heerenveen vs RKC Waalwijk | 3-2 |
| 21/08/2021 | 20:00 | PSV vs SC Cambuur | 4-1 |
| 21/08/2021 | 20:00 | Sparta Rotterdam vs Heracles Almelo | 1-1 |
| 21/08/2021 | 21:00 | FC Groningen vs FC Utrecht | 0-0 |
| 22/08/2021 | 12:15 | FC Twente vs Ajax | 1-1 |
| 22/08/2021 | 14:30 | Feyenoord vs Go Ahead Eagles | 2-0 |
| 22/08/2021 | 16:45 | Vitesse vs Willem II | 0-3 |
| 02/12/2021 | 18:45 | AZ vs Fortuna Sittard | 2-1 |
| 27/08/2021 | 20:00 | Fortuna Sittard vs RKC Waalwijk | 2-2 |
| 28/08/2021 | 18:45 | SC Cambuur vs FC Twente | 2-0 |
| 28/08/2021 | 20:00 | Go Ahead Eagles vs Sparta Rotterdam | 2-0 |
| 28/08/2021 | 20:00 | PSV vs FC Groningen | 5-2 |
| 28/08/2021 | 21:00 | Willem II vs PEC Zwolle | 1-0 |
| 29/08/2021 | 12:15 | FC Utrecht vs Feyenoord | 3-1 |
| 29/08/2021 | 14:30 | Ajax vs Vitesse | 5-0 |
| 29/08/2021 | 14:30 | Heracles Almelo vs NEC Nijmegen | 0-1 |
| 29/08/2021 | 16:45 | SC Heerenveen vs AZ | 1-3 |
| 11/09/2021 | 16:30 | FC Twente vs FC Utrecht | 1-0 |
| 11/09/2021 | 18:45 | PEC Zwolle vs Ajax | 0-2 |
| 11/09/2021 | 18:45 | SC Cambuur vs Go Ahead Eagles | 5-2 |
| 11/09/2021 | 21:00 | AZ vs PSV | 0-3 |
| 12/09/2021 | 12:15 | NEC Nijmegen vs Willem II | 0-0 |
| 12/09/2021 | 14:30 | Sparta Rotterdam vs Fortuna Sittard | 3-1 |
| 12/09/2021 | 14:30 | FC Groningen vs SC Heerenveen | 1-1 |
| 12/09/2021 | 16:45 | RKC Waalwijk vs Vitesse | 1-2 |
| 01/12/2021 | 20:00 | Feyenoord vs Heracles Almelo | 2-1 |
| 17/09/2021 | 20:00 | Sparta Rotterdam vs NEC Nijmegen | 1-1 |
| 18/09/2021 | 16:30 | SC Heerenveen vs Fortuna Sittard | 1-0 |
| 18/09/2021 | 18:45 | Willem II vs FC Groningen | 2-1 |
| 18/09/2021 | 20:00 | Ajax vs SC Cambuur | 9-0 |
| 18/09/2021 | 21:00 | FC Utrecht vs RKC Waalwijk | 2-2 |
| 19/09/2021 | 12:15 | Go Ahead Eagles vs PEC Zwolle | 1-0 |
| 19/09/2021 | 14:30 | PSV vs Feyenoord | 0-4 |
| 19/09/2021 | 16:45 | Vitesse vs FC Twente | 1-4 |
| 19/09/2021 | 16:45 | Heracles Almelo vs AZ | 3-2 |
| 21/09/2021 | 18:45 | Fortuna Sittard vs Ajax | 0-5 |
| 21/09/2021 | 21:00 | RKC Waalwijk vs Willem II | 1-2 |
| 22/09/2021 | 18:45 | Go Ahead Eagles vs PSV | 1-2 |
| 22/09/2021 | 18:45 | NEC Nijmegen vs FC Utrecht | 0-3 |
| 22/09/2021 | 20:00 | FC Groningen vs Vitesse | 0-1 |
| 22/09/2021 | 21:00 | Feyenoord vs SC Heerenveen | 3-1 |
| 22/09/2021 | 21:00 | PEC Zwolle vs Sparta Rotterdam | 1-1 |
| 23/09/2021 | 18:45 | SC Cambuur vs Heracles Almelo | 2-1 |
| 23/09/2021 | 21:00 | FC Twente vs AZ | 3-1 |
| 25/09/2021 | 16:30 | Willem II vs PSV | 2-1 |
| 25/09/2021 | 18:45 | Ajax vs FC Groningen | 3-0 |
| 25/09/2021 | 18:45 | Vitesse vs Fortuna Sittard | 1-1 |
| 25/09/2021 | 21:00 | Feyenoord vs NEC Nijmegen | 5-3 |
| 25/09/2021 | 21:00 | FC Utrecht vs PEC Zwolle | 5-1 |
| 26/09/2021 | 12:15 | Sparta Rotterdam vs SC Cambuur | 0-4 |
| 26/09/2021 | 14:30 | AZ vs Go Ahead Eagles | 5-0 |
| 26/09/2021 | 14:30 | SC Heerenveen vs FC Twente | 2-3 |
| 26/09/2021 | 16:45 | Heracles Almelo vs RKC Waalwijk | 1-0 |
| 01/10/2021 | 20:00 | FC Groningen vs FC Twente | 1-1 |
| 02/10/2021 | 18:45 | RKC Waalwijk vs Go Ahead Eagles | 1-1 |
| 02/10/2021 | 20:00 | Heracles Almelo vs Willem II | 3-2 |
| 02/10/2021 | 20:00 | PEC Zwolle vs SC Heerenveen | 0-1 |
| 02/10/2021 | 21:00 | Fortuna Sittard vs NEC Nijmegen | 1-3 |
| 03/10/2021 | 14:30 | Ajax vs FC Utrecht | 0-1 |
| 03/10/2021 | 14:30 | SC Cambuur vs AZ | 1-3 |
| 03/10/2021 | 16:45 | Vitesse vs Feyenoord | 2-1 |
| 03/10/2021 | 20:00 | PSV vs Sparta Rotterdam | 2-1 |
| 16/10/2021 | 16:30 | Feyenoord vs RKC Waalwijk | 2-2 |
| 16/10/2021 | 18:45 | SC Heerenveen vs Ajax | 0-2 |
| 16/10/2021 | 18:45 | Go Ahead Eagles vs Heracles Almelo | 4-2 |
| 16/10/2021 | 21:00 | Fortuna Sittard vs SC Cambuur | 1-0 |
| 16/10/2021 | 21:00 | PSV vs PEC Zwolle | 3-1 |
| 17/10/2021 | 12:15 | AZ vs FC Utrecht | 5-1 |
| 17/10/2021 | 14:30 | NEC Nijmegen vs Vitesse | 0-1 |
| 17/10/2021 | 14:30 | Sparta Rotterdam vs FC Groningen | 1-1 |
| 17/10/2021 | 16:45 | FC Twente vs Willem II | 1-1 |
| 22/10/2021 | 20:00 | Willem II vs Fortuna Sittard | 1-1 |
| 23/10/2021 | 18:45 | FC Utrecht vs SC Heerenveen | 2-1 |
| 23/10/2021 | 20:00 | PEC Zwolle vs Heracles Almelo | 1-0 |
| 23/10/2021 | 21:00 | RKC Waalwijk vs Sparta Rotterdam | 1-0 |
| 24/10/2021 | 12:15 | FC Twente vs NEC Nijmegen | 1-2 |
| 24/10/2021 | 14:30 | SC Cambuur vs Feyenoord | 2-3 |
| 24/10/2021 | 14:30 | Vitesse vs Go Ahead Eagles | 1-2 |
| 24/10/2021 | 16:45 | Ajax vs PSV | 5-0 |
| 24/10/2021 | 20:00 | FC Groningen vs AZ | 2-0 |
| 30/10/2021 | 16:30 | PSV vs FC Twente | 5-2 |
| 30/10/2021 | 18:45 | Heracles Almelo vs Ajax | 0-0 |
| 30/10/2021 | 20:00 | SC Heerenveen vs Vitesse | 1-2 |
| 30/10/2021 | 21:00 | AZ vs PEC Zwolle | 3-2 |
| 31/10/2021 | 12:15 | Sparta Rotterdam vs Feyenoord | 0-1 |
| 31/10/2021 | 14:30 | NEC Nijmegen vs FC Groningen | 3-0 |
| 31/10/2021 | 16:45 | FC Utrecht vs Willem II | 5-1 |
| 31/10/2021 | 16:45 | RKC Waalwijk vs SC Cambuur | 0-1 |
| 31/10/2021 | 20:00 | Go Ahead Eagles vs Fortuna Sittard | 4-3 |
| 05/11/2021 | 20:00 | FC Twente vs Heracles Almelo | 1-0 |
| 06/11/2021 | 18:45 | NEC Nijmegen vs SC Heerenveen | 1-1 |
| 06/11/2021 | 20:00 | Willem II vs Sparta Rotterdam | 0-3 |
| 06/11/2021 | 21:00 | PEC Zwolle vs SC Cambuur | 1-2 |
| 07/11/2021 | 12:15 | FC Groningen vs RKC Waalwijk | 1-1 |
| 07/11/2021 | 14:30 | Fortuna Sittard vs PSV | 1-4 |
| 07/11/2021 | 16:45 | Vitesse vs FC Utrecht | 2-1 |
| 07/11/2021 | 16:45 | Feyenoord vs AZ | 1-0 |
| 07/11/2021 | 20:00 | Ajax vs Go Ahead Eagles | 0-0 |
| 20/11/2021 | 16:30 | PSV vs Vitesse | 2-0 |
| 20/11/2021 | 18:45 | Sparta Rotterdam vs FC Twente | 0-1 |
| 20/11/2021 | 20:00 | AZ vs NEC Nijmegen | 1-1 |
| 20/11/2021 | 21:00 | Heracles Almelo vs Fortuna Sittard | 3-1 |
| 21/11/2021 | 12:15 | Go Ahead Eagles vs FC Groningen | 0-1 |
| 21/11/2021 | 14:30 | Feyenoord vs PEC Zwolle | 4-0 |
| 21/11/2021 | 14:30 | SC Heerenveen vs Willem II | 2-1 |
| 21/11/2021 | 16:45 | RKC Waalwijk vs Ajax | 0-5 |
| 21/11/2021 | 20:00 | SC Cambuur vs FC Utrecht | 2-1 |
| 26/11/2021 | 20:00 | NEC Nijmegen vs SC Cambuur | 2-3 |
| 27/11/2021 | 18:45 | Fortuna Sittard vs FC Groningen | 1-4 |
| 27/11/2021 | 20:00 | PEC Zwolle vs RKC Waalwijk | 0-0 |
| 27/11/2021 | 21:00 | Willem II vs Go Ahead Eagles | 0-1 |
| 28/11/2021 | 12:15 | Sparta Rotterdam vs Ajax | 0-1 |
| 28/11/2021 | 14:30 | FC Twente vs Feyenoord | 0-0 |
| 28/11/2021 | 14:30 | FC Utrecht vs Heracles Almelo | 1-0 |
| 28/11/2021 | 16:45 | SC Heerenveen vs PSV | 1-1 |
| 28/11/2021 | 20:00 | Vitesse vs AZ | 0-0 |
| 02/12/2021 | 21:00 | Ajax vs Willem II | 5-0 |
| 03/12/2021 | 20:00 | FC Groningen vs PEC Zwolle | 1-1 |
| 04/12/2021 | 16:30 | PSV vs FC Utrecht | 4-1 |
| 04/12/2021 | 18:45 | SC Cambuur vs Vitesse | 1-6 |
| 04/12/2021 | 21:00 | Heracles Almelo vs SC Heerenveen | 0-1 |
| 05/12/2021 | 12:15 | RKC Waalwijk vs NEC Nijmegen | 2-1 |
| 05/12/2021 | 14:30 | AZ vs Sparta Rotterdam | 3-1 |
| 05/12/2021 | 14:30 | Go Ahead Eagles vs FC Twente | 1-2 |
| 05/12/2021 | 16:45 | Feyenoord vs Fortuna Sittard | 5-0 |
| 10/12/2021 | 20:00 | Willem II vs SC Cambuur | 1-3 |
| 11/12/2021 | 18:45 | FC Utrecht vs Go Ahead Eagles | 0-0 |
| 11/12/2021 | 20:00 | SC Heerenveen vs Sparta Rotterdam | 0-0 |
| 11/12/2021 | 21:00 | PEC Zwolle vs Fortuna Sittard | 0-1 |
| 12/12/2021 | 12:15 | FC Twente vs RKC Waalwijk | 2-1 |
| 12/12/2021 | 14:30 | FC Groningen vs Feyenoord | 1-1 |
| 12/12/2021 | 14:30 | Vitesse vs Heracles Almelo | 2-1 |
| 12/12/2021 | 16:45 | Ajax vs AZ | 1-2 |
| 12/12/2021 | 20:00 | NEC Nijmegen vs PSV | 1-2 |
| 18/12/2021 | 16:30 | Fortuna Sittard vs FC Utrecht | 2-2 |
| 18/12/2021 | 18:45 | Sparta Rotterdam vs Vitesse | 2-2 |
| 18/12/2021 | 20:00 | AZ vs Willem II | 4-1 |
| 18/12/2021 | 20:00 | Heracles Almelo vs FC Groningen | 4-2 |
| 18/12/2021 | 21:00 | PEC Zwolle vs FC Twente | 1-3 |
| 19/12/2021 | 12:15 | SC Cambuur vs SC Heerenveen | 1-2 |
| 19/12/2021 | 14:30 | Feyenoord vs Ajax | 0-2 |
| 19/12/2021 | 14:30 | Go Ahead Eagles vs NEC Nijmegen | 0-2 |
| 19/12/2021 | 16:45 | RKC Waalwijk vs PSV | 1-4 |
| 21/12/2021 | 18:45 | Vitesse vs PEC Zwolle | 1-0 |
| 21/12/2021 | 21:00 | AZ vs FC Groningen | 1-0 |
| 22/12/2021 | 18:45 | SC Heerenveen vs Feyenoord | 0-3 |
| 22/12/2021 | 18:45 | Willem II vs NEC Nijmegen | 0-1 |
| 22/12/2021 | 20:00 | Heracles Almelo vs SC Cambuur | 1-1 |
| 22/12/2021 | 21:00 | FC Utrecht vs FC Twente | 1-1 |
| 22/12/2021 | 21:00 | Ajax vs Fortuna Sittard | 5-0 |
| 23/12/2021 | 18:45 | PSV vs Go Ahead Eagles | 2-0 |
| 23/12/2021 | 21:00 | Sparta Rotterdam vs RKC Waalwijk | 1-1 |
| 14/01/2022 | 20:00 | PEC Zwolle vs Willem II | 2-0 |
| 15/01/2022 | 18:45 | NEC Nijmegen vs Heracles Almelo | 0-0 |
| 15/01/2022 | 20:00 | Feyenoord vs Vitesse | 0-1 |
| 15/01/2022 | 20:00 | FC Twente vs SC Heerenveen | 2-0 |
| 15/01/2022 | 21:00 | Go Ahead Eagles vs RKC Waalwijk | 0-2 |
| 16/01/2022 | 12:15 | FC Utrecht vs Ajax | 0-3 |
| 16/01/2022 | 14:30 | FC Groningen vs PSV | 0-1 |
| 16/01/2022 | 14:30 | SC Cambuur vs Sparta Rotterdam | 1-1 |
| 16/01/2022 | 16:45 | Fortuna Sittard vs AZ | 1-2 |
| 22/01/2022 | 18:45 | Vitesse vs FC Groningen | 1-3 |
| 22/01/2022 | 20:00 | AZ vs SC Cambuur | 0-0 |
| 22/01/2022 | 20:00 | SC Heerenveen vs PEC Zwolle | 0-1 |
| 22/01/2022 | 21:00 | Willem II vs FC Twente | 0-1 |
| 23/01/2022 | 12:15 | NEC Nijmegen vs Feyenoord | 1-4 |
| 23/01/2022 | 14:30 | Heracles Almelo vs Go Ahead Eagles | 1-1 |
| 23/01/2022 | 14:30 | PSV vs Ajax | 1-2 |
| 23/01/2022 | 16:45 | Sparta Rotterdam vs FC Utrecht | 0-3 |
| 23/01/2022 | 20:00 | RKC Waalwijk vs Fortuna Sittard | 2-1 |
| 05/02/2022 | 16:30 | FC Utrecht vs SC Cambuur | 3-2 |
| 05/02/2022 | 18:45 | Fortuna Sittard vs SC Heerenveen | 2-0 |
| 05/02/2022 | 20:00 | PEC Zwolle vs NEC Nijmegen | 1-1 |
| 05/02/2022 | 20:00 | PSV vs AZ | 1-2 |
| 05/02/2022 | 21:00 | FC Twente vs Vitesse | 3-0 |
| 06/02/2022 | 12:15 | Feyenoord vs Sparta Rotterdam | 4-0 |
| 06/02/2022 | 14:30 | FC Groningen vs Go Ahead Eagles | 2-1 |
| 06/02/2022 | 14:30 | Willem II vs RKC Waalwijk | 3-1 |
| 06/02/2022 | 16:45 | Ajax vs Heracles Almelo | 3-0 |
| 11/02/2022 | 20:00 | Heracles Almelo vs FC Utrecht | 1-0 |
| 12/02/2022 | 18:45 | FC Groningen vs Fortuna Sittard | 0-1 |
| 12/02/2022 | 18:45 | SC Cambuur vs PEC Zwolle | 3-4 |
| 12/02/2022 | 20:00 | Vitesse vs PSV | 0-5 |
| 13/02/2022 | 12:15 | Go Ahead Eagles vs AZ | 1-4 |
| 13/02/2022 | 12:15 | Sparta Rotterdam vs Willem II | 1-0 |
| 13/02/2022 | 14:30 | RKC Waalwijk vs Feyenoord | 0-2 |
| 13/02/2022 | 14:30 | SC Heerenveen vs NEC Nijmegen | 0-1 |
| 13/02/2022 | 16:45 | Ajax vs FC Twente | 5-0 |
| 19/02/2022 | 16:30 | NEC Nijmegen vs RKC Waalwijk | 1-1 |
| 19/02/2022 | 18:45 | Willem II vs Ajax | 0-1 |
| 19/02/2022 | 21:00 | AZ vs Heracles Almelo | 2-1 |
| 20/02/2022 | 12:15 | PEC Zwolle vs FC Groningen | 1-1 |
| 20/02/2022 | 14:30 | FC Twente vs Go Ahead Eagles | 2-2 |
| 20/02/2022 | 14:30 | Feyenoord vs SC Cambuur | 3-1 |
| 20/02/2022 | 16:45 | FC Utrecht vs Vitesse | 1-1 |
| 20/02/2022 | 16:45 | PSV vs SC Heerenveen | 3-1 |
| 16/04/2022 | 18:45 | Fortuna Sittard vs Sparta Rotterdam | 3-0 |
| 25/02/2022 | 20:00 | RKC Waalwijk vs FC Twente | 1-2 |
| 26/02/2022 | 16:30 | Heracles Almelo vs PEC Zwolle | 2-0 |
| 26/02/2022 | 18:45 | FC Groningen vs Willem II | 1-0 |
| 26/02/2022 | 21:00 | SC Cambuur vs Fortuna Sittard | 2-1 |
| 27/02/2022 | 12:15 | AZ vs Feyenoord | 2-1 |
| 27/02/2022 | 12:15 | Vitesse vs NEC Nijmegen | 4-1 |
| 27/02/2022 | 14:30 | Sparta Rotterdam vs PSV | 1-2 |
| 27/02/2022 | 16:45 | Go Ahead Eagles vs Ajax | 2-1 |
| 27/02/2022 | 20:00 | SC Heerenveen vs FC Utrecht | 1-2 |
| 05/03/2022 | 16:30 | Willem II vs SC Heerenveen | 0-0 |
| 05/03/2022 | 18:45 | Go Ahead Eagles vs FC Utrecht | 1-1 |
| 05/03/2022 | 21:00 | Feyenoord vs FC Groningen | 1-1 |
| 06/03/2022 | 12:15 | PSV vs Heracles Almelo | 3-1 |
| 06/03/2022 | 14:30 | FC Twente vs SC Cambuur | 1-0 |
| 06/03/2022 | 16:45 | Ajax vs RKC Waalwijk | 3-2 |
| 06/03/2022 | 16:45 | NEC Nijmegen vs AZ | 1-3 |
| 06/03/2022 | 20:00 | Fortuna Sittard vs PEC Zwolle | 0-1 |
| 19/04/2022 | 18:45 | Vitesse vs Sparta Rotterdam | 0-1 |
| 11/03/2022 | 20:00 | SC Cambuur vs Ajax | 2-3 |
| 12/03/2022 | 16:30 | Sparta Rotterdam vs Go Ahead Eagles | 1-0 |
| 12/03/2022 | 18:45 | FC Groningen vs NEC Nijmegen | 4-3 |
| 12/03/2022 | 21:00 | RKC Waalwijk vs SC Heerenveen | 0-0 |
| 13/03/2022 | 12:15 | Fortuna Sittard vs Willem II | 1-0 |
| 13/03/2022 | 14:30 | FC Utrecht vs PSV | 0-1 |
| 13/03/2022 | 14:30 | Heracles Almelo vs Vitesse | 0-0 |
| 13/03/2022 | 16:45 | PEC Zwolle vs Feyenoord | 1-2 |
| 13/03/2022 | 20:00 | AZ vs FC Twente | 0-1 |
| 18/03/2022 | 20:00 | SC Heerenveen vs Heracles Almelo | 2-0 |
| 19/03/2022 | 18:45 | Go Ahead Eagles vs SC Cambuur | 3-0 |
| 19/03/2022 | 20:00 | FC Twente vs PEC Zwolle | 1-0 |
| 19/03/2022 | 21:00 | NEC Nijmegen vs Sparta Rotterdam | 0-0 |
| 20/03/2022 | 12:15 | FC Utrecht vs FC Groningen | 1-3 |
| 20/03/2022 | 14:30 | Ajax vs Feyenoord | 3-2 |
| 20/03/2022 | 16:45 | PSV vs Fortuna Sittard | 5-0 |
| 20/03/2022 | 16:45 | Vitesse vs RKC Waalwijk | 1-2 |
| 20/03/2022 | 20:00 | Willem II vs AZ | 2-2 |
| 02/04/2022 | 16:30 | FC Groningen vs Ajax | 1-3 |
| 02/04/2022 | 18:45 | FC Twente vs PSV | 3-3 |
| 02/04/2022 | 20:00 | AZ vs Vitesse | 3-1 |
| 02/04/2022 | 20:00 | RKC Waalwijk vs FC Utrecht | 1-1 |
| 02/04/2022 | 21:00 | Feyenoord vs Willem II | 2-0 |
| 03/04/2022 | 12:15 | PEC Zwolle vs Go Ahead Eagles | 0-1 |
| 03/04/2022 | 14:30 | Fortuna Sittard vs Heracles Almelo | 0-2 |
| 03/04/2022 | 14:30 | Sparta Rotterdam vs SC Heerenveen | 1-1 |
| 03/04/2022 | 16:45 | SC Cambuur vs NEC Nijmegen | 1-2 |
| 08/04/2022 | 20:00 | Go Ahead Eagles vs Willem II | 4-0 |
| 09/04/2022 | 18:45 | FC Utrecht vs Fortuna Sittard | 1-1 |
| 09/04/2022 | 20:00 | Ajax vs Sparta Rotterdam | 2-1 |
| 09/04/2022 | 21:00 | NEC Nijmegen vs FC Twente | 0-2 |
| 10/04/2022 | 12:15 | SC Heerenveen vs FC Groningen | 3-1 |
| 10/04/2022 | 14:30 | PSV vs RKC Waalwijk | 2-0 |
| 10/04/2022 | 14:30 | Vitesse vs SC Cambuur | 1-0 |
| 10/04/2022 | 16:45 | Heracles Almelo vs Feyenoord | 1-4 |
| 10/04/2022 | 20:00 | PEC Zwolle vs AZ | 2-1 |
| 22/04/2022 | 20:00 | FC Twente vs Sparta Rotterdam | 2-0 |
| 23/04/2022 | 16:30 | NEC Nijmegen vs Ajax | 0-1 |
| 23/04/2022 | 18:45 | AZ vs SC Heerenveen | 2-1 |
| 23/04/2022 | 20:00 | RKC Waalwijk vs PEC Zwolle | 0-2 |
| 23/04/2022 | 21:00 | SC Cambuur vs PSV | 1-2 |
| 24/04/2022 | 12:15 | Willem II vs Vitesse | 1-0 |
| 24/04/2022 | 14:30 | FC Groningen vs Heracles Almelo | 0-1 |
| 24/04/2022 | 14:30 | Feyenoord vs FC Utrecht | 2-1 |
| 24/04/2022 | 16:45 | Fortuna Sittard vs Go Ahead Eagles | 1-0 |
| 29/04/2022 | 20:00 | FC Utrecht vs NEC Nijmegen | 1-0 |
| 30/04/2022 | 18:45 | Ajax vs PEC Zwolle | 3-0 |
| 30/04/2022 | 20:00 | Heracles Almelo vs FC Twente | 1-1 |
| 30/04/2022 | 21:00 | Sparta Rotterdam vs AZ | 1-1 |
| 01/05/2022 | 12:15 | SC Heerenveen vs SC Cambuur | 3-3 |
| 01/05/2022 | 14:30 | Go Ahead Eagles vs Vitesse | 1-2 |
| 01/05/2022 | 14:30 | PSV vs Willem II | 4-2 |
| 01/05/2022 | 16:45 | Fortuna Sittard vs Feyenoord | 1-3 |
| 01/05/2022 | 20:00 | RKC Waalwijk vs FC Groningen | 3-1 |
| 06/05/2022 | 20:00 | SC Cambuur vs RKC Waalwijk | 1-1 |
| 07/05/2022 | 18:45 | FC Twente vs Fortuna Sittard | 1-2 |
| 07/05/2022 | 20:00 | PEC Zwolle vs FC Utrecht | 1-1 |
| 07/05/2022 | 20:00 | Willem II vs Heracles Almelo | 2-0 |
| 07/05/2022 | 21:00 | FC Groningen vs Sparta Rotterdam | 1-2 |
| 08/05/2022 | 12:15 | NEC Nijmegen vs Go Ahead Eagles | 1-0 |
| 08/05/2022 | 14:30 | AZ vs Ajax | 2-2 |
| 08/05/2022 | 14:30 | Vitesse vs SC Heerenveen | 1-2 |
| 08/05/2022 | 16:45 | Feyenoord vs PSV | 2-2 |
| 11/05/2022 | 20:00 | Ajax vs SC Heerenveen | 5-0 |
| 11/05/2022 | 20:00 | SC Cambuur vs Willem II | 1-1 |
| 11/05/2022 | 20:00 | Fortuna Sittard vs Vitesse | 1-2 |
| 11/05/2022 | 20:00 | Go Ahead Eagles vs Feyenoord | 0-1 |
| 11/05/2022 | 20:00 | PSV vs NEC Nijmegen | 3-2 |
| 11/05/2022 | 20:00 | RKC Waalwijk vs Heracles Almelo | 2-0 |
| 11/05/2022 | 20:00 | Sparta Rotterdam vs PEC Zwolle | 2-0 |
| 11/05/2022 | 20:00 | FC Twente vs FC Groningen | 3-0 |
| 11/05/2022 | 20:00 | FC Utrecht vs AZ | 2-2 |
| 15/05/2022 | 14:30 | AZ vs RKC Waalwijk | 1-3 |
| 15/05/2022 | 14:30 | Feyenoord vs FC Twente | 1-2 |
| 15/05/2022 | 14:30 | FC Groningen vs SC Cambuur | 2-3 |
| 15/05/2022 | 14:30 | Heracles Almelo vs Sparta Rotterdam | 1-3 |
| 15/05/2022 | 14:30 | SC Heerenveen vs Go Ahead Eagles | 3-1 |
| 15/05/2022 | 14:30 | NEC Nijmegen vs Fortuna Sittard | 0-1 |
| 15/05/2022 | 14:30 | PEC Zwolle vs PSV | 1-2 |
| 15/05/2022 | 14:30 | Vitesse vs Ajax | 2-2 |
| 15/05/2022 | 14:30 | Willem II vs FC Utrecht | 3-0 |
| 19/05/2022 | 18:45 | SC Heerenveen vs AZ | 3-2 |
| 19/05/2022 | 21:00 | FC Utrecht vs Vitesse | 3-1 |
| 22/05/2022 | 14:30 | AZ vs SC Heerenveen | 2-0 |
| 22/05/2022 | 18:00 | Vitesse vs FC Utrecht | 3-0 |
| 26/05/2022 | 20:00 | Vitesse vs AZ | 2-1 |
| 29/05/2022 | 14:30 | AZ vs Vitesse | 6-1 |