| 13.08.2021 | 19:30 | Beşiktaş - Rizespor | 3:0 |
| 14.08.2021 | 18:15 | Fatih Karagümrük - Gaziantep F.K. | 3:2 |
| 14.08.2021 | 20:45 | Altay - Kayserispor | 3:0 |
| 14.08.2021 | 20:45 | Hatayspor - Kasımpaşa | 1:1 |
| 15.08.2021 | 18:15 | İstanbul Başakşehir - Alanyaspor | 0:1 |
| 15.08.2021 | 20:45 | Antalyaspor - Göztepe | 1:1 |
| 15.08.2021 | 20:45 | Adana Demirspor - Fenerbahçe | 0:1 |
| 16.08.2021 | 18:15 | Yeni Malatyaspor - Trabzonspor | 1:5 |
| 16.08.2021 | 18:15 | Sivasspor - Konyaspor | 0:1 |
| 16.08.2021 | 20:45 | Giresunspor - Galatasaray | 0:2 |
| 20.08.2021 | 19:30 | Kayserispor - Adana Demirspor | 1:1 |
| 21.08.2021 | 18:15 | Kasımpaşa - Giresunspor | 2:0 |
| 21.08.2021 | 18:15 | Rizespor - Fatih Karagümrük | 0:0 |
| 21.08.2021 | 20:45 | Gaziantep F.K. - Beşiktaş | 0:0 |
| 21.08.2021 | 20:45 | Alanyaspor - Altay | 1:4 |
| 22.08.2021 | 18:15 | Konyaspor - İstanbul Başakşehir | 2:1 |
| 22.08.2021 | 20:45 | Fenerbahçe - Antalyaspor | 2:0 |
| 22.08.2021 | 20:45 | Göztepe - Yeni Malatyaspor | 0:1 |
| 23.08.2021 | 18:15 | Trabzonspor - Sivasspor | 2:1 |
| 23.08.2021 | 20:45 | Galatasaray - Hatayspor | 2:1 |
| 27.08.2021 | 19:30 | Antalyaspor - Rizespor | 3:2 |
| 27.08.2021 | 20:45 | Adana Demirspor - Konyaspor | 1:1 |
| 28.08.2021 | 18:15 | Yeni Malatyaspor - Gaziantep F.K. | 2:0 |
| 28.08.2021 | 18:15 | İstanbul Başakşehir - Kayserispor | 0:1 |
| 28.08.2021 | 20:45 | Beşiktaş - Fatih Karagümrük | 1:0 |
| 28.08.2021 | 20:45 | Hatayspor - Alanyaspor | 5:0 |
| 29.08.2021 | 18:15 | Kasımpaşa - Galatasaray | 2:2 |
| 29.08.2021 | 18:15 | Sivasspor - Göztepe | 2:2 |
| 29.08.2021 | 20:45 | Giresunspor - Trabzonspor | 0:1 |
| 29.08.2021 | 20:45 | Altay - Fenerbahçe | 0:2 |
| 11.09.2021 | 16:00 | Fatih Karagümrük - Adana Demirspor | 4:0 |
| 11.09.2021 | 16:00 | Konyaspor - Altay | 3:1 |
| 11.09.2021 | 19:00 | Beşiktaş - Yeni Malatyaspor | 3:0 |
| 11.09.2021 | 19:00 | Kayserispor - Kasımpaşa | 2:0 |
| 12.09.2021 | 16:00 | Fenerbahçe - Sivasspor | 1:1 |
| 12.09.2021 | 16:00 | Rizespor - Hatayspor | 0:2 |
| 12.09.2021 | 19:00 | Trabzonspor - Galatasaray | 2:2 |
| 12.09.2021 | 19:00 | Göztepe - İstanbul Başakşehir | 2:1 |
| 13.09.2021 | 19:00 | Gaziantep F.K. - Antalyaspor | 2:0 |
| 13.09.2021 | 19:00 | Alanyaspor - Giresunspor | 1:0 |
| 17.09.2021 | 19:00 | Yeni Malatyaspor - Fatih Karagümrük | 3:4 |
| 17.09.2021 | 19:00 | Altay - Göztepe | 2:1 |
| 18.09.2021 | 12:30 | Sivasspor - Gaziantep F.K. | 1:1 |
| 18.09.2021 | 15:00 | Kasımpaşa - Trabzonspor | 0:1 |
| 18.09.2021 | 18:00 | Antalyaspor - Beşiktaş | 2:3 |
| 18.09.2021 | 18:00 | Adana Demirspor - Rizespor | 3:1 |
| 19.09.2021 | 12:30 | Giresunspor - Konyaspor | 0:0 |
| 19.09.2021 | 15:00 | Galatasaray - Alanyaspor | 0:1 |
| 19.09.2021 | 18:00 | İstanbul Başakşehir - Fenerbahçe | 2:0 |
| 19.09.2021 | 18:00 | Hatayspor - Kayserispor | 2:1 |
| 21.09.2021 | 16:00 | Fatih Karagümrük - Antalyaspor | 0:0 |
| 21.09.2021 | 16:00 | Rizespor - Altay | 1:2 |
| 21.09.2021 | 19:00 | Beşiktaş - Adana Demirspor | 3:3 |
| 21.09.2021 | 19:00 | Yeni Malatyaspor - Sivasspor | 0:1 |
| 22.09.2021 | 16:00 | Gaziantep F.K. - İstanbul Başakşehir | 1:0 |
| 22.09.2021 | 19:00 | Kayserispor - Galatasaray | 3:0 |
| 22.09.2021 | 19:00 | Göztepe - Hatayspor | 0:2 |
| 23.09.2021 | 16:00 | Konyaspor - Trabzonspor | 2:2 |
| 23.09.2021 | 19:00 | Alanyaspor - Kasımpaşa | 2:0 |
| 23.09.2021 | 19:00 | Fenerbahçe - Giresunspor | 2:1 |
| 24.09.2021 | 19:00 | Altay - Beşiktaş | 2:1 |
| 25.09.2021 | 12:30 | Sivasspor - Fatih Karagümrük | 4:0 |
| 25.09.2021 | 15:00 | Antalyaspor - Yeni Malatyaspor | 1:0 |
| 25.09.2021 | 18:00 | Adana Demirspor - Gaziantep F.K. | 4:0 |
| 26.09.2021 | 12:30 | Giresunspor - Kayserispor | 1:1 |
| 26.09.2021 | 15:00 | İstanbul Başakşehir - Rizespor | 3:0 |
| 26.09.2021 | 15:00 | Hatayspor - Fenerbahçe | 1:2 |
| 26.09.2021 | 18:00 | Galatasaray - Göztepe | 2:1 |
| 27.09.2021 | 19:00 | Kasımpaşa - Konyaspor | 2:2 |
| 27.09.2021 | 19:00 | Trabzonspor - Alanyaspor | 1:1 |
| 01.10.2021 | 19:00 | Fatih Karagümrük - İstanbul Başakşehir | 3:1 |
| 01.10.2021 | 19:00 | Antalyaspor - Adana Demirspor | 1:2 |
| 02.10.2021 | 12:30 | Konyaspor - Alanyaspor | 1:1 |
| 02.10.2021 | 15:00 | Kayserispor - Trabzonspor | 1:2 |
| 02.10.2021 | 15:00 | Göztepe - Giresunspor | 0:1 |
| 02.10.2021 | 18:00 | Beşiktaş - Sivasspor | 2:1 |
| 03.10.2021 | 12:30 | Yeni Malatyaspor - Hatayspor | 0:2 |
| 03.10.2021 | 15:00 | Gaziantep F.K. - Altay | 4:1 |
| 03.10.2021 | 15:00 | Fenerbahçe - Kasımpaşa | 2:1 |
| 03.10.2021 | 18:00 | Rizespor - Galatasaray | 2:3 |
| 15.10.2021 | 19:00 | İstanbul Başakşehir - Beşiktaş | 3:2 |
| 16.10.2021 | 12:30 | Giresunspor - Rizespor | 2:0 |
| 16.10.2021 | 15:00 | Sivasspor - Antalyaspor | 2:2 |
| 16.10.2021 | 18:00 | Adana Demirspor - Yeni Malatyaspor | 0:2 |
| 17.10.2021 | 12:30 | Kasımpaşa - Göztepe | 1:2 |
| 17.10.2021 | 15:00 | Galatasaray - Konyaspor | 1:0 |
| 17.10.2021 | 15:00 | Altay - Fatih Karagümrük | 0:1 |
| 17.10.2021 | 19:00 | Trabzonspor - Fenerbahçe | 3:1 |
| 18.10.2021 | 19:00 | Alanyaspor - Kayserispor | 6:3 |
| 18.10.2021 | 19:00 | Hatayspor - Gaziantep F.K. | 2:1 |
| 22.10.2021 | 19:00 | Yeni Malatyaspor - Altay | 2:1 |
| 23.10.2021 | 12:30 | Rizespor - Kasımpaşa | 2:1 |
| 23.10.2021 | 15:00 | Gaziantep F.K. - Giresunspor | 1:1 |
| 23.10.2021 | 15:00 | Konyaspor - Kayserispor | 2:0 |
| 23.10.2021 | 19:00 | Göztepe - Trabzonspor | 0:1 |
| 24.10.2021 | 12:30 | Fatih Karagümrük - Hatayspor | 1:1 |
| 24.10.2021 | 15:00 | Antalyaspor - İstanbul Başakşehir | 1:2 |
| 24.10.2021 | 15:00 | Sivasspor - Adana Demirspor | 1:1 |
| 24.10.2021 | 18:00 | Fenerbahçe - Alanyaspor | 1:2 |
| 25.10.2021 | 19:00 | Beşiktaş - Galatasaray | 2:1 |
| 29.10.2021 | 19:00 | Trabzonspor - Rizespor | 2:1 |
| 30.10.2021 | 12:30 | Kasımpaşa - Yeni Malatyaspor | 2:0 |
| 30.10.2021 | 15:00 | Altay - Sivasspor | 1:1 |
| 30.10.2021 | 15:00 | Hatayspor - Beşiktaş | 1:0 |
| 30.10.2021 | 19:00 | Konyaspor - Fenerbahçe | 2:1 |
| 31.10.2021 | 11:30 | Kayserispor - Fatih Karagümrük | 2:1 |
| 31.10.2021 | 14:00 | Alanyaspor - Göztepe | 2:2 |
| 31.10.2021 | 17:00 | Galatasaray - Gaziantep F.K. | 2:0 |
| 01.11.2021 | 18:00 | Giresunspor - Antalyaspor | 1:2 |
| 01.11.2021 | 18:00 | İstanbul Başakşehir - Adana Demirspor | 2:1 |
| 05.11.2021 | 18:00 | Gaziantep F.K. - Kasımpaşa | 2:0 |
| 05.11.2021 | 18:00 | Rizespor - Alanyaspor | 2:0 |
| 06.11.2021 | 11:30 | Sivasspor - Giresunspor | 0:0 |
| 06.11.2021 | 14:00 | Yeni Malatyaspor - İstanbul Başakşehir | 1:3 |
| 06.11.2021 | 14:00 | Antalyaspor - Altay | 1:0 |
| 06.11.2021 | 17:00 | Beşiktaş - Trabzonspor | 1:2 |
| 07.11.2021 | 11:30 | Göztepe - Konyaspor | 0:2 |
| 07.11.2021 | 14:00 | Fatih Karagümrük - Galatasaray | 1:1 |
| 07.11.2021 | 14:00 | Adana Demirspor - Hatayspor | 1:0 |
| 07.11.2021 | 17:00 | Fenerbahçe - Kayserispor | 2:2 |
| 20.11.2021 | 11:30 | Hatayspor - Antalyaspor | 3:1 |
| 20.11.2021 | 14:00 | Giresunspor - Yeni Malatyaspor | 1:0 |
| 20.11.2021 | 14:00 | İstanbul Başakşehir - Sivasspor | 2:1 |
| 20.11.2021 | 17:00 | Alanyaspor - Beşiktaş | 2:0 |
| 21.11.2021 | 11:30 | Kasımpaşa - Fatih Karagümrük | 1:3 |
| 21.11.2021 | 14:00 | Konyaspor - Rizespor | 3:0 |
| 21.11.2021 | 14:00 | Altay - Adana Demirspor | 1:3 |
| 21.11.2021 | 17:00 | Galatasaray - Fenerbahçe | 1:2 |
| 22.11.2021 | 18:00 | Trabzonspor - Gaziantep F.K. | 3:0 |
| 22.11.2021 | 18:00 | Kayserispor - Göztepe | 1:1 |
| 26.11.2021 | 18:00 | Adana Demirspor - Kasımpaşa | 0:0 |
| 26.11.2021 | 18:00 | İstanbul Başakşehir - Altay | 0:0 |
| 27.11.2021 | 11:30 | Antalyaspor - Alanyaspor | 3:0 |
| 27.11.2021 | 14:00 | Rizespor - Kayserispor | 1:0 |
| 27.11.2021 | 17:00 | Beşiktaş - Giresunspor | 0:4 |
| 28.11.2021 | 11:30 | Gaziantep F.K. - Konyaspor | 3:2 |
| 28.11.2021 | 14:00 | Fatih Karagümrük - Trabzonspor | 0:2 |
| 28.11.2021 | 14:00 | Sivasspor - Hatayspor | 4:0 |
| 28.11.2021 | 17:00 | Yeni Malatyaspor - Galatasaray | 0:0 |
| 29.11.2021 | 18:00 | Göztepe - Fenerbahçe | 1:1 |
| 03.12.2021 | 18:00 | Kasımpaşa - Beşiktaş | 1:1 |
| 04.12.2021 | 11:30 | Alanyaspor - Sivasspor | 0:1 |
| 04.12.2021 | 14:00 | Trabzonspor - Adana Demirspor | 2:0 |
| 04.12.2021 | 17:00 | Galatasaray - Altay | 2:2 |
| 05.12.2021 | 11:30 | Kayserispor - Antalyaspor | 2:0 |
| 05.12.2021 | 14:00 | Giresunspor - Fatih Karagümrük | 3:1 |
| 05.12.2021 | 14:00 | Hatayspor - İstanbul Başakşehir | 0:3 |
| 05.12.2021 | 17:00 | Fenerbahçe - Rizespor | 4:0 |
| 06.12.2021 | 18:00 | Konyaspor - Yeni Malatyaspor | 0:0 |
| 06.12.2021 | 18:00 | Göztepe - Gaziantep F.K. | 2:1 |
| 10.12.2021 | 18:00 | Altay - Hatayspor | 1:2 |
| 11.12.2021 | 11:30 | Fatih Karagümrük - Konyaspor | 1:4 |
| 11.12.2021 | 14:00 | İstanbul Başakşehir - Kasımpaşa | 2:1 |
| 11.12.2021 | 14:00 | Rizespor - Göztepe | 3:1 |
| 11.12.2021 | 17:00 | Antalyaspor - Trabzonspor | 2:1 |
| 12.12.2021 | 11:30 | Adana Demirspor - Giresunspor | 1:0 |
| 12.12.2021 | 14:00 | Yeni Malatyaspor - Alanyaspor | 2:6 |
| 12.12.2021 | 17:00 | Beşiktaş - Kayserispor | 4:2 |
| 13.12.2021 | 16:00 | Sivasspor - Galatasaray | 1:0 |
| 13.12.2021 | 18:30 | Gaziantep F.K. - Fenerbahçe | 3:2 |
| 17.12.2021 | 18:00 | Giresunspor - Altay | 3:1 |
| 18.12.2021 | 11:30 | Kasımpaşa - Sivasspor | 1:3 |
| 18.12.2021 | 14:00 | Trabzonspor - Hatayspor | 2:0 |
| 18.12.2021 | 14:00 | Konyaspor - Antalyaspor | 1:0 |
| 18.12.2021 | 17:00 | Galatasaray - İstanbul Başakşehir | 1:1 |
| 18.12.2021 | 17:00 | Alanyaspor - Adana Demirspor | 1:3 |
| 19.12.2021 | 11:30 | Rizespor - Yeni Malatyaspor | 1:0 |
| 19.12.2021 | 14:00 | Kayserispor - Gaziantep F.K. | 0:0 |
| 19.12.2021 | 14:00 | Göztepe - Fatih Karagümrük | 0:1 |
| 19.12.2021 | 17:00 | Fenerbahçe - Beşiktaş | 2:2 |
| 21.12.2021 | 15:00 | Antalyaspor - Kasımpaşa | 1:1 |
| 21.12.2021 | 15:00 | İstanbul Başakşehir - Giresunspor | 3:1 |
| 21.12.2021 | 18:00 | Adana Demirspor - Galatasaray | 2:0 |
| 21.12.2021 | 18:00 | Altay - Trabzonspor | 1:2 |
| 22.12.2021 | 15:00 | Sivasspor - Rizespor | 1:1 |
| 22.12.2021 | 15:00 | Hatayspor - Konyaspor | 1:3 |
| 22.12.2021 | 18:00 | Gaziantep F.K. - Alanyaspor | 2:1 |
| 22.12.2021 | 18:00 | Fatih Karagümrük - Fenerbahçe | 1:1 |
| 23.12.2021 | 15:00 | Yeni Malatyaspor - Kayserispor | 2:2 |
| 23.12.2021 | 18:00 | Beşiktaş - Göztepe | 2:1 |
| 25.12.2021 | 11:30 | Kasımpaşa - Altay | 2:0 |
| 25.12.2021 | 14:00 | Giresunspor - Hatayspor | 0:1 |
| 25.12.2021 | 14:00 | Galatasaray - Antalyaspor | 2:0 |
| 25.12.2021 | 17:00 | Trabzonspor - İstanbul Başakşehir | 0:0 |
| 26.12.2021 | 11:30 | Rizespor - Gaziantep F.K. | 0:1 |
| 26.12.2021 | 14:00 | Alanyaspor - Fatih Karagümrük | 1:1 |
| 26.12.2021 | 14:00 | Göztepe - Adana Demirspor | 1:1 |
| 26.12.2021 | 17:00 | Fenerbahçe - Yeni Malatyaspor | 2:0 |
| 27.12.2021 | 18:00 | Kayserispor - Sivasspor | 3:0 |
| 27.12.2021 | 18:00 | Konyaspor - Beşiktaş | 1:0 |
| 07.01.2022 | 18:00 | Trabzonspor - Yeni Malatyaspor | 1:0 |
| 08.01.2022 | 11:30 | Gaziantep F.K. - Fatih Karagümrük | 3:1 |
| 08.01.2022 | 14:00 | Alanyaspor - İstanbul Başakşehir | 1:1 |
| 08.01.2022 | 14:00 | Kasımpaşa - Hatayspor | 3:1 |
| 08.01.2022 | 17:00 | Galatasaray - Giresunspor | 0:1 |
| 09.01.2022 | 11:30 | Konyaspor - Sivasspor | 0:1 |
| 09.01.2022 | 14:00 | Göztepe - Antalyaspor | 4:0 |
| 09.01.2022 | 14:00 | Kayserispor - Altay | 1:0 |
| 09.01.2022 | 17:00 | Rizespor - Beşiktaş | 2:2 |
| 10.01.2022 | 18:00 | Fenerbahçe - Adana Demirspor | 1:2 |
| 14.01.2022 | 18:00 | Beşiktaş - Gaziantep F.K. | 1:0 |
| 14.01.2022 | 18:00 | Yeni Malatyaspor - Göztepe | 1:2 |
| 15.01.2022 | 11:30 | Adana Demirspor - Kayserispor | 1:1 |
| 15.01.2022 | 14:00 | Sivasspor - Trabzonspor | 1:1 |
| 15.01.2022 | 14:00 | Fatih Karagümrük - Rizespor | 2:0 |
| 15.01.2022 | 17:00 | Antalyaspor - Fenerbahçe | 1:1 |
| 16.01.2022 | 11:30 | Altay - Alanyaspor | 0:2 |
| 16.01.2022 | 14:00 | Giresunspor - Kasımpaşa | 0:2 |
| 16.01.2022 | 17:00 | Hatayspor - Galatasaray | 4:2 |
| 22.02.2022 | 18:00 | İstanbul Başakşehir - Konyaspor | 2:1 |
| 18.01.2022 | 18:00 | Fatih Karagümrük - Beşiktaş | 0:1 |
| 18.01.2022 | 18:00 | Konyaspor - Adana Demirspor | 1:0 |
| 19.01.2022 | 15:00 | Göztepe - Sivasspor | 2:1 |
| 19.01.2022 | 16:00 | Kayserispor - İstanbul Başakşehir | 1:0 |
| 19.01.2022 | 18:00 | Trabzonspor - Giresunspor | 1:1 |
| 19.01.2022 | 18:00 | Fenerbahçe - Altay | 2:1 |
| 20.01.2022 | 15:00 | Rizespor - Antalyaspor | 2:1 |
| 20.01.2022 | 15:00 | Alanyaspor - Hatayspor | 6:0 |
| 20.01.2022 | 18:00 | Galatasaray - Kasımpaşa | 1:3 |
| 23.02.2022 | 18:00 | Gaziantep F.K. - Yeni Malatyaspor | 0:0 |
| 22.01.2022 | 11:30 | Yeni Malatyaspor - Beşiktaş | 1:1 |
| 22.01.2022 | 14:00 | Adana Demirspor - Fatih Karagümrük | 5:0 |
| 22.01.2022 | 14:00 | Sivasspor - Fenerbahçe | 1:1 |
| 22.01.2022 | 17:00 | İstanbul Başakşehir - Göztepe | 1:2 |
| 23.01.2022 | 11:30 | Kasımpaşa - Kayserispor | 3:1 |
| 23.01.2022 | 11:30 | Hatayspor - Rizespor | 0:0 |
| 23.01.2022 | 14:00 | Antalyaspor - Gaziantep F.K. | 0:0 |
| 23.01.2022 | 14:00 | Giresunspor - Alanyaspor | 1:3 |
| 23.01.2022 | 14:00 | Altay - Konyaspor | 0:1 |
| 23.01.2022 | 17:00 | Galatasaray - Trabzonspor | 1:2 |
| 04.02.2022 | 18:00 | Konyaspor - Giresunspor | 1:0 |
| 04.02.2022 | 18:00 | Kayserispor - Hatayspor | 4:3 |
| 05.02.2022 | 11:30 | Gaziantep F.K. - Sivasspor | 5:1 |
| 05.02.2022 | 14:00 | Trabzonspor - Kasımpaşa | 1:0 |
| 05.02.2022 | 14:00 | Fatih Karagümrük - Yeni Malatyaspor | 1:0 |
| 05.02.2022 | 17:00 | Fenerbahçe - İstanbul Başakşehir | 0:1 |
| 06.02.2022 | 14:00 | Alanyaspor - Galatasaray | 1:1 |
| 06.02.2022 | 14:00 | Rizespor - Adana Demirspor | 1:3 |
| 06.02.2022 | 17:00 | Beşiktaş - Antalyaspor | 0:0 |
| 06.02.2022 | 17:00 | Göztepe - Altay | 0:2 |
| 11.02.2022 | 18:00 | Altay - Rizespor | 0:0 |
| 12.02.2022 | 14:00 | İstanbul Başakşehir - Gaziantep F.K. | 2:0 |
| 12.02.2022 | 14:00 | Giresunspor - Fenerbahçe | 1:2 |
| 12.02.2022 | 17:00 | Galatasaray - Kayserispor | 1:1 |
| 13.02.2022 | 11:30 | Sivasspor - Yeni Malatyaspor | 2:1 |
| 13.02.2022 | 14:00 | Antalyaspor - Fatih Karagümrük | 3:0 |
| 13.02.2022 | 17:00 | Kasımpaşa - Alanyaspor | 2:2 |
| 13.02.2022 | 17:00 | Trabzonspor - Konyaspor | 2:1 |
| 14.02.2022 | 18:00 | Adana Demirspor - Beşiktaş | 1:1 |
| 14.02.2022 | 18:00 | Hatayspor - Göztepe | 2:1 |
| 18.02.2022 | 18:00 | Konyaspor - Kasımpaşa | 4:4 |
| 18.02.2022 | 18:00 | Rizespor - İstanbul Başakşehir | 0:2 |
| 19.02.2022 | 11:30 | Yeni Malatyaspor - Antalyaspor | 1:2 |
| 19.02.2022 | 14:00 | Kayserispor - Giresunspor | 2:1 |
| 19.02.2022 | 17:00 | Beşiktaş - Altay | 1:0 |
| 20.02.2022 | 11:30 | Gaziantep F.K. - Adana Demirspor | 0:3 |
| 20.02.2022 | 14:00 | Alanyaspor - Trabzonspor | 0:4 |
| 20.02.2022 | 14:00 | Fatih Karagümrük - Sivasspor | 1:0 |
| 20.02.2022 | 17:00 | Fenerbahçe - Hatayspor | 2:0 |
| 21.02.2022 | 18:00 | Göztepe - Galatasaray | 2:3 |
| 25.02.2022 | 18:00 | Adana Demirspor - Antalyaspor | 0:0 |
| 25.02.2022 | 18:00 | Trabzonspor - Kayserispor | 3:2 |
| 26.02.2022 | 14:00 | İstanbul Başakşehir - Fatih Karagümrük | 1:2 |
| 26.02.2022 | 17:00 | Sivasspor - Beşiktaş | 2:3 |
| 27.02.2022 | 11:30 | Altay - Gaziantep F.K. | 3:2 |
| 27.02.2022 | 11:30 | Giresunspor - Göztepe | 3:1 |
| 27.02.2022 | 14:00 | Hatayspor - Yeni Malatyaspor | 5:2 |
| 27.02.2022 | 14:00 | Alanyaspor - Konyaspor | 5:1 |
| 27.02.2022 | 17:00 | Galatasaray - Rizespor | 4:2 |
| 28.02.2022 | 18:00 | Kasımpaşa - Fenerbahçe | 1:2 |
| 04.03.2022 | 18:00 | Yeni Malatyaspor - Adana Demirspor | 1:0 |
| 05.03.2022 | 14:00 | Rizespor - Giresunspor | 1:2 |
| 05.03.2022 | 14:00 | Göztepe - Kasımpaşa | 2:3 |
| 05.03.2022 | 17:00 | Konyaspor - Galatasaray | 2:0 |
| 06.03.2022 | 14:00 | Fatih Karagümrük - Altay | 0:0 |
| 06.03.2022 | 17:00 | Fenerbahçe - Trabzonspor | 1:1 |
| 06.03.2022 | 17:00 | Antalyaspor - Sivasspor | 1:0 |
| 07.03.2022 | 18:00 | Kayserispor - Alanyaspor | 1:2 |
| 07.03.2022 | 18:00 | Beşiktaş - İstanbul Başakşehir | 2:2 |
| 07.03.2022 | 18:00 | Gaziantep F.K. - Hatayspor | 2:2 |
| 12.03.2022 | 11:30 | Hatayspor - Fatih Karagümrük | 3:0 |
| 12.03.2022 | 14:00 | Altay - Yeni Malatyaspor | 1:0 |
| 12.03.2022 | 14:00 | Kasımpaşa - Rizespor | 3:1 |
| 12.03.2022 | 17:00 | Trabzonspor - Göztepe | 4:2 |
| 13.03.2022 | 11:30 | Kayserispor - Konyaspor | 2:3 |
| 13.03.2022 | 14:00 | Adana Demirspor - Sivasspor | 2:3 |
| 13.03.2022 | 17:00 | Alanyaspor - Fenerbahçe | 2:5 |
| 14.03.2022 | 14:00 | İstanbul Başakşehir - Antalyaspor | 0:1 |
| 14.03.2022 | 18:00 | Galatasaray - Beşiktaş | 2:1 |
| 14.03.2022 | 18:00 | Giresunspor - Gaziantep F.K. | 2:1 |
| 18.03.2022 | 18:00 | Rizespor - Trabzonspor | 3:2 |
| 18.03.2022 | 18:00 | Fatih Karagümrük - Kayserispor | 3:0 |
| 19.03.2022 | 11:30 | Yeni Malatyaspor - Kasımpaşa | 0:2 |
| 19.03.2022 | 14:00 | Göztepe - Alanyaspor | 0:2 |
| 19.03.2022 | 14:00 | Adana Demirspor - İstanbul Başakşehir | 2:1 |
| 19.03.2022 | 17:00 | Beşiktaş - Hatayspor | 1:1 |
| 20.03.2022 | 11:30 | Antalyaspor - Giresunspor | 4:1 |
| 20.03.2022 | 11:30 | Sivasspor - Altay | 2:1 |
| 20.03.2022 | 14:00 | Gaziantep F.K. - Galatasaray | 3:1 |
| 20.03.2022 | 17:00 | Fenerbahçe - Konyaspor | 2:1 |
| 02.04.2022 | 12:30 | Giresunspor - Sivasspor | 2:2 |
| 02.04.2022 | 15:00 | Altay - Antalyaspor | 1:2 |
| 02.04.2022 | 15:00 | Kayserispor - Fenerbahçe | 0:4 |
| 02.04.2022 | 19:30 | Galatasaray - Fatih Karagümrük | 2:0 |
| 03.04.2022 | 12:30 | Kasımpaşa - Gaziantep F.K. | 2:1 |
| 03.04.2022 | 15:00 | Konyaspor - Göztepe | 3:0 |
| 03.04.2022 | 15:00 | Alanyaspor - Rizespor | 2:1 |
| 03.04.2022 | 19:30 | Trabzonspor - Beşiktaş | 1:1 |
| 04.04.2022 | 19:30 | İstanbul Başakşehir - Yeni Malatyaspor | 1:0 |
| 04.04.2022 | 19:30 | Hatayspor - Adana Demirspor | 0:0 |
| 09.04.2022 | 12:30 | Fatih Karagümrük - Kasımpaşa | 3:2 |
| 09.04.2022 | 15:00 | Göztepe - Kayserispor | 1:2 |
| 09.04.2022 | 15:00 | Rizespor - Konyaspor | 2:1 |
| 09.04.2022 | 19:30 | Gaziantep F.K. - Trabzonspor | 0:0 |
| 09.04.2022 | 19:30 | Beşiktaş - Alanyaspor | 4:1 |
| 10.04.2022 | 12:30 | Yeni Malatyaspor - Giresunspor | 0:1 |
| 10.04.2022 | 15:00 | Sivasspor - İstanbul Başakşehir | 0:2 |
| 10.04.2022 | 15:00 | Adana Demirspor - Altay | 3:1 |
| 10.04.2022 | 19:30 | Fenerbahçe - Galatasaray | 2:0 |
| 11.04.2022 | 19:30 | Antalyaspor - Hatayspor | 4:1 |
| 15.04.2022 | 19:30 | Trabzonspor - Fatih Karagümrük | 1:1 |
| 15.04.2022 | 19:30 | Kayserispor - Rizespor | 1:1 |
| 16.04.2022 | 12:30 | Hatayspor - Sivasspor | 1:1 |
| 16.04.2022 | 15:00 | Alanyaspor - Antalyaspor | 1:3 |
| 16.04.2022 | 15:00 | Altay - İstanbul Başakşehir | 1:1 |
| 16.04.2022 | 19:30 | Fenerbahçe - Göztepe | 2:0 |
| 17.04.2022 | 12:30 | Konyaspor - Gaziantep F.K. | 4:1 |
| 17.04.2022 | 15:00 | Kasımpaşa - Adana Demirspor | 4:0 |
| 17.04.2022 | 19:30 | Giresunspor - Beşiktaş | 0:0 |
| 18.04.2022 | 19:30 | Galatasaray - Yeni Malatyaspor | 2:0 |
| 22.04.2022 | 19:30 | Rizespor - Fenerbahçe | 0:6 |
| 23.04.2022 | 15:00 | Fatih Karagümrük - Giresunspor | 2:1 |
| 23.04.2022 | 15:00 | Gaziantep F.K. - Göztepe | 1:1 |
| 23.04.2022 | 19:30 | Adana Demirspor - Trabzonspor | 1:3 |
| 24.04.2022 | 15:00 | Yeni Malatyaspor - Konyaspor | 2:3 |
| 24.04.2022 | 15:00 | İstanbul Başakşehir - Hatayspor | 3:0 |
| 24.04.2022 | 19:30 | Altay - Galatasaray | 0:1 |
| 24.04.2022 | 19:30 | Antalyaspor - Kayserispor | 1:1 |
| 25.04.2022 | 19:30 | Beşiktaş - Kasımpaşa | 0:3 |
| 25.04.2022 | 19:30 | Sivasspor - Alanyaspor | 1:0 |
| 29.04.2022 | 19:30 | Fenerbahçe - Gaziantep F.K. | 3:2 |
| 29.04.2022 | 19:30 | Giresunspor - Adana Demirspor | 2:0 |
| 30.04.2022 | 15:00 | Konyaspor - Fatih Karagümrük | 1:2 |
| 30.04.2022 | 15:00 | Kasımpaşa - İstanbul Başakşehir | 2:3 |
| 30.04.2022 | 19:30 | Trabzonspor - Antalyaspor | 2:2 |
| 30.04.2022 | 19:30 | Hatayspor - Altay | 0:1 |
| 01.05.2022 | 15:00 | Kayserispor - Beşiktaş | 2:3 |
| 01.05.2022 | 15:00 | Alanyaspor - Yeni Malatyaspor | 2:1 |
| 01.05.2022 | 19:30 | Galatasaray - Sivasspor | 2:3 |
| 01.05.2022 | 19:30 | Göztepe - Rizespor | 1:7 |
| 06.05.2022 | 19:00 | Hatayspor - Trabzonspor | 1:1 |
| 06.05.2022 | 19:00 | Gaziantep F.K. - Kayserispor | 1:1 |
| 07.05.2022 | 15:00 | Fatih Karagümrük - Göztepe | 3:1 |
| 07.05.2022 | 16:00 | Sivasspor - Kasımpaşa | 1:3 |
| 07.05.2022 | 18:00 | Adana Demirspor - Alanyaspor | 1:2 |
| 07.05.2022 | 19:00 | İstanbul Başakşehir - Galatasaray | 0:0 |
| 08.05.2022 | 15:00 | Altay - Giresunspor | 1:1 |
| 08.05.2022 | 15:00 | Yeni Malatyaspor - Rizespor | 1:3 |
| 08.05.2022 | 19:00 | Beşiktaş - Fenerbahçe | 1:1 |
| 09.05.2022 | 19:00 | Antalyaspor - Konyaspor | 3:2 |
| 14.05.2022 | 19:00 | Kayserispor - Yeni Malatyaspor | 3:0 |
| 15.05.2022 | 15:00 | Göztepe - Beşiktaş | 0:2 |
| 15.05.2022 | 15:00 | Trabzonspor - Altay | 2:1 |
| 15.05.2022 | 18:00 | Konyaspor - Hatayspor | 3:1 |
| 15.05.2022 | 19:00 | Alanyaspor - Gaziantep F.K. | 3:0 |
| 15.05.2022 | 19:00 | Fenerbahçe - Fatih Karagümrük | 0:0 |
| 15.05.2022 | 19:00 | Kasımpaşa - Antalyaspor | 2:4 |
| 15.05.2022 | 19:00 | Giresunspor - İstanbul Başakşehir | 1:1 |
| 16.05.2022 | 19:00 | Rizespor - Sivasspor | 1:2 |
| 16.05.2022 | 19:00 | Galatasaray - Adana Demirspor | 3:2 |
| 20.05.2022 | 19:00 | Antalyaspor - Galatasaray | 1:1 |
| 20.05.2022 | 19:00 | Gaziantep F.K. - Rizespor | 2:0 |
| 21.05.2022 | 15:00 | Altay - Kasımpaşa | 2:4 |
| 21.05.2022 | 15:00 | Sivasspor - Kayserispor | 2:1 |
| 21.05.2022 | 18:00 | Yeni Malatyaspor - Fenerbahçe | 0:5 |
| 21.05.2022 | 19:00 | Beşiktaş - Konyaspor | 1:1 |
| 22.05.2022 | 15:00 | İstanbul Başakşehir - Trabzonspor | 3:1 |
| 22.05.2022 | 15:00 | Fatih Karagümrük - Alanyaspor | 0:1 |
| 22.05.2022 | 18:00 | Adana Demirspor - Göztepe | 7:0 |
| 22.05.2022 | 19:00 | Hatayspor - Giresunspor | 4:1 |