| 06/08/2021 | 20:45 | AFC Bournemouth vs West Bromwich Albion | 2-2 |
| 07/08/2021 | 16:00 | Blackburn Rovers vs Swansea City | 2-1 |
| 07/08/2021 | 16:00 | Bristol City vs Blackpool | 1-1 |
| 07/08/2021 | 16:00 | Cardiff City vs Barnsley | 1-1 |
| 07/08/2021 | 16:00 | Derby County vs Huddersfield Town | 1-1 |
| 07/08/2021 | 16:00 | Luton Town vs Peterborough United | 3-0 |
| 07/08/2021 | 16:00 | Preston North End vs Hull City | 1-4 |
| 07/08/2021 | 16:00 | Queens Park Rangers vs Millwall | 1-1 |
| 07/08/2021 | 16:00 | Stoke City vs Reading | 3-2 |
| 07/08/2021 | 21:00 | Sheffield United vs Birmingham City | 0-1 |
| 08/08/2021 | 14:30 | Fulham vs Middlesbrough | 1-1 |
| 08/08/2021 | 17:30 | Coventry City vs Nottingham Forest | 2-1 |
| 14/08/2021 | 13:30 | Peterborough United vs Derby County | 2-1 |
| 14/08/2021 | 16:00 | Barnsley vs Coventry City | 1-0 |
| 14/08/2021 | 16:00 | Birmingham City vs Stoke City | 0-0 |
| 14/08/2021 | 16:00 | Blackpool vs Cardiff City | 0-2 |
| 14/08/2021 | 16:00 | Huddersfield Town vs Fulham | 1-5 |
| 14/08/2021 | 16:00 | Hull City vs Queens Park Rangers | 0-3 |
| 14/08/2021 | 16:00 | Middlesbrough vs Bristol City | 2-1 |
| 14/08/2021 | 16:00 | Millwall vs Blackburn Rovers | 1-1 |
| 14/08/2021 | 16:00 | Nottingham Forest vs AFC Bournemouth | 1-2 |
| 14/08/2021 | 16:00 | Reading vs Preston North End | 2-1 |
| 14/08/2021 | 16:00 | West Bromwich Albion vs Luton Town | 3-2 |
| 14/08/2021 | 21:00 | Swansea City vs Sheffield United | 0-0 |
| 17/08/2021 | 20:45 | Barnsley vs Luton Town | 0-1 |
| 17/08/2021 | 20:45 | Blackpool vs Coventry City | 0-1 |
| 17/08/2021 | 20:45 | Huddersfield Town vs Preston North End | 1-0 |
| 17/08/2021 | 20:45 | Millwall vs Fulham | 1-2 |
| 17/08/2021 | 20:45 | Peterborough United vs Cardiff City | 2-2 |
| 17/08/2021 | 20:45 | Swansea City vs Stoke City | 1-3 |
| 17/08/2021 | 21:00 | Reading vs Bristol City | 2-3 |
| 18/08/2021 | 20:45 | Birmingham City vs AFC Bournemouth | 0-2 |
| 18/08/2021 | 20:45 | Hull City vs Derby County | 0-1 |
| 18/08/2021 | 20:45 | Middlesbrough vs Queens Park Rangers | 2-3 |
| 18/08/2021 | 20:45 | Nottingham Forest vs Blackburn Rovers | 1-2 |
| 18/08/2021 | 21:00 | West Bromwich Albion vs Sheffield United | 4-0 |
| 20/08/2021 | 20:45 | Bristol City vs Swansea City | 0-1 |
| 21/08/2021 | 13:30 | Queens Park Rangers vs Barnsley | 2-2 |
| 21/08/2021 | 16:00 | AFC Bournemouth vs Blackpool | 2-2 |
| 21/08/2021 | 16:00 | Blackburn Rovers vs West Bromwich Albion | 1-2 |
| 21/08/2021 | 16:00 | Cardiff City vs Millwall | 3-1 |
| 21/08/2021 | 16:00 | Coventry City vs Reading | 2-1 |
| 21/08/2021 | 16:00 | Derby County vs Middlesbrough | 0-0 |
| 21/08/2021 | 16:00 | Fulham vs Hull City | 2-0 |
| 21/08/2021 | 16:00 | Luton Town vs Birmingham City | 0-5 |
| 21/08/2021 | 16:00 | Preston North End vs Peterborough United | 1-0 |
| 21/08/2021 | 16:00 | Sheffield United vs Huddersfield Town | 1-2 |
| 21/08/2021 | 16:00 | Stoke City vs Nottingham Forest | 1-0 |
| 28/08/2021 | 13:30 | Cardiff City vs Bristol City | 1-2 |
| 28/08/2021 | 13:30 | Derby County vs Nottingham Forest | 1-1 |
| 28/08/2021 | 16:00 | Barnsley vs Birmingham City | 1-1 |
| 28/08/2021 | 16:00 | Fulham vs Stoke City | 3-0 |
| 28/08/2021 | 16:00 | Huddersfield Town vs Reading | 4-0 |
| 28/08/2021 | 16:00 | Hull City vs AFC Bournemouth | 0-0 |
| 28/08/2021 | 16:00 | Luton Town vs Sheffield United | 0-0 |
| 28/08/2021 | 16:00 | Middlesbrough vs Blackburn Rovers | 1-1 |
| 28/08/2021 | 16:00 | Millwall vs Blackpool | 2-1 |
| 28/08/2021 | 16:00 | Preston North End vs Swansea City | 3-1 |
| 28/08/2021 | 16:00 | Queens Park Rangers vs Coventry City | 2-0 |
| 28/08/2021 | 21:00 | Peterborough United vs West Bromwich Albion | 0-1 |
| 10/09/2021 | 21:00 | Birmingham City vs Derby County | 2-0 |
| 11/09/2021 | 16:00 | AFC Bournemouth vs Barnsley | 3-0 |
| 11/09/2021 | 16:00 | Blackburn Rovers vs Luton Town | 2-2 |
| 11/09/2021 | 16:00 | Blackpool vs Fulham | 1-0 |
| 11/09/2021 | 16:00 | Bristol City vs Preston North End | 0-0 |
| 11/09/2021 | 16:00 | Coventry City vs Middlesbrough | 2-0 |
| 11/09/2021 | 16:00 | Reading vs Queens Park Rangers | 3-3 |
| 11/09/2021 | 16:00 | Sheffield United vs Peterborough United | 6-2 |
| 11/09/2021 | 16:00 | Stoke City vs Huddersfield Town | 2-1 |
| 11/09/2021 | 16:00 | Swansea City vs Hull City | 0-0 |
| 11/09/2021 | 16:00 | West Bromwich Albion vs Millwall | 1-1 |
| 12/09/2021 | 15:30 | Nottingham Forest vs Cardiff City | 1-2 |
| 14/09/2021 | 20:45 | AFC Bournemouth vs Queens Park Rangers | 2-1 |
| 14/09/2021 | 20:45 | Blackburn Rovers vs Hull City | 2-0 |
| 14/09/2021 | 20:45 | Blackpool vs Huddersfield Town | 0-3 |
| 14/09/2021 | 20:45 | Sheffield United vs Preston North End | 2-2 |
| 14/09/2021 | 21:00 | Reading vs Peterborough United | 3-1 |
| 14/09/2021 | 21:00 | West Bromwich Albion vs Derby County | 0-0 |
| 15/09/2021 | 20:45 | Birmingham City vs Fulham | 1-4 |
| 15/09/2021 | 20:45 | Bristol City vs Luton Town | 1-1 |
| 15/09/2021 | 20:45 | Coventry City vs Cardiff City | 1-0 |
| 15/09/2021 | 20:45 | Nottingham Forest vs Middlesbrough | 0-2 |
| 15/09/2021 | 20:45 | Swansea City vs Millwall | 0-0 |
| 15/09/2021 | 20:45 | Stoke City vs Barnsley | 1-1 |
| 18/09/2021 | 13:30 | Hull City vs Sheffield United | 1-3 |
| 18/09/2021 | 16:00 | Barnsley vs Blackburn Rovers | 0-0 |
| 18/09/2021 | 16:00 | Cardiff City vs AFC Bournemouth | 0-1 |
| 18/09/2021 | 16:00 | Derby County vs Stoke City | 2-1 |
| 18/09/2021 | 16:00 | Fulham vs Reading | 1-2 |
| 18/09/2021 | 16:00 | Huddersfield Town vs Nottingham Forest | 0-2 |
| 18/09/2021 | 16:00 | Luton Town vs Swansea City | 3-3 |
| 18/09/2021 | 16:00 | Middlesbrough vs Blackpool | 1-2 |
| 18/09/2021 | 16:00 | Millwall vs Coventry City | 1-1 |
| 18/09/2021 | 16:00 | Peterborough United vs Birmingham City | 3-0 |
| 18/09/2021 | 16:00 | Preston North End vs West Bromwich Albion | 1-1 |
| 18/09/2021 | 16:00 | Queens Park Rangers vs Bristol City | 1-2 |
| 24/09/2021 | 20:45 | Coventry City vs Peterborough United | 3-0 |
| 24/09/2021 | 21:00 | West Bromwich Albion vs Queens Park Rangers | 2-1 |
| 25/09/2021 | 13:30 | Reading vs Middlesbrough | 1-0 |
| 25/09/2021 | 16:00 | AFC Bournemouth vs Luton Town | 2-1 |
| 25/09/2021 | 16:00 | Birmingham City vs Preston North End | 0-0 |
| 25/09/2021 | 16:00 | Blackburn Rovers vs Cardiff City | 5-1 |
| 25/09/2021 | 16:00 | Blackpool vs Barnsley | 1-0 |
| 25/09/2021 | 16:00 | Bristol City vs Fulham | 1-1 |
| 25/09/2021 | 16:00 | Nottingham Forest vs Millwall | 1-1 |
| 25/09/2021 | 16:00 | Sheffield United vs Derby County | 1-0 |
| 25/09/2021 | 16:00 | Stoke City vs Hull City | 2-0 |
| 25/09/2021 | 16:00 | Swansea City vs Huddersfield Town | 1-0 |
| 28/09/2021 | 20:45 | Cardiff City vs West Bromwich Albion | 0-4 |
| 28/09/2021 | 20:45 | Huddersfield Town vs Blackburn Rovers | 3-2 |
| 28/09/2021 | 20:45 | Hull City vs Blackpool | 1-1 |
| 28/09/2021 | 20:45 | Middlesbrough vs Sheffield United | 2-0 |
| 28/09/2021 | 20:45 | Preston North End vs Stoke City | 1-1 |
| 28/09/2021 | 20:45 | Queens Park Rangers vs Birmingham City | 2-0 |
| 29/09/2021 | 20:45 | Barnsley vs Nottingham Forest | 1-3 |
| 29/09/2021 | 20:45 | Derby County vs Reading | 1-0 |
| 29/09/2021 | 20:45 | Fulham vs Swansea City | 3-1 |
| 29/09/2021 | 20:45 | Luton Town vs Coventry City | 5-0 |
| 29/09/2021 | 20:45 | Millwall vs Bristol City | 1-0 |
| 29/09/2021 | 20:45 | Peterborough United vs AFC Bournemouth | 0-0 |
| 01/10/2021 | 20:45 | Stoke City vs West Bromwich Albion | 1-0 |
| 02/10/2021 | 13:30 | Coventry City vs Fulham | 4-1 |
| 02/10/2021 | 16:00 | AFC Bournemouth vs Sheffield United | 2-1 |
| 02/10/2021 | 16:00 | Barnsley vs Millwall | 0-1 |
| 02/10/2021 | 16:00 | Birmingham City vs Nottingham Forest | 0-3 |
| 02/10/2021 | 16:00 | Blackpool vs Blackburn Rovers | 2-1 |
| 02/10/2021 | 16:00 | Cardiff City vs Reading | 0-1 |
| 02/10/2021 | 16:00 | Derby County vs Swansea City | 0-0 |
| 02/10/2021 | 16:00 | Hull City vs Middlesbrough | 2-0 |
| 02/10/2021 | 16:00 | Luton Town vs Huddersfield Town | 0-0 |
| 02/10/2021 | 16:00 | Peterborough United vs Bristol City | 2-3 |
| 02/10/2021 | 16:00 | Queens Park Rangers vs Preston North End | 3-2 |
| 15/10/2021 | 21:00 | West Bromwich Albion vs Birmingham City | 1-0 |
| 16/10/2021 | 13:30 | Fulham vs Queens Park Rangers | 4-1 |
| 16/10/2021 | 16:00 | Blackburn Rovers vs Coventry City | 2-2 |
| 16/10/2021 | 16:00 | Bristol City vs AFC Bournemouth | 0-2 |
| 16/10/2021 | 16:00 | Huddersfield Town vs Hull City | 2-0 |
| 16/10/2021 | 16:00 | Middlesbrough vs Peterborough United | 2-0 |
| 16/10/2021 | 16:00 | Millwall vs Luton Town | 0-2 |
| 16/10/2021 | 16:00 | Nottingham Forest vs Blackpool | 2-1 |
| 16/10/2021 | 16:00 | Preston North End vs Derby County | 0-0 |
| 16/10/2021 | 16:00 | Reading vs Barnsley | 1-0 |
| 16/10/2021 | 16:00 | Sheffield United vs Stoke City | 2-1 |
| 17/10/2021 | 13:00 | Swansea City vs Cardiff City | 3-0 |
| 19/10/2021 | 20:45 | Bristol City vs Nottingham Forest | 1-2 |
| 19/10/2021 | 20:45 | Derby County vs Luton Town | 2-2 |
| 19/10/2021 | 20:45 | Queens Park Rangers vs Blackburn Rovers | 1-0 |
| 19/10/2021 | 20:45 | Sheffield United vs Millwall | 1-2 |
| 19/10/2021 | 20:45 | Stoke City vs AFC Bournemouth | 0-1 |
| 20/10/2021 | 20:45 | Fulham vs Cardiff City | 2-0 |
| 20/10/2021 | 20:45 | Huddersfield Town vs Birmingham City | 0-0 |
| 20/10/2021 | 20:45 | Hull City vs Peterborough United | 1-2 |
| 20/10/2021 | 20:45 | Middlesbrough vs Barnsley | 2-0 |
| 20/10/2021 | 20:45 | Preston North End vs Coventry City | 2-1 |
| 20/10/2021 | 20:45 | Swansea City vs West Bromwich Albion | 2-1 |
| 20/10/2021 | 21:00 | Reading vs Blackpool | 2-3 |
| 23/10/2021 | 13:30 | Cardiff City vs Middlesbrough | 0-2 |
| 23/10/2021 | 16:00 | AFC Bournemouth vs Huddersfield Town | 3-0 |
| 23/10/2021 | 16:00 | Birmingham City vs Swansea City | 2-1 |
| 23/10/2021 | 16:00 | Blackburn Rovers vs Reading | 2-0 |
| 23/10/2021 | 16:00 | Blackpool vs Preston North End | 2-0 |
| 23/10/2021 | 16:00 | Coventry City vs Derby County | 1-1 |
| 23/10/2021 | 16:00 | Luton Town vs Hull City | 1-0 |
| 23/10/2021 | 16:00 | Millwall vs Stoke City | 2-1 |
| 23/10/2021 | 16:00 | Peterborough United vs Queens Park Rangers | 2-1 |
| 23/10/2021 | 16:00 | West Bromwich Albion vs Bristol City | 3-0 |
| 24/10/2021 | 13:30 | Barnsley vs Sheffield United | 2-3 |
| 24/10/2021 | 16:00 | Nottingham Forest vs Fulham | 0-4 |
| 29/10/2021 | 20:45 | Queens Park Rangers vs Nottingham Forest | 1-1 |
| 30/10/2021 | 13:30 | Fulham vs West Bromwich Albion | 3-0 |
| 30/10/2021 | 16:00 | Bristol City vs Barnsley | 2-1 |
| 30/10/2021 | 16:00 | Derby County vs Blackburn Rovers | 1-2 |
| 30/10/2021 | 16:00 | Huddersfield Town vs Millwall | 1-0 |
| 30/10/2021 | 16:00 | Hull City vs Coventry City | 0-1 |
| 30/10/2021 | 16:00 | Middlesbrough vs Birmingham City | 0-2 |
| 30/10/2021 | 16:00 | Preston North End vs Luton Town | 2-0 |
| 30/10/2021 | 16:00 | Sheffield United vs Blackpool | 0-1 |
| 30/10/2021 | 16:00 | Stoke City vs Cardiff City | 3-3 |
| 30/10/2021 | 16:00 | Swansea City vs Peterborough United | 3-0 |
| 30/10/2021 | 21:00 | Reading vs AFC Bournemouth | 0-2 |
| 02/11/2021 | 20:45 | Birmingham City vs Bristol City | 3-0 |
| 02/11/2021 | 20:45 | Coventry City vs Swansea City | 1-2 |
| 02/11/2021 | 20:45 | Luton Town vs Middlesbrough | 3-1 |
| 02/11/2021 | 20:45 | Millwall vs Reading | 1-0 |
| 02/11/2021 | 20:45 | Nottingham Forest vs Sheffield United | 1-1 |
| 02/11/2021 | 20:45 | Peterborough United vs Huddersfield Town | 1-1 |
| 03/11/2021 | 20:45 | AFC Bournemouth vs Preston North End | 1-2 |
| 03/11/2021 | 20:45 | Barnsley vs Derby County | 2-1 |
| 03/11/2021 | 20:45 | Blackburn Rovers vs Fulham | 0-7 |
| 03/11/2021 | 20:45 | Blackpool vs Stoke City | 0-1 |
| 03/11/2021 | 20:45 | Cardiff City vs Queens Park Rangers | 0-1 |
| 03/11/2021 | 21:00 | West Bromwich Albion vs Hull City | 1-0 |
| 06/11/2021 | 16:00 | AFC Bournemouth vs Swansea City | 4-0 |
| 06/11/2021 | 16:00 | Barnsley vs Hull City | 0-2 |
| 06/11/2021 | 16:00 | Blackburn Rovers vs Sheffield United | 3-1 |
| 06/11/2021 | 16:00 | Cardiff City vs Huddersfield Town | 2-1 |
| 06/11/2021 | 16:00 | Coventry City vs Bristol City | 3-2 |
| 06/11/2021 | 16:00 | Luton Town vs Stoke City | 0-1 |
| 06/11/2021 | 16:00 | Millwall vs Derby County | 1-1 |
| 06/11/2021 | 16:00 | Nottingham Forest vs Preston North End | 3-0 |
| 06/11/2021 | 16:00 | Peterborough United vs Fulham | 0-1 |
| 06/11/2021 | 16:00 | West Bromwich Albion vs Middlesbrough | 1-1 |
| 06/11/2021 | 16:30 | Birmingham City vs Reading | 1-2 |
| 06/11/2021 | 18:30 | Blackpool vs Queens Park Rangers | 1-1 |
| 19/11/2021 | 20:45 | Queens Park Rangers vs Luton Town | 2-0 |
| 20/11/2021 | 13:30 | Sheffield United vs Coventry City | 0-0 |
| 20/11/2021 | 16:00 | Bristol City vs Blackburn Rovers | 1-1 |
| 20/11/2021 | 16:00 | Fulham vs Barnsley | 4-1 |
| 20/11/2021 | 16:00 | Huddersfield Town vs West Bromwich Albion | 1-0 |
| 20/11/2021 | 16:00 | Hull City vs Birmingham City | 2-0 |
| 20/11/2021 | 16:00 | Middlesbrough vs Millwall | 1-1 |
| 20/11/2021 | 16:00 | Preston North End vs Cardiff City | 1-2 |
| 20/11/2021 | 16:00 | Reading vs Nottingham Forest | 1-1 |
| 20/11/2021 | 16:00 | Stoke City vs Peterborough United | 2-0 |
| 20/11/2021 | 16:00 | Swansea City vs Blackpool | 1-1 |
| 21/11/2021 | 13:00 | Derby County vs AFC Bournemouth | 3-2 |
| 23/11/2021 | 20:45 | Blackpool vs West Bromwich Albion | 0-0 |
| 23/11/2021 | 20:45 | Coventry City vs Birmingham City | 0-0 |
| 23/11/2021 | 20:45 | Middlesbrough vs Preston North End | 1-2 |
| 23/11/2021 | 20:45 | Nottingham Forest vs Luton Town | 0-0 |
| 23/11/2021 | 21:00 | Reading vs Sheffield United | 0-1 |
| 24/11/2021 | 20:45 | Fulham vs Derby County | 0-0 |
| 24/11/2021 | 20:45 | Barnsley vs Swansea City | 0-2 |
| 24/11/2021 | 20:45 | Blackburn Rovers vs Peterborough United | 4-0 |
| 24/11/2021 | 20:45 | Bristol City vs Stoke City | 1-0 |
| 24/11/2021 | 20:45 | Cardiff City vs Hull City | 0-1 |
| 24/11/2021 | 20:45 | Millwall vs AFC Bournemouth | 1-1 |
| 24/11/2021 | 20:45 | Queens Park Rangers vs Huddersfield Town | 1-0 |
| 26/11/2021 | 21:00 | West Bromwich Albion vs Nottingham Forest | 0-0 |
| 27/11/2021 | 13:30 | Preston North End vs Fulham | 1-1 |
| 27/11/2021 | 16:00 | AFC Bournemouth vs Coventry City | 2-2 |
| 27/11/2021 | 16:00 | Birmingham City vs Blackpool | 1-0 |
| 27/11/2021 | 16:00 | Huddersfield Town vs Middlesbrough | 1-2 |
| 27/11/2021 | 16:00 | Hull City vs Millwall | 2-1 |
| 27/11/2021 | 16:00 | Luton Town vs Cardiff City | 1-2 |
| 27/11/2021 | 16:00 | Peterborough United vs Barnsley | 0-0 |
| 27/11/2021 | 16:00 | Stoke City vs Blackburn Rovers | 0-1 |
| 27/11/2021 | 16:00 | Swansea City vs Reading | 2-3 |
| 28/11/2021 | 13:30 | Sheffield United vs Bristol City | 2-0 |
| 29/11/2021 | 20:45 | Derby County vs Queens Park Rangers | 1-2 |
| 03/12/2021 | 20:45 | Fulham vs AFC Bournemouth | 1-1 |
| 04/12/2021 | 13:30 | Coventry City vs West Bromwich Albion | 1-2 |
| 04/12/2021 | 16:00 | Barnsley vs Huddersfield Town | 1-1 |
| 04/12/2021 | 16:00 | Blackburn Rovers vs Preston North End | 1-0 |
| 04/12/2021 | 16:00 | Blackpool vs Luton Town | 0-3 |
| 04/12/2021 | 16:00 | Bristol City vs Derby County | 1-0 |
| 04/12/2021 | 16:00 | Cardiff City vs Sheffield United | 2-3 |
| 04/12/2021 | 16:00 | Middlesbrough vs Swansea City | 1-0 |
| 04/12/2021 | 16:00 | Millwall vs Birmingham City | 3-1 |
| 04/12/2021 | 16:00 | Nottingham Forest vs Peterborough United | 2-0 |
| 04/12/2021 | 16:00 | Reading vs Hull City | 1-1 |
| 05/12/2021 | 15:30 | Queens Park Rangers vs Stoke City | 0-2 |
| 11/12/2021 | 13:30 | Huddersfield Town vs Coventry City | 1-1 |
| 11/12/2021 | 16:00 | AFC Bournemouth vs Blackburn Rovers | 0-2 |
| 11/12/2021 | 16:00 | Birmingham City vs Cardiff City | 2-2 |
| 11/12/2021 | 16:00 | Derby County vs Blackpool | 1-0 |
| 11/12/2021 | 16:00 | Hull City vs Bristol City | 2-2 |
| 11/12/2021 | 16:00 | Luton Town vs Fulham | 1-1 |
| 11/12/2021 | 16:00 | Peterborough United vs Millwall | 2-1 |
| 11/12/2021 | 16:00 | Preston North End vs Barnsley | 2-1 |
| 11/12/2021 | 16:00 | Stoke City vs Middlesbrough | 0-0 |
| 11/12/2021 | 16:00 | Swansea City vs Nottingham Forest | 1-4 |
| 11/12/2021 | 16:00 | West Bromwich Albion vs Reading | 1-0 |
| 05/04/2022 | 20:45 | Sheffield United vs Queens Park Rangers | 1-0 |
| 17/12/2021 | 20:45 | Barnsley vs West Bromwich Albion | 0-0 |
| 18/12/2021 | 13:30 | Middlesbrough vs AFC Bournemouth | 1-0 |
| 18/12/2021 | 16:00 | Blackburn Rovers vs Birmingham City | 4-0 |
| 18/12/2021 | 16:00 | Blackpool vs Peterborough United | 3-1 |
| 18/12/2021 | 16:00 | Bristol City vs Huddersfield Town | 2-3 |
| 18/12/2021 | 16:00 | Nottingham Forest vs Hull City | 2-1 |
| 20/12/2021 | 20:45 | Fulham vs Sheffield United | 0-1 |
| 19/01/2022 | 21:00 | Reading vs Luton Town | 0-2 |
| 25/01/2022 | 20:45 | Coventry City vs Stoke City | 1-0 |
| 25/01/2022 | 20:45 | Queens Park Rangers vs Swansea City | 0-0 |
| 01/02/2022 | 20:45 | Millwall vs Preston North End | 0-0 |
| 01/03/2022 | 20:45 | Cardiff City vs Derby County | 1-0 |
| 26/12/2021 | 16:00 | Huddersfield Town vs Blackpool | 3-2 |
| 26/12/2021 | 16:00 | Middlesbrough vs Nottingham Forest | 2-0 |
| 27/12/2021 | 16:00 | Derby County vs West Bromwich Albion | 1-0 |
| 27/12/2021 | 18:30 | Queens Park Rangers vs AFC Bournemouth | 0-1 |
| 18/01/2022 | 20:45 | Fulham vs Birmingham City | 6-2 |
| 18/01/2022 | 20:45 | Preston North End vs Sheffield United | 2-2 |
| 19/01/2022 | 20:45 | Hull City vs Blackburn Rovers | 2-0 |
| 25/01/2022 | 20:45 | Luton Town vs Bristol City | 2-1 |
| 15/02/2022 | 20:45 | Cardiff City vs Coventry City | 2-0 |
| 16/02/2022 | 20:45 | Peterborough United vs Reading | 0-0 |
| 08/03/2022 | 20:45 | Barnsley vs Stoke City | 1-1 |
| 05/04/2022 | 20:45 | Millwall vs Swansea City | 0-1 |
| 29/12/2021 | 20:45 | Blackburn Rovers vs Barnsley | 2-1 |
| 29/12/2021 | 20:45 | Blackpool vs Middlesbrough | 1-2 |
| 29/12/2021 | 20:45 | Coventry City vs Millwall | 0-1 |
| 30/12/2021 | 20:45 | AFC Bournemouth vs Cardiff City | 3-0 |
| 30/12/2021 | 20:45 | Bristol City vs Queens Park Rangers | 1-2 |
| 30/12/2021 | 20:45 | Nottingham Forest vs Huddersfield Town | 0-1 |
| 30/12/2021 | 20:45 | Stoke City vs Derby County | 1-2 |
| 11/01/2022 | 21:00 | Reading vs Fulham | 0-7 |
| 25/01/2022 | 20:45 | Birmingham City vs Peterborough United | 2-2 |
| 26/01/2022 | 21:00 | West Bromwich Albion vs Preston North End | 0-2 |
| 01/02/2022 | 20:45 | Swansea City vs Luton Town | 0-1 |
| 15/02/2022 | 20:45 | Sheffield United vs Hull City | 0-0 |
| 01/01/2022 | 16:00 | Blackpool vs Hull City | 1-0 |
| 02/01/2022 | 14:00 | Bristol City vs Millwall | 3-2 |
| 02/01/2022 | 15:00 | Birmingham City vs Queens Park Rangers | 1-2 |
| 02/01/2022 | 15:00 | Blackburn Rovers vs Huddersfield Town | 0-0 |
| 02/01/2022 | 15:00 | West Bromwich Albion vs Cardiff City | 1-1 |
| 03/01/2022 | 16:00 | Reading vs Derby County | 2-2 |
| 03/01/2022 | 16:00 | Stoke City vs Preston North End | 1-2 |
| 25/01/2022 | 20:45 | Nottingham Forest vs Barnsley | 3-0 |
| 08/03/2022 | 20:45 | AFC Bournemouth vs Peterborough United | 1-1 |
| 08/03/2022 | 20:45 | Coventry City vs Luton Town | 0-1 |
| 08/03/2022 | 20:45 | Sheffield United vs Middlesbrough | 4-1 |
| 08/03/2022 | 20:45 | Swansea City vs Fulham | 1-5 |
| 15/01/2022 | 13:30 | Cardiff City vs Blackburn Rovers | 0-1 |
| 15/01/2022 | 13:30 | Luton Town vs AFC Bournemouth | 3-2 |
| 15/01/2022 | 16:00 | Derby County vs Sheffield United | 2-0 |
| 15/01/2022 | 16:00 | Fulham vs Bristol City | 6-2 |
| 15/01/2022 | 16:00 | Huddersfield Town vs Swansea City | 1-1 |
| 15/01/2022 | 16:00 | Middlesbrough vs Reading | 2-1 |
| 15/01/2022 | 16:00 | Millwall vs Nottingham Forest | 0-1 |
| 15/01/2022 | 16:00 | Peterborough United vs Coventry City | 1-4 |
| 15/01/2022 | 16:00 | Preston North End vs Birmingham City | 1-1 |
| 15/01/2022 | 16:00 | Queens Park Rangers vs West Bromwich Albion | 1-0 |
| 16/01/2022 | 13:00 | Hull City vs Stoke City | 0-2 |
| 26/04/2022 | 20:45 | Barnsley vs Blackpool | 0-2 |
| 22/01/2022 | 13:30 | Bristol City vs Cardiff City | 3-2 |
| 22/01/2022 | 13:30 | Nottingham Forest vs Derby County | 2-1 |
| 22/01/2022 | 16:00 | AFC Bournemouth vs Hull City | 0-1 |
| 22/01/2022 | 16:00 | Birmingham City vs Barnsley | 2-1 |
| 22/01/2022 | 16:00 | Blackpool vs Millwall | 1-0 |
| 22/01/2022 | 16:00 | Coventry City vs Queens Park Rangers | 1-2 |
| 22/01/2022 | 16:00 | Reading vs Huddersfield Town | 3-4 |
| 22/01/2022 | 16:00 | Sheffield United vs Luton Town | 2-0 |
| 22/01/2022 | 16:00 | Stoke City vs Fulham | 2-3 |
| 22/01/2022 | 16:00 | Swansea City vs Preston North End | 1-0 |
| 22/01/2022 | 16:00 | West Bromwich Albion vs Peterborough United | 3-0 |
| 24/01/2022 | 20:45 | Blackburn Rovers vs Middlesbrough | 1-0 |
| 28/01/2022 | 20:45 | Huddersfield Town vs Stoke City | 1-1 |
| 29/01/2022 | 16:00 | Barnsley vs AFC Bournemouth | 0-1 |
| 29/01/2022 | 16:00 | Fulham vs Blackpool | 1-1 |
| 29/01/2022 | 16:00 | Hull City vs Swansea City | 2-0 |
| 29/01/2022 | 16:00 | Luton Town vs Blackburn Rovers | 0-0 |
| 29/01/2022 | 16:00 | Middlesbrough vs Coventry City | 1-0 |
| 29/01/2022 | 16:00 | Millwall vs West Bromwich Albion | 2-0 |
| 29/01/2022 | 16:00 | Preston North End vs Bristol City | 2-2 |
| 29/01/2022 | 16:00 | Queens Park Rangers vs Reading | 4-0 |
| 29/01/2022 | 18:30 | Peterborough United vs Sheffield United | 0-2 |
| 30/01/2022 | 14:30 | Derby County vs Birmingham City | 2-2 |
| 30/01/2022 | 17:00 | Cardiff City vs Nottingham Forest | 2-1 |
| 02/02/2022 | 20:45 | Barnsley vs Cardiff City | 0-1 |
| 02/02/2022 | 20:45 | Huddersfield Town vs Derby County | 2-0 |
| 04/02/2022 | 20:45 | Birmingham City vs Sheffield United | 1-2 |
| 05/02/2022 | 16:00 | Blackpool vs Bristol City | 3-1 |
| 05/02/2022 | 16:00 | Hull City vs Preston North End | 0-1 |
| 05/02/2022 | 18:30 | Swansea City vs Blackburn Rovers | 1-0 |
| 15/02/2022 | 20:45 | Millwall vs Queens Park Rangers | 2-0 |
| 05/04/2022 | 20:45 | Peterborough United vs Luton Town | 1-1 |
| 05/04/2022 | 21:00 | Reading vs Stoke City | 2-1 |
| 06/04/2022 | 20:45 | Middlesbrough vs Fulham | 0-1 |
| 06/04/2022 | 20:45 | Nottingham Forest vs Coventry City | 2-0 |
| 06/04/2022 | 21:00 | West Bromwich Albion vs AFC Bournemouth | 2-0 |
| 08/02/2022 | 20:45 | Coventry City vs Blackpool | 1-1 |
| 08/02/2022 | 20:45 | Derby County vs Hull City | 3-1 |
| 08/02/2022 | 20:45 | Fulham vs Millwall | 3-0 |
| 08/02/2022 | 20:45 | Luton Town vs Barnsley | 2-1 |
| 08/02/2022 | 20:45 | Stoke City vs Swansea City | 3-0 |
| 09/02/2022 | 20:45 | Cardiff City vs Peterborough United | 4-0 |
| 09/02/2022 | 20:45 | AFC Bournemouth vs Birmingham City | 3-1 |
| 09/02/2022 | 20:45 | Blackburn Rovers vs Nottingham Forest | 0-2 |
| 09/02/2022 | 20:45 | Bristol City vs Reading | 2-1 |
| 09/02/2022 | 20:45 | Preston North End vs Huddersfield Town | 0-0 |
| 09/02/2022 | 20:45 | Queens Park Rangers vs Middlesbrough | 2-2 |
| 09/02/2022 | 20:45 | Sheffield United vs West Bromwich Albion | 2-0 |
| 12/02/2022 | 13:30 | Huddersfield Town vs Sheffield United | 0-0 |
| 12/02/2022 | 16:00 | Barnsley vs Queens Park Rangers | 1-0 |
| 12/02/2022 | 16:00 | Birmingham City vs Luton Town | 3-0 |
| 12/02/2022 | 16:00 | Blackpool vs AFC Bournemouth | 1-2 |
| 12/02/2022 | 16:00 | Hull City vs Fulham | 0-1 |
| 12/02/2022 | 16:00 | Middlesbrough vs Derby County | 4-1 |
| 12/02/2022 | 16:00 | Millwall vs Cardiff City | 2-1 |
| 12/02/2022 | 16:00 | Nottingham Forest vs Stoke City | 2-2 |
| 12/02/2022 | 16:00 | Peterborough United vs Preston North End | 0-1 |
| 12/02/2022 | 16:00 | Reading vs Coventry City | 2-3 |
| 13/02/2022 | 14:00 | Swansea City vs Bristol City | 3-1 |
| 14/02/2022 | 21:00 | West Bromwich Albion vs Blackburn Rovers | 0-0 |
| 19/02/2022 | 13:30 | Fulham vs Huddersfield Town | 1-2 |
| 19/02/2022 | 16:00 | Bristol City vs Middlesbrough | 2-1 |
| 19/02/2022 | 16:00 | Cardiff City vs Blackpool | 1-1 |
| 19/02/2022 | 16:00 | Coventry City vs Barnsley | 1-0 |
| 19/02/2022 | 16:00 | Derby County vs Peterborough United | 1-0 |
| 19/02/2022 | 16:00 | Luton Town vs West Bromwich Albion | 2-0 |
| 19/02/2022 | 16:00 | Preston North End vs Reading | 2-3 |
| 19/02/2022 | 16:00 | Queens Park Rangers vs Hull City | 1-1 |
| 19/02/2022 | 16:00 | Sheffield United vs Swansea City | 4-0 |
| 19/02/2022 | 16:00 | Stoke City vs Birmingham City | 2-2 |
| 08/03/2022 | 20:45 | Blackburn Rovers vs Millwall | 0-0 |
| 03/05/2022 | 20:00 | AFC Bournemouth vs Nottingham Forest | 1-0 |
| 22/02/2022 | 20:45 | Bristol City vs Coventry City | 1-2 |
| 22/02/2022 | 20:45 | Hull City vs Barnsley | 0-2 |
| 22/02/2022 | 20:45 | Middlesbrough vs West Bromwich Albion | 2-1 |
| 22/02/2022 | 20:45 | Preston North End vs Nottingham Forest | 0-0 |
| 22/02/2022 | 21:00 | Reading vs Birmingham City | 2-1 |
| 23/02/2022 | 20:45 | Derby County vs Millwall | 1-2 |
| 23/02/2022 | 20:45 | Fulham vs Peterborough United | 2-1 |
| 23/02/2022 | 20:45 | Huddersfield Town vs Cardiff City | 2-1 |
| 23/02/2022 | 20:45 | Queens Park Rangers vs Blackpool | 2-1 |
| 23/02/2022 | 20:45 | Sheffield United vs Blackburn Rovers | 1-0 |
| 23/02/2022 | 20:45 | Stoke City vs Luton Town | 1-2 |
| 26/04/2022 | 20:45 | Swansea City vs AFC Bournemouth | 3-3 |
| 26/02/2022 | 13:30 | Blackburn Rovers vs Queens Park Rangers | 1-0 |
| 26/02/2022 | 16:00 | AFC Bournemouth vs Stoke City | 2-1 |
| 26/02/2022 | 16:00 | Barnsley vs Middlesbrough | 3-2 |
| 26/02/2022 | 16:00 | Birmingham City vs Huddersfield Town | 0-2 |
| 26/02/2022 | 16:00 | Blackpool vs Reading | 4-1 |
| 26/02/2022 | 16:00 | Cardiff City vs Fulham | 0-1 |
| 26/02/2022 | 16:00 | Coventry City vs Preston North End | 1-1 |
| 26/02/2022 | 16:00 | Luton Town vs Derby County | 1-0 |
| 26/02/2022 | 16:00 | Millwall vs Sheffield United | 1-0 |
| 26/02/2022 | 16:00 | Nottingham Forest vs Bristol City | 2-0 |
| 26/02/2022 | 16:00 | Peterborough United vs Hull City | 0-3 |
| 28/02/2022 | 21:00 | West Bromwich Albion vs Swansea City | 0-2 |
| 04/03/2022 | 20:45 | Huddersfield Town vs Peterborough United | 3-0 |
| 04/03/2022 | 20:45 | Sheffield United vs Nottingham Forest | 1-1 |
| 05/03/2022 | 13:30 | Fulham vs Blackburn Rovers | 2-0 |
| 05/03/2022 | 16:00 | Bristol City vs Birmingham City | 1-2 |
| 05/03/2022 | 16:00 | Derby County vs Barnsley | 2-0 |
| 05/03/2022 | 16:00 | Hull City vs West Bromwich Albion | 0-2 |
| 05/03/2022 | 16:00 | Middlesbrough vs Luton Town | 2-1 |
| 05/03/2022 | 16:00 | Preston North End vs AFC Bournemouth | 2-1 |
| 05/03/2022 | 16:00 | Queens Park Rangers vs Cardiff City | 1-2 |
| 05/03/2022 | 16:00 | Reading vs Millwall | 0-1 |
| 05/03/2022 | 16:00 | Stoke City vs Blackpool | 0-1 |
| 05/03/2022 | 16:00 | Swansea City vs Coventry City | 3-1 |
| 11/03/2022 | 21:00 | West Bromwich Albion vs Huddersfield Town | 2-2 |
| 12/03/2022 | 13:30 | Barnsley vs Fulham | 1-1 |
| 12/03/2022 | 16:00 | AFC Bournemouth vs Derby County | 2-0 |
| 12/03/2022 | 16:00 | Birmingham City vs Hull City | 0-0 |
| 12/03/2022 | 16:00 | Blackburn Rovers vs Bristol City | 0-1 |
| 12/03/2022 | 16:00 | Blackpool vs Swansea City | 1-0 |
| 12/03/2022 | 16:00 | Cardiff City vs Preston North End | 0-0 |
| 12/03/2022 | 16:00 | Coventry City vs Sheffield United | 4-1 |
| 12/03/2022 | 16:00 | Millwall vs Middlesbrough | 0-0 |
| 12/03/2022 | 16:00 | Nottingham Forest vs Reading | 4-0 |
| 12/03/2022 | 16:00 | Peterborough United vs Stoke City | 2-2 |
| 13/03/2022 | 13:00 | Luton Town vs Queens Park Rangers | 1-2 |
| 15/03/2022 | 20:45 | AFC Bournemouth vs Reading | 1-1 |
| 15/03/2022 | 20:45 | Barnsley vs Bristol City | 2-0 |
| 15/03/2022 | 20:45 | Birmingham City vs Middlesbrough | 0-2 |
| 15/03/2022 | 20:45 | Blackburn Rovers vs Derby County | 3-1 |
| 15/03/2022 | 21:00 | West Bromwich Albion vs Fulham | 1-0 |
| 16/03/2022 | 20:45 | Nottingham Forest vs Queens Park Rangers | 3-1 |
| 16/03/2022 | 20:45 | Blackpool vs Sheffield United | 0-0 |
| 16/03/2022 | 20:45 | Cardiff City vs Stoke City | 2-1 |
| 16/03/2022 | 20:45 | Coventry City vs Hull City | 0-2 |
| 16/03/2022 | 20:45 | Luton Town vs Preston North End | 4-0 |
| 16/03/2022 | 20:45 | Millwall vs Huddersfield Town | 2-0 |
| 16/03/2022 | 20:45 | Peterborough United vs Swansea City | 2-3 |
| 19/03/2022 | 13:30 | Derby County vs Coventry City | 1-1 |
| 19/03/2022 | 13:30 | Sheffield United vs Barnsley | 2-0 |
| 19/03/2022 | 16:00 | Bristol City vs West Bromwich Albion | 2-2 |
| 19/03/2022 | 16:00 | Huddersfield Town vs AFC Bournemouth | 0-3 |
| 19/03/2022 | 16:00 | Hull City vs Luton Town | 1-3 |
| 19/03/2022 | 16:00 | Reading vs Blackburn Rovers | 1-0 |
| 19/03/2022 | 16:00 | Stoke City vs Millwall | 2-0 |
| 19/03/2022 | 16:00 | Swansea City vs Birmingham City | 0-0 |
| 20/03/2022 | 13:30 | Queens Park Rangers vs Peterborough United | 1-3 |
| 05/04/2022 | 20:45 | Preston North End vs Blackpool | 1-0 |
| 26/04/2022 | 20:45 | Fulham vs Nottingham Forest | 0-1 |
| 27/04/2022 | 20:45 | Middlesbrough vs Cardiff City | 2-0 |
| 01/04/2022 | 20:45 | Hull City vs Huddersfield Town | 0-1 |
| 02/04/2022 | 13:30 | Blackpool vs Nottingham Forest | 1-4 |
| 02/04/2022 | 16:00 | AFC Bournemouth vs Bristol City | 3-2 |
| 02/04/2022 | 16:00 | Barnsley vs Reading | 1-1 |
| 02/04/2022 | 16:00 | Cardiff City vs Swansea City | 0-4 |
| 02/04/2022 | 16:00 | Coventry City vs Blackburn Rovers | 2-2 |
| 02/04/2022 | 16:00 | Derby County vs Preston North End | 1-0 |
| 02/04/2022 | 16:00 | Luton Town vs Millwall | 2-2 |
| 02/04/2022 | 16:00 | Peterborough United vs Middlesbrough | 0-4 |
| 02/04/2022 | 16:00 | Queens Park Rangers vs Fulham | 0-2 |
| 02/04/2022 | 16:00 | Stoke City vs Sheffield United | 1-0 |
| 03/04/2022 | 16:00 | Birmingham City vs West Bromwich Albion | 1-0 |
| 09/04/2022 | 13:45 | Sheffield United vs AFC Bournemouth | 0-0 |
| 09/04/2022 | 16:00 | Blackburn Rovers vs Blackpool | 1-1 |
| 09/04/2022 | 16:00 | Bristol City vs Peterborough United | 1-1 |
| 09/04/2022 | 16:00 | Middlesbrough vs Hull City | 0-1 |
| 09/04/2022 | 16:00 | Millwall vs Barnsley | 4-1 |
| 09/04/2022 | 16:00 | Nottingham Forest vs Birmingham City | 2-0 |
| 09/04/2022 | 16:00 | Preston North End vs Queens Park Rangers | 2-1 |
| 09/04/2022 | 16:00 | Reading vs Cardiff City | 1-2 |
| 09/04/2022 | 16:00 | Swansea City vs Derby County | 2-1 |
| 09/04/2022 | 16:00 | West Bromwich Albion vs Stoke City | 1-3 |
| 10/04/2022 | 16:00 | Fulham vs Coventry City | 1-3 |
| 11/04/2022 | 20:45 | Huddersfield Town vs Luton Town | 2-0 |
| 15/04/2022 | 13:30 | Luton Town vs Nottingham Forest | 1-0 |
| 15/04/2022 | 16:00 | AFC Bournemouth vs Middlesbrough | 0-0 |
| 15/04/2022 | 16:00 | Birmingham City vs Coventry City | 2-4 |
| 15/04/2022 | 16:00 | Hull City vs Cardiff City | 2-1 |
| 15/04/2022 | 16:00 | Peterborough United vs Blackburn Rovers | 2-1 |
| 15/04/2022 | 16:00 | Preston North End vs Millwall | 1-1 |
| 15/04/2022 | 16:00 | Sheffield United vs Reading | 1-2 |
| 15/04/2022 | 16:00 | Stoke City vs Bristol City | 0-1 |
| 15/04/2022 | 16:00 | Swansea City vs Barnsley | 1-1 |
| 15/04/2022 | 16:00 | West Bromwich Albion vs Blackpool | 2-1 |
| 15/04/2022 | 18:30 | Huddersfield Town vs Queens Park Rangers | 2-2 |
| 15/04/2022 | 21:00 | Derby County vs Fulham | 2-1 |
| 18/04/2022 | 13:30 | Middlesbrough vs Huddersfield Town | 0-2 |
| 18/04/2022 | 16:00 | Barnsley vs Peterborough United | 0-2 |
| 18/04/2022 | 16:00 | Blackburn Rovers vs Stoke City | 0-1 |
| 18/04/2022 | 16:00 | Blackpool vs Birmingham City | 6-1 |
| 18/04/2022 | 16:00 | Cardiff City vs Luton Town | 0-1 |
| 18/04/2022 | 16:00 | Coventry City vs AFC Bournemouth | 0-3 |
| 18/04/2022 | 16:00 | Millwall vs Hull City | 2-1 |
| 18/04/2022 | 16:00 | Queens Park Rangers vs Derby County | 1-0 |
| 18/04/2022 | 16:00 | Reading vs Swansea City | 4-4 |
| 18/04/2022 | 18:30 | Bristol City vs Sheffield United | 1-1 |
| 18/04/2022 | 21:00 | Nottingham Forest vs West Bromwich Albion | 4-0 |
| 19/04/2022 | 20:45 | Fulham vs Preston North End | 3-0 |
| 22/04/2022 | 20:45 | Huddersfield Town vs Barnsley | 2-1 |
| 23/04/2022 | 13:30 | Luton Town vs Blackpool | 1-1 |
| 23/04/2022 | 16:00 | AFC Bournemouth vs Fulham | 1-1 |
| 23/04/2022 | 16:00 | Birmingham City vs Millwall | 2-2 |
| 23/04/2022 | 16:00 | Derby County vs Bristol City | 1-3 |
| 23/04/2022 | 16:00 | Hull City vs Reading | 3-0 |
| 23/04/2022 | 16:00 | Peterborough United vs Nottingham Forest | 0-1 |
| 23/04/2022 | 16:00 | Sheffield United vs Cardiff City | 1-0 |
| 23/04/2022 | 16:00 | Stoke City vs Queens Park Rangers | 1-0 |
| 23/04/2022 | 16:00 | Swansea City vs Middlesbrough | 1-1 |
| 23/04/2022 | 16:00 | West Bromwich Albion vs Coventry City | 0-0 |
| 25/04/2022 | 20:30 | Preston North End vs Blackburn Rovers | 1-4 |
| 29/04/2022 | 20:45 | Queens Park Rangers vs Sheffield United | 1-3 |
| 30/04/2022 | 13:30 | Barnsley vs Preston North End | 1-3 |
| 30/04/2022 | 16:00 | Blackburn Rovers vs AFC Bournemouth | 0-3 |
| 30/04/2022 | 16:00 | Blackpool vs Derby County | 0-2 |
| 30/04/2022 | 16:00 | Bristol City vs Hull City | 5-0 |
| 30/04/2022 | 16:00 | Cardiff City vs Birmingham City | 1-1 |
| 30/04/2022 | 16:00 | Coventry City vs Huddersfield Town | 1-2 |
| 30/04/2022 | 16:00 | Middlesbrough vs Stoke City | 3-1 |
| 30/04/2022 | 16:00 | Millwall vs Peterborough United | 3-0 |
| 30/04/2022 | 16:00 | Nottingham Forest vs Swansea City | 5-1 |
| 30/04/2022 | 16:00 | Reading vs West Bromwich Albion | 0-1 |
| 02/05/2022 | 18:15 | Fulham vs Luton Town | 7-0 |
| 07/05/2022 | 13:30 | AFC Bournemouth vs Millwall | 1-0 |
| 07/05/2022 | 13:30 | Birmingham City vs Blackburn Rovers | 1-2 |
| 07/05/2022 | 13:30 | Derby County vs Cardiff City | 0-1 |
| 07/05/2022 | 13:30 | Huddersfield Town vs Bristol City | 2-0 |
| 07/05/2022 | 13:30 | Hull City vs Nottingham Forest | 1-1 |
| 07/05/2022 | 13:30 | Luton Town vs Reading | 1-0 |
| 07/05/2022 | 13:30 | Peterborough United vs Blackpool | 5-0 |
| 07/05/2022 | 13:30 | Preston North End vs Middlesbrough | 4-1 |
| 07/05/2022 | 13:30 | Sheffield United vs Fulham | 4-0 |
| 07/05/2022 | 13:30 | Stoke City vs Coventry City | 1-1 |
| 07/05/2022 | 13:30 | Swansea City vs Queens Park Rangers | 0-1 |
| 07/05/2022 | 13:30 | West Bromwich Albion vs Barnsley | 4-0 |
| 13/05/2022 | 20:45 | Luton Town vs Huddersfield Town | 1-1 |
| 14/05/2022 | 16:00 | Sheffield United vs Nottingham Forest | 1-2 |
| 16/05/2022 | 20:45 | Huddersfield Town vs Luton Town | 1-0 |
| 17/05/2022 | 20:45 | Nottingham Forest vs Sheffield United | 2-2 |
| 29/05/2022 | 17:30 | Huddersfield Town vs Nottingham Forest | 0-1 |