| 13/08/2021 | 20:30 | Borussia Mönchengladbach vs FC Bayern München | 1-1 |
| 14/08/2021 | 15:30 | VfL Wolfsburg vs VfL Bochum 1848 | 1-0 |
| 14/08/2021 | 15:30 | FC Union Berlin vs Bayer 04 Leverkusen | 1-1 |
| 14/08/2021 | 15:30 | VfB Stuttgart vs SpVgg Greuther Fürth | 5-1 |
| 14/08/2021 | 15:30 | FC Augsburg vs TSG Hoffenheim | 0-4 |
| 14/08/2021 | 15:30 | DSC Arminia Bielefeld vs SC Freiburg | 0-0 |
| 14/08/2021 | 18:30 | Borussia Dortmund vs Eintracht Frankfurt | 5-2 |
| 15/08/2021 | 15:30 | FSV Mainz 05 vs RB Leipzig | 1-0 |
| 15/08/2021 | 17:30 | FC Köln vs Hertha BSC | 3-1 |
| 20/08/2021 | 20:30 | RB Leipzig vs VfB Stuttgart | 4-0 |
| 21/08/2021 | 15:30 | Eintracht Frankfurt vs FC Augsburg | 0-0 |
| 21/08/2021 | 15:30 | SC Freiburg vs Borussia Dortmund | 2-1 |
| 21/08/2021 | 15:30 | Hertha BSC vs VfL Wolfsburg | 1-2 |
| 21/08/2021 | 15:30 | VfL Bochum 1848 vs FSV Mainz 05 | 2-0 |
| 21/08/2021 | 15:30 | SpVgg Greuther Fürth vs DSC Arminia Bielefeld | 1-1 |
| 21/08/2021 | 18:30 | Bayer 04 Leverkusen vs Borussia Mönchengladbach | 4-0 |
| 22/08/2021 | 15:30 | TSG Hoffenheim vs FC Union Berlin | 2-2 |
| 22/08/2021 | 17:30 | FC Bayern München vs FC Köln | 3-2 |
| 27/08/2021 | 20:30 | Borussia Dortmund vs TSG Hoffenheim | 3-2 |
| 28/08/2021 | 15:30 | VfB Stuttgart vs SC Freiburg | 2-3 |
| 28/08/2021 | 15:30 | FSV Mainz 05 vs SpVgg Greuther Fürth | 3-0 |
| 28/08/2021 | 15:30 | FC Augsburg vs Bayer 04 Leverkusen | 1-4 |
| 28/08/2021 | 15:30 | DSC Arminia Bielefeld vs Eintracht Frankfurt | 1-1 |
| 28/08/2021 | 15:30 | FC Köln vs VfL Bochum 1848 | 2-1 |
| 28/08/2021 | 18:30 | FC Bayern München vs Hertha BSC | 5-0 |
| 29/08/2021 | 15:30 | FC Union Berlin vs Borussia Mönchengladbach | 2-1 |
| 29/08/2021 | 17:30 | VfL Wolfsburg vs RB Leipzig | 1-0 |
| 11/09/2021 | 15:30 | Bayer 04 Leverkusen vs Borussia Dortmund | 3-4 |
| 11/09/2021 | 15:30 | FC Union Berlin vs FC Augsburg | 0-0 |
| 11/09/2021 | 15:30 | SC Freiburg vs FC Köln | 1-1 |
| 11/09/2021 | 15:30 | TSG Hoffenheim vs FSV Mainz 05 | 0-2 |
| 11/09/2021 | 15:30 | SpVgg Greuther Fürth vs VfL Wolfsburg | 0-2 |
| 11/09/2021 | 18:30 | RB Leipzig vs FC Bayern München | 1-4 |
| 12/09/2021 | 15:30 | Eintracht Frankfurt vs VfB Stuttgart | 1-1 |
| 12/09/2021 | 17:30 | VfL Bochum 1848 vs Hertha BSC | 1-3 |
| 12/09/2021 | 19:30 | Borussia Mönchengladbach vs DSC Arminia Bielefeld | 3-1 |
| 17/09/2021 | 20:30 | Hertha BSC vs SpVgg Greuther Fürth | 2-1 |
| 18/09/2021 | 15:30 | FC Bayern München vs VfL Bochum 1848 | 7-0 |
| 18/09/2021 | 15:30 | FSV Mainz 05 vs SC Freiburg | 0-0 |
| 18/09/2021 | 15:30 | FC Augsburg vs Borussia Mönchengladbach | 1-0 |
| 18/09/2021 | 15:30 | DSC Arminia Bielefeld vs TSG Hoffenheim | 0-0 |
| 18/09/2021 | 18:30 | FC Köln vs RB Leipzig | 1-1 |
| 19/09/2021 | 15:30 | VfB Stuttgart vs Bayer 04 Leverkusen | 1-3 |
| 19/09/2021 | 17:30 | Borussia Dortmund vs FC Union Berlin | 4-2 |
| 19/09/2021 | 19:30 | VfL Wolfsburg vs Eintracht Frankfurt | 1-1 |
| 24/09/2021 | 20:30 | SpVgg Greuther Fürth vs FC Bayern München | 1-3 |
| 25/09/2021 | 15:30 | RB Leipzig vs Hertha BSC | 6-0 |
| 25/09/2021 | 15:30 | Eintracht Frankfurt vs FC Köln | 1-1 |
| 25/09/2021 | 15:30 | Bayer 04 Leverkusen vs FSV Mainz 05 | 1-0 |
| 25/09/2021 | 15:30 | FC Union Berlin vs DSC Arminia Bielefeld | 1-0 |
| 25/09/2021 | 15:30 | TSG Hoffenheim vs VfL Wolfsburg | 3-1 |
| 25/09/2021 | 18:30 | Borussia Mönchengladbach vs Borussia Dortmund | 1-0 |
| 26/09/2021 | 15:30 | VfL Bochum 1848 vs VfB Stuttgart | 0-0 |
| 26/09/2021 | 17:30 | SC Freiburg vs FC Augsburg | 3-0 |
| 01/10/2021 | 20:30 | FC Köln vs SpVgg Greuther Fürth | 3-1 |
| 02/10/2021 | 15:30 | Borussia Dortmund vs FC Augsburg | 2-1 |
| 02/10/2021 | 15:30 | VfL Wolfsburg vs Borussia Mönchengladbach | 1-3 |
| 02/10/2021 | 15:30 | VfB Stuttgart vs TSG Hoffenheim | 3-1 |
| 02/10/2021 | 15:30 | Hertha BSC vs SC Freiburg | 1-2 |
| 02/10/2021 | 18:30 | RB Leipzig vs VfL Bochum 1848 | 3-0 |
| 03/10/2021 | 15:30 | FSV Mainz 05 vs FC Union Berlin | 1-2 |
| 03/10/2021 | 17:30 | FC Bayern München vs Eintracht Frankfurt | 1-2 |
| 03/10/2021 | 19:30 | DSC Arminia Bielefeld vs Bayer 04 Leverkusen | 0-4 |
| 15/10/2021 | 20:30 | TSG Hoffenheim vs FC Köln | 5-0 |
| 16/10/2021 | 15:30 | Borussia Dortmund vs FSV Mainz 05 | 3-1 |
| 16/10/2021 | 15:30 | Eintracht Frankfurt vs Hertha BSC | 1-2 |
| 16/10/2021 | 15:30 | FC Union Berlin vs VfL Wolfsburg | 2-0 |
| 16/10/2021 | 15:30 | SC Freiburg vs RB Leipzig | 1-1 |
| 16/10/2021 | 15:30 | SpVgg Greuther Fürth vs VfL Bochum 1848 | 0-1 |
| 16/10/2021 | 18:30 | Borussia Mönchengladbach vs VfB Stuttgart | 1-1 |
| 17/10/2021 | 15:30 | Bayer 04 Leverkusen vs FC Bayern München | 1-5 |
| 17/10/2021 | 17:30 | FC Augsburg vs DSC Arminia Bielefeld | 1-1 |
| 22/10/2021 | 20:30 | FSV Mainz 05 vs FC Augsburg | 4-1 |
| 23/10/2021 | 15:30 | FC Bayern München vs TSG Hoffenheim | 4-0 |
| 23/10/2021 | 15:30 | RB Leipzig vs SpVgg Greuther Fürth | 4-1 |
| 23/10/2021 | 15:30 | VfL Wolfsburg vs SC Freiburg | 0-2 |
| 23/10/2021 | 15:30 | DSC Arminia Bielefeld vs Borussia Dortmund | 1-3 |
| 23/10/2021 | 18:30 | Hertha BSC vs Borussia Mönchengladbach | 1-0 |
| 24/10/2021 | 15:30 | FC Köln vs Bayer 04 Leverkusen | 2-2 |
| 24/10/2021 | 17:30 | VfB Stuttgart vs FC Union Berlin | 1-1 |
| 24/10/2021 | 19:30 | VfL Bochum 1848 vs Eintracht Frankfurt | 2-0 |
| 29/10/2021 | 20:30 | TSG Hoffenheim vs Hertha BSC | 2-0 |
| 30/10/2021 | 15:30 | Borussia Dortmund vs FC Köln | 2-0 |
| 30/10/2021 | 15:30 | Bayer 04 Leverkusen vs VfL Wolfsburg | 0-2 |
| 30/10/2021 | 15:30 | FC Union Berlin vs FC Bayern München | 2-5 |
| 30/10/2021 | 15:30 | SC Freiburg vs SpVgg Greuther Fürth | 3-1 |
| 30/10/2021 | 15:30 | DSC Arminia Bielefeld vs FSV Mainz 05 | 1-2 |
| 30/10/2021 | 18:30 | Eintracht Frankfurt vs RB Leipzig | 1-1 |
| 31/10/2021 | 15:30 | FC Augsburg vs VfB Stuttgart | 4-1 |
| 31/10/2021 | 17:30 | Borussia Mönchengladbach vs VfL Bochum 1848 | 2-1 |
| 05/11/2021 | 20:30 | FSV Mainz 05 vs Borussia Mönchengladbach | 1-1 |
| 06/11/2021 | 15:30 | FC Bayern München vs SC Freiburg | 2-1 |
| 06/11/2021 | 15:30 | VfL Wolfsburg vs FC Augsburg | 1-0 |
| 06/11/2021 | 15:30 | VfB Stuttgart vs DSC Arminia Bielefeld | 0-1 |
| 06/11/2021 | 15:30 | VfL Bochum 1848 vs TSG Hoffenheim | 2-0 |
| 06/11/2021 | 18:30 | RB Leipzig vs Borussia Dortmund | 2-1 |
| 07/11/2021 | 15:30 | Hertha BSC vs Bayer 04 Leverkusen | 1-1 |
| 07/11/2021 | 17:30 | FC Köln vs FC Union Berlin | 2-2 |
| 07/11/2021 | 19:30 | SpVgg Greuther Fürth vs Eintracht Frankfurt | 1-2 |
| 19/11/2021 | 20:30 | FC Augsburg vs FC Bayern München | 2-1 |
| 20/11/2021 | 15:30 | Borussia Dortmund vs VfB Stuttgart | 2-1 |
| 20/11/2021 | 15:30 | Bayer 04 Leverkusen vs VfL Bochum 1848 | 1-0 |
| 20/11/2021 | 15:30 | Borussia Mönchengladbach vs SpVgg Greuther Fürth | 4-0 |
| 20/11/2021 | 15:30 | TSG Hoffenheim vs RB Leipzig | 2-0 |
| 20/11/2021 | 15:30 | DSC Arminia Bielefeld vs VfL Wolfsburg | 2-2 |
| 20/11/2021 | 18:30 | FC Union Berlin vs Hertha BSC | 2-0 |
| 21/11/2021 | 15:30 | SC Freiburg vs Eintracht Frankfurt | 0-2 |
| 21/11/2021 | 17:30 | FSV Mainz 05 vs FC Köln | 1-1 |
| 26/11/2021 | 20:30 | VfB Stuttgart vs FSV Mainz 05 | 2-1 |
| 27/11/2021 | 15:30 | VfL Wolfsburg vs Borussia Dortmund | 1-3 |
| 27/11/2021 | 15:30 | Hertha BSC vs FC Augsburg | 1-1 |
| 27/11/2021 | 15:30 | FC Köln vs Borussia Mönchengladbach | 4-1 |
| 27/11/2021 | 15:30 | VfL Bochum 1848 vs SC Freiburg | 2-1 |
| 27/11/2021 | 15:30 | SpVgg Greuther Fürth vs TSG Hoffenheim | 3-6 |
| 27/11/2021 | 18:30 | FC Bayern München vs DSC Arminia Bielefeld | 1-0 |
| 28/11/2021 | 15:30 | Eintracht Frankfurt vs FC Union Berlin | 2-1 |
| 28/11/2021 | 17:30 | RB Leipzig vs Bayer 04 Leverkusen | 1-3 |
| 03/12/2021 | 20:30 | FC Union Berlin vs RB Leipzig | 2-1 |
| 04/12/2021 | 15:30 | Bayer 04 Leverkusen vs SpVgg Greuther Fürth | 7-1 |
| 04/12/2021 | 15:30 | TSG Hoffenheim vs Eintracht Frankfurt | 3-2 |
| 04/12/2021 | 15:30 | FSV Mainz 05 vs VfL Wolfsburg | 3-0 |
| 04/12/2021 | 15:30 | FC Augsburg vs VfL Bochum 1848 | 2-3 |
| 04/12/2021 | 15:30 | DSC Arminia Bielefeld vs FC Köln | 1-1 |
| 04/12/2021 | 18:30 | Borussia Dortmund vs FC Bayern München | 2-3 |
| 05/12/2021 | 15:30 | VfB Stuttgart vs Hertha BSC | 2-2 |
| 05/12/2021 | 17:30 | Borussia Mönchengladbach vs SC Freiburg | 0-6 |
| 10/12/2021 | 20:30 | FC Köln vs FC Augsburg | 0-2 |
| 11/12/2021 | 15:30 | FC Bayern München vs FSV Mainz 05 | 2-1 |
| 11/12/2021 | 15:30 | RB Leipzig vs Borussia Mönchengladbach | 4-1 |
| 11/12/2021 | 15:30 | SC Freiburg vs TSG Hoffenheim | 1-2 |
| 11/12/2021 | 15:30 | Hertha BSC vs DSC Arminia Bielefeld | 2-0 |
| 11/12/2021 | 15:30 | VfL Bochum 1848 vs Borussia Dortmund | 1-1 |
| 11/12/2021 | 18:30 | VfL Wolfsburg vs VfB Stuttgart | 0-2 |
| 12/12/2021 | 15:30 | SpVgg Greuther Fürth vs FC Union Berlin | 1-0 |
| 12/12/2021 | 17:30 | Eintracht Frankfurt vs Bayer 04 Leverkusen | 5-2 |
| 14/12/2021 | 18:30 | VfB Stuttgart vs FC Bayern München | 0-5 |
| 14/12/2021 | 20:30 | VfL Wolfsburg vs FC Köln | 2-3 |
| 14/12/2021 | 20:30 | FSV Mainz 05 vs Hertha BSC | 4-0 |
| 14/12/2021 | 20:30 | DSC Arminia Bielefeld vs VfL Bochum 1848 | 2-0 |
| 15/12/2021 | 18:30 | Borussia Mönchengladbach vs Eintracht Frankfurt | 2-3 |
| 15/12/2021 | 20:30 | Borussia Dortmund vs SpVgg Greuther Fürth | 3-0 |
| 15/12/2021 | 20:30 | Bayer 04 Leverkusen vs TSG Hoffenheim | 2-2 |
| 15/12/2021 | 20:30 | FC Union Berlin vs SC Freiburg | 0-0 |
| 15/12/2021 | 20:30 | FC Augsburg vs RB Leipzig | 1-1 |
| 17/12/2021 | 20:30 | FC Bayern München vs VfL Wolfsburg | 4-0 |
| 18/12/2021 | 15:30 | RB Leipzig vs DSC Arminia Bielefeld | 0-2 |
| 18/12/2021 | 15:30 | Eintracht Frankfurt vs FSV Mainz 05 | 1-0 |
| 18/12/2021 | 15:30 | TSG Hoffenheim vs Borussia Mönchengladbach | 1-1 |
| 18/12/2021 | 15:30 | VfL Bochum 1848 vs FC Union Berlin | 0-1 |
| 18/12/2021 | 15:30 | SpVgg Greuther Fürth vs FC Augsburg | 0-0 |
| 18/12/2021 | 18:30 | Hertha BSC vs Borussia Dortmund | 3-2 |
| 19/12/2021 | 15:30 | SC Freiburg vs Bayer 04 Leverkusen | 2-1 |
| 19/12/2021 | 17:30 | FC Köln vs VfB Stuttgart | 1-0 |
| 07/01/2022 | 20:30 | FC Bayern München vs Borussia Mönchengladbach | 1-2 |
| 08/01/2022 | 15:30 | RB Leipzig vs FSV Mainz 05 | 4-1 |
| 08/01/2022 | 15:30 | Bayer 04 Leverkusen vs FC Union Berlin | 2-2 |
| 08/01/2022 | 15:30 | SC Freiburg vs DSC Arminia Bielefeld | 2-2 |
| 08/01/2022 | 15:30 | TSG Hoffenheim vs FC Augsburg | 3-1 |
| 08/01/2022 | 15:30 | SpVgg Greuther Fürth vs VfB Stuttgart | 0-0 |
| 08/01/2022 | 18:30 | Eintracht Frankfurt vs Borussia Dortmund | 2-3 |
| 09/01/2022 | 15:30 | Hertha BSC vs FC Köln | 1-3 |
| 09/01/2022 | 17:30 | VfL Bochum 1848 vs VfL Wolfsburg | 1-0 |
| 14/01/2022 | 20:30 | Borussia Dortmund vs SC Freiburg | 5-1 |
| 15/01/2022 | 15:30 | VfL Wolfsburg vs Hertha BSC | 0-0 |
| 15/01/2022 | 15:30 | FC Union Berlin vs TSG Hoffenheim | 2-1 |
| 15/01/2022 | 15:30 | VfB Stuttgart vs RB Leipzig | 0-2 |
| 15/01/2022 | 15:30 | FSV Mainz 05 vs VfL Bochum 1848 | 1-0 |
| 15/01/2022 | 15:30 | FC Köln vs FC Bayern München | 0-4 |
| 15/01/2022 | 18:30 | Borussia Mönchengladbach vs Bayer 04 Leverkusen | 1-2 |
| 16/01/2022 | 15:30 | FC Augsburg vs Eintracht Frankfurt | 1-1 |
| 16/01/2022 | 17:30 | DSC Arminia Bielefeld vs SpVgg Greuther Fürth | 2-2 |
| 21/01/2022 | 20:30 | Eintracht Frankfurt vs DSC Arminia Bielefeld | 0-2 |
| 22/01/2022 | 15:30 | Bayer 04 Leverkusen vs FC Augsburg | 5-1 |
| 22/01/2022 | 15:30 | Borussia Mönchengladbach vs FC Union Berlin | 1-2 |
| 22/01/2022 | 15:30 | SC Freiburg vs VfB Stuttgart | 2-0 |
| 22/01/2022 | 15:30 | TSG Hoffenheim vs Borussia Dortmund | 2-3 |
| 22/01/2022 | 15:30 | SpVgg Greuther Fürth vs FSV Mainz 05 | 2-1 |
| 22/01/2022 | 18:30 | VfL Bochum 1848 vs FC Köln | 2-2 |
| 23/01/2022 | 15:30 | RB Leipzig vs VfL Wolfsburg | 2-0 |
| 23/01/2022 | 17:30 | Hertha BSC vs FC Bayern München | 1-4 |
| 04/02/2022 | 20:30 | Hertha BSC vs VfL Bochum 1848 | 1-1 |
| 05/02/2022 | 15:30 | VfB Stuttgart vs Eintracht Frankfurt | 2-3 |
| 05/02/2022 | 15:30 | FSV Mainz 05 vs TSG Hoffenheim | 2-0 |
| 05/02/2022 | 15:30 | FC Augsburg vs FC Union Berlin | 2-0 |
| 05/02/2022 | 15:30 | DSC Arminia Bielefeld vs Borussia Mönchengladbach | 1-1 |
| 05/02/2022 | 15:30 | FC Köln vs SC Freiburg | 1-0 |
| 05/02/2022 | 18:30 | FC Bayern München vs RB Leipzig | 3-2 |
| 06/02/2022 | 15:30 | Borussia Dortmund vs Bayer 04 Leverkusen | 2-5 |
| 06/02/2022 | 17:30 | VfL Wolfsburg vs SpVgg Greuther Fürth | 4-1 |
| 11/02/2022 | 20:30 | RB Leipzig vs FC Köln | 3-1 |
| 12/02/2022 | 15:30 | Eintracht Frankfurt vs VfL Wolfsburg | 0-2 |
| 12/02/2022 | 15:30 | Borussia Mönchengladbach vs FC Augsburg | 3-2 |
| 12/02/2022 | 15:30 | SC Freiburg vs FSV Mainz 05 | 1-1 |
| 12/02/2022 | 15:30 | VfL Bochum 1848 vs FC Bayern München | 4-2 |
| 12/02/2022 | 15:30 | SpVgg Greuther Fürth vs Hertha BSC | 2-1 |
| 12/02/2022 | 18:30 | Bayer 04 Leverkusen vs VfB Stuttgart | 4-2 |
| 13/02/2022 | 15:30 | FC Union Berlin vs Borussia Dortmund | 0-3 |
| 13/02/2022 | 17:30 | TSG Hoffenheim vs DSC Arminia Bielefeld | 2-0 |
| 18/02/2022 | 20:30 | FSV Mainz 05 vs Bayer 04 Leverkusen | 3-2 |
| 19/02/2022 | 15:30 | VfL Wolfsburg vs TSG Hoffenheim | 1-2 |
| 19/02/2022 | 15:30 | VfB Stuttgart vs VfL Bochum 1848 | 1-1 |
| 19/02/2022 | 15:30 | FC Augsburg vs SC Freiburg | 1-2 |
| 19/02/2022 | 15:30 | DSC Arminia Bielefeld vs FC Union Berlin | 1-0 |
| 19/02/2022 | 18:30 | FC Köln vs Eintracht Frankfurt | 1-0 |
| 20/02/2022 | 15:30 | FC Bayern München vs SpVgg Greuther Fürth | 4-1 |
| 20/02/2022 | 17:30 | Borussia Dortmund vs Borussia Mönchengladbach | 6-0 |
| 20/02/2022 | 19:30 | Hertha BSC vs RB Leipzig | 1-6 |
| 25/02/2022 | 20:30 | TSG Hoffenheim vs VfB Stuttgart | 2-1 |
| 26/02/2022 | 15:30 | Bayer 04 Leverkusen vs DSC Arminia Bielefeld | 3-0 |
| 26/02/2022 | 15:30 | FC Union Berlin vs FSV Mainz 05 | 3-1 |
| 26/02/2022 | 15:30 | Borussia Mönchengladbach vs VfL Wolfsburg | 2-2 |
| 26/02/2022 | 15:30 | SC Freiburg vs Hertha BSC | 3-0 |
| 26/02/2022 | 15:30 | SpVgg Greuther Fürth vs FC Köln | 1-1 |
| 26/02/2022 | 18:30 | Eintracht Frankfurt vs FC Bayern München | 0-1 |
| 27/02/2022 | 15:30 | VfL Bochum 1848 vs RB Leipzig | 0-1 |
| 27/02/2022 | 17:30 | FC Augsburg vs Borussia Dortmund | 1-1 |
| 04/03/2022 | 20:30 | DSC Arminia Bielefeld vs FC Augsburg | 0-1 |
| 05/03/2022 | 15:30 | FC Bayern München vs Bayer 04 Leverkusen | 1-1 |
| 05/03/2022 | 15:30 | RB Leipzig vs SC Freiburg | 1-1 |
| 05/03/2022 | 15:30 | VfL Wolfsburg vs FC Union Berlin | 1-0 |
| 05/03/2022 | 15:30 | Hertha BSC vs Eintracht Frankfurt | 1-4 |
| 05/03/2022 | 15:30 | VfL Bochum 1848 vs SpVgg Greuther Fürth | 2-1 |
| 05/03/2022 | 18:30 | VfB Stuttgart vs Borussia Mönchengladbach | 3-2 |
| 06/03/2022 | 17:30 | FC Köln vs TSG Hoffenheim | 0-1 |
| 16/03/2022 | 18:30 | FSV Mainz 05 vs Borussia Dortmund | 0-1 |
| 12/03/2022 | 15:30 | FC Union Berlin vs VfB Stuttgart | 1-1 |
| 12/03/2022 | 15:30 | SC Freiburg vs VfL Wolfsburg | 3-2 |
| 12/03/2022 | 15:30 | TSG Hoffenheim vs FC Bayern München | 1-1 |
| 12/03/2022 | 18:30 | Borussia Mönchengladbach vs Hertha BSC | 2-0 |
| 13/03/2022 | 15:30 | Bayer 04 Leverkusen vs FC Köln | 0-1 |
| 13/03/2022 | 17:30 | Borussia Dortmund vs DSC Arminia Bielefeld | 1-0 |
| 13/03/2022 | 17:30 | Eintracht Frankfurt vs VfL Bochum 1848 | 2-1 |
| 13/03/2022 | 19:30 | SpVgg Greuther Fürth vs RB Leipzig | 1-6 |
| 06/04/2022 | 18:30 | FC Augsburg vs FSV Mainz 05 | 2-1 |
| 18/03/2022 | 20:30 | VfL Bochum 1848 vs Borussia Mönchengladbach | 0-2 |
| 19/03/2022 | 15:30 | VfB Stuttgart vs FC Augsburg | 3-2 |
| 19/03/2022 | 15:30 | FSV Mainz 05 vs DSC Arminia Bielefeld | 4-0 |
| 19/03/2022 | 15:30 | Hertha BSC vs TSG Hoffenheim | 3-0 |
| 19/03/2022 | 15:30 | SpVgg Greuther Fürth vs SC Freiburg | 0-0 |
| 19/03/2022 | 18:30 | FC Bayern München vs FC Union Berlin | 4-0 |
| 20/03/2022 | 15:30 | RB Leipzig vs Eintracht Frankfurt | 0-0 |
| 20/03/2022 | 17:30 | VfL Wolfsburg vs Bayer 04 Leverkusen | 0-2 |
| 20/03/2022 | 19:30 | FC Köln vs Borussia Dortmund | 1-1 |
| 01/04/2022 | 20:30 | FC Union Berlin vs FC Köln | 1-0 |
| 02/04/2022 | 15:30 | Eintracht Frankfurt vs SpVgg Greuther Fürth | 0-0 |
| 02/04/2022 | 15:30 | Bayer 04 Leverkusen vs Hertha BSC | 2-1 |
| 02/04/2022 | 15:30 | SC Freiburg vs FC Bayern München | 1-4 |
| 02/04/2022 | 15:30 | TSG Hoffenheim vs VfL Bochum 1848 | 1-2 |
| 02/04/2022 | 15:30 | DSC Arminia Bielefeld vs VfB Stuttgart | 1-1 |
| 02/04/2022 | 18:30 | Borussia Dortmund vs RB Leipzig | 1-4 |
| 03/04/2022 | 15:30 | FC Augsburg vs VfL Wolfsburg | 3-0 |
| 03/04/2022 | 17:30 | Borussia Mönchengladbach vs FSV Mainz 05 | 1-1 |
| 08/04/2022 | 20:30 | VfB Stuttgart vs Borussia Dortmund | 0-2 |
| 09/04/2022 | 15:30 | FC Bayern München vs FC Augsburg | 1-0 |
| 09/04/2022 | 15:30 | VfL Wolfsburg vs DSC Arminia Bielefeld | 4-0 |
| 09/04/2022 | 15:30 | FC Köln vs FSV Mainz 05 | 3-2 |
| 09/04/2022 | 15:30 | SpVgg Greuther Fürth vs Borussia Mönchengladbach | 0-2 |
| 09/04/2022 | 18:30 | Hertha BSC vs FC Union Berlin | 1-4 |
| 10/04/2022 | 15:30 | VfL Bochum 1848 vs Bayer 04 Leverkusen | 0-0 |
| 10/04/2022 | 17:30 | Eintracht Frankfurt vs SC Freiburg | 1-2 |
| 10/04/2022 | 19:30 | RB Leipzig vs TSG Hoffenheim | 3-0 |
| 16/04/2022 | 15:30 | Borussia Dortmund vs VfL Wolfsburg | 6-1 |
| 16/04/2022 | 15:30 | SC Freiburg vs VfL Bochum 1848 | 3-0 |
| 16/04/2022 | 15:30 | FSV Mainz 05 vs VfB Stuttgart | 0-0 |
| 16/04/2022 | 15:30 | FC Augsburg vs Hertha BSC | 0-1 |
| 16/04/2022 | 18:30 | Borussia Mönchengladbach vs FC Köln | 1-3 |
| 17/04/2022 | 15:30 | DSC Arminia Bielefeld vs FC Bayern München | 0-3 |
| 17/04/2022 | 17:30 | FC Union Berlin vs Eintracht Frankfurt | 2-0 |
| 17/04/2022 | 17:30 | TSG Hoffenheim vs SpVgg Greuther Fürth | 0-0 |
| 17/04/2022 | 19:30 | Bayer 04 Leverkusen vs RB Leipzig | 0-1 |
| 22/04/2022 | 20:30 | VfL Wolfsburg vs FSV Mainz 05 | 5-0 |
| 23/04/2022 | 15:30 | RB Leipzig vs FC Union Berlin | 1-2 |
| 23/04/2022 | 15:30 | Eintracht Frankfurt vs TSG Hoffenheim | 2-2 |
| 23/04/2022 | 15:30 | SC Freiburg vs Borussia Mönchengladbach | 3-3 |
| 23/04/2022 | 15:30 | FC Köln vs DSC Arminia Bielefeld | 3-1 |
| 23/04/2022 | 15:30 | SpVgg Greuther Fürth vs Bayer 04 Leverkusen | 1-4 |
| 23/04/2022 | 18:30 | FC Bayern München vs Borussia Dortmund | 3-1 |
| 24/04/2022 | 15:30 | VfL Bochum 1848 vs FC Augsburg | 0-2 |
| 24/04/2022 | 17:30 | Hertha BSC vs VfB Stuttgart | 2-0 |
| 29/04/2022 | 20:30 | FC Union Berlin vs SpVgg Greuther Fürth | 1-1 |
| 30/04/2022 | 15:30 | Borussia Dortmund vs VfL Bochum 1848 | 3-4 |
| 30/04/2022 | 15:30 | VfB Stuttgart vs VfL Wolfsburg | 1-1 |
| 30/04/2022 | 15:30 | FSV Mainz 05 vs FC Bayern München | 3-1 |
| 30/04/2022 | 15:30 | FC Augsburg vs FC Köln | 1-4 |
| 30/04/2022 | 15:30 | DSC Arminia Bielefeld vs Hertha BSC | 1-1 |
| 30/04/2022 | 18:30 | TSG Hoffenheim vs SC Freiburg | 3-4 |
| 02/05/2022 | 20:30 | Bayer 04 Leverkusen vs Eintracht Frankfurt | 2-0 |
| 02/05/2022 | 20:30 | Borussia Mönchengladbach vs RB Leipzig | 3-1 |
| 06/05/2022 | 20:30 | VfL Bochum 1848 vs DSC Arminia Bielefeld | 2-1 |
| 07/05/2022 | 15:30 | SC Freiburg vs FC Union Berlin | 1-4 |
| 07/05/2022 | 15:30 | TSG Hoffenheim vs Bayer 04 Leverkusen | 2-4 |
| 07/05/2022 | 15:30 | FC Köln vs VfL Wolfsburg | 0-1 |
| 07/05/2022 | 15:30 | SpVgg Greuther Fürth vs Borussia Dortmund | 1-3 |
| 07/05/2022 | 18:30 | Hertha BSC vs FSV Mainz 05 | 1-2 |
| 08/05/2022 | 15:30 | Eintracht Frankfurt vs Borussia Mönchengladbach | 1-1 |
| 08/05/2022 | 17:30 | FC Bayern München vs VfB Stuttgart | 2-2 |
| 08/05/2022 | 19:30 | RB Leipzig vs FC Augsburg | 4-0 |
| 14/05/2022 | 15:30 | Borussia Dortmund vs Hertha BSC | 2-1 |
| 14/05/2022 | 15:30 | VfL Wolfsburg vs FC Bayern München | 2-2 |
| 14/05/2022 | 15:30 | Bayer 04 Leverkusen vs SC Freiburg | 2-1 |
| 14/05/2022 | 15:30 | FC Union Berlin vs VfL Bochum 1848 | 3-2 |
| 14/05/2022 | 15:30 | Borussia Mönchengladbach vs TSG Hoffenheim | 5-1 |
| 14/05/2022 | 15:30 | VfB Stuttgart vs FC Köln | 2-1 |
| 14/05/2022 | 15:30 | FSV Mainz 05 vs Eintracht Frankfurt | 2-2 |
| 14/05/2022 | 15:30 | FC Augsburg vs SpVgg Greuther Fürth | 2-1 |
| 14/05/2022 | 15:30 | DSC Arminia Bielefeld vs RB Leipzig | 1-1 |