| 17.04.2021 | 02:00 | Houston Dynamo - SJ Earthquakes | 2:1 |
| 17.04.2021 | 03:30 | Seattle Sounders - Minnesota United | 4:0 |
| 17.04.2021 | 20:00 | CF Montréal - Toronto | 4:2 |
| 17.04.2021 | 21:00 | Orlando City - Atlanta United | 0:0 |
| 18.04.2021 | 00:00 | Los Angeles FC - Austin | 2:0 |
| 18.04.2021 | 02:00 | New York RB - Sporting KC | 1:2 |
| 18.04.2021 | 02:00 | Dallas - Colorado Rapids | 0:0 |
| 18.04.2021 | 02:00 | DC United - New York City | 2:1 |
| 18.04.2021 | 02:30 | Nashville SC - Cincinnati | 2:2 |
| 18.04.2021 | 02:30 | Chicago Fire - New England | 2:2 |
| 18.04.2021 | 21:00 | Inter Miami - LA Galaxy | 2:3 |
| 18.04.2021 | 23:30 | Columbus Crew - Philadelphia Union | 0:0 |
| 19.04.2021 | 04:00 | Vancouver Whitecaps - Portland Timbers | 1:0 |
| 24.04.2021 | 01:30 | Sporting KC - Orlando City | 1:1 |
| 24.04.2021 | 19:00 | New York City - Cincinnati | 5:0 |
| 24.04.2021 | 20:00 | Nashville SC - CF Montréal | 2:2 |
| 24.04.2021 | 21:00 | Toronto - Vancouver Whitecaps | 2:2 |
| 24.04.2021 | 21:30 | SJ Earthquakes - Dallas | 3:1 |
| 25.04.2021 | 00:00 | Los Angeles FC - Seattle Sounders | 1:1 |
| 25.04.2021 | 02:00 | Atlanta United - Chicago Fire | 3:1 |
| 25.04.2021 | 02:00 | Minnesota United - Real Salt Lake | 1:2 |
| 25.04.2021 | 02:00 | New England - DC United | 1:0 |
| 25.04.2021 | 02:00 | Philadelphia Union - Inter Miami | 1:2 |
| 25.04.2021 | 03:00 | Colorado Rapids - Austin | 1:3 |
| 25.04.2021 | 04:30 | Portland Timbers - Houston Dynamo | 2:1 |
| 25.04.2021 | 23:30 | LA Galaxy - New York RB | 3:2 |
| 01.05.2021 | 19:00 | New York RB - Chicago Fire | 2:0 |
| 01.05.2021 | 20:00 | Real Salt Lake - Sporting KC | 3:1 |
| 01.05.2021 | 21:00 | CF Montréal - Columbus Crew | 0:0 |
| 01.05.2021 | 21:30 | Houston Dynamo - Los Angeles FC | 1:1 |
| 02.05.2021 | 01:00 | New England - Atlanta United | 2:1 |
| 02.05.2021 | 01:30 | Philadelphia Union - New York City | 0:2 |
| 02.05.2021 | 01:30 | Orlando City - Cincinnati | 3:0 |
| 02.05.2021 | 02:00 | Dallas - Portland Timbers | 4:1 |
| 02.05.2021 | 02:00 | Minnesota United - Austin | 0:1 |
| 02.05.2021 | 05:00 | SJ Earthquakes - DC United | 4:1 |
| 02.05.2021 | 19:00 | Nashville SC - Inter Miami | 0:0 |
| 03.05.2021 | 03:00 | Seattle Sounders - LA Galaxy | 3:0 |
| 03.05.2021 | 04:00 | Vancouver Whitecaps - Colorado Rapids | 0:1 |
| 08.05.2021 | 03:30 | Real Salt Lake - SJ Earthquakes | 1:2 |
| 08.05.2021 | 19:00 | Chicago Fire - Philadelphia Union | 0:2 |
| 08.05.2021 | 19:00 | New York RB - Toronto | 2:0 |
| 08.05.2021 | 19:30 | Nashville SC - New England | 2:0 |
| 08.05.2021 | 19:30 | Columbus Crew - DC United | 2:4 |
| 08.05.2021 | 21:00 | Vancouver Whitecaps - CF Montréal | 2:0 |
| 08.05.2021 | 21:30 | Dallas - Houston Dynamo | 1:1 |
| 09.05.2021 | 00:00 | Orlando City - New York City | 1:1 |
| 09.05.2021 | 02:00 | LA Galaxy - Los Angeles FC | 2:1 |
| 09.05.2021 | 04:00 | Colorado Rapids - Minnesota United | 3:2 |
| 09.05.2021 | 19:00 | Inter Miami - Atlanta United | 1:1 |
| 09.05.2021 | 21:00 | Portland Timbers - Seattle Sounders | 1:2 |
| 10.05.2021 | 01:30 | Sporting KC - Austin | 2:1 |
| 13.05.2021 | 01:00 | Toronto - Columbus Crew | 2:0 |
| 13.05.2021 | 01:30 | Philadelphia Union - New England | 1:1 |
| 13.05.2021 | 01:30 | Inter Miami - CF Montréal | 0:2 |
| 13.05.2021 | 02:30 | Houston Dynamo - Sporting KC | 1:0 |
| 13.05.2021 | 03:00 | Minnesota United - Vancouver Whitecaps | 1:0 |
| 13.05.2021 | 04:30 | SJ Earthquakes - Seattle Sounders | 0:1 |
| 14.05.2021 | 02:00 | DC United - Chicago Fire | 1:0 |
| 15.05.2021 | 19:00 | New York City - Toronto | 1:1 |
| 15.05.2021 | 21:30 | LA Galaxy - Austin | 2:0 |
| 16.05.2021 | 01:00 | Atlanta United - CF Montréal | 1:0 |
| 16.05.2021 | 01:30 | Philadelphia Union - New York RB | 1:0 |
| 16.05.2021 | 02:00 | Minnesota United - Dallas | 1:0 |
| 16.05.2021 | 03:00 | Colorado Rapids - Houston Dynamo | 3:1 |
| 16.05.2021 | 03:30 | Real Salt Lake - Nashville SC | 0:0 |
| 16.05.2021 | 04:00 | SJ Earthquakes - Portland Timbers | 0:2 |
| 16.05.2021 | 20:00 | Sporting KC - Vancouver Whitecaps | 3:0 |
| 16.05.2021 | 22:30 | Cincinnati - Inter Miami | 2:3 |
| 17.05.2021 | 00:00 | New England - Columbus Crew | 1:0 |
| 17.05.2021 | 02:00 | DC United - Orlando City | 0:1 |
| 17.05.2021 | 03:30 | Seattle Sounders - Los Angeles FC | 2:0 |
| 22.05.2021 | 19:00 | CF Montréal - Cincinnati | 1:2 |
| 22.05.2021 | 21:30 | Portland Timbers - LA Galaxy | 3:0 |
| 23.05.2021 | 00:00 | Chicago Fire - Inter Miami | 1:0 |
| 23.05.2021 | 01:00 | Orlando City - Toronto | 1:0 |
| 23.05.2021 | 01:30 | New York City - Columbus Crew | 1:2 |
| 23.05.2021 | 02:00 | Dallas - Real Salt Lake | 2:2 |
| 23.05.2021 | 02:00 | New England - New York RB | 3:1 |
| 23.05.2021 | 03:00 | Houston Dynamo - Vancouver Whitecaps | 2:1 |
| 23.05.2021 | 04:00 | SJ Earthquakes - Sporting KC | 1:3 |
| 23.05.2021 | 04:30 | Los Angeles FC - Colorado Rapids | 2:1 |
| 23.05.2021 | 22:30 | Seattle Sounders - Atlanta United | 1:1 |
| 24.05.2021 | 01:15 | DC United - Philadelphia Union | 0:1 |
| 24.05.2021 | 03:00 | Nashville SC - Austin | 1:0 |
| 29.05.2021 | 19:00 | New York RB - Orlando City | 2:1 |
| 29.05.2021 | 19:00 | Chicago Fire - CF Montréal | 0:1 |
| 29.05.2021 | 21:00 | Cincinnati - New England | 0:1 |
| 29.05.2021 | 21:00 | Columbus Crew - Toronto | 2:1 |
| 29.05.2021 | 21:30 | Atlanta United - Nashville SC | 2:2 |
| 29.05.2021 | 23:00 | Los Angeles FC - New York City | 1:2 |
| 30.05.2021 | 01:00 | LA Galaxy - SJ Earthquakes | 1:0 |
| 30.05.2021 | 02:00 | Inter Miami - DC United | 0:3 |
| 30.05.2021 | 02:30 | Sporting KC - Houston Dynamo | 3:2 |
| 30.05.2021 | 03:00 | Colorado Rapids - Dallas | 3:0 |
| 30.05.2021 | 03:30 | Real Salt Lake - Minnesota United | 1:1 |
| 31.05.2021 | 01:00 | Philadelphia Union - Portland Timbers | 3:0 |
| 31.05.2021 | 03:30 | Seattle Sounders - Austin | 0:0 |
| 12.06.2021 | 21:00 | Sporting KC - Austin | 1:1 |
| 19.06.2021 | 02:00 | New York RB - Nashville SC | 2:0 |
| 19.06.2021 | 04:00 | Real Salt Lake - Vancouver Whitecaps | 3:1 |
| 20.06.2021 | 01:30 | New York City - New England | 2:3 |
| 20.06.2021 | 01:30 | Columbus Crew - Chicago Fire | 2:0 |
| 20.06.2021 | 01:30 | Toronto - Orlando City | 2:3 |
| 20.06.2021 | 01:30 | Cincinnati - Colorado Rapids | 0:2 |
| 20.06.2021 | 02:00 | DC United - Inter Miami | 1:0 |
| 20.06.2021 | 02:30 | Dallas - Minnesota United | 1:1 |
| 20.06.2021 | 03:00 | Austin - SJ Earthquakes | 0:0 |
| 20.06.2021 | 03:00 | LA Galaxy - Seattle Sounders | 1:2 |
| 20.06.2021 | 04:30 | Portland Timbers - Sporting KC | 2:1 |
| 20.06.2021 | 05:00 | Los Angeles FC - Houston Dynamo | 1:1 |
| 20.06.2021 | 20:00 | Atlanta United - Philadelphia Union | 2:2 |
| 23.06.2021 | 02:02 | Orlando City - SJ Earthquakes | 5:0 |
| 24.06.2021 | 01:00 | New England - New York RB | 3:2 |
| 24.06.2021 | 01:30 | Philadelphia Union - Columbus Crew | 1:0 |
| 24.06.2021 | 01:30 | New York City - Atlanta United | 1:0 |
| 24.06.2021 | 02:00 | Chicago Fire - Cincinnati | 0:1 |
| 24.06.2021 | 02:00 | CF Montréal - DC United | 0:0 |
| 24.06.2021 | 02:00 | Minnesota United - Austin | 2:0 |
| 24.06.2021 | 02:30 | Houston Dynamo - Portland Timbers | 2:2 |
| 24.06.2021 | 02:30 | Sporting KC - Colorado Rapids | 3:1 |
| 24.06.2021 | 02:30 | Nashville SC - Toronto | 3:2 |
| 24.06.2021 | 04:00 | Seattle Sounders - Real Salt Lake | 2:1 |
| 24.06.2021 | 04:30 | Vancouver Whitecaps - LA Galaxy | 1:2 |
| 24.06.2021 | 04:30 | Los Angeles FC - Dallas | 2:0 |
| 26.06.2021 | 02:00 | Inter Miami - Orlando City | 1:2 |
| 26.06.2021 | 23:30 | Sporting KC - Los Angeles FC | 2:1 |
| 27.06.2021 | 01:00 | Toronto - Cincinnati | 3:2 |
| 27.06.2021 | 02:00 | Chicago Fire - Philadelphia Union | 3:3 |
| 27.06.2021 | 02:00 | Real Salt Lake - Houston Dynamo | 1:1 |
| 27.06.2021 | 02:30 | Nashville SC - CF Montréal | 1:1 |
| 27.06.2021 | 03:00 | Seattle Sounders - Vancouver Whitecaps | 2:2 |
| 27.06.2021 | 04:00 | SJ Earthquakes - LA Galaxy | 1:3 |
| 27.06.2021 | 05:30 | Portland Timbers - Minnesota United | 0:1 |
| 27.06.2021 | 21:30 | Atlanta United - New York RB | 0:0 |
| 28.06.2021 | 00:00 | New York City - DC United | 2:1 |
| 28.06.2021 | 02:00 | Austin - Columbus Crew | 0:0 |
| 28.06.2021 | 03:00 | Dallas - New England | 2:1 |
| 02.07.2021 | 03:30 | Austin - Portland Timbers | 4:1 |
| 03.07.2021 | 23:00 | Columbus Crew - New England | 2:2 |
| 03.07.2021 | 23:30 | DC United - Toronto | 7:1 |
| 04.07.2021 | 01:30 | CF Montréal - Inter Miami | 1:0 |
| 04.07.2021 | 01:30 | Orlando City - New York RB | 1:2 |
| 04.07.2021 | 02:00 | Chicago Fire - Atlanta United | 3:0 |
| 04.07.2021 | 02:00 | Minnesota United - SJ Earthquakes | 2:2 |
| 04.07.2021 | 02:00 | Nashville SC - Philadelphia Union | 1:0 |
| 04.07.2021 | 02:30 | Houston Dynamo - Cincinnati | 1:1 |
| 04.07.2021 | 04:00 | Real Salt Lake - Los Angeles FC | 0:1 |
| 05.07.2021 | 02:30 | Dallas - Vancouver Whitecaps | 2:2 |
| 05.07.2021 | 03:00 | Colorado Rapids - Seattle Sounders | 1:1 |
| 05.07.2021 | 04:30 | LA Galaxy - Sporting KC | 0:2 |
| 08.07.2021 | 01:00 | New England - Toronto | 2:3 |
| 08.07.2021 | 01:30 | CF Montréal - New York City | 2:1 |
| 08.07.2021 | 02:00 | Chicago Fire - Orlando City | 3:1 |
| 08.07.2021 | 03:00 | Seattle Sounders - Houston Dynamo | 2:0 |
| 08.07.2021 | 03:00 | Austin - Los Angeles FC | 0:2 |
| 08.07.2021 | 03:00 | Colorado Rapids - Minnesota United | 2:0 |
| 08.07.2021 | 04:00 | Vancouver Whitecaps - Real Salt Lake | 0:4 |
| 08.07.2021 | 04:30 | LA Galaxy - Dallas | 3:1 |
| 09.07.2021 | 02:30 | Nashville SC - Atlanta United | 2:2 |
| 09.07.2021 | 02:30 | New York RB - Philadelphia Union | 1:1 |
| 10.07.2021 | 01:30 | Cincinnati - Columbus Crew | 2:2 |
| 17.07.2021 | 23:00 | Atlanta United - New England | 0:1 |
| 18.07.2021 | 01:30 | Columbus Crew - New York City | 2:1 |
| 18.07.2021 | 01:30 | Philadelphia Union - DC United | 2:1 |
| 18.07.2021 | 01:30 | Toronto - Orlando City | 1:1 |
| 18.07.2021 | 01:30 | CF Montréal - Cincinnati | 5:4 |
| 18.07.2021 | 02:30 | Nashville SC - Chicago Fire | 5:1 |
| 18.07.2021 | 03:00 | Colorado Rapids - SJ Earthquakes | 1:1 |
| 18.07.2021 | 04:00 | Vancouver Whitecaps - LA Galaxy | 2:1 |
| 18.07.2021 | 04:30 | Los Angeles FC - Real Salt Lake | 2:1 |
| 18.07.2021 | 04:30 | Portland Timbers - Dallas | 1:0 |
| 18.07.2021 | 20:00 | Minnesota United - Seattle Sounders | 1:0 |
| 21.07.2021 | 04:00 | Vancouver Whitecaps - Houston Dynamo | 0:0 |
| 22.07.2021 | 01:30 | Columbus Crew - Nashville SC | 0:0 |
| 22.07.2021 | 01:30 | Inter Miami - New England | 0:5 |
| 22.07.2021 | 01:30 | Toronto - New York RB | 1:1 |
| 22.07.2021 | 01:30 | New York City - CF Montréal | 1:0 |
| 22.07.2021 | 02:00 | Chicago Fire - DC United | 2:2 |
| 22.07.2021 | 02:00 | Cincinnati - Atlanta United | 1:1 |
| 22.07.2021 | 02:30 | Sporting KC - SJ Earthquakes | 1:1 |
| 22.07.2021 | 03:00 | Colorado Rapids - Dallas | 2:0 |
| 22.07.2021 | 04:00 | Real Salt Lake - LA Galaxy | 2:2 |
| 22.07.2021 | 04:30 | Portland Timbers - Los Angeles FC | 2:1 |
| 23.07.2021 | 02:25 | Orlando City - Philadelphia Union | 2:1 |
| 23.07.2021 | 03:30 | Austin - Seattle Sounders | 0:1 |
| 24.07.2021 | 21:30 | Atlanta United - Columbus Crew | 0:1 |
| 25.07.2021 | 02:00 | Chicago Fire - Toronto | 1:2 |
| 25.07.2021 | 02:00 | Minnesota United - Portland Timbers | 2:1 |
| 25.07.2021 | 02:30 | Dallas - LA Galaxy | 4:0 |
| 25.07.2021 | 02:30 | Nashville SC - Cincinnati | 3:0 |
| 25.07.2021 | 04:00 | Real Salt Lake - Colorado Rapids | 3:0 |
| 25.07.2021 | 04:00 | SJ Earthquakes - Houston Dynamo | 1:1 |
| 25.07.2021 | 04:30 | Los Angeles FC - Vancouver Whitecaps | 2:2 |
| 26.07.2021 | 00:00 | New England - CF Montréal | 2:1 |
| 26.07.2021 | 00:00 | New York City - Orlando City | 5:0 |
| 26.07.2021 | 01:30 | Inter Miami - Philadelphia Union | 1:1 |
| 26.07.2021 | 02:00 | DC United - New York RB | 1:0 |
| 26.07.2021 | 03:00 | Seattle Sounders - Sporting KC | 1:3 |
| 29.07.2021 | 04:30 | Los Angeles FC - Minnesota United | 2:2 |
| 31.07.2021 | 01:30 | New York City - Columbus Crew | 4:1 |
| 31.07.2021 | 02:00 | Orlando City - Atlanta United | 3:2 |
| 31.07.2021 | 04:00 | LA Galaxy - Portland Timbers | 4:1 |
| 31.07.2021 | 23:00 | Seattle Sounders - SJ Earthquakes | 0:1 |
| 01.08.2021 | 00:00 | New York RB - New England | 2:3 |
| 01.08.2021 | 01:30 | Cincinnati - DC United | 0:0 |
| 01.08.2021 | 02:00 | Inter Miami - CF Montréal | 2:1 |
| 01.08.2021 | 02:30 | Houston Dynamo - Real Salt Lake | 0:0 |
| 01.08.2021 | 02:30 | Sporting KC - Dallas | 1:2 |
| 01.08.2021 | 03:00 | Austin - Colorado Rapids | 0:1 |
| 01.08.2021 | 04:00 | Vancouver Whitecaps - Minnesota United | 2:2 |
| 02.08.2021 | 00:00 | Philadelphia Union - Chicago Fire | 1:1 |
| 02.08.2021 | 01:30 | Toronto - Nashville SC | 1:1 |
| 05.08.2021 | 01:00 | New England - Nashville SC | 0:0 |
| 05.08.2021 | 01:30 | Philadelphia Union - Toronto | 3:0 |
| 05.08.2021 | 01:30 | CF Montréal - Atlanta United | 2:2 |
| 05.08.2021 | 01:30 | Columbus Crew - DC United | 2:4 |
| 05.08.2021 | 02:00 | Chicago Fire - New York City | 0:0 |
| 05.08.2021 | 02:00 | New York RB - Cincinnati | 0:0 |
| 05.08.2021 | 02:00 | Orlando City - Inter Miami | 1:1 |
| 05.08.2021 | 03:00 | Austin - Houston Dynamo | 3:2 |
| 05.08.2021 | 04:00 | Seattle Sounders - Dallas | 1:1 |
| 05.08.2021 | 04:30 | LA Galaxy - Real Salt Lake | 1:0 |
| 05.08.2021 | 04:30 | Los Angeles FC - Sporting KC | 1:4 |
| 05.08.2021 | 04:30 | Portland Timbers - SJ Earthquakes | 1:1 |
| 08.08.2021 | 01:30 | Columbus Crew - Atlanta United | 2:3 |
| 08.08.2021 | 01:30 | Cincinnati - Orlando City | 1:1 |
| 08.08.2021 | 02:00 | Toronto - New York City | 2:2 |
| 08.08.2021 | 02:00 | Minnesota United - Houston Dynamo | 2:0 |
| 08.08.2021 | 02:30 | Dallas - Austin | 2:0 |
| 08.08.2021 | 03:00 | Colorado Rapids - Sporting KC | 0:0 |
| 08.08.2021 | 04:30 | Portland Timbers - Real Salt Lake | 3:2 |
| 09.08.2021 | 00:00 | Chicago Fire - New York RB | 2:1 |
| 09.08.2021 | 00:00 | New England - Philadelphia Union | 2:1 |
| 09.08.2021 | 00:00 | Inter Miami - Nashville SC | 1:5 |
| 09.08.2021 | 01:00 | SJ Earthquakes - Los Angeles FC | 2:1 |
| 09.08.2021 | 02:00 | LA Galaxy - Vancouver Whitecaps | 1:1 |
| 09.08.2021 | 02:00 | DC United - CF Montréal | 2:1 |
| 14.08.2021 | 04:30 | SJ Earthquakes - Vancouver Whitecaps | 0:0 |
| 15.08.2021 | 00:00 | Minnesota United - LA Galaxy | 0:1 |
| 15.08.2021 | 02:00 | New York City - Inter Miami | 2:0 |
| 15.08.2021 | 02:00 | Toronto - New England | 1:2 |
| 15.08.2021 | 02:00 | CF Montréal - New York RB | 2:1 |
| 15.08.2021 | 02:30 | Dallas - Sporting KC | 0:2 |
| 15.08.2021 | 02:30 | Houston Dynamo - Colorado Rapids | 1:3 |
| 15.08.2021 | 04:00 | Real Salt Lake - Austin | 1:0 |
| 15.08.2021 | 22:00 | Atlanta United - Los Angeles FC | 1:0 |
| 16.08.2021 | 00:00 | Chicago Fire - Columbus Crew | 1:0 |
| 16.08.2021 | 01:00 | Nashville SC - DC United | 5:2 |
| 16.08.2021 | 04:00 | Portland Timbers - Seattle Sounders | 2:6 |
| 18.08.2021 | 04:30 | SJ Earthquakes - Minnesota United | 1:1 |
| 18.08.2021 | 04:30 | LA Galaxy - Colorado Rapids | 1:2 |
| 19.08.2021 | 01:00 | Atlanta United - Toronto | 1:0 |
| 19.08.2021 | 01:00 | New England - DC United | 3:2 |
| 19.08.2021 | 01:30 | Inter Miami - Chicago Fire | 3:2 |
| 19.08.2021 | 01:30 | Philadelphia Union - New York City | 1:0 |
| 19.08.2021 | 01:30 | Cincinnati - CF Montréal | 0:0 |
| 19.08.2021 | 02:00 | New York RB - Columbus Crew | 1:0 |
| 19.08.2021 | 02:30 | Dallas - Seattle Sounders | 0:1 |
| 19.08.2021 | 02:30 | Nashville SC - Orlando City | 1:1 |
| 19.08.2021 | 02:30 | Sporting KC - Portland Timbers | 1:1 |
| 19.08.2021 | 03:00 | Austin - Vancouver Whitecaps | 1:2 |
| 19.08.2021 | 04:00 | Real Salt Lake - Houston Dynamo | 2:1 |
| 21.08.2021 | 04:30 | LA Galaxy - SJ Earthquakes | 1:2 |
| 21.08.2021 | 21:30 | Minnesota United - Sporting KC | 0:0 |
| 21.08.2021 | 23:30 | Columbus Crew - Seattle Sounders | 1:2 |
| 22.08.2021 | 02:00 | Inter Miami - Toronto | 3:1 |
| 22.08.2021 | 02:00 | Philadelphia Union - CF Montréal | 1:1 |
| 22.08.2021 | 02:00 | DC United - Atlanta United | 1:2 |
| 22.08.2021 | 02:00 | New England - Cincinnati | 4:1 |
| 22.08.2021 | 02:30 | Houston Dynamo - Dallas | 2:2 |
| 22.08.2021 | 02:45 | Orlando City - Chicago Fire | 1:0 |
| 22.08.2021 | 03:00 | Austin - Portland Timbers | 3:1 |
| 22.08.2021 | 03:00 | Colorado Rapids - Real Salt Lake | 2:1 |
| 22.08.2021 | 04:00 | Vancouver Whitecaps - Los Angeles FC | 2:1 |
| 28.08.2021 | 00:30 | Columbus Crew - Cincinnati | 3:2 |
| 28.08.2021 | 01:30 | CF Montréal - Toronto | 3:1 |
| 28.08.2021 | 02:30 | Orlando City - Inter Miami | 0:0 |
| 28.08.2021 | 21:30 | Atlanta United - Nashville SC | 0:2 |
| 29.08.2021 | 00:00 | New York RB - Chicago Fire | 0:1 |
| 29.08.2021 | 01:00 | Los Angeles FC - LA Galaxy | 3:3 |
| 29.08.2021 | 01:30 | New York City - New England | 2:0 |
| 29.08.2021 | 02:00 | DC United - Philadelphia Union | 3:1 |
| 29.08.2021 | 03:00 | Houston Dynamo - Minnesota United | 1:2 |
| 29.08.2021 | 03:00 | Sporting KC - Colorado Rapids | 1:1 |
| 30.08.2021 | 02:00 | Austin - Dallas | 3:5 |
| 30.08.2021 | 04:00 | Vancouver Whitecaps - Real Salt Lake | 4:1 |
| 30.08.2021 | 04:30 | Seattle Sounders - Portland Timbers | 0:2 |
| 04.09.2021 | 01:30 | Nashville SC - New York City | 3:1 |
| 04.09.2021 | 01:30 | Philadelphia Union - New England | 0:1 |
| 04.09.2021 | 02:00 | Houston Dynamo - Portland Timbers | 0:2 |
| 04.09.2021 | 04:00 | Los Angeles FC - Sporting KC | 4:0 |
| 05.09.2021 | 01:00 | Vancouver Whitecaps - Austin | 2:1 |
| 05.09.2021 | 01:30 | Orlando City - Columbus Crew | 3:2 |
| 05.09.2021 | 02:00 | Cincinnati - Inter Miami | 0:1 |
| 05.09.2021 | 02:00 | Real Salt Lake - Dallas | 3:2 |
| 05.09.2021 | 04:00 | SJ Earthquakes - Colorado Rapids | 0:1 |
| 11.09.2021 | 01:00 | Atlanta United - Orlando City | 3:0 |
| 11.09.2021 | 04:00 | Vancouver Whitecaps - Portland Timbers | 0:1 |
| 11.09.2021 | 21:30 | Colorado Rapids - LA Galaxy | 1:1 |
| 11.09.2021 | 23:00 | Seattle Sounders - Minnesota United | 1:0 |
| 12.09.2021 | 01:00 | New York RB - DC United | 1:1 |
| 12.09.2021 | 01:00 | New England - New York City | 2:1 |
| 12.09.2021 | 02:00 | Inter Miami - Columbus Crew | 1:0 |
| 12.09.2021 | 02:00 | Cincinnati - Toronto | 2:0 |
| 12.09.2021 | 02:00 | CF Montréal - Nashville SC | 0:1 |
| 12.09.2021 | 02:30 | Dallas - SJ Earthquakes | 1:1 |
| 12.09.2021 | 02:30 | Houston Dynamo - Austin | 3:0 |
| 12.09.2021 | 02:30 | Sporting KC - Chicago Fire | 2:0 |
| 13.09.2021 | 04:30 | Los Angeles FC - Real Salt Lake | 3:2 |
| 15.09.2021 | 01:30 | Toronto - Inter Miami | 0:1 |
| 15.09.2021 | 01:30 | New York City - Dallas | 3:3 |
| 15.09.2021 | 01:30 | Columbus Crew - New York RB | 2:1 |
| 16.09.2021 | 01:00 | Atlanta United - Cincinnati | 4:0 |
| 16.09.2021 | 01:30 | DC United - Chicago Fire | 3:0 |
| 16.09.2021 | 01:30 | Orlando City - CF Montréal | 1:1 |
| 16.09.2021 | 02:30 | Sporting KC - Minnesota United | 4:0 |
| 16.09.2021 | 03:00 | Austin - Los Angeles FC | 1:2 |
| 16.09.2021 | 04:00 | Portland Timbers - Colorado Rapids | 2:2 |
| 16.09.2021 | 04:30 | SJ Earthquakes - Real Salt Lake | 3:4 |
| 16.09.2021 | 04:30 | LA Galaxy - Houston Dynamo | 1:1 |
| 18.09.2021 | 01:00 | Inter Miami - New York RB | 0:4 |
| 18.09.2021 | 21:30 | Atlanta United - DC United | 3:2 |
| 19.09.2021 | 01:00 | New England - Columbus Crew | 1:1 |
| 19.09.2021 | 01:30 | Toronto - Nashville SC | 2:1 |
| 19.09.2021 | 01:30 | Cincinnati - New York City | 1:2 |
| 19.09.2021 | 02:00 | Minnesota United - LA Galaxy | 3:0 |
| 19.09.2021 | 02:00 | Austin - SJ Earthquakes | 3:4 |
| 19.09.2021 | 03:30 | Real Salt Lake - Seattle Sounders | 1:0 |
| 19.09.2021 | 03:30 | Houston Dynamo - Dallas | 3:2 |
| 19.09.2021 | 19:00 | CF Montréal - Chicago Fire | 2:0 |
| 19.09.2021 | 22:00 | Philadelphia Union - Orlando City | 3:1 |
| 20.09.2021 | 01:30 | Portland Timbers - Los Angeles FC | 2:1 |
| 20.09.2021 | 03:00 | Colorado Rapids - Vancouver Whitecaps | 1:1 |
| 23.09.2021 | 01:30 | Inter Miami - Nashville SC | 1:5 |
| 23.09.2021 | 02:00 | New York RB - New York City | 1:1 |
| 23.09.2021 | 02:00 | Chicago Fire - New England | 2:3 |
| 25.09.2021 | 21:30 | Philadelphia Union - Atlanta United | 1:0 |
| 26.09.2021 | 01:00 | New England - Orlando City | 2:1 |
| 26.09.2021 | 01:30 | Columbus Crew - CF Montréal | 2:1 |
| 26.09.2021 | 01:30 | DC United - Cincinnati | 4:2 |
| 26.09.2021 | 02:00 | New York City - New York RB | 0:1 |
| 26.09.2021 | 02:00 | Minnesota United - Houston Dynamo | 2:0 |
| 26.09.2021 | 02:00 | Colorado Rapids - Toronto | 0:0 |
| 26.09.2021 | 04:00 | Vancouver Whitecaps - Dallas | 1:0 |
| 26.09.2021 | 04:00 | SJ Earthquakes - Los Angeles FC | 2:0 |
| 26.09.2021 | 04:30 | Portland Timbers - Real Salt Lake | 6:1 |
| 26.09.2021 | 19:00 | Chicago Fire - Nashville SC | 0:0 |
| 27.09.2021 | 01:00 | Sporting KC - Seattle Sounders | 1:2 |
| 27.09.2021 | 03:30 | Austin - LA Galaxy | 2:0 |
| 30.09.2021 | 01:00 | Atlanta United - Inter Miami | 1:0 |
| 30.09.2021 | 01:00 | Toronto - Cincinnati | 3:2 |
| 30.09.2021 | 01:30 | CF Montréal - New England | 1:4 |
| 30.09.2021 | 01:30 | DC United - Minnesota United | 3:1 |
| 30.09.2021 | 01:30 | New York RB - Philadelphia Union | 1:1 |
| 30.09.2021 | 02:00 | Chicago Fire - New York City | 2:0 |
| 30.09.2021 | 02:00 | Dallas - Sporting KC | 1:3 |
| 30.09.2021 | 02:30 | Nashville SC - Orlando City | 2:2 |
| 30.09.2021 | 03:00 | Colorado Rapids - Austin | 3:0 |
| 30.09.2021 | 03:00 | Houston Dynamo - Vancouver Whitecaps | 0:0 |
| 30.09.2021 | 03:30 | Real Salt Lake - LA Galaxy | 2:1 |
| 30.09.2021 | 04:30 | SJ Earthquakes - Seattle Sounders | 1:3 |
| 30.09.2021 | 04:30 | Los Angeles FC - Portland Timbers | 1:2 |
| 02.10.2021 | 21:30 | Austin - Real Salt Lake | 2:1 |
| 03.10.2021 | 01:00 | CF Montréal - Atlanta United | 2:1 |
| 03.10.2021 | 01:30 | Cincinnati - New York RB | 0:1 |
| 03.10.2021 | 01:30 | Orlando City - DC United | 2:1 |
| 03.10.2021 | 02:00 | Dallas - Minnesota United | 0:0 |
| 03.10.2021 | 04:00 | Vancouver Whitecaps - SJ Earthquakes | 3:0 |
| 03.10.2021 | 18:00 | New York City - Nashville SC | 0:0 |
| 03.10.2021 | 22:00 | Philadelphia Union - Columbus Crew | 3:0 |
| 03.10.2021 | 22:00 | Sporting KC - Houston Dynamo | 4:2 |
| 03.10.2021 | 22:00 | Toronto - Chicago Fire | 3:1 |
| 03.10.2021 | 23:30 | Portland Timbers - Inter Miami | 1:0 |
| 04.10.2021 | 02:00 | LA Galaxy - Los Angeles FC | 1:1 |
| 04.10.2021 | 04:00 | Seattle Sounders - Colorado Rapids | 3:0 |
| 10.10.2021 | 00:00 | New York RB - Inter Miami | 1:0 |
| 10.10.2021 | 02:00 | Cincinnati - Philadelphia Union | 1:2 |
| 10.10.2021 | 03:00 | Seattle Sounders - Vancouver Whitecaps | 4:1 |
| 10.10.2021 | 22:00 | Minnesota United - Colorado Rapids | 1:3 |
| 16.10.2021 | 19:00 | CF Montréal - Philadelphia Union | 2:2 |
| 16.10.2021 | 21:30 | Los Angeles FC - SJ Earthquakes | 3:1 |
| 17.10.2021 | 00:00 | Columbus Crew - Inter Miami | 4:0 |
| 17.10.2021 | 01:00 | New England - Chicago Fire | 2:2 |
| 17.10.2021 | 01:30 | Toronto - Atlanta United | 0:2 |
| 17.10.2021 | 01:30 | DC United - Nashville SC | 0:0 |
| 17.10.2021 | 01:30 | Cincinnati - Orlando City | 0:1 |
| 17.10.2021 | 02:30 | Houston Dynamo - Seattle Sounders | 2:1 |
| 17.10.2021 | 03:00 | Austin - Minnesota United | 0:1 |
| 17.10.2021 | 03:30 | Real Salt Lake - Colorado Rapids | 3:1 |
| 17.10.2021 | 04:30 | LA Galaxy - Portland Timbers | 2:1 |
| 17.10.2021 | 19:00 | New York RB - New York City | 1:0 |
| 18.10.2021 | 04:00 | Vancouver Whitecaps - Sporting KC | 2:1 |
| 21.10.2021 | 01:30 | Atlanta United - New York City | 1:1 |
| 21.10.2021 | 01:30 | Cincinnati - Chicago Fire | 3:4 |
| 21.10.2021 | 01:30 | DC United - New England | 2:3 |
| 21.10.2021 | 01:30 | Orlando City - CF Montréal | 1:1 |
| 21.10.2021 | 01:30 | Inter Miami - Toronto | 3:0 |
| 21.10.2021 | 02:00 | Dallas - Los Angeles FC | 2:3 |
| 21.10.2021 | 02:00 | Minnesota United - Philadelphia Union | 3:2 |
| 21.10.2021 | 02:30 | Houston Dynamo - LA Galaxy | 0:3 |
| 21.10.2021 | 02:30 | Nashville SC - Columbus Crew | 1:1 |
| 21.10.2021 | 03:00 | Colorado Rapids - Seattle Sounders | 1:1 |
| 21.10.2021 | 04:00 | Portland Timbers - Vancouver Whitecaps | 2:3 |
| 21.10.2021 | 04:30 | SJ Earthquakes - Austin | 4:0 |
| 23.10.2021 | 21:30 | Seattle Sounders - Sporting KC | 1:2 |
| 24.10.2021 | 00:00 | Columbus Crew - New York RB | 1:2 |
| 24.10.2021 | 01:30 | Philadelphia Union - Nashville SC | 1:0 |
| 24.10.2021 | 01:30 | Toronto - CF Montréal | 1:1 |
| 24.10.2021 | 01:30 | New York City - DC United | 6:0 |
| 24.10.2021 | 02:00 | Chicago Fire - Real Salt Lake | 1:0 |
| 24.10.2021 | 02:00 | Inter Miami - Cincinnati | 5:1 |
| 24.10.2021 | 02:00 | Minnesota United - Los Angeles FC | 1:1 |
| 24.10.2021 | 03:00 | Colorado Rapids - Portland Timbers | 2:0 |
| 24.10.2021 | 04:00 | LA Galaxy - Dallas | 2:2 |
| 24.10.2021 | 04:00 | SJ Earthquakes - Vancouver Whitecaps | 1:1 |
| 24.10.2021 | 23:00 | Austin - Houston Dynamo | 2:1 |
| 25.10.2021 | 01:30 | Orlando City - New England | 2:2 |
| 27.10.2021 | 04:30 | Los Angeles FC - Seattle Sounders | 3:0 |
| 28.10.2021 | 01:00 | New England - Colorado Rapids | 1:0 |
| 28.10.2021 | 01:30 | Columbus Crew - Orlando City | 3:2 |
| 28.10.2021 | 01:30 | Toronto - Philadelphia Union | 2:2 |
| 28.10.2021 | 01:30 | Cincinnati - Nashville SC | 3:6 |
| 28.10.2021 | 01:30 | New York City - Chicago Fire | 1:0 |
| 28.10.2021 | 01:30 | Atlanta United - Inter Miami | 2:1 |
| 28.10.2021 | 01:30 | DC United - New York RB | 1:0 |
| 28.10.2021 | 02:00 | Dallas - Real Salt Lake | 1:2 |
| 28.10.2021 | 02:30 | Sporting KC - LA Galaxy | 2:0 |
| 28.10.2021 | 04:00 | Vancouver Whitecaps - Minnesota United | 2:1 |
| 28.10.2021 | 04:00 | Portland Timbers - SJ Earthquakes | 2:0 |
| 30.10.2021 | 19:30 | Inter Miami - New York City | 1:3 |
| 30.10.2021 | 21:30 | Real Salt Lake - SJ Earthquakes | 3:4 |
| 30.10.2021 | 22:00 | New York RB - CF Montréal | 1:0 |
| 31.10.2021 | 00:00 | Atlanta United - Toronto | 1:1 |
| 31.10.2021 | 01:30 | DC United - Columbus Crew | 1:3 |
| 31.10.2021 | 02:00 | Dallas - Austin | 2:1 |
| 31.10.2021 | 18:00 | Minnesota United - Sporting KC | 2:1 |
| 31.10.2021 | 20:00 | Houston Dynamo - Colorado Rapids | 0:1 |
| 31.10.2021 | 21:00 | Orlando City - Nashville SC | 1:1 |
| 01.11.2021 | 00:30 | Philadelphia Union - Cincinnati | 2:0 |
| 02.11.2021 | 03:00 | Seattle Sounders - LA Galaxy | 1:1 |
| 03.11.2021 | 03:30 | Los Angeles FC - Vancouver Whitecaps | 1:1 |
| 04.11.2021 | 00:30 | CF Montréal - Houston Dynamo | 2:0 |
| 04.11.2021 | 00:30 | New York RB - Atlanta United | 0:0 |
| 04.11.2021 | 02:00 | Austin - Sporting KC | 3:1 |
| 04.11.2021 | 03:30 | Real Salt Lake - Portland Timbers | 1:3 |
| 07.11.2021 | 21:30 | Cincinnati - Atlanta United | 1:2 |
| 07.11.2021 | 21:30 | Columbus Crew - Chicago Fire | 2:0 |
| 07.11.2021 | 21:30 | New England - Inter Miami | 0:1 |
| 07.11.2021 | 21:30 | New York City - Philadelphia Union | 1:1 |
| 07.11.2021 | 21:30 | Toronto - DC United | 1:3 |
| 07.11.2021 | 21:30 | CF Montréal - Orlando City | 0:2 |
| 08.11.2021 | 00:00 | Colorado Rapids - Los Angeles FC | 5:2 |
| 08.11.2021 | 00:00 | LA Galaxy - Minnesota United | 3:3 |
| 08.11.2021 | 00:00 | Portland Timbers - Austin | 3:0 |
| 08.11.2021 | 00:00 | SJ Earthquakes - Dallas | 1:1 |
| 08.11.2021 | 00:00 | Sporting KC - Real Salt Lake | 0:1 |
| 08.11.2021 | 00:00 | Vancouver Whitecaps - Seattle Sounders | 1:1 |
| 20.11.2021 | 20:30 | Philadelphia Union - New York RB | 1:0 |
| 20.11.2021 | 23:00 | Sporting KC - Vancouver Whitecaps | 3:1 |
| 21.11.2021 | 21:00 | New York City - Atlanta United | 2:0 |
| 21.11.2021 | 23:30 | Portland Timbers - Minnesota United | 3:1 |
| 24.11.2021 | 02:00 | Nashville SC - Orlando City | 3:1 |
| 24.11.2021 | 04:30 | Seattle Sounders - Real Salt Lake | 0:1 |
| 25.11.2021 | 22:30 | Colorado Rapids - Portland Timbers | 0:1 |
| 28.11.2021 | 21:00 | Sporting KC - Real Salt Lake | 1:2 |
| 28.11.2021 | 23:30 | Philadelphia Union - Nashville SC | 1:1 |
| 01.12.2021 | 01:30 | New England - New York City | 2:3 |
| 05.12.2021 | 00:30 | Portland Timbers - Real Salt Lake | 2:0 |
| 05.12.2021 | 21:00 | Philadelphia Union - New York City | 1:2 |
| 11.12.2021 | 21:00 | Portland Timbers - New York City | 1:2 |