| 23/07/2021 | 20:45 | Standard Liège vs Genk | 1-1 |
| 24/07/2021 | 16:15 | OH Leuven vs Zulte-Waregem | 1-1 |
| 24/07/2021 | 18:30 | KV Kortrijk vs RFC Seraing | 2-0 |
| 24/07/2021 | 20:45 | KV Oostende vs Sporting Charleroi | 0-3 |
| 25/07/2021 | 13:30 | Mechelen vs Antwerp | 3-2 |
| 25/07/2021 | 16:00 | Club Brugge vs KAS Eupen | 2-2 |
| 25/07/2021 | 18:30 | Anderlecht vs Union Saint-Gilloise | 1-3 |
| 25/07/2021 | 21:00 | Sint-Truiden vs Gent | 2-1 |
| 27/07/2021 | 20:00 | K. Beerschot V.A. vs Cercle Brugge | 0-1 |
| 30/07/2021 | 20:45 | Genk vs KV Oostende | 3-4 |
| 31/07/2021 | 16:15 | Sporting Charleroi vs Sint-Truiden | 0-0 |
| 31/07/2021 | 18:30 | RFC Seraing vs Mechelen | 1-0 |
| 31/07/2021 | 18:30 | Cercle Brugge vs OH Leuven | 1-1 |
| 31/07/2021 | 20:45 | KAS Eupen vs Anderlecht | 1-1 |
| 01/08/2021 | 13:30 | Union Saint-Gilloise vs Club Brugge | 0-1 |
| 01/08/2021 | 16:00 | Zulte-Waregem vs Standard Liège | 1-2 |
| 01/08/2021 | 18:30 | Gent vs K. Beerschot V.A. | 2-2 |
| 01/08/2021 | 21:00 | Antwerp vs KV Kortrijk | 0-1 |
| 06/08/2021 | 20:45 | Club Brugge vs Cercle Brugge | 1-1 |
| 07/08/2021 | 16:15 | K. Beerschot V.A. vs Union Saint-Gilloise | 0-3 |
| 07/08/2021 | 18:30 | Mechelen vs KAS Eupen | 1-3 |
| 07/08/2021 | 18:30 | Sint-Truiden vs Zulte-Waregem | 1-3 |
| 07/08/2021 | 20:45 | KV Kortrijk vs Genk | 1-2 |
| 08/08/2021 | 13:30 | Standard Liège vs Antwerp | 2-5 |
| 08/08/2021 | 16:00 | OH Leuven vs Sporting Charleroi | 1-1 |
| 08/08/2021 | 18:30 | Anderlecht vs RFC Seraing | 3-0 |
| 08/08/2021 | 21:00 | KV Oostende vs Gent | 1-0 |
| 13/08/2021 | 20:45 | Sporting Charleroi vs Antwerp | 1-1 |
| 14/08/2021 | 16:15 | Union Saint-Gilloise vs KV Kortrijk | 2-0 |
| 14/08/2021 | 18:30 | RFC Seraing vs KV Oostende | 2-3 |
| 14/08/2021 | 18:30 | KAS Eupen vs Sint-Truiden | 2-1 |
| 14/08/2021 | 20:45 | Genk vs OH Leuven | 4-0 |
| 15/08/2021 | 13:30 | K. Beerschot V.A. vs Standard Liège | 0-1 |
| 15/08/2021 | 16:00 | Gent vs Mechelen | 2-0 |
| 15/08/2021 | 18:30 | Cercle Brugge vs Anderlecht | 1-2 |
| 15/08/2021 | 21:00 | Zulte-Waregem vs Club Brugge | 0-4 |
| 20/08/2021 | 20:45 | Standard Liège vs KV Oostende | 1-0 |
| 21/08/2021 | 16:15 | RFC Seraing vs Cercle Brugge | 2-1 |
| 21/08/2021 | 18:30 | OH Leuven vs KAS Eupen | 1-4 |
| 21/08/2021 | 20:45 | Sint-Truiden vs KV Kortrijk | 0-2 |
| 22/08/2021 | 16:00 | Zulte-Waregem vs Sporting Charleroi | 2-2 |
| 22/08/2021 | 18:30 | Club Brugge vs K. Beerschot V.A. | 3-2 |
| 22/08/2021 | 21:00 | Mechelen vs Union Saint-Gilloise | 3-1 |
| 22/09/2021 | 20:45 | Antwerp vs Genk | 4-2 |
| 23/09/2021 | 20:45 | Anderlecht vs Gent | 1-1 |
| 27/08/2021 | 20:45 | KV Kortrijk vs Mechelen | 2-2 |
| 28/08/2021 | 16:15 | Sporting Charleroi vs K. Beerschot V.A. | 5-2 |
| 28/08/2021 | 18:30 | Cercle Brugge vs Sint-Truiden | 0-1 |
| 28/08/2021 | 18:30 | KAS Eupen vs RFC Seraing | 1-2 |
| 28/08/2021 | 20:45 | Union Saint-Gilloise vs Standard Liège | 4-0 |
| 29/08/2021 | 13:30 | Gent vs Club Brugge | 6-1 |
| 29/08/2021 | 16:00 | Antwerp vs OH Leuven | 2-2 |
| 29/08/2021 | 18:30 | Genk vs Anderlecht | 1-0 |
| 29/08/2021 | 21:00 | KV Oostende vs Zulte-Waregem | 0-2 |
| 10/09/2021 | 20:45 | Club Brugge vs KV Oostende | 3-0 |
| 11/09/2021 | 16:15 | KAS Eupen vs Antwerp | 0-1 |
| 11/09/2021 | 18:30 | Zulte-Waregem vs Cercle Brugge | 2-4 |
| 12/09/2021 | 13:30 | Anderlecht vs Mechelen | 7-2 |
| 12/09/2021 | 16:00 | Gent vs Sporting Charleroi | 2-3 |
| 12/09/2021 | 18:30 | RFC Seraing vs Standard Liège | 0-1 |
| 12/09/2021 | 21:00 | Genk vs Union Saint-Gilloise | 1-1 |
| 12/09/2021 | 21:00 | OH Leuven vs KV Kortrijk | 2-1 |
| 13/09/2021 | 20:00 | K. Beerschot V.A. vs Sint-Truiden | 0-1 |
| 17/09/2021 | 20:45 | Cercle Brugge vs KAS Eupen | 1-2 |
| 18/09/2021 | 16:15 | KV Oostende vs K. Beerschot V.A. | 3-1 |
| 18/09/2021 | 18:30 | Union Saint-Gilloise vs Zulte-Waregem | 2-1 |
| 18/09/2021 | 18:30 | Mechelen vs OH Leuven | 2-0 |
| 18/09/2021 | 20:45 | Sporting Charleroi vs Club Brugge | 0-1 |
| 19/09/2021 | 13:30 | Sint-Truiden vs Genk | 1-2 |
| 19/09/2021 | 16:00 | Antwerp vs RFC Seraing | 2-1 |
| 19/09/2021 | 18:30 | Standard Liège vs Anderlecht | 0-1 |
| 19/09/2021 | 21:00 | KV Kortrijk vs Gent | 1-0 |
| 24/09/2021 | 20:45 | Club Brugge vs OH Leuven | 1-1 |
| 25/09/2021 | 16:15 | K. Beerschot V.A. vs KAS Eupen | 0-3 |
| 25/09/2021 | 18:30 | Zulte-Waregem vs KV Kortrijk | 2-2 |
| 25/09/2021 | 20:45 | Standard Liège vs Sint-Truiden | 1-2 |
| 26/09/2021 | 13:30 | Union Saint-Gilloise vs Antwerp | 1-2 |
| 26/09/2021 | 16:00 | Gent vs Cercle Brugge | 2-1 |
| 26/09/2021 | 18:30 | KV Oostende vs Anderlecht | 2-2 |
| 26/09/2021 | 21:00 | Genk vs RFC Seraing | 3-0 |
| 26/09/2021 | 21:00 | Sporting Charleroi vs Mechelen | 0-2 |
| 01/10/2021 | 20:45 | Mechelen vs Standard Liège | 3-1 |
| 02/10/2021 | 16:15 | KV Kortrijk vs Sporting Charleroi | 2-2 |
| 02/10/2021 | 18:30 | Cercle Brugge vs Union Saint-Gilloise | 0-3 |
| 02/10/2021 | 18:30 | Sint-Truiden vs KV Oostende | 1-1 |
| 02/10/2021 | 20:45 | OH Leuven vs K. Beerschot V.A. | 0-0 |
| 03/10/2021 | 13:30 | Anderlecht vs Club Brugge | 1-1 |
| 03/10/2021 | 16:00 | RFC Seraing vs Zulte-Waregem | 5-1 |
| 03/10/2021 | 18:30 | Antwerp vs Gent | 1-0 |
| 03/10/2021 | 21:00 | KAS Eupen vs Genk | 3-2 |
| 15/10/2021 | 20:45 | Club Brugge vs KV Kortrijk | 2-0 |
| 16/10/2021 | 16:15 | Union Saint-Gilloise vs RFC Seraing | 4-2 |
| 16/10/2021 | 18:30 | Zulte-Waregem vs Antwerp | 2-1 |
| 16/10/2021 | 18:30 | KV Oostende vs Cercle Brugge | 2-1 |
| 16/10/2021 | 20:45 | Standard Liège vs OH Leuven | 2-2 |
| 17/10/2021 | 13:30 | Sint-Truiden vs Anderlecht | 2-2 |
| 17/10/2021 | 17:00 | K. Beerschot V.A. vs Mechelen | 0-1 |
| 17/10/2021 | 18:30 | Sporting Charleroi vs Genk | 2-0 |
| 17/10/2021 | 21:00 | Gent vs KAS Eupen | 2-0 |
| 22/10/2021 | 20:45 | RFC Seraing vs Sporting Charleroi | 1-3 |
| 23/10/2021 | 16:15 | Cercle Brugge vs Standard Liège | 1-1 |
| 23/10/2021 | 18:30 | KV Kortrijk vs KV Oostende | 1-0 |
| 23/10/2021 | 18:30 | Mechelen vs Zulte-Waregem | 2-2 |
| 23/10/2021 | 20:45 | KAS Eupen vs Union Saint-Gilloise | 2-3 |
| 24/10/2021 | 13:30 | Antwerp vs Club Brugge | 1-1 |
| 24/10/2021 | 17:00 | Anderlecht vs K. Beerschot V.A. | 4-2 |
| 24/10/2021 | 18:30 | Genk vs Gent | 0-3 |
| 24/10/2021 | 21:00 | OH Leuven vs Sint-Truiden | 4-1 |
| 29/10/2021 | 20:45 | KV Oostende vs Mechelen | 2-4 |
| 30/10/2021 | 16:15 | Sporting Charleroi vs KAS Eupen | 3-0 |
| 30/10/2021 | 18:30 | Standard Liège vs KV Kortrijk | 1-1 |
| 30/10/2021 | 18:30 | K. Beerschot V.A. vs RFC Seraing | 3-0 |
| 30/10/2021 | 20:45 | Sint-Truiden vs Club Brugge | 1-2 |
| 31/10/2021 | 13:30 | Zulte-Waregem vs Genk | 2-6 |
| 31/10/2021 | 16:00 | Cercle Brugge vs Antwerp | 0-1 |
| 31/10/2021 | 18:30 | Anderlecht vs OH Leuven | 2-2 |
| 31/10/2021 | 21:00 | Gent vs Union Saint-Gilloise | 0-2 |
| 05/11/2021 | 20:45 | OH Leuven vs KV Oostende | 1-0 |
| 06/11/2021 | 16:15 | KAS Eupen vs Zulte-Waregem | 1-1 |
| 06/11/2021 | 18:30 | KV Kortrijk vs K. Beerschot V.A. | 1-1 |
| 06/11/2021 | 18:30 | Mechelen vs Sint-Truiden | 0-1 |
| 06/11/2021 | 20:45 | Union Saint-Gilloise vs Sporting Charleroi | 4-0 |
| 07/11/2021 | 13:30 | Club Brugge vs Standard Liège | 2-2 |
| 07/11/2021 | 16:00 | RFC Seraing vs Gent | 0-0 |
| 07/11/2021 | 18:30 | Antwerp vs Anderlecht | 2-0 |
| 07/11/2021 | 21:00 | Genk vs Cercle Brugge | 1-1 |
| 19/11/2021 | 20:45 | Mechelen vs Club Brugge | 2-1 |
| 20/11/2021 | 16:15 | Cercle Brugge vs Sporting Charleroi | 1-2 |
| 20/11/2021 | 18:30 | OH Leuven vs RFC Seraing | 1-3 |
| 20/11/2021 | 18:30 | Zulte-Waregem vs Gent | 1-2 |
| 20/11/2021 | 20:45 | Standard Liège vs KAS Eupen | 1-0 |
| 21/11/2021 | 13:30 | Anderlecht vs KV Kortrijk | 1-1 |
| 21/11/2021 | 16:00 | Sint-Truiden vs Antwerp | 2-1 |
| 21/11/2021 | 18:30 | KV Oostende vs Union Saint-Gilloise | 1-7 |
| 21/11/2021 | 21:00 | K. Beerschot V.A. vs Genk | 2-0 |
| 26/11/2021 | 20:45 | Union Saint-Gilloise vs OH Leuven | 1-3 |
| 27/11/2021 | 16:15 | RFC Seraing vs Sint-Truiden | 2-0 |
| 27/11/2021 | 18:30 | Cercle Brugge vs Mechelen | 3-1 |
| 27/11/2021 | 18:30 | KAS Eupen vs KV Kortrijk | 2-2 |
| 27/11/2021 | 20:45 | Sporting Charleroi vs Anderlecht | 1-3 |
| 28/11/2021 | 13:30 | Genk vs Club Brugge | 2-3 |
| 28/11/2021 | 16:00 | Zulte-Waregem vs K. Beerschot V.A. | 2-0 |
| 28/11/2021 | 18:30 | Gent vs Standard Liège | 3-1 |
| 28/11/2021 | 21:00 | Antwerp vs KV Oostende | 3-0 |
| 03/12/2021 | 20:45 | Sint-Truiden vs Union Saint-Gilloise | 1-2 |
| 04/12/2021 | 16:15 | OH Leuven vs Gent | 0-1 |
| 04/12/2021 | 18:30 | KV Kortrijk vs Cercle Brugge | 0-2 |
| 04/12/2021 | 18:30 | KV Oostende vs KAS Eupen | 2-1 |
| 04/12/2021 | 20:45 | Club Brugge vs RFC Seraing | 3-2 |
| 05/12/2021 | 13:30 | K. Beerschot V.A. vs Antwerp | 0-1 |
| 05/12/2021 | 16:00 | Anderlecht vs Zulte-Waregem | 3-2 |
| 05/12/2021 | 18:30 | Standard Liège vs Sporting Charleroi | 0-3 |
| 05/12/2021 | 21:00 | Mechelen vs Genk | 1-1 |
| 10/12/2021 | 20:45 | Sporting Charleroi vs KV Oostende | 1-0 |
| 11/12/2021 | 16:15 | KV Kortrijk vs OH Leuven | 2-1 |
| 11/12/2021 | 18:30 | Sint-Truiden vs Cercle Brugge | 1-2 |
| 11/12/2021 | 18:30 | KAS Eupen vs K. Beerschot V.A. | 1-0 |
| 11/12/2021 | 20:45 | RFC Seraing vs Anderlecht | 0-5 |
| 12/12/2021 | 13:30 | Antwerp vs Standard Liège | 2-3 |
| 12/12/2021 | 16:00 | Union Saint-Gilloise vs Mechelen | 2-0 |
| 12/12/2021 | 18:30 | Gent vs Genk | 1-0 |
| 12/12/2021 | 21:00 | Club Brugge vs Zulte-Waregem | 3-0 |
| 14/12/2021 | 18:45 | Cercle Brugge vs RFC Seraing | 2-0 |
| 14/12/2021 | 21:00 | Anderlecht vs Sint-Truiden | 2-0 |
| 14/12/2021 | 21:00 | KV Oostende vs KV Kortrijk | 0-2 |
| 15/12/2021 | 18:45 | Zulte-Waregem vs Union Saint-Gilloise | 0-2 |
| 15/12/2021 | 18:45 | Mechelen vs Gent | 4-3 |
| 15/12/2021 | 21:00 | OH Leuven vs Club Brugge | 1-4 |
| 16/12/2021 | 18:45 | Antwerp vs KAS Eupen | 4-2 |
| 16/12/2021 | 21:00 | Genk vs Sporting Charleroi | 4-2 |
| 02/03/2022 | 18:45 | Standard Liège vs K. Beerschot V.A. | 1-0 |
| 17/12/2021 | 20:45 | RFC Seraing vs KV Kortrijk | 0-2 |
| 18/12/2021 | 16:15 | K. Beerschot V.A. vs KV Oostende | 0-2 |
| 18/12/2021 | 18:30 | Union Saint-Gilloise vs Cercle Brugge | 3-2 |
| 18/12/2021 | 18:30 | Zulte-Waregem vs Mechelen | 3-2 |
| 18/12/2021 | 20:45 | Gent vs Sint-Truiden | 2-1 |
| 19/12/2021 | 13:30 | Club Brugge vs Anderlecht | 2-2 |
| 19/12/2021 | 16:00 | KAS Eupen vs Sporting Charleroi | 0-4 |
| 19/12/2021 | 18:30 | Genk vs Antwerp | 1-1 |
| 19/12/2021 | 21:00 | OH Leuven vs Standard Liège | 2-1 |
| 26/12/2021 | 13:30 | Cercle Brugge vs Club Brugge | 2-0 |
| 26/12/2021 | 16:00 | Standard Liège vs Zulte-Waregem | 0-1 |
| 26/12/2021 | 18:30 | Union Saint-Gilloise vs Gent | 0-0 |
| 26/12/2021 | 21:00 | KV Oostende vs Genk | 0-4 |
| 27/12/2021 | 18:45 | Mechelen vs RFC Seraing | 2-0 |
| 27/12/2021 | 18:45 | Sporting Charleroi vs OH Leuven | 0-3 |
| 27/12/2021 | 21:00 | Sint-Truiden vs KAS Eupen | 2-0 |
| 27/12/2021 | 21:00 | K. Beerschot V.A. vs Anderlecht | 0-7 |
| 02/02/2022 | 18:45 | KV Kortrijk vs Antwerp | 0-2 |
| 14/01/2022 | 20:45 | Gent vs KV Kortrijk | 2-2 |
| 15/01/2022 | 16:15 | OH Leuven vs Mechelen | 5-0 |
| 15/01/2022 | 20:45 | Club Brugge vs Sint-Truiden | 2-0 |
| 16/01/2022 | 13:30 | Antwerp vs Sporting Charleroi | 3-0 |
| 16/01/2022 | 16:00 | KAS Eupen vs Cercle Brugge | 0-2 |
| 16/01/2022 | 18:30 | Anderlecht vs Standard Liège | 1-1 |
| 16/01/2022 | 21:00 | Genk vs K. Beerschot V.A. | 4-1 |
| 18/01/2022 | 20:00 | RFC Seraing vs Union Saint-Gilloise | 0-4 |
| 09/02/2022 | 18:45 | Zulte-Waregem vs KV Oostende | 0-0 |
| 21/01/2022 | 20:45 | KV Oostende vs Antwerp | 1-2 |
| 22/01/2022 | 16:15 | KV Kortrijk vs KAS Eupen | 1-1 |
| 22/01/2022 | 18:30 | Sint-Truiden vs RFC Seraing | 3-1 |
| 22/01/2022 | 18:30 | K. Beerschot V.A. vs OH Leuven | 3-1 |
| 22/01/2022 | 20:45 | Sporting Charleroi vs Gent | 0-0 |
| 23/01/2022 | 13:30 | Standard Liège vs Club Brugge | 2-2 |
| 23/01/2022 | 16:00 | Union Saint-Gilloise vs Genk | 2-1 |
| 23/01/2022 | 18:30 | Mechelen vs Anderlecht | 0-1 |
| 23/01/2022 | 21:00 | Cercle Brugge vs Zulte-Waregem | 3-1 |
| 25/01/2022 | 18:45 | Antwerp vs Sint-Truiden | 1-1 |
| 25/01/2022 | 21:00 | Gent vs KV Oostende | 1-1 |
| 25/01/2022 | 21:00 | Sporting Charleroi vs KV Kortrijk | 1-1 |
| 26/01/2022 | 18:45 | Zulte-Waregem vs OH Leuven | 1-1 |
| 26/01/2022 | 18:45 | KAS Eupen vs Standard Liège | 0-2 |
| 26/01/2022 | 21:00 | Anderlecht vs Cercle Brugge | 0-2 |
| 26/01/2022 | 21:00 | RFC Seraing vs K. Beerschot V.A. | 2-1 |
| 27/01/2022 | 20:45 | Club Brugge vs Union Saint-Gilloise | 0-0 |
| 16/02/2022 | 18:45 | Genk vs Mechelen | 4-1 |
| 28/01/2022 | 20:45 | Sint-Truiden vs Sporting Charleroi | 0-1 |
| 29/01/2022 | 16:15 | K. Beerschot V.A. vs Zulte-Waregem | 3-3 |
| 29/01/2022 | 18:30 | RFC Seraing vs KAS Eupen | 0-0 |
| 29/01/2022 | 20:45 | Cercle Brugge vs KV Oostende | 0-1 |
| 30/01/2022 | 13:30 | Union Saint-Gilloise vs Anderlecht | 1-0 |
| 30/01/2022 | 16:00 | Gent vs Antwerp | 0-1 |
| 30/01/2022 | 18:30 | Standard Liège vs Mechelen | 1-2 |
| 30/01/2022 | 21:00 | KV Kortrijk vs Club Brugge | 0-1 |
| 09/02/2022 | 21:00 | OH Leuven vs Genk | 2-1 |
| 04/02/2022 | 20:45 | Sporting Charleroi vs RFC Seraing | 2-0 |
| 05/02/2022 | 16:15 | KV Kortrijk vs Sint-Truiden | 1-3 |
| 05/02/2022 | 18:30 | Standard Liège vs Cercle Brugge | 1-1 |
| 05/02/2022 | 18:30 | KV Oostende vs OH Leuven | 1-3 |
| 05/02/2022 | 20:45 | Antwerp vs Union Saint-Gilloise | 0-2 |
| 06/02/2022 | 13:30 | Club Brugge vs Gent | 1-2 |
| 06/02/2022 | 16:00 | Mechelen vs K. Beerschot V.A. | 3-2 |
| 06/02/2022 | 18:30 | Anderlecht vs KAS Eupen | 4-1 |
| 06/02/2022 | 21:00 | Genk vs Zulte-Waregem | 2-0 |
| 11/02/2022 | 20:45 | RFC Seraing vs Antwerp | 0-1 |
| 12/02/2022 | 16:15 | KAS Eupen vs Gent | 0-1 |
| 12/02/2022 | 18:30 | OH Leuven vs Cercle Brugge | 3-2 |
| 12/02/2022 | 18:30 | Mechelen vs KV Oostende | 3-0 |
| 12/02/2022 | 20:45 | Zulte-Waregem vs Anderlecht | 1-2 |
| 13/02/2022 | 13:30 | Genk vs Standard Liège | 2-0 |
| 13/02/2022 | 16:00 | Union Saint-Gilloise vs Sint-Truiden | 0-1 |
| 13/02/2022 | 18:30 | Club Brugge vs Sporting Charleroi | 2-0 |
| 13/02/2022 | 21:00 | K. Beerschot V.A. vs KV Kortrijk | 2-1 |
| 19/02/2022 | 16:15 | Cercle Brugge vs K. Beerschot V.A. | 2-0 |
| 19/02/2022 | 18:30 | KV Kortrijk vs Zulte-Waregem | 5-0 |
| 19/02/2022 | 18:30 | KV Oostende vs Standard Liège | 1-0 |
| 19/02/2022 | 20:45 | Sporting Charleroi vs Union Saint-Gilloise | 0-3 |
| 20/02/2022 | 13:30 | Antwerp vs Mechelen | 1-2 |
| 20/02/2022 | 16:00 | KAS Eupen vs Club Brugge | 1-3 |
| 20/02/2022 | 18:30 | Anderlecht vs Genk | 2-0 |
| 20/02/2022 | 21:00 | Sint-Truiden vs OH Leuven | 2-0 |
| 23/02/2022 | 18:45 | Gent vs RFC Seraing | 4-0 |
| 25/02/2022 | 20:45 | K. Beerschot V.A. vs Sporting Charleroi | 2-3 |
| 26/02/2022 | 16:15 | Union Saint-Gilloise vs KAS Eupen | 0-0 |
| 26/02/2022 | 18:30 | Mechelen vs Cercle Brugge | 2-2 |
| 26/02/2022 | 18:30 | KV Oostende vs Sint-Truiden | 0-0 |
| 26/02/2022 | 20:45 | OH Leuven vs Anderlecht | 0-0 |
| 27/02/2022 | 13:30 | Club Brugge vs Antwerp | 4-1 |
| 27/02/2022 | 16:00 | Genk vs KV Kortrijk | 2-0 |
| 27/02/2022 | 18:30 | Standard Liège vs Gent | 0-1 |
| 27/02/2022 | 21:00 | Zulte-Waregem vs RFC Seraing | 1-0 |
| 04/03/2022 | 20:45 | Sint-Truiden vs Mechelen | 1-1 |
| 05/03/2022 | 16:15 | Cercle Brugge vs Genk | 2-2 |
| 05/03/2022 | 18:30 | KV Kortrijk vs Union Saint-Gilloise | 2-3 |
| 05/03/2022 | 20:45 | RFC Seraing vs Club Brugge | 0-5 |
| 06/03/2022 | 13:30 | Antwerp vs K. Beerschot V.A. | 2-1 |
| 06/03/2022 | 16:00 | Anderlecht vs KV Oostende | 3-0 |
| 06/03/2022 | 18:30 | Sporting Charleroi vs Standard Liège | 0-0 |
| 06/03/2022 | 21:00 | Gent vs Zulte-Waregem | 2-1 |
| 06/03/2022 | 21:00 | KAS Eupen vs OH Leuven | 3-1 |
| 11/03/2022 | 20:45 | OH Leuven vs Union Saint-Gilloise | 1-4 |
| 12/03/2022 | 16:15 | Mechelen vs Sporting Charleroi | 2-2 |
| 12/03/2022 | 18:30 | Cercle Brugge vs KV Kortrijk | 2-0 |
| 12/03/2022 | 18:30 | Zulte-Waregem vs KAS Eupen | 3-0 |
| 12/03/2022 | 20:45 | KV Oostende vs Club Brugge | 1-3 |
| 13/03/2022 | 13:30 | Anderlecht vs Antwerp | 2-1 |
| 13/03/2022 | 16:00 | Genk vs Sint-Truiden | 0-1 |
| 13/03/2022 | 18:30 | K. Beerschot V.A. vs Gent | 0-2 |
| 13/03/2022 | 21:00 | Standard Liège vs RFC Seraing | 0-1 |
| 18/03/2022 | 20:45 | Union Saint-Gilloise vs KV Oostende | 1-1 |
| 19/03/2022 | 16:15 | KAS Eupen vs Mechelen | 1-1 |
| 19/03/2022 | 18:30 | RFC Seraing vs OH Leuven | 1-1 |
| 19/03/2022 | 18:30 | Sporting Charleroi vs Cercle Brugge | 5-0 |
| 19/03/2022 | 20:45 | Antwerp vs Zulte-Waregem | 1-0 |
| 20/03/2022 | 13:30 | Club Brugge vs Genk | 3-1 |
| 20/03/2022 | 16:00 | KV Kortrijk vs Standard Liège | 0-1 |
| 20/03/2022 | 18:30 | Gent vs Anderlecht | 1-0 |
| 20/03/2022 | 21:00 | Sint-Truiden vs K. Beerschot V.A. | 3-2 |
| 01/04/2022 | 20:45 | K. Beerschot V.A. vs Club Brugge | 1-3 |
| 02/04/2022 | 16:15 | Zulte-Waregem vs Sint-Truiden | 0-2 |
| 02/04/2022 | 18:30 | Mechelen vs KV Kortrijk | 3-2 |
| 02/04/2022 | 18:30 | KV Oostende vs RFC Seraing | 2-2 |
| 02/04/2022 | 20:45 | OH Leuven vs Antwerp | 0-1 |
| 03/04/2022 | 13:30 | Standard Liège vs Union Saint-Gilloise | 1-3 |
| 03/04/2022 | 17:00 | Cercle Brugge vs Gent | 2-2 |
| 03/04/2022 | 18:30 | Anderlecht vs Sporting Charleroi | 4-0 |
| 03/04/2022 | 21:00 | Genk vs KAS Eupen | 5-0 |
| 09/04/2022 | 18:30 | KAS Eupen vs KV Oostende | 0-2 |
| 09/04/2022 | 20:45 | Antwerp vs Cercle Brugge | 1-1 |
| 10/04/2022 | 18:30 | Club Brugge vs Mechelen | 2-0 |
| 10/04/2022 | 18:30 | Gent vs OH Leuven | 5-0 |
| 10/04/2022 | 18:30 | KV Kortrijk vs Anderlecht | 2-3 |
| 10/04/2022 | 18:30 | RFC Seraing vs Genk | 0-2 |
| 10/04/2022 | 18:30 | Union Saint-Gilloise vs K. Beerschot V.A. | 0-0 |
| 10/04/2022 | 18:30 | Sint-Truiden vs Standard Liège | 3-0 |
| 10/04/2022 | 18:30 | Sporting Charleroi vs Zulte-Waregem | 3-0 |
| 23/04/2022 | 20:45 | Mechelen vs Sporting Charleroi | 1-0 |
| 24/04/2022 | 16:00 | Gent vs Genk | 0-1 |
| 24/04/2022 | 13:30 | Club Brugge vs Antwerp | 1-0 |
| 24/04/2022 | 18:30 | Union Saint-Gilloise vs Anderlecht | 3-1 |
| 29/04/2022 | 20:45 | Genk vs Mechelen | 4-2 |
| 30/04/2022 | 18:30 | Sporting Charleroi vs Gent | 1-3 |
| 01/05/2022 | 13:30 | Antwerp vs Union Saint-Gilloise | 0-0 |
| 01/05/2022 | 18:30 | Anderlecht vs Club Brugge | 0-0 |
| 06/05/2022 | 20:45 | Sporting Charleroi vs Genk | 2-2 |
| 07/05/2022 | 20:45 | Gent vs Mechelen | 1-0 |
| 08/05/2022 | 13:30 | Union Saint-Gilloise vs Club Brugge | 0-2 |
| 08/05/2022 | 18:30 | Antwerp vs Anderlecht | 0-4 |
| 10/05/2022 | 18:45 | Mechelen vs Gent | 1-2 |
| 10/05/2022 | 21:00 | Genk vs Sporting Charleroi | 3-2 |
| 11/05/2022 | 20:30 | Club Brugge vs Union Saint-Gilloise | 1-0 |
| 12/05/2022 | 20:30 | Anderlecht vs Antwerp | 2-1 |
| 14/05/2022 | 20:45 | Sporting Charleroi vs Mechelen | 3-2 |
| 15/05/2022 | 16:00 | Genk vs Gent | 0-2 |
| 15/05/2022 | 13:30 | Antwerp vs Club Brugge | 1-3 |
| 15/05/2022 | 18:30 | Anderlecht vs Union Saint-Gilloise | 0-2 |
| 21/05/2022 | 20:45 | Gent vs Sporting Charleroi | 1-2 |
| 21/05/2022 | 20:45 | Mechelen vs Genk | 0-0 |
| 22/05/2022 | 16:00 | Union Saint-Gilloise vs Antwerp | 0-1 |
| 22/05/2022 | 18:30 | Club Brugge vs Anderlecht | 1-1 |