| 06.08.2021 | 21:15 | Sporting CP - Vizela | 3:0 |
| 07.08.2021 | 13:45 | Arouca - Estoril | 0:2 |
| 07.08.2021 | 19:00 | Moreirense - Benfica | 1:2 |
| 07.08.2021 | 21:30 | Marítimo - Sporting Braga | 0:2 |
| 08.08.2021 | 16:30 | Vitória Guimarães - Portimonense | 0:1 |
| 08.08.2021 | 16:30 | Tondela - Santa Clara | 3:0 |
| 08.08.2021 | 19:00 | Porto - Belenenses | 2:0 |
| 08.08.2021 | 21:30 | Paços de Ferreira - Famalicão | 2:0 |
| 09.08.2021 | 21:15 | Gil Vicente - Boavista | 3:0 |
| 13.08.2021 | 21:15 | Estoril - Vitória Guimarães | 0:0 |
| 14.08.2021 | 16:30 | Vizela - Tondela | 2:1 |
| 14.08.2021 | 19:00 | Benfica - Arouca | 2:0 |
| 14.08.2021 | 21:30 | Sporting Braga - Sporting CP | 1:2 |
| 15.08.2021 | 16:30 | Portimonense - Gil Vicente | 0:1 |
| 15.08.2021 | 19:00 | Famalicão - Porto | 1:2 |
| 15.08.2021 | 21:30 | Santa Clara - Moreirense | 2:2 |
| 16.08.2021 | 20:00 | Boavista - Paços de Ferreira | 3:0 |
| 16.08.2021 | 22:15 | Belenenses - Marítimo | 1:2 |
| 20.08.2021 | 20:00 | Arouca - Famalicão | 2:1 |
| 20.08.2021 | 22:15 | Moreirense - Sporting Braga | 2:3 |
| 21.08.2021 | 19:00 | Gil Vicente - Benfica | 0:2 |
| 21.08.2021 | 21:30 | Sporting CP - Belenenses | 2:0 |
| 22.08.2021 | 16:30 | Tondela - Portimonense | 0:3 |
| 22.08.2021 | 19:00 | Marítimo - Porto | 1:1 |
| 22.08.2021 | 21:30 | Vitória Guimarães - Vizela | 4:0 |
| 23.08.2021 | 20:00 | Paços de Ferreira - Estoril | 1:3 |
| 23.08.2021 | 22:15 | Boavista - Santa Clara | 2:0 |
| 27.08.2021 | 20:00 | Belenenses - Moreirense | 1:1 |
| 27.08.2021 | 22:15 | Estoril - Marítimo | 2:1 |
| 28.08.2021 | 16:30 | Vizela - Boavista | 1:1 |
| 28.08.2021 | 19:00 | Porto - Arouca | 3:0 |
| 28.08.2021 | 21:30 | Famalicão - Sporting CP | 1:1 |
| 29.08.2021 | 19:00 | Benfica - Tondela | 2:1 |
| 29.08.2021 | 19:00 | Sporting Braga - Vitória Guimarães | 0:0 |
| 29.08.2021 | 21:30 | Santa Clara - Gil Vicente | 1:0 |
| 29.08.2021 | 21:30 | Portimonense - Paços de Ferreira | 0:1 |
| 11.09.2021 | 16:30 | Paços de Ferreira - Sporting Braga | 0:0 |
| 11.09.2021 | 19:00 | Santa Clara - Benfica | 0:5 |
| 11.09.2021 | 21:30 | Sporting CP - Porto | 1:1 |
| 12.09.2021 | 16:30 | Moreirense - Famalicão | 2:2 |
| 12.09.2021 | 19:00 | Gil Vicente - Vizela | 2:2 |
| 12.09.2021 | 19:00 | Boavista - Portimonense | 1:1 |
| 12.09.2021 | 21:30 | Vitória Guimarães - Belenenses | 0:0 |
| 13.09.2021 | 20:00 | Marítimo - Arouca | 2:2 |
| 13.09.2021 | 22:15 | Tondela - Estoril | 1:2 |
| 17.09.2021 | 21:15 | Portimonense - Santa Clara | 2:1 |
| 18.09.2021 | 16:30 | Famalicão - Marítimo | 0:0 |
| 18.09.2021 | 19:00 | Belenenses - Gil Vicente | 1:1 |
| 18.09.2021 | 21:30 | Arouca - Vitória Guimarães | 2:2 |
| 19.09.2021 | 16:30 | Vizela - Paços de Ferreira | 1:1 |
| 19.09.2021 | 19:00 | Porto - Moreirense | 5:0 |
| 19.09.2021 | 21:30 | Estoril - Sporting CP | 0:1 |
| 20.09.2021 | 20:00 | Benfica - Boavista | 3:1 |
| 20.09.2021 | 22:15 | Sporting Braga - Tondela | 3:1 |
| 24.09.2021 | 20:00 | Sporting CP - Marítimo | 1:0 |
| 24.09.2021 | 22:15 | Gil Vicente - Porto | 1:2 |
| 25.09.2021 | 16:30 | Moreirense - Arouca | 2:1 |
| 25.09.2021 | 19:00 | Vitória Guimarães - Benfica | 1:3 |
| 25.09.2021 | 21:30 | Tondela - Famalicão | 3:2 |
| 26.09.2021 | 19:00 | Santa Clara - Sporting Braga | 1:1 |
| 26.09.2021 | 21:30 | Portimonense - Vizela | 0:0 |
| 27.09.2021 | 20:00 | Paços de Ferreira - Belenenses | 2:2 |
| 27.09.2021 | 22:15 | Boavista - Estoril | 1:1 |
| 01.10.2021 | 20:00 | Marítimo - Moreirense | 0:0 |
| 01.10.2021 | 22:15 | Famalicão - Vitória Guimarães | 1:2 |
| 02.10.2021 | 16:30 | Vizela - Santa Clara | 1:1 |
| 02.10.2021 | 19:00 | Porto - Paços de Ferreira | 2:1 |
| 02.10.2021 | 21:30 | Arouca - Sporting CP | 1:2 |
| 03.10.2021 | 16:30 | Belenenses - Tondela | 0:2 |
| 03.10.2021 | 19:00 | Benfica - Portimonense | 0:1 |
| 03.10.2021 | 19:00 | Estoril - Gil Vicente | 2:2 |
| 03.10.2021 | 21:30 | Sporting Braga - Boavista | 2:2 |
| 22.10.2021 | 21:15 | Vitória Guimarães - Marítimo | 2:1 |
| 23.10.2021 | 16:30 | Santa Clara - Famalicão | 0:2 |
| 23.10.2021 | 19:00 | Tondela - Porto | 1:3 |
| 23.10.2021 | 21:30 | Sporting CP - Moreirense | 1:0 |
| 24.10.2021 | 16:30 | Paços de Ferreira - Arouca | 0:0 |
| 24.10.2021 | 19:00 | Vizela - Benfica | 0:1 |
| 24.10.2021 | 21:30 | Portimonense - Estoril | 0:2 |
| 25.10.2021 | 20:00 | Gil Vicente - Sporting Braga | 0:1 |
| 25.10.2021 | 22:15 | Boavista - Belenenses | 0:0 |
| 29.10.2021 | 21:15 | Arouca - Tondela | 2:0 |
| 30.10.2021 | 18:00 | Porto - Boavista | 4:1 |
| 30.10.2021 | 20:00 | Estoril - Benfica | 1:1 |
| 30.10.2021 | 22:15 | Sporting CP - Vitória Guimarães | 1:0 |
| 31.10.2021 | 16:30 | Marítimo - Gil Vicente | 1:2 |
| 31.10.2021 | 19:00 | Belenenses - Santa Clara | 2:1 |
| 31.10.2021 | 21:30 | Famalicão - Vizela | 1:1 |
| 01.11.2021 | 20:00 | Sporting Braga - Portimonense | 3:0 |
| 01.11.2021 | 22:15 | Moreirense - Paços de Ferreira | 1:1 |
| 05.11.2021 | 20:00 | Gil Vicente - Arouca | 1:1 |
| 05.11.2021 | 22:15 | Boavista - Famalicão | 2:5 |
| 06.11.2021 | 16:30 | Vizela - Estoril | 1:1 |
| 06.11.2021 | 19:00 | Portimonense - Belenenses | 2:0 |
| 06.11.2021 | 21:30 | Vitória Guimarães - Moreirense | 2:1 |
| 07.11.2021 | 15:00 | Tondela - Marítimo | 4:2 |
| 07.11.2021 | 18:00 | Santa Clara - Porto | 0:3 |
| 07.11.2021 | 20:00 | Paços de Ferreira - Sporting CP | 0:2 |
| 07.11.2021 | 22:15 | Benfica - Sporting Braga | 6:1 |
| 26.11.2021 | 21:15 | Moreirense - Gil Vicente | 2:2 |
| 27.11.2021 | 16:30 | Famalicão - Portimonense | 0:3 |
| 27.11.2021 | 19:00 | Arouca - Boavista | 2:1 |
| 27.11.2021 | 21:30 | Belenenses - Benfica | 0:7 |
| 28.11.2021 | 16:30 | Marítimo - Paços de Ferreira | 2:0 |
| 28.11.2021 | 19:00 | Sporting CP - Tondela | 2:0 |
| 28.11.2021 | 21:30 | Porto - Vitória Guimarães | 2:1 |
| 29.11.2021 | 21:15 | Estoril - Santa Clara | 2:2 |
| 30.11.2021 | 21:15 | Sporting Braga - Vizela | 4:1 |
| 03.12.2021 | 20:00 | Portimonense - Porto | 0:3 |
| 03.12.2021 | 22:15 | Benfica - Sporting CP | 1:3 |
| 04.12.2021 | 19:00 | Boavista - Marítimo | 1:1 |
| 04.12.2021 | 21:30 | Paços de Ferreira - Vitória Guimarães | 1:2 |
| 05.12.2021 | 16:30 | Santa Clara - Arouca | 2:1 |
| 05.12.2021 | 19:00 | Gil Vicente - Famalicão | 4:0 |
| 05.12.2021 | 21:30 | Sporting Braga - Estoril | 2:0 |
| 02.01.2022 | 19:30 | Vizela - Belenenses | 2:0 |
| 03.01.2022 | 21:15 | Tondela - Moreirense | 2:1 |
| 10.12.2021 | 21:15 | Paços de Ferreira - Gil Vicente | 0:1 |
| 11.12.2021 | 16:30 | Marítimo - Santa Clara | 4:1 |
| 11.12.2021 | 19:00 | Vitória Guimarães - Tondela | 5:2 |
| 11.12.2021 | 21:30 | Sporting CP - Boavista | 2:0 |
| 12.12.2021 | 16:30 | Moreirense - Portimonense | 0:1 |
| 12.12.2021 | 16:30 | Belenenses - Estoril | 0:1 |
| 12.12.2021 | 19:00 | Famalicão - Benfica | 1:4 |
| 12.12.2021 | 21:30 | Porto - Sporting Braga | 1:0 |
| 13.12.2021 | 21:15 | Arouca - Vizela | 1:4 |
| 17.12.2021 | 20:00 | Santa Clara - Vitória Guimarães | 1:0 |
| 17.12.2021 | 22:15 | Estoril - Famalicão | 2:2 |
| 18.12.2021 | 16:30 | Tondela - Paços de Ferreira | 0:1 |
| 18.12.2021 | 16:30 | Portimonense - Arouca | 1:1 |
| 18.12.2021 | 21:30 | Gil Vicente - Sporting CP | 0:3 |
| 19.12.2021 | 18:00 | Benfica - Marítimo | 7:1 |
| 19.12.2021 | 18:00 | Boavista - Moreirense | 1:0 |
| 19.12.2021 | 20:00 | Vizela - Porto | 0:4 |
| 19.12.2021 | 22:00 | Sporting Braga - Belenenses | 1:0 |
| 28.12.2021 | 18:00 | Tondela - Gil Vicente | 0:3 |
| 28.12.2021 | 20:00 | Marítimo - Vizela | 2:0 |
| 28.12.2021 | 22:00 | Moreirense - Estoril | 1:0 |
| 29.12.2021 | 20:00 | Vitória Guimarães - Boavista | 1:1 |
| 29.12.2021 | 22:00 | Sporting CP - Portimonense | 3:2 |
| 30.12.2021 | 18:00 | Paços de Ferreira - Santa Clara | 2:1 |
| 30.12.2021 | 20:00 | Arouca - Sporting Braga | 0:6 |
| 30.12.2021 | 22:00 | Porto - Benfica | 3:1 |
| 13.01.2022 | 19:00 | Famalicão - Belenenses | 1:0 |
| 07.01.2022 | 19:30 | Santa Clara - Sporting CP | 3:2 |
| 08.01.2022 | 16:30 | Vizela - Moreirense | 0:1 |
| 08.01.2022 | 19:00 | Estoril - Porto | 2:3 |
| 08.01.2022 | 21:30 | Boavista - Tondela | 1:1 |
| 09.01.2022 | 16:30 | Portimonense - Marítimo | 1:2 |
| 09.01.2022 | 19:00 | Benfica - Paços de Ferreira | 2:0 |
| 09.01.2022 | 19:00 | Sporting Braga - Famalicão | 2:2 |
| 09.01.2022 | 21:30 | Belenenses - Arouca | 2:1 |
| 10.01.2022 | 21:15 | Gil Vicente - Vitória Guimarães | 3:2 |
| 15.01.2022 | 16:30 | Boavista - Gil Vicente | 1:1 |
| 15.01.2022 | 19:00 | Benfica - Moreirense | 1:1 |
| 15.01.2022 | 19:00 | Sporting Braga - Marítimo | 0:1 |
| 16.01.2022 | 16:30 | Santa Clara - Tondela | 2:2 |
| 16.01.2022 | 19:00 | Vizela - Sporting CP | 0:2 |
| 16.01.2022 | 19:30 | Famalicão - Paços de Ferreira | 0:0 |
| 16.01.2022 | 21:30 | Belenenses - Porto | 1:4 |
| 17.01.2022 | 21:15 | Portimonense - Vitória Guimarães | 1:1 |
| 27.01.2022 | 21:15 | Estoril - Arouca | 1:2 |
| 21.01.2022 | 20:00 | Arouca - Benfica | 0:2 |
| 21.01.2022 | 22:15 | Paços de Ferreira - Boavista | 1:1 |
| 22.01.2022 | 16:30 | Moreirense - Santa Clara | 0:2 |
| 22.01.2022 | 19:00 | Tondela - Vizela | 2:3 |
| 22.01.2022 | 21:30 | Sporting CP - Sporting Braga | 1:2 |
| 23.01.2022 | 16:30 | Marítimo - Belenenses | 1:1 |
| 23.01.2022 | 16:30 | Vitória Guimarães - Estoril | 3:1 |
| 23.01.2022 | 19:00 | Gil Vicente - Portimonense | 1:0 |
| 23.01.2022 | 21:30 | Porto - Famalicão | 3:1 |
| 30.01.2022 | 16:30 | Vizela - Vitória Guimarães | 3:2 |
| 30.01.2022 | 16:30 | Portimonense - Tondela | 1:2 |
| 30.01.2022 | 19:00 | Sporting Braga - Moreirense | 2:0 |
| 30.01.2022 | 21:30 | Porto - Marítimo | 2:1 |
| 31.01.2022 | 20:00 | Estoril - Paços de Ferreira | 0:0 |
| 31.01.2022 | 22:15 | Famalicão - Arouca | 0:0 |
| 01.02.2022 | 21:15 | Santa Clara - Boavista | 2:1 |
| 02.02.2022 | 20:00 | Benfica - Gil Vicente | 1:2 |
| 02.02.2022 | 21:45 | Belenenses - Sporting CP | 1:4 |
| 05.02.2022 | 16:30 | Marítimo - Estoril | 0:0 |
| 05.02.2022 | 19:00 | Paços de Ferreira - Portimonense | 1:1 |
| 05.02.2022 | 21:30 | Vitória Guimarães - Sporting Braga | 2:1 |
| 06.02.2022 | 16:30 | Gil Vicente - Santa Clara | 2:2 |
| 06.02.2022 | 16:30 | Boavista - Vizela | 2:2 |
| 06.02.2022 | 19:00 | Arouca - Porto | 0:2 |
| 06.02.2022 | 21:30 | Sporting CP - Famalicão | 2:0 |
| 07.02.2022 | 20:00 | Tondela - Benfica | 1:3 |
| 07.02.2022 | 22:15 | Moreirense - Belenenses | 4:1 |
| 11.02.2022 | 21:15 | Porto - Sporting CP | 2:2 |
| 12.02.2022 | 16:30 | Sporting Braga - Paços de Ferreira | 2:1 |
| 12.02.2022 | 19:00 | Benfica - Santa Clara | 2:1 |
| 12.02.2022 | 19:00 | Portimonense - Boavista | 1:1 |
| 12.02.2022 | 21:30 | Estoril - Tondela | 1:0 |
| 13.02.2022 | 16:30 | Famalicão - Moreirense | 5:0 |
| 13.02.2022 | 19:00 | Belenenses - Vitória Guimarães | 1:0 |
| 13.02.2022 | 21:30 | Vizela - Gil Vicente | 0:1 |
| 14.02.2022 | 21:15 | Arouca - Marítimo | 0:3 |
| 18.02.2022 | 21:15 | Boavista - Benfica | 2:2 |
| 19.02.2022 | 16:30 | Gil Vicente - Belenenses | 2:0 |
| 19.02.2022 | 19:00 | Paços de Ferreira - Vizela | 2:1 |
| 19.02.2022 | 21:30 | Vitória Guimarães - Arouca | 1:3 |
| 20.02.2022 | 16:30 | Marítimo - Famalicão | 0:1 |
| 20.02.2022 | 19:00 | Sporting CP - Estoril | 3:0 |
| 20.02.2022 | 21:00 | Moreirense - Porto | 0:1 |
| 20.02.2022 | 21:45 | Tondela - Sporting Braga | 0:1 |
| 21.02.2022 | 21:15 | Santa Clara - Portimonense | 1:1 |
| 25.02.2022 | 21:15 | Belenenses - Paços de Ferreira | 0:2 |
| 26.02.2022 | 16:30 | Famalicão - Tondela | 2:1 |
| 26.02.2022 | 19:00 | Marítimo - Sporting CP | 1:1 |
| 26.02.2022 | 21:30 | Arouca - Moreirense | 1:1 |
| 27.02.2022 | 16:30 | Vizela - Portimonense | 1:1 |
| 27.02.2022 | 19:00 | Benfica - Vitória Guimarães | 3:0 |
| 27.02.2022 | 19:00 | Estoril - Boavista | 2:3 |
| 27.02.2022 | 21:30 | Porto - Gil Vicente | 1:1 |
| 28.02.2022 | 21:15 | Sporting Braga - Santa Clara | 0:0 |
| 04.03.2022 | 21:15 | Gil Vicente - Estoril | 0:0 |
| 05.03.2022 | 16:30 | Boavista - Sporting Braga | 1:1 |
| 05.03.2022 | 19:00 | Portimonense - Benfica | 1:2 |
| 05.03.2022 | 21:30 | Sporting CP - Arouca | 2:0 |
| 06.03.2022 | 16:30 | Moreirense - Marítimo | 0:1 |
| 06.03.2022 | 19:00 | Paços de Ferreira - Porto | 2:4 |
| 06.03.2022 | 21:30 | Vitória Guimarães - Famalicão | 2:1 |
| 06.03.2022 | 21:30 | Santa Clara - Vizela | 3:1 |
| 07.03.2022 | 21:15 | Tondela - Belenenses | 1:1 |
| 11.03.2022 | 21:15 | Benfica - Vizela | 1:1 |
| 12.03.2022 | 16:30 | Famalicão - Santa Clara | 0:0 |
| 12.03.2022 | 16:30 | Estoril - Portimonense | 2:0 |
| 12.03.2022 | 19:00 | Arouca - Paços de Ferreira | 0:1 |
| 12.03.2022 | 21:30 | Belenenses - Boavista | 0:0 |
| 13.03.2022 | 16:30 | Marítimo - Vitória Guimarães | 0:1 |
| 13.03.2022 | 19:00 | Porto - Tondela | 4:0 |
| 13.03.2022 | 21:30 | Sporting Braga - Gil Vicente | 0:1 |
| 14.03.2022 | 21:15 | Moreirense - Sporting CP | 0:2 |
| 18.03.2022 | 21:15 | Vizela - Famalicão | 1:1 |
| 19.03.2022 | 16:30 | Tondela - Arouca | 2:2 |
| 19.03.2022 | 19:00 | Santa Clara - Belenenses | 0:0 |
| 19.03.2022 | 21:30 | Vitória Guimarães - Sporting CP | 1:3 |
| 20.03.2022 | 16:30 | Paços de Ferreira - Moreirense | 2:1 |
| 20.03.2022 | 16:30 | Gil Vicente - Marítimo | 1:1 |
| 20.03.2022 | 19:00 | Benfica - Estoril | 2:1 |
| 20.03.2022 | 21:00 | Portimonense - Sporting Braga | 1:2 |
| 20.03.2022 | 21:45 | Boavista - Porto | 0:1 |
| 01.04.2022 | 21:15 | Sporting Braga - Benfica | 3:2 |
| 02.04.2022 | 16:30 | Belenenses - Portimonense | 2:0 |
| 02.04.2022 | 19:00 | Arouca - Gil Vicente | 2:1 |
| 02.04.2022 | 19:00 | Estoril - Vizela | 1:2 |
| 02.04.2022 | 21:30 | Famalicão - Boavista | 1:2 |
| 03.04.2022 | 16:30 | Marítimo - Tondela | 1:3 |
| 03.04.2022 | 19:00 | Moreirense - Vitória Guimarães | 0:1 |
| 03.04.2022 | 21:30 | Sporting CP - Paços de Ferreira | 2:0 |
| 04.04.2022 | 21:15 | Porto - Santa Clara | 3:0 |
| 08.04.2022 | 21:15 | Gil Vicente - Moreirense | 1:2 |
| 09.04.2022 | 16:30 | Paços de Ferreira - Marítimo | 2:0 |
| 09.04.2022 | 19:00 | Benfica - Belenenses | 3:1 |
| 09.04.2022 | 19:00 | Boavista - Arouca | 1:0 |
| 09.04.2022 | 21:30 | Tondela - Sporting CP | 1:3 |
| 10.04.2022 | 16:30 | Portimonense - Famalicão | 1:0 |
| 10.04.2022 | 16:30 | Santa Clara - Estoril | 2:0 |
| 10.04.2022 | 19:00 | Vitória Guimarães - Porto | 0:1 |
| 10.04.2022 | 21:30 | Vizela - Sporting Braga | 0:1 |
| 15.04.2022 | 16:30 | Arouca - Santa Clara | 1:1 |
| 15.04.2022 | 19:00 | Famalicão - Gil Vicente | 2:2 |
| 15.04.2022 | 21:30 | Vitória Guimarães - Paços de Ferreira | 4:0 |
| 16.04.2022 | 16:30 | Moreirense - Tondela | 2:0 |
| 16.04.2022 | 19:00 | Marítimo - Boavista | 4:0 |
| 16.04.2022 | 19:00 | Belenenses - Vizela | 1:0 |
| 16.04.2022 | 21:30 | Porto - Portimonense | 7:0 |
| 17.04.2022 | 21:30 | Sporting CP - Benfica | 0:2 |
| 18.04.2022 | 21:30 | Estoril - Sporting Braga | 0:0 |
| 22.04.2022 | 21:15 | Vizela - Arouca | 2:1 |
| 23.04.2022 | 16:30 | Portimonense - Moreirense | 1:0 |
| 23.04.2022 | 19:00 | Benfica - Famalicão | 0:0 |
| 23.04.2022 | 19:00 | Santa Clara - Marítimo | 2:2 |
| 23.04.2022 | 21:30 | Gil Vicente - Paços de Ferreira | 1:1 |
| 24.04.2022 | 19:00 | Estoril - Belenenses | 2:2 |
| 24.04.2022 | 21:30 | Tondela - Vitória Guimarães | 1:1 |
| 25.04.2022 | 19:00 | Sporting Braga - Porto | 1:0 |
| 25.04.2022 | 21:30 | Boavista - Sporting CP | 0:3 |
| 29.04.2022 | 21:15 | Famalicão - Estoril | 3:1 |
| 30.04.2022 | 16:00 | Arouca - Portimonense | 1:0 |
| 30.04.2022 | 18:00 | Marítimo - Benfica | 0:1 |
| 30.04.2022 | 20:00 | Porto - Vizela | 4:2 |
| 30.04.2022 | 22:00 | Belenenses - Sporting Braga | 0:1 |
| 01.05.2022 | 16:30 | Vitória Guimarães - Santa Clara | 1:1 |
| 01.05.2022 | 19:00 | Moreirense - Boavista | 1:2 |
| 01.05.2022 | 21:30 | Sporting CP - Gil Vicente | 4:1 |
| 02.05.2022 | 21:15 | Paços de Ferreira - Tondela | 1:1 |
| 06.05.2022 | 21:15 | Boavista - Vitória Guimarães | 1:1 |
| 07.05.2022 | 16:30 | Estoril - Moreirense | 1:0 |
| 07.05.2022 | 19:00 | Benfica - Porto | 0:1 |
| 07.05.2022 | 21:30 | Portimonense - Sporting CP | 2:3 |
| 08.05.2022 | 16:30 | Gil Vicente - Tondela | 3:0 |
| 08.05.2022 | 16:30 | Vizela - Marítimo | 1:1 |
| 08.05.2022 | 19:00 | Sporting Braga - Arouca | 1:0 |
| 08.05.2022 | 21:30 | Santa Clara - Paços de Ferreira | 2:0 |
| 09.05.2022 | 21:15 | Belenenses - Famalicão | 2:3 |
| 13.05.2022 | 21:15 | Paços de Ferreira - Benfica | 0:2 |
| 14.05.2022 | 16:30 | Arouca - Belenenses | 0:0 |
| 14.05.2022 | 16:30 | Tondela - Boavista | 2:2 |
| 14.05.2022 | 16:30 | Moreirense - Vizela | 4:1 |
| 14.05.2022 | 19:00 | Marítimo - Portimonense | 0:1 |
| 14.05.2022 | 19:00 | Porto - Estoril | 2:0 |
| 14.05.2022 | 21:30 | Sporting CP - Santa Clara | 4:0 |
| 15.05.2022 | 19:00 | Famalicão - Sporting Braga | 3:2 |
| 15.05.2022 | 21:30 | Vitória Guimarães - Gil Vicente | 5:0 |