| 07.08.2021 | 16:00 | Bolton Wanderers - Milton Keynes Dons | 3:3 |
| 07.08.2021 | 16:00 | Cambridge United - Oxford United | 1:1 |
| 07.08.2021 | 16:00 | Crewe Alexandra - Cheltenham Town | 1:1 |
| 07.08.2021 | 16:00 | Doncaster Rovers - AFC Wimbledon | 1:2 |
| 07.08.2021 | 16:00 | Fleetwood Town - Portsmouth | 0:1 |
| 07.08.2021 | 16:00 | Gillingham - Lincoln City | 1:1 |
| 07.08.2021 | 16:00 | Ipswich Town - Morecambe | 2:2 |
| 07.08.2021 | 16:00 | Rotherham United - Plymouth Argyle | 2:0 |
| 07.08.2021 | 16:00 | Shrewsbury Town - Burton Albion | 0:1 |
| 07.08.2021 | 16:00 | Sunderland - Wigan Athletic | 2:1 |
| 07.08.2021 | 16:00 | Wycombe Wanderers - Accrington Stanley | 2:1 |
| 07.08.2021 | 18:30 | Charlton Athletic - Sheffield Wednesday | 0:0 |
| 14.08.2021 | 16:00 | AFC Wimbledon - Bolton Wanderers | 3:3 |
| 14.08.2021 | 16:00 | Accrington Stanley - Cambridge United | 2:1 |
| 14.08.2021 | 16:00 | Burton Albion - Ipswich Town | 2:1 |
| 14.08.2021 | 16:00 | Cheltenham Town - Wycombe Wanderers | 1:3 |
| 14.08.2021 | 16:00 | Lincoln City - Fleetwood Town | 2:1 |
| 14.08.2021 | 16:00 | Milton Keynes Dons - Sunderland | 1:2 |
| 14.08.2021 | 16:00 | Morecambe - Shrewsbury Town | 2:0 |
| 14.08.2021 | 16:00 | Oxford United - Charlton Athletic | 2:1 |
| 14.08.2021 | 16:00 | Plymouth Argyle - Gillingham | 1:0 |
| 14.08.2021 | 16:00 | Portsmouth - Crewe Alexandra | 2:0 |
| 14.08.2021 | 16:00 | Sheffield Wednesday - Doncaster Rovers | 2:0 |
| 14.08.2021 | 16:00 | Wigan Athletic - Rotherham United | 1:0 |
| 17.08.2021 | 20:45 | AFC Wimbledon - Gillingham | 1:1 |
| 17.08.2021 | 20:45 | Accrington Stanley - Doncaster Rovers | 1:0 |
| 17.08.2021 | 20:45 | Burton Albion - Sunderland | 1:0 |
| 17.08.2021 | 20:45 | Cheltenham Town - Ipswich Town | 2:1 |
| 17.08.2021 | 20:45 | Lincoln City - Bolton Wanderers | 0:1 |
| 17.08.2021 | 20:45 | Milton Keynes Dons - Charlton Athletic | 2:1 |
| 17.08.2021 | 20:45 | Morecambe - Rotherham United | 0:1 |
| 17.08.2021 | 20:45 | Oxford United - Crewe Alexandra | 1:0 |
| 17.08.2021 | 20:45 | Plymouth Argyle - Cambridge United | 1:1 |
| 17.08.2021 | 20:45 | Portsmouth - Shrewsbury Town | 1:0 |
| 17.08.2021 | 20:45 | Sheffield Wednesday - Fleetwood Town | 1:0 |
| 17.08.2021 | 20:45 | Wigan Athletic - Wycombe Wanderers | 1:1 |
| 21.08.2021 | 14:15 | Rotherham United - Sheffield Wednesday | 0:2 |
| 21.08.2021 | 16:00 | Bolton Wanderers - Oxford United | 2:1 |
| 21.08.2021 | 16:00 | Cambridge United - Burton Albion | 3:0 |
| 21.08.2021 | 16:00 | Charlton Athletic - Wigan Athletic | 0:2 |
| 21.08.2021 | 16:00 | Crewe Alexandra - Accrington Stanley | 0:1 |
| 21.08.2021 | 16:00 | Doncaster Rovers - Portsmouth | 0:0 |
| 21.08.2021 | 16:00 | Fleetwood Town - Cheltenham Town | 3:2 |
| 21.08.2021 | 16:00 | Gillingham - Morecambe | 2:1 |
| 21.08.2021 | 16:00 | Ipswich Town - Milton Keynes Dons | 2:2 |
| 21.08.2021 | 16:00 | Shrewsbury Town - Plymouth Argyle | 0:3 |
| 21.08.2021 | 16:00 | Sunderland - AFC Wimbledon | 1:0 |
| 21.08.2021 | 16:00 | Wycombe Wanderers - Lincoln City | 1:0 |
| 27.08.2021 | 20:45 | Burton Albion - Cheltenham Town | 1:1 |
| 28.08.2021 | 14:00 | Rotherham United - Doncaster Rovers | 2:0 |
| 28.08.2021 | 16:00 | Cambridge United - Bolton Wanderers | 1:0 |
| 28.08.2021 | 16:00 | Charlton Athletic - Crewe Alexandra | 2:0 |
| 28.08.2021 | 16:00 | Ipswich Town - AFC Wimbledon | 2:2 |
| 28.08.2021 | 16:00 | Milton Keynes Dons - Accrington Stanley | 2:0 |
| 28.08.2021 | 16:00 | Morecambe - Sheffield Wednesday | 1:0 |
| 28.08.2021 | 16:00 | Oxford United - Lincoln City | 3:1 |
| 28.08.2021 | 16:00 | Plymouth Argyle - Fleetwood Town | 1:1 |
| 28.08.2021 | 16:00 | Shrewsbury Town - Gillingham | 2:1 |
| 28.08.2021 | 16:00 | Sunderland - Wycombe Wanderers | 3:1 |
| 28.08.2021 | 16:00 | Wigan Athletic - Portsmouth | 1:0 |
| 04.09.2021 | 16:00 | AFC Wimbledon - Oxford United | 3:1 |
| 04.09.2021 | 16:00 | Accrington Stanley - Shrewsbury Town | 1:0 |
| 04.09.2021 | 16:00 | Cheltenham Town - Milton Keynes Dons | 1:1 |
| 06.09.2021 | 21:00 | Bolton Wanderers - Burton Albion | 0:0 |
| 14.09.2021 | 20:45 | Lincoln City - Rotherham United | 1:1 |
| 21.09.2021 | 20:45 | Crewe Alexandra - Morecambe | 1:3 |
| 21.09.2021 | 20:45 | Gillingham - Charlton Athletic | 1:1 |
| 21.09.2021 | 20:45 | Portsmouth - Plymouth Argyle | 2:2 |
| 26.10.2021 | 20:45 | Doncaster Rovers - Cambridge United | 1:1 |
| 02.11.2021 | 20:45 | Fleetwood Town - Wigan Athletic | 2:3 |
| 02.11.2021 | 20:45 | Sheffield Wednesday - Sunderland | 3:0 |
| 02.11.2021 | 20:45 | Wycombe Wanderers - Ipswich Town | 1:4 |
| 11.09.2021 | 16:00 | Burton Albion - Gillingham | 1:1 |
| 11.09.2021 | 16:00 | Cambridge United - Lincoln City | 1:5 |
| 11.09.2021 | 16:00 | Charlton Athletic - Cheltenham Town | 1:2 |
| 11.09.2021 | 16:00 | Ipswich Town - Bolton Wanderers | 2:5 |
| 11.09.2021 | 16:00 | Milton Keynes Dons - Portsmouth | 1:0 |
| 11.09.2021 | 16:00 | Morecambe - AFC Wimbledon | 3:4 |
| 11.09.2021 | 16:00 | Oxford United - Wycombe Wanderers | 0:0 |
| 11.09.2021 | 16:00 | Plymouth Argyle - Sheffield Wednesday | 3:0 |
| 11.09.2021 | 16:00 | Rotherham United - Fleetwood Town | 2:4 |
| 11.09.2021 | 16:00 | Shrewsbury Town - Crewe Alexandra | 1:1 |
| 11.09.2021 | 16:00 | Sunderland - Accrington Stanley | 2:1 |
| 11.09.2021 | 16:00 | Wigan Athletic - Doncaster Rovers | 2:1 |
| 18.09.2021 | 16:00 | AFC Wimbledon - Plymouth Argyle | 0:1 |
| 18.09.2021 | 16:00 | Accrington Stanley - Wigan Athletic | 1:4 |
| 18.09.2021 | 16:00 | Bolton Wanderers - Rotherham United | 0:2 |
| 18.09.2021 | 16:00 | Cheltenham Town - Oxford United | 1:0 |
| 18.09.2021 | 16:00 | Crewe Alexandra - Burton Albion | 2:0 |
| 18.09.2021 | 16:00 | Doncaster Rovers - Morecambe | 1:0 |
| 18.09.2021 | 16:00 | Fleetwood Town - Sunderland | 2:2 |
| 18.09.2021 | 16:00 | Gillingham - Milton Keynes Dons | 1:4 |
| 18.09.2021 | 16:00 | Lincoln City - Ipswich Town | 0:1 |
| 18.09.2021 | 16:00 | Portsmouth - Cambridge United | 1:2 |
| 18.09.2021 | 16:00 | Sheffield Wednesday - Shrewsbury Town | 1:1 |
| 18.09.2021 | 16:00 | Wycombe Wanderers - Charlton Athletic | 2:1 |
| 25.09.2021 | 16:00 | Burton Albion - Lincoln City | 1:2 |
| 25.09.2021 | 16:00 | Cambridge United - Fleetwood Town | 2:2 |
| 25.09.2021 | 16:00 | Charlton Athletic - Portsmouth | 2:2 |
| 25.09.2021 | 16:00 | Ipswich Town - Sheffield Wednesday | 1:1 |
| 25.09.2021 | 16:00 | Milton Keynes Dons - Wycombe Wanderers | 1:0 |
| 25.09.2021 | 16:00 | Morecambe - Accrington Stanley | 3:3 |
| 25.09.2021 | 16:00 | Oxford United - Gillingham | 1:1 |
| 25.09.2021 | 16:00 | Plymouth Argyle - Doncaster Rovers | 2:1 |
| 25.09.2021 | 16:00 | Rotherham United - Crewe Alexandra | 1:1 |
| 25.09.2021 | 16:00 | Shrewsbury Town - AFC Wimbledon | 2:1 |
| 25.09.2021 | 16:00 | Sunderland - Bolton Wanderers | 1:0 |
| 25.09.2021 | 16:00 | Wigan Athletic - Cheltenham Town | 2:0 |
| 28.09.2021 | 20:45 | Burton Albion - Portsmouth | 2:1 |
| 28.09.2021 | 20:45 | Cambridge United - Gillingham | 0:2 |
| 28.09.2021 | 20:45 | Charlton Athletic - Bolton Wanderers | 1:4 |
| 28.09.2021 | 20:45 | Ipswich Town - Doncaster Rovers | 6:0 |
| 28.09.2021 | 20:45 | Milton Keynes Dons - Fleetwood Town | 3:3 |
| 28.09.2021 | 20:45 | Morecambe - Lincoln City | 2:0 |
| 28.09.2021 | 20:45 | Oxford United - Accrington Stanley | 5:1 |
| 28.09.2021 | 20:45 | Plymouth Argyle - Crewe Alexandra | 1:1 |
| 28.09.2021 | 20:45 | Rotherham United - AFC Wimbledon | 3:0 |
| 28.09.2021 | 20:45 | Shrewsbury Town - Wycombe Wanderers | 1:2 |
| 28.09.2021 | 20:45 | Sunderland - Cheltenham Town | 5:0 |
| 28.09.2021 | 20:45 | Wigan Athletic - Sheffield Wednesday | 1:2 |
| 02.10.2021 | 16:00 | AFC Wimbledon - Burton Albion | 1:1 |
| 02.10.2021 | 16:00 | Accrington Stanley - Ipswich Town | 2:1 |
| 02.10.2021 | 16:00 | Bolton Wanderers - Shrewsbury Town | 2:1 |
| 02.10.2021 | 16:00 | Cheltenham Town - Rotherham United | 0:2 |
| 02.10.2021 | 16:00 | Crewe Alexandra - Cambridge United | 2:2 |
| 02.10.2021 | 16:00 | Doncaster Rovers - Milton Keynes Dons | 2:1 |
| 02.10.2021 | 16:00 | Fleetwood Town - Charlton Athletic | 1:2 |
| 02.10.2021 | 16:00 | Gillingham - Wigan Athletic | 0:2 |
| 02.10.2021 | 16:00 | Lincoln City - Plymouth Argyle | 2:2 |
| 02.10.2021 | 16:00 | Portsmouth - Sunderland | 4:0 |
| 02.10.2021 | 16:00 | Sheffield Wednesday - Oxford United | 1:2 |
| 02.10.2021 | 16:00 | Wycombe Wanderers - Morecambe | 4:3 |
| 09.10.2021 | 16:00 | Ipswich Town - Shrewsbury Town | 2:1 |
| 09.10.2021 | 16:00 | Plymouth Argyle - Burton Albion | 2:1 |
| 09.10.2021 | 16:00 | Sheffield Wednesday - Bolton Wanderers | 1:0 |
| 09.10.2021 | 16:00 | Wycombe Wanderers - Gillingham | 2:0 |
| 26.10.2021 | 20:45 | Wigan Athletic - Lincoln City | 1:2 |
| 02.11.2021 | 20:45 | Charlton Athletic - Rotherham United | 1:1 |
| 02.11.2021 | 20:45 | Crewe Alexandra - Doncaster Rovers | 1:1 |
| 02.11.2021 | 20:45 | Morecambe - Cambridge United | 0:2 |
| 02.11.2021 | 20:45 | Portsmouth - Cheltenham Town | 1:1 |
| 04.12.2021 | 16:00 | Accrington Stanley - Fleetwood Town | 5:1 |
| 04.12.2021 | 16:00 | Sunderland - Oxford United | 1:1 |
| 11.01.2022 | 20:45 | Milton Keynes Dons - AFC Wimbledon | 1:0 |
| 15.10.2021 | 20:45 | Burton Albion - Morecambe | 3:2 |
| 16.10.2021 | 16:00 | AFC Wimbledon - Sheffield Wednesday | 2:2 |
| 16.10.2021 | 16:00 | Bolton Wanderers - Wigan Athletic | 0:4 |
| 16.10.2021 | 16:00 | Cambridge United - Ipswich Town | 2:2 |
| 16.10.2021 | 16:00 | Cheltenham Town - Accrington Stanley | 1:0 |
| 16.10.2021 | 16:00 | Doncaster Rovers - Wycombe Wanderers | 0:2 |
| 16.10.2021 | 16:00 | Fleetwood Town - Crewe Alexandra | 3:0 |
| 16.10.2021 | 16:00 | Gillingham - Sunderland | 1:2 |
| 16.10.2021 | 16:00 | Lincoln City - Charlton Athletic | 2:1 |
| 16.10.2021 | 16:00 | Oxford United - Plymouth Argyle | 1:3 |
| 16.10.2021 | 16:00 | Rotherham United - Portsmouth | 4:1 |
| 16.10.2021 | 16:00 | Shrewsbury Town - Milton Keynes Dons | 1:0 |
| 19.10.2021 | 20:45 | Cambridge United - Sheffield Wednesday | 1:1 |
| 19.10.2021 | 20:45 | Charlton Athletic - Accrington Stanley | 2:3 |
| 19.10.2021 | 20:45 | Cheltenham Town - Morecambe | 3:1 |
| 19.10.2021 | 20:45 | Crewe Alexandra - Sunderland | 0:4 |
| 19.10.2021 | 20:45 | Fleetwood Town - Burton Albion | 0:1 |
| 19.10.2021 | 20:45 | Gillingham - Doncaster Rovers | 1:0 |
| 19.10.2021 | 20:45 | Lincoln City - AFC Wimbledon | 0:1 |
| 19.10.2021 | 20:45 | Oxford United - Shrewsbury Town | 2:0 |
| 19.10.2021 | 20:45 | Plymouth Argyle - Bolton Wanderers | 3:0 |
| 19.10.2021 | 20:45 | Portsmouth - Ipswich Town | 0:4 |
| 19.10.2021 | 20:45 | Rotherham United - Wycombe Wanderers | 0:0 |
| 19.10.2021 | 20:45 | Wigan Athletic - Milton Keynes Dons | 1:2 |
| 23.10.2021 | 16:00 | AFC Wimbledon - Wigan Athletic | 0:2 |
| 23.10.2021 | 16:00 | Accrington Stanley - Portsmouth | 2:2 |
| 23.10.2021 | 16:00 | Bolton Wanderers - Gillingham | 2:2 |
| 23.10.2021 | 16:00 | Burton Albion - Oxford United | 1:3 |
| 23.10.2021 | 16:00 | Doncaster Rovers - Cheltenham Town | 3:2 |
| 23.10.2021 | 16:00 | Ipswich Town - Fleetwood Town | 2:1 |
| 23.10.2021 | 16:00 | Milton Keynes Dons - Rotherham United | 0:3 |
| 23.10.2021 | 16:00 | Morecambe - Plymouth Argyle | 1:1 |
| 23.10.2021 | 16:00 | Sheffield Wednesday - Lincoln City | 1:1 |
| 23.10.2021 | 16:00 | Shrewsbury Town - Cambridge United | 4:1 |
| 23.10.2021 | 16:00 | Sunderland - Charlton Athletic | 0:1 |
| 23.10.2021 | 16:00 | Wycombe Wanderers - Crewe Alexandra | 2:1 |
| 30.10.2021 | 16:00 | Cambridge United - AFC Wimbledon | 1:0 |
| 30.10.2021 | 16:00 | Charlton Athletic - Doncaster Rovers | 4:0 |
| 30.10.2021 | 16:00 | Cheltenham Town - Sheffield Wednesday | 2:2 |
| 30.10.2021 | 16:00 | Crewe Alexandra - Milton Keynes Dons | 1:4 |
| 30.10.2021 | 16:00 | Fleetwood Town - Wycombe Wanderers | 3:3 |
| 30.10.2021 | 16:00 | Gillingham - Accrington Stanley | 0:0 |
| 30.10.2021 | 16:00 | Lincoln City - Shrewsbury Town | 1:1 |
| 30.10.2021 | 16:00 | Oxford United - Morecambe | 3:1 |
| 30.10.2021 | 16:00 | Plymouth Argyle - Ipswich Town | 2:1 |
| 30.10.2021 | 16:00 | Portsmouth - Bolton Wanderers | 1:0 |
| 30.10.2021 | 16:00 | Rotherham United - Sunderland | 5:1 |
| 30.10.2021 | 16:00 | Wigan Athletic - Burton Albion | 2:0 |
| 12.11.2021 | 21:00 | Bolton Wanderers - Crewe Alexandra | 2:0 |
| 13.11.2021 | 16:00 | Accrington Stanley - Plymouth Argyle | 1:4 |
| 13.11.2021 | 16:00 | Burton Albion - Charlton Athletic | 0:1 |
| 13.11.2021 | 16:00 | Ipswich Town - Oxford United | 0:0 |
| 13.11.2021 | 16:00 | Milton Keynes Dons - Cambridge United | 4:1 |
| 13.11.2021 | 16:00 | Sheffield Wednesday - Gillingham | 1:1 |
| 13.11.2021 | 16:00 | Wycombe Wanderers - Portsmouth | 0:1 |
| 08.01.2022 | 16:00 | Doncaster Rovers - Fleetwood Town | 0:1 |
| 11.01.2022 | 20:45 | Sunderland - Lincoln City | 1:3 |
| 18.01.2022 | 20:45 | Morecambe - Wigan Athletic | 1:2 |
| 01.02.2022 | 20:45 | AFC Wimbledon - Cheltenham Town | 2:2 |
| 01.03.2022 | 20:45 | Shrewsbury Town - Rotherham United | 0:0 |
| 20.11.2021 | 16:00 | Accrington Stanley - Sheffield Wednesday | 2:3 |
| 20.11.2021 | 16:00 | Charlton Athletic - Plymouth Argyle | 2:0 |
| 20.11.2021 | 16:00 | Cheltenham Town - Shrewsbury Town | 2:1 |
| 20.11.2021 | 16:00 | Crewe Alexandra - Gillingham | 2:0 |
| 20.11.2021 | 16:00 | Doncaster Rovers - Lincoln City | 0:0 |
| 20.11.2021 | 16:00 | Fleetwood Town - Morecambe | 1:2 |
| 20.11.2021 | 16:00 | Milton Keynes Dons - Burton Albion | 1:0 |
| 20.11.2021 | 16:00 | Portsmouth - AFC Wimbledon | 2:1 |
| 20.11.2021 | 16:00 | Rotherham United - Cambridge United | 3:1 |
| 20.11.2021 | 16:00 | Sunderland - Ipswich Town | 2:0 |
| 20.11.2021 | 16:00 | Wycombe Wanderers - Bolton Wanderers | 1:0 |
| 01.02.2022 | 20:45 | Wigan Athletic - Oxford United | 1:1 |
| 23.11.2021 | 20:45 | AFC Wimbledon - Crewe Alexandra | 3:2 |
| 23.11.2021 | 20:45 | Burton Albion - Accrington Stanley | 4:0 |
| 23.11.2021 | 20:45 | Cambridge United - Wigan Athletic | 2:2 |
| 23.11.2021 | 20:45 | Gillingham - Cheltenham Town | 0:2 |
| 23.11.2021 | 20:45 | Ipswich Town - Rotherham United | 0:2 |
| 23.11.2021 | 20:45 | Lincoln City - Portsmouth | 0:3 |
| 23.11.2021 | 20:45 | Morecambe - Charlton Athletic | 2:2 |
| 23.11.2021 | 20:45 | Oxford United - Fleetwood Town | 3:1 |
| 23.11.2021 | 20:45 | Plymouth Argyle - Wycombe Wanderers | 0:3 |
| 23.11.2021 | 20:45 | Sheffield Wednesday - Milton Keynes Dons | 2:1 |
| 23.11.2021 | 20:45 | Shrewsbury Town - Sunderland | 1:1 |
| 23.11.2021 | 21:00 | Bolton Wanderers - Doncaster Rovers | 3:0 |
| 27.11.2021 | 16:00 | AFC Wimbledon - Fleetwood Town | 2:2 |
| 27.11.2021 | 16:00 | Bolton Wanderers - Cheltenham Town | 2:2 |
| 27.11.2021 | 16:00 | Burton Albion - Doncaster Rovers | 2:0 |
| 27.11.2021 | 16:00 | Cambridge United - Sunderland | 1:2 |
| 27.11.2021 | 16:00 | Gillingham - Portsmouth | 0:1 |
| 27.11.2021 | 16:00 | Morecambe - Milton Keynes Dons | 0:4 |
| 27.11.2021 | 16:00 | Oxford United - Rotherham United | 0:0 |
| 27.11.2021 | 16:00 | Plymouth Argyle - Wigan Athletic | 1:2 |
| 27.11.2021 | 16:00 | Sheffield Wednesday - Wycombe Wanderers | 2:2 |
| 27.11.2021 | 16:00 | Shrewsbury Town - Charlton Athletic | 1:0 |
| 27.11.2021 | 16:15 | Lincoln City - Accrington Stanley | 0:1 |
| 28.11.2021 | 16:00 | Ipswich Town - Crewe Alexandra | 2:1 |
| 07.12.2021 | 20:45 | Accrington Stanley - AFC Wimbledon | 0:2 |
| 07.12.2021 | 20:45 | Charlton Athletic - Ipswich Town | 2:0 |
| 07.12.2021 | 20:45 | Cheltenham Town - Cambridge United | 0:5 |
| 07.12.2021 | 20:45 | Crewe Alexandra - Lincoln City | 2:0 |
| 07.12.2021 | 20:45 | Doncaster Rovers - Oxford United | 1:2 |
| 07.12.2021 | 20:45 | Fleetwood Town - Bolton Wanderers | 3:0 |
| 07.12.2021 | 20:45 | Portsmouth - Sheffield Wednesday | 0:0 |
| 07.12.2021 | 20:45 | Rotherham United - Gillingham | 5:1 |
| 07.12.2021 | 20:45 | Sunderland - Morecambe | 5:0 |
| 07.12.2021 | 20:45 | Wycombe Wanderers - Burton Albion | 2:1 |
| 08.12.2021 | 20:45 | Milton Keynes Dons - Plymouth Argyle | 1:1 |
| 08.12.2021 | 20:45 | Wigan Athletic - Shrewsbury Town | 2:1 |
| 11.12.2021 | 16:00 | Accrington Stanley - Bolton Wanderers | 1:0 |
| 11.12.2021 | 16:00 | Charlton Athletic - Cambridge United | 2:0 |
| 11.12.2021 | 16:00 | Cheltenham Town - Lincoln City | 2:2 |
| 11.12.2021 | 16:00 | Crewe Alexandra - Sheffield Wednesday | 0:2 |
| 11.12.2021 | 16:00 | Doncaster Rovers - Shrewsbury Town | 1:0 |
| 11.12.2021 | 16:00 | Fleetwood Town - Gillingham | 2:1 |
| 11.12.2021 | 16:00 | Milton Keynes Dons - Oxford United | 1:2 |
| 11.12.2021 | 16:00 | Portsmouth - Morecambe | 2:0 |
| 11.12.2021 | 16:00 | Rotherham United - Burton Albion | 3:1 |
| 11.12.2021 | 16:00 | Sunderland - Plymouth Argyle | 2:1 |
| 11.12.2021 | 16:00 | Wigan Athletic - Ipswich Town | 1:1 |
| 11.12.2021 | 16:00 | Wycombe Wanderers - AFC Wimbledon | 2:2 |
| 18.12.2021 | 16:00 | Cambridge United - Rotherham United | 0:1 |
| 18.12.2021 | 16:00 | Ipswich Town - Sunderland | 1:1 |
| 18.12.2021 | 16:00 | Morecambe - Fleetwood Town | 0:0 |
| 18.12.2021 | 16:00 | Oxford United - Wigan Athletic | 2:3 |
| 18.12.2021 | 16:00 | Plymouth Argyle - Charlton Athletic | 1:0 |
| 18.12.2021 | 16:00 | Shrewsbury Town - Cheltenham Town | 3:1 |
| 11.01.2022 | 21:00 | Bolton Wanderers - Wycombe Wanderers | 0:2 |
| 18.01.2022 | 20:45 | AFC Wimbledon - Portsmouth | 0:0 |
| 25.01.2022 | 20:45 | Burton Albion - Milton Keynes Dons | 0:1 |
| 01.02.2022 | 20:45 | Gillingham - Crewe Alexandra | 1:0 |
| 15.02.2022 | 20:45 | Lincoln City - Doncaster Rovers | 0:1 |
| 15.03.2022 | 20:45 | Sheffield Wednesday - Accrington Stanley | 1:1 |
| 26.12.2021 | 16:00 | Accrington Stanley - Rotherham United | 1:0 |
| 26.12.2021 | 16:00 | Cheltenham Town - Plymouth Argyle | 0:2 |
| 26.12.2021 | 16:00 | Fleetwood Town - Shrewsbury Town | 0:3 |
| 26.12.2021 | 16:00 | Lincoln City - Milton Keynes Dons | 2:3 |
| 27.12.2021 | 13:30 | Doncaster Rovers - Sunderland | 0:3 |
| 08.01.2022 | 16:00 | Gillingham - Ipswich Town | 0:4 |
| 01.03.2022 | 20:45 | Portsmouth - Oxford United | 3:2 |
| 01.03.2022 | 20:45 | Sheffield Wednesday - Burton Albion | 5:2 |
| 01.03.2022 | 20:45 | Wycombe Wanderers - Cambridge United | 3:0 |
| 08.03.2022 | 21:00 | Bolton Wanderers - Morecambe | 1:1 |
| 15.03.2022 | 20:45 | Crewe Alexandra - Wigan Athletic | 0:2 |
| 05.04.2022 | 20:45 | AFC Wimbledon - Charlton Athletic | 1:1 |
| 29.12.2021 | 20:45 | Ipswich Town - Wycombe Wanderers | 1:0 |
| 29.12.2021 | 20:45 | Morecambe - Crewe Alexandra | 1:2 |
| 29.12.2021 | 20:45 | Oxford United - AFC Wimbledon | 3:0 |
| 29.12.2021 | 20:45 | Shrewsbury Town - Accrington Stanley | 0:0 |
| 30.12.2021 | 20:45 | Sunderland - Sheffield Wednesday | 5:0 |
| 18.01.2022 | 20:45 | Cambridge United - Doncaster Rovers | 3:1 |
| 15.02.2022 | 20:45 | Burton Albion - Bolton Wanderers | 3:1 |
| 01.03.2022 | 20:45 | Wigan Athletic - Fleetwood Town | 2:0 |
| 08.03.2022 | 20:45 | Milton Keynes Dons - Cheltenham Town | 3:1 |
| 15.03.2022 | 20:45 | Charlton Athletic - Gillingham | 1:0 |
| 15.03.2022 | 20:45 | Plymouth Argyle - Portsmouth | 1:0 |
| 15.03.2022 | 20:45 | Rotherham United - Lincoln City | 2:1 |
| 01.01.2022 | 16:00 | Burton Albion - Crewe Alexandra | 4:1 |
| 01.01.2022 | 16:00 | Charlton Athletic - Wycombe Wanderers | 0:1 |
| 01.01.2022 | 16:00 | Milton Keynes Dons - Gillingham | 0:0 |
| 01.01.2022 | 16:00 | Oxford United - Cheltenham Town | 1:1 |
| 01.01.2022 | 16:00 | Rotherham United - Bolton Wanderers | 2:1 |
| 02.01.2022 | 16:00 | Morecambe - Doncaster Rovers | 4:3 |
| 02.01.2022 | 16:00 | Shrewsbury Town - Sheffield Wednesday | 1:0 |
| 03.01.2022 | 16:00 | Cambridge United - Portsmouth | 0:0 |
| 08.03.2022 | 20:45 | Ipswich Town - Lincoln City | 2:0 |
| 08.03.2022 | 20:45 | Plymouth Argyle - AFC Wimbledon | 2:0 |
| 08.03.2022 | 20:45 | Sunderland - Fleetwood Town | 3:1 |
| 05.04.2022 | 20:45 | Wigan Athletic - Accrington Stanley | 3:0 |
| 08.01.2022 | 13:30 | Wycombe Wanderers - Sunderland | 3:3 |
| 08.01.2022 | 16:00 | Accrington Stanley - Milton Keynes Dons | 1:1 |
| 08.01.2022 | 16:00 | Cheltenham Town - Burton Albion | 1:1 |
| 08.01.2022 | 16:00 | Lincoln City - Oxford United | 2:0 |
| 12.01.2022 | 20:45 | Crewe Alexandra - Charlton Athletic | 2:1 |
| 25.01.2022 | 20:45 | AFC Wimbledon - Ipswich Town | 0:2 |
| 25.01.2022 | 20:45 | Fleetwood Town - Plymouth Argyle | 3:3 |
| 25.01.2022 | 20:45 | Gillingham - Shrewsbury Town | 0:0 |
| 01.02.2022 | 20:45 | Doncaster Rovers - Rotherham United | 0:5 |
| 01.02.2022 | 20:45 | Sheffield Wednesday - Morecambe | 2:0 |
| 01.02.2022 | 21:00 | Bolton Wanderers - Cambridge United | 2:0 |
| 26.04.2022 | 20:45 | Portsmouth - Wigan Athletic | 3:2 |
| 15.01.2022 | 16:00 | AFC Wimbledon - Morecambe | 0:0 |
| 15.01.2022 | 16:00 | Accrington Stanley - Sunderland | 1:1 |
| 15.01.2022 | 16:00 | Bolton Wanderers - Ipswich Town | 2:0 |
| 15.01.2022 | 16:00 | Cheltenham Town - Charlton Athletic | 1:1 |
| 15.01.2022 | 16:00 | Crewe Alexandra - Shrewsbury Town | 0:0 |
| 15.01.2022 | 16:00 | Doncaster Rovers - Wigan Athletic | 1:2 |
| 15.01.2022 | 16:00 | Fleetwood Town - Rotherham United | 1:0 |
| 15.01.2022 | 16:00 | Gillingham - Burton Albion | 1:3 |
| 15.01.2022 | 16:00 | Lincoln City - Cambridge United | 0:1 |
| 15.01.2022 | 16:00 | Portsmouth - Milton Keynes Dons | 1:2 |
| 15.01.2022 | 16:00 | Sheffield Wednesday - Plymouth Argyle | 4:2 |
| 15.01.2022 | 16:00 | Wycombe Wanderers - Oxford United | 2:0 |
| 22.01.2022 | 16:00 | Burton Albion - AFC Wimbledon | 1:1 |
| 22.01.2022 | 16:00 | Cambridge United - Crewe Alexandra | 1:0 |
| 22.01.2022 | 16:00 | Charlton Athletic - Fleetwood Town | 2:0 |
| 22.01.2022 | 16:00 | Ipswich Town - Accrington Stanley | 2:1 |
| 22.01.2022 | 16:00 | Milton Keynes Dons - Doncaster Rovers | 0:1 |
| 22.01.2022 | 16:00 | Morecambe - Wycombe Wanderers | 3:2 |
| 22.01.2022 | 16:00 | Oxford United - Sheffield Wednesday | 3:2 |
| 22.01.2022 | 16:00 | Plymouth Argyle - Lincoln City | 1:2 |
| 22.01.2022 | 16:00 | Rotherham United - Cheltenham Town | 1:0 |
| 22.01.2022 | 16:00 | Shrewsbury Town - Bolton Wanderers | 0:1 |
| 22.01.2022 | 16:00 | Sunderland - Portsmouth | 1:0 |
| 22.01.2022 | 16:00 | Wigan Athletic - Gillingham | 3:2 |
| 29.01.2022 | 16:00 | AFC Wimbledon - Shrewsbury Town | 1:1 |
| 29.01.2022 | 16:00 | Accrington Stanley - Morecambe | 2:2 |
| 29.01.2022 | 16:00 | Bolton Wanderers - Sunderland | 6:0 |
| 29.01.2022 | 16:00 | Cheltenham Town - Wigan Athletic | 0:0 |
| 29.01.2022 | 16:00 | Crewe Alexandra - Rotherham United | 0:2 |
| 29.01.2022 | 16:00 | Doncaster Rovers - Plymouth Argyle | 1:3 |
| 29.01.2022 | 16:00 | Fleetwood Town - Cambridge United | 1:1 |
| 29.01.2022 | 16:00 | Gillingham - Oxford United | 2:7 |
| 29.01.2022 | 16:00 | Lincoln City - Burton Albion | 1:2 |
| 29.01.2022 | 16:00 | Sheffield Wednesday - Ipswich Town | 1:0 |
| 29.01.2022 | 16:00 | Wycombe Wanderers - Milton Keynes Dons | 0:1 |
| 31.01.2022 | 20:45 | Portsmouth - Charlton Athletic | 1:2 |
| 05.02.2022 | 16:00 | Burton Albion - Sheffield Wednesday | 0:2 |
| 05.02.2022 | 16:00 | Charlton Athletic - AFC Wimbledon | 3:2 |
| 05.02.2022 | 16:00 | Ipswich Town - Gillingham | 1:0 |
| 05.02.2022 | 16:00 | Milton Keynes Dons - Lincoln City | 2:1 |
| 05.02.2022 | 16:00 | Morecambe - Bolton Wanderers | 1:1 |
| 05.02.2022 | 16:00 | Oxford United - Portsmouth | 3:2 |
| 05.02.2022 | 16:00 | Rotherham United - Accrington Stanley | 1:0 |
| 05.02.2022 | 16:00 | Shrewsbury Town - Fleetwood Town | 1:1 |
| 05.02.2022 | 16:00 | Sunderland - Doncaster Rovers | 1:2 |
| 15.02.2022 | 20:45 | Wigan Athletic - Crewe Alexandra | 2:0 |
| 22.03.2022 | 20:45 | Plymouth Argyle - Cheltenham Town | 2:0 |
| 05.04.2022 | 20:45 | Cambridge United - Wycombe Wanderers | 1:4 |
| 08.02.2022 | 20:45 | AFC Wimbledon - Rotherham United | 0:1 |
| 08.02.2022 | 20:45 | Accrington Stanley - Oxford United | 2:0 |
| 08.02.2022 | 20:45 | Cheltenham Town - Sunderland | 2:1 |
| 08.02.2022 | 20:45 | Crewe Alexandra - Plymouth Argyle | 1:4 |
| 08.02.2022 | 20:45 | Doncaster Rovers - Ipswich Town | 0:1 |
| 08.02.2022 | 20:45 | Fleetwood Town - Milton Keynes Dons | 1:1 |
| 08.02.2022 | 20:45 | Gillingham - Cambridge United | 1:0 |
| 08.02.2022 | 20:45 | Lincoln City - Morecambe | 2:1 |
| 08.02.2022 | 20:45 | Portsmouth - Burton Albion | 2:1 |
| 08.02.2022 | 20:45 | Sheffield Wednesday - Wigan Athletic | 1:0 |
| 08.02.2022 | 20:45 | Wycombe Wanderers - Shrewsbury Town | 0:0 |
| 08.02.2022 | 21:00 | Bolton Wanderers - Charlton Athletic | 2:1 |
| 12.02.2022 | 16:00 | AFC Wimbledon - Sunderland | 1:1 |
| 12.02.2022 | 16:00 | Accrington Stanley - Crewe Alexandra | 4:1 |
| 12.02.2022 | 16:00 | Burton Albion - Cambridge United | 2:2 |
| 12.02.2022 | 16:00 | Cheltenham Town - Fleetwood Town | 2:0 |
| 12.02.2022 | 16:00 | Lincoln City - Wycombe Wanderers | 1:1 |
| 12.02.2022 | 16:00 | Milton Keynes Dons - Ipswich Town | 0:0 |
| 12.02.2022 | 16:00 | Morecambe - Gillingham | 1:1 |
| 12.02.2022 | 16:00 | Oxford United - Bolton Wanderers | 2:3 |
| 12.02.2022 | 16:00 | Plymouth Argyle - Shrewsbury Town | 1:0 |
| 12.02.2022 | 16:00 | Portsmouth - Doncaster Rovers | 4:0 |
| 12.02.2022 | 16:00 | Wigan Athletic - Charlton Athletic | 2:1 |
| 13.02.2022 | 13:00 | Sheffield Wednesday - Rotherham United | 0:2 |
| 18.02.2022 | 20:45 | Rotherham United - Wigan Athletic | 1:1 |
| 19.02.2022 | 16:00 | Bolton Wanderers - AFC Wimbledon | 4:0 |
| 19.02.2022 | 16:00 | Cambridge United - Accrington Stanley | 2:0 |
| 19.02.2022 | 16:00 | Charlton Athletic - Oxford United | 0:4 |
| 19.02.2022 | 16:00 | Doncaster Rovers - Sheffield Wednesday | 1:3 |
| 19.02.2022 | 16:00 | Gillingham - Plymouth Argyle | 0:2 |
| 19.02.2022 | 16:00 | Ipswich Town - Burton Albion | 3:0 |
| 19.02.2022 | 16:00 | Sunderland - Milton Keynes Dons | 1:2 |
| 19.02.2022 | 16:00 | Wycombe Wanderers - Cheltenham Town | 5:5 |
| 08.03.2022 | 20:45 | Crewe Alexandra - Portsmouth | 1:3 |
| 15.03.2022 | 20:45 | Shrewsbury Town - Morecambe | 5:0 |
| 05.04.2022 | 20:45 | Fleetwood Town - Lincoln City | 1:1 |
| 22.02.2022 | 20:45 | Cambridge United - Plymouth Argyle | 2:0 |
| 22.02.2022 | 20:45 | Charlton Athletic - Milton Keynes Dons | 0:2 |
| 22.02.2022 | 20:45 | Crewe Alexandra - Oxford United | 0:1 |
| 22.02.2022 | 20:45 | Doncaster Rovers - Accrington Stanley | 2:0 |
| 22.02.2022 | 20:45 | Gillingham - AFC Wimbledon | 0:0 |
| 22.02.2022 | 20:45 | Ipswich Town - Cheltenham Town | 0:0 |
| 22.02.2022 | 20:45 | Rotherham United - Morecambe | 2:0 |
| 22.02.2022 | 20:45 | Shrewsbury Town - Portsmouth | 1:2 |
| 22.02.2022 | 20:45 | Sunderland - Burton Albion | 1:1 |
| 22.02.2022 | 20:45 | Wycombe Wanderers - Wigan Athletic | 1:3 |
| 22.02.2022 | 21:00 | Bolton Wanderers - Lincoln City | 3:1 |
| 26.04.2022 | 20:45 | Fleetwood Town - Sheffield Wednesday | 2:3 |
| 26.02.2022 | 16:00 | AFC Wimbledon - Doncaster Rovers | 2:2 |
| 26.02.2022 | 16:00 | Accrington Stanley - Wycombe Wanderers | 3:2 |
| 26.02.2022 | 16:00 | Burton Albion - Shrewsbury Town | 0:2 |
| 26.02.2022 | 16:00 | Cheltenham Town - Crewe Alexandra | 1:2 |
| 26.02.2022 | 16:00 | Lincoln City - Gillingham | 0:2 |
| 26.02.2022 | 16:00 | Milton Keynes Dons - Bolton Wanderers | 2:0 |
| 26.02.2022 | 16:00 | Morecambe - Ipswich Town | 1:1 |
| 26.02.2022 | 16:00 | Oxford United - Cambridge United | 4:2 |
| 26.02.2022 | 16:00 | Plymouth Argyle - Rotherham United | 0:1 |
| 26.02.2022 | 16:00 | Portsmouth - Fleetwood Town | 3:3 |
| 26.02.2022 | 16:00 | Sheffield Wednesday - Charlton Athletic | 2:0 |
| 26.02.2022 | 16:00 | Wigan Athletic - Sunderland | 0:3 |
| 05.03.2022 | 16:00 | Cambridge United - Shrewsbury Town | 0:0 |
| 05.03.2022 | 16:00 | Charlton Athletic - Sunderland | 0:0 |
| 05.03.2022 | 16:00 | Cheltenham Town - Doncaster Rovers | 4:0 |
| 05.03.2022 | 16:00 | Crewe Alexandra - Wycombe Wanderers | 1:3 |
| 05.03.2022 | 16:00 | Fleetwood Town - Ipswich Town | 0:2 |
| 05.03.2022 | 16:00 | Gillingham - Bolton Wanderers | 0:3 |
| 05.03.2022 | 16:00 | Lincoln City - Sheffield Wednesday | 3:1 |
| 05.03.2022 | 16:00 | Oxford United - Burton Albion | 4:1 |
| 05.03.2022 | 16:00 | Plymouth Argyle - Morecambe | 2:0 |
| 05.03.2022 | 16:00 | Portsmouth - Accrington Stanley | 4:0 |
| 05.03.2022 | 16:00 | Rotherham United - Milton Keynes Dons | 1:2 |
| 05.03.2022 | 16:00 | Wigan Athletic - AFC Wimbledon | 1:0 |
| 12.03.2022 | 16:00 | AFC Wimbledon - Lincoln City | 0:2 |
| 12.03.2022 | 16:00 | Accrington Stanley - Charlton Athletic | 2:1 |
| 12.03.2022 | 16:00 | Bolton Wanderers - Plymouth Argyle | 0:1 |
| 12.03.2022 | 16:00 | Burton Albion - Fleetwood Town | 3:2 |
| 12.03.2022 | 16:00 | Doncaster Rovers - Gillingham | 0:1 |
| 12.03.2022 | 16:00 | Ipswich Town - Portsmouth | 0:0 |
| 12.03.2022 | 16:00 | Milton Keynes Dons - Wigan Athletic | 1:1 |
| 12.03.2022 | 16:00 | Morecambe - Cheltenham Town | 1:3 |
| 12.03.2022 | 16:00 | Sheffield Wednesday - Cambridge United | 6:0 |
| 12.03.2022 | 16:00 | Shrewsbury Town - Oxford United | 1:2 |
| 12.03.2022 | 16:00 | Sunderland - Crewe Alexandra | 2:0 |
| 12.03.2022 | 16:00 | Wycombe Wanderers - Rotherham United | 0:0 |
| 15.03.2022 | 20:45 | Wycombe Wanderers - Fleetwood Town | 1:0 |
| 26.03.2022 | 16:00 | AFC Wimbledon - Cambridge United | 0:1 |
| 26.03.2022 | 16:00 | Accrington Stanley - Gillingham | 1:2 |
| 26.03.2022 | 16:00 | Doncaster Rovers - Charlton Athletic | 0:1 |
| 26.03.2022 | 16:00 | Ipswich Town - Plymouth Argyle | 1:0 |
| 26.03.2022 | 16:00 | Sheffield Wednesday - Cheltenham Town | 4:1 |
| 26.03.2022 | 16:00 | Shrewsbury Town - Lincoln City | 1:0 |
| 05.04.2022 | 20:45 | Milton Keynes Dons - Crewe Alexandra | 2:1 |
| 05.04.2022 | 20:45 | Morecambe - Oxford United | 2:1 |
| 05.04.2022 | 21:00 | Bolton Wanderers - Portsmouth | 1:1 |
| 12.04.2022 | 20:45 | Burton Albion - Wigan Athletic | 0:0 |
| 26.04.2022 | 20:45 | Sunderland - Rotherham United | 1:1 |
| 19.03.2022 | 16:00 | Cambridge United - Milton Keynes Dons | 0:1 |
| 19.03.2022 | 16:00 | Charlton Athletic - Burton Albion | 2:0 |
| 19.03.2022 | 16:00 | Cheltenham Town - AFC Wimbledon | 3:1 |
| 19.03.2022 | 16:00 | Crewe Alexandra - Bolton Wanderers | 0:1 |
| 19.03.2022 | 16:00 | Fleetwood Town - Doncaster Rovers | 0:0 |
| 19.03.2022 | 16:00 | Gillingham - Sheffield Wednesday | 0:0 |
| 19.03.2022 | 16:00 | Lincoln City - Sunderland | 0:0 |
| 19.03.2022 | 16:00 | Oxford United - Ipswich Town | 1:1 |
| 19.03.2022 | 16:00 | Plymouth Argyle - Accrington Stanley | 4:0 |
| 19.03.2022 | 16:00 | Portsmouth - Wycombe Wanderers | 0:0 |
| 19.03.2022 | 16:00 | Rotherham United - Shrewsbury Town | 0:3 |
| 19.03.2022 | 16:00 | Wigan Athletic - Morecambe | 4:1 |
| 02.04.2022 | 13:30 | Wigan Athletic - Bolton Wanderers | 1:1 |
| 02.04.2022 | 16:00 | Accrington Stanley - Cheltenham Town | 4:4 |
| 02.04.2022 | 16:00 | Charlton Athletic - Lincoln City | 1:2 |
| 02.04.2022 | 16:00 | Crewe Alexandra - Fleetwood Town | 1:3 |
| 02.04.2022 | 16:00 | Ipswich Town - Cambridge United | 0:1 |
| 02.04.2022 | 16:00 | Milton Keynes Dons - Shrewsbury Town | 2:0 |
| 02.04.2022 | 16:00 | Morecambe - Burton Albion | 3:0 |
| 02.04.2022 | 16:00 | Plymouth Argyle - Oxford United | 1:0 |
| 02.04.2022 | 16:00 | Sheffield Wednesday - AFC Wimbledon | 2:1 |
| 02.04.2022 | 16:00 | Sunderland - Gillingham | 1:0 |
| 02.04.2022 | 16:00 | Wycombe Wanderers - Doncaster Rovers | 2:0 |
| 12.04.2022 | 20:45 | Portsmouth - Rotherham United | 3:0 |
| 09.04.2022 | 16:00 | AFC Wimbledon - Milton Keynes Dons | 1:1 |
| 09.04.2022 | 16:00 | Bolton Wanderers - Sheffield Wednesday | 1:1 |
| 09.04.2022 | 16:00 | Burton Albion - Plymouth Argyle | 0:0 |
| 09.04.2022 | 16:00 | Cambridge United - Morecambe | 2:1 |
| 09.04.2022 | 16:00 | Cheltenham Town - Portsmouth | 1:0 |
| 09.04.2022 | 16:00 | Doncaster Rovers - Crewe Alexandra | 2:0 |
| 09.04.2022 | 16:00 | Fleetwood Town - Accrington Stanley | 1:2 |
| 09.04.2022 | 16:00 | Gillingham - Wycombe Wanderers | 1:1 |
| 09.04.2022 | 16:00 | Lincoln City - Wigan Athletic | 1:3 |
| 09.04.2022 | 16:00 | Oxford United - Sunderland | 1:2 |
| 09.04.2022 | 16:00 | Rotherham United - Charlton Athletic | 0:1 |
| 09.04.2022 | 16:00 | Shrewsbury Town - Ipswich Town | 1:1 |
| 15.04.2022 | 16:00 | Accrington Stanley - Burton Albion | 0:0 |
| 15.04.2022 | 16:00 | Charlton Athletic - Morecambe | 2:3 |
| 15.04.2022 | 16:00 | Cheltenham Town - Gillingham | 2:2 |
| 15.04.2022 | 16:00 | Crewe Alexandra - AFC Wimbledon | 3:1 |
| 15.04.2022 | 16:00 | Doncaster Rovers - Bolton Wanderers | 1:2 |
| 15.04.2022 | 16:00 | Fleetwood Town - Oxford United | 2:3 |
| 15.04.2022 | 16:00 | Portsmouth - Lincoln City | 3:2 |
| 15.04.2022 | 16:00 | Sunderland - Shrewsbury Town | 3:2 |
| 15.04.2022 | 16:00 | Wycombe Wanderers - Plymouth Argyle | 2:0 |
| 16.04.2022 | 13:30 | Rotherham United - Ipswich Town | 1:0 |
| 16.04.2022 | 18:15 | Wigan Athletic - Cambridge United | 1:2 |
| 16.04.2022 | 20:45 | Milton Keynes Dons - Sheffield Wednesday | 2:3 |
| 18.04.2022 | 16:00 | AFC Wimbledon - Wycombe Wanderers | 1:1 |
| 18.04.2022 | 16:00 | Bolton Wanderers - Accrington Stanley | 3:1 |
| 18.04.2022 | 16:00 | Gillingham - Fleetwood Town | 0:0 |
| 18.04.2022 | 16:00 | Lincoln City - Cheltenham Town | 3:0 |
| 18.04.2022 | 16:00 | Morecambe - Portsmouth | 1:1 |
| 18.04.2022 | 16:00 | Plymouth Argyle - Sunderland | 0:0 |
| 18.04.2022 | 16:00 | Shrewsbury Town - Doncaster Rovers | 3:3 |
| 19.04.2022 | 20:45 | Burton Albion - Rotherham United | 2:0 |
| 19.04.2022 | 20:45 | Cambridge United - Charlton Athletic | 0:2 |
| 19.04.2022 | 20:45 | Ipswich Town - Wigan Athletic | 2:2 |
| 19.04.2022 | 20:45 | Oxford United - Milton Keynes Dons | 1:0 |
| 19.04.2022 | 20:45 | Sheffield Wednesday - Crewe Alexandra | 1:0 |
| 23.04.2022 | 16:00 | Accrington Stanley - Lincoln City | 2:1 |
| 23.04.2022 | 16:00 | Charlton Athletic - Shrewsbury Town | 2:0 |
| 23.04.2022 | 16:00 | Cheltenham Town - Bolton Wanderers | 1:2 |
| 23.04.2022 | 16:00 | Crewe Alexandra - Ipswich Town | 1:1 |
| 23.04.2022 | 16:00 | Doncaster Rovers - Burton Albion | 2:0 |
| 23.04.2022 | 16:00 | Fleetwood Town - AFC Wimbledon | 1:1 |
| 23.04.2022 | 16:00 | Milton Keynes Dons - Morecambe | 2:0 |
| 23.04.2022 | 16:00 | Portsmouth - Gillingham | 3:1 |
| 23.04.2022 | 16:00 | Rotherham United - Oxford United | 2:1 |
| 23.04.2022 | 16:00 | Sunderland - Cambridge United | 5:1 |
| 23.04.2022 | 16:00 | Wigan Athletic - Plymouth Argyle | 1:1 |
| 23.04.2022 | 16:00 | Wycombe Wanderers - Sheffield Wednesday | 1:0 |
| 30.04.2022 | 13:30 | AFC Wimbledon - Accrington Stanley | 3:4 |
| 30.04.2022 | 13:30 | Bolton Wanderers - Fleetwood Town | 4:2 |
| 30.04.2022 | 13:30 | Burton Albion - Wycombe Wanderers | 1:2 |
| 30.04.2022 | 13:30 | Cambridge United - Cheltenham Town | 2:2 |
| 30.04.2022 | 13:30 | Gillingham - Rotherham United | 0:2 |
| 30.04.2022 | 13:30 | Lincoln City - Crewe Alexandra | 2:1 |
| 30.04.2022 | 13:30 | Morecambe - Sunderland | 0:1 |
| 30.04.2022 | 13:30 | Oxford United - Doncaster Rovers | 1:1 |
| 30.04.2022 | 13:30 | Plymouth Argyle - Milton Keynes Dons | 0:5 |
| 30.04.2022 | 13:30 | Sheffield Wednesday - Portsmouth | 4:1 |
| 30.04.2022 | 13:30 | Shrewsbury Town - Wigan Athletic | 0:3 |
| 30.04.2022 | 14:30 | Ipswich Town - Charlton Athletic | 4:0 |
| 05.05.2022 | 20:45 | Wycombe Wanderers - Milton Keynes Dons | 2:0 |
| 06.05.2022 | 20:45 | Sunderland - Sheffield Wednesday | 1:0 |
| 08.05.2022 | 19:30 | Milton Keynes Dons - Wycombe Wanderers | 1:0 |
| 09.05.2022 | 20:45 | Sheffield Wednesday - Sunderland | 1:1 |
| 21.05.2022 | 16:00 | Sunderland - Wycombe Wanderers | 2:0 |